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ADNI_126_S_4507_MR_Accelerated_Sag_IR-FSPGR___br_raw_20140114155416501_56_S210193_I404763	On a T1-weighted brain MRI we observed: For the subcortical structures: - no clear atrophic alterations are visible in the caudate - accumbens appears within normal limits without apparent atrophy - no observable atrophic changes in the amygdala - no evident atrophy or tissue thinning seen in the thalamus - pallidum maintains a normal appearance with no observable atrophic features - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - putamen maintains a normal appearance with no observable atrophic features For the ventricles: - no appreciable enlargement noted in the external csf - mild bilateral enlargement of the lateral ventricle - no findings suggestive of enlargement are seen in the 3rd ventricle - mild-to-moderate bilateral enlargement of the inf. lateral ventricle - 4th ventricle maintains a typical volume without observable enlargement For the cerebral cortex: - insular cortex demonstrates a healthy morphology without signs of atrophy - occipital lobe maintains a normal appearance with no observable atrophic features - parietal lobe appears within normal limits without apparent atrophy - no observable atrophic changes in the temporal lobe - no observable atrophic changes in the frontal lobe - limbic cortex maintains a normal appearance with no observable atrophic features	AD	We have the following subject's personal information: - The subject is a male of 80.1 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 25. In his MMSE test, he has an orientation to time score of 4. In his MMSE test, he has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - The subject has a Boston Naming Test (BNT) total score of 28. - On the semantic categorical fluency test, the subject named 15 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 1. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine. The subject has difficulity, but does by himself, for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for preparing a balanced meal, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject requires assitance for shopping alone for clothes, household necessities, or groceries, for remembering appointments, family occasions, holidays, medications. - On the Trail Making Test Part A, his total number of seconds to complete is 48. On the Trail Making Test Part B, his total number of seconds to complete is 242. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 2.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_116_S_4483_MR_MPRAGE_br_raw_20120125125758694_69_S138478_I280672	On a T1-weighted brain MRI we observed: For the subcortical structures: - accumbens appears within normal limits without apparent atrophy - hippocampus maintains a normal appearance with no observable atrophic features - no evident atrophy or tissue thinning seen in the putamen - caudate appears preserved, with no observable tissue loss - amygdala appears within normal limits without apparent atrophy - thalamus appears within normal limits without apparent atrophy - the pallidum shows no notable changes suggestive of atrophy For the ventricles: - no clear enlargement or abnormal growth seen in the 4th ventricle - 3rd ventricle maintains a typical volume without observable enlargement - external csf appears within normal size limits with no apparent enlargement - inf. lateral ventricle appears within normal size limits with no apparent enlargement - no observable enlargement of the lateral ventricle For the cerebral cortex: - frontal lobe demonstrates a healthy morphology without signs of atrophy - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: parahippocampal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) - parietal lobe appears preserved, with no observable tissue loss - insular cortex demonstrates a healthy morphology without signs of atrophy - occipital lobe appears within normal limits without apparent atrophy - temporal lobe appears within normal limits without apparent atrophy	CN	We have the following subject's personal information: - The subject is a female of 69.6 years old. - Subject's current marrietal status is: married. - She has 15.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 17. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
NIFD_1_S_0003_MR_t1_mprage_S3_DIS3D_br_raw_20110414102634247_37_S104274_I227698	On a T1-weighted brain MRI we observed: For the cerebral cortex: - atrophy of the temporal lobe with marked asymmetry (moderate left, severe right); focal volume loss observed in the following subregions: temporal pole (mild-to-moderate atrophy on the left and moderate atrophy on the right), inf. temporal gyrus (mild atrophy on the left and moderate atrophy on the right), fusiform gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), middle temporal gyrus (normal on the left and moderate atrophy on the right), planum polare (normal on the left and mild-to-moderate atrophy on the right) and sup. temporal gyrus (normal on the left and mild atrophy on the right) - mild-to-moderate bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: anterior insula (mild-to-moderate atrophy on the left and moderate atrophy on the right), posterior insula (mild-to-moderate atrophy on the left and moderate atrophy on the right) and frontal operculum (mild atrophy on the left and normal-to-mild atrophy on the right) - frontal lobe appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the occipital lobe - mild-to-moderate bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: entorhinal area (mild-to-moderate atrophy both left and right), anterior cingulate gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right) and parahippocampal gyrus (mild atrophy both left and right) - no appreciable degenerative or atrophic changes observed in the parietal lobe For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - mild-to-moderate enlargement of the external csf - mild-to-moderate enlargement of the 3rd ventricle - moderate bilateral enlargement of the lateral ventricle - no clear enlargement or abnormal growth seen in the 4th ventricle For the subcortical structures: - severe bilateral atrophy of the amygdala - atrophy of the caudate with marked asymmetry (normal left, mild-to-moderate right) - atrophy of the putamen with marked asymmetry (normal left, mild-to-moderate right) - mild bilateral atrophy of the thalamus - mild-to-moderate atrophy of the right pallidum; the left pallidum is normal - mild atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus - atrophy of the accumbens with marked asymmetry (mild left, moderate right)	SV	We have the following subject's personal information: - The subject is a male of 66.0 years old. - He has 12.0 years of education (equivalent to high school or GRE) We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 3. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal. The subject has difficulity, but does by himself, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine. The subject requires assitance for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in agitation or aggression, irritability or lability, a moderate (significant, but not dramatic) change in anxiety, apathy or indifference, a mild (noticeable, but not significant) change in elation or euphoria. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 5.0. --- ## 📋 Detailed Domain Scores * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
ADNI_127_S_5228_MR_Accelerated_Sag_IR-FSPGR_br_raw_20130624154135623_65_S193156_I377858	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no evident atrophy or tissue thinning seen in the frontal lobe - no clear atrophic alterations are visible in the temporal lobe - insular cortex demonstrates a healthy morphology without signs of atrophy - occipital lobe maintains a normal appearance with no observable atrophic features - limbic cortex demonstrates a healthy morphology without signs of atrophy - no evident atrophy or tissue thinning seen in the parietal lobe For the subcortical structures: - no observable atrophic changes in the pallidum - no appreciable degenerative or atrophic changes observed in the thalamus - hippocampus appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the caudate - the accumbens shows no notable changes suggestive of atrophy - amygdala appears preserved, with no observable tissue loss - putamen maintains a normal appearance with no observable atrophic features For the ventricles: - lateral ventricle maintains a typical volume without observable enlargement - no evident size increase noted in the 3rd ventricle - 4th ventricle maintains its expected proportions without signs of enlargement - no findings suggestive of enlargement are seen in the external csf - the inf. lateral ventricle shows no notable changes suggestive of enlargement	CN	We have the following subject's personal information: - The subject is a female of 77.9 years old. - Subject's current marrietal status is: married. - She has 15.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 27. In her MMSE test, she has an orientation to time score of 4. In her MMSE test, she has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 13. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_016_S_6708_MR_Accelerated_Sagittal_MPRAGE__br_raw_20190404142449518_88_S812850_I1151022	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild bilateral atrophy of the caudate - mild bilateral atrophy of the amygdala - pallidum appears preserved, with no observable tissue loss - putamen appears preserved, with no observable tissue loss - thalamus appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the accumbens - hippocampus appears within normal limits without apparent atrophy For the cerebral cortex: - no clear atrophic alterations are visible in the limbic cortex - mild bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: precentral gyrus (normal on the left and mild atrophy on the right) and opercular inf. frontal gyrus (mild atrophy on the left) - the insular cortex shows no notable changes suggestive of atrophy - occipital lobe demonstrates a healthy morphology without signs of atrophy - parietal lobe appears within normal limits without apparent atrophy - mild-to-moderate bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: fusiform gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), planum temporale (mild atrophy on the left and normal on the right) and sup. temporal gyrus (mild atrophy on the left and normal on the right) For the ventricles: - mild enlargement of the 4th ventricle - mild-to-moderate bilateral enlargement of the inf. lateral ventricle - mild-to-moderate enlargement of the external csf - no observable enlargement of the lateral ventricle - no clear enlargement or abnormal growth seen in the 3rd ventricle	AD	We have the following subject's personal information: - The subject is a male of 56.0 years old. - Subject's current marrietal status is: married. - He has 14.0 years of education - The subject is left-handed We have the following subject's family history information: - His mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 27. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 1. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 2.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e4,e4 with 2 copies of e4 allele.
FTLD_203813234_02431_MR_Sagittal_MP-Rage_br_raw_20230209101907239_I10183427	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no appreciable degenerative or atrophic changes observed in the limbic cortex - no evident atrophy or tissue thinning seen in the frontal lobe - no observable atrophic changes in the occipital lobe - mild bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: frontal operculum (mild atrophy on the left and normal on the right) - parietal lobe demonstrates a healthy morphology without signs of atrophy - temporal lobe demonstrates a healthy morphology without signs of atrophy For the subcortical structures: - moderate bilateral atrophy of the pallidum - atrophy of the thalamus with marked asymmetry (moderate left, mild-to-moderate right) - atrophy of the accumbens with marked asymmetry (severe left, mild right) - moderate bilateral atrophy of the putamen - atrophy of the caudate with marked asymmetry (moderate left, normal-to-mild right) - mild bilateral atrophy of the amygdala - mild atrophy of the left hippocampus (marked asymmetry favoring the left) For the ventricles: - mild enlargement of the 4th ventricle - mild enlargement of the external csf - severe bilateral enlargement of the inf. lateral ventricle - severe bilateral enlargement of the lateral ventricle - severe enlargement of the 3rd ventricle	BV	We have the following subject's personal information: - The subject is a male of 55.0 years old. - He has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 16. - On the semantic categorical fluency test, the subject named 3 animals in 60 seconds. He named 2 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 0. - On the Number Span forward test, his longest span forward was 5. On the Number Span backward test, his longest span backward was 0. - On the Trail Making Test Part A, his total number of seconds to complete is 150, his number of commission errors is 0, his number of correct lines is 21. On the Trail Making Test Part B, his total number of seconds to complete is 300, his number of commission errors is 2, his number of correct lines is 4. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in irritability or lability, appetite and eating, a mild (noticeable, but not significant) change in delusions, anxiety, motor disturbance. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 2.0, corresponding to moderate impairment. His standard CDR Sum of Boxes score is 8.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 2.0 (moderate impairment). Description: Severely impaired in handling problems, similarities, and differences; social judgment usually impaired. * Community affairs: Score 2.0 (moderate impairment). Description: No pretense of independent function outside the home; appears well enough to be taken to functions outside the family home. * Home and hobbies: Score 2.0 (moderate impairment). Description: Only simple chores preserved; very restricted interests, poorly maintained. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
ADNI_301_S_10139_MR_Accelerated_Sagittal_MPRAGE_MSV21_br_raw_20240617183514870_1_I10666918	On a T1-weighted brain MRI we observed: For the cerebral cortex: - insular cortex demonstrates a healthy morphology without signs of atrophy - temporal lobe appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the limbic cortex - no clear atrophic alterations are visible in the frontal lobe - mild bilateral atrophy of the occipital lobe; focal volume loss observed in the following subregions: middle occipital gyrus (mild-to-moderate atrophy on the left and normal on the right) and inf. occipital gyrus (normal on the left and mild atrophy on the right) - the parietal lobe shows no notable changes suggestive of atrophy For the subcortical structures: - no evident atrophy or tissue thinning seen in the hippocampus - no findings suggestive of atrophy are seen in the putamen - thalamus appears within normal limits without apparent atrophy - accumbens demonstrates a healthy morphology without signs of atrophy - pallidum appears within normal limits without apparent atrophy - no findings suggestive of atrophy are seen in the amygdala - no evident atrophy or tissue thinning seen in the caudate For the ventricles: - 4th ventricle maintains its expected proportions without signs of enlargement - no appreciable enlargement noted in the 3rd ventricle - the inf. lateral ventricle shows no notable changes suggestive of enlargement - no observable enlargement of the lateral ventricle - external csf maintains a typical volume without observable enlargement	CN	We have the following subject's personal information: - The subject is a female of 59.7 years old. - Subject's current marrietal status is: married. - She has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following subject's family history information: - Her mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 18. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_130_S_6043_MR_Sagittal_3D_Accelerated_MPRAGE_br_raw_20200805115511270_99_S581424_I871899	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no findings suggestive of atrophy are seen in the insular cortex - no evident atrophy or tissue thinning seen in the parietal lobe - frontal lobe maintains a normal appearance with no observable atrophic features - no appreciable degenerative or atrophic changes observed in the limbic cortex - no appreciable degenerative or atrophic changes observed in the occipital lobe - temporal lobe demonstrates a healthy morphology without signs of atrophy For the subcortical structures: - thalamus maintains a normal appearance with no observable atrophic features - amygdala appears within normal limits without apparent atrophy - mild bilateral atrophy of the accumbens - mild bilateral atrophy of the caudate - mild bilateral atrophy of the pallidum - mild bilateral atrophy of the putamen - no observable atrophic changes in the hippocampus For the ventricles: - moderate bilateral enlargement of the inf. lateral ventricle - external csf appears to be of normal dimensions, with no observable increase in size - mild bilateral enlargement of the lateral ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - mild enlargement of the 3rd ventricle	CN	We have the following subject's personal information: - The subject is a male of 78.9 years old. - Subject's current marrietal status is: married. - He has 20.0 years of education (equivalent to doctorate) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 14. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_006_S_5153_MR_MPRAGE_br_raw_20130422151103640_137_S187543_I368152	On a T1-weighted brain MRI we observed: For the ventricles: - no findings suggestive of enlargement are seen in the 4th ventricle - lateral ventricle appears to be of normal dimensions, with no observable increase in size - external csf maintains a typical volume without observable enlargement - no evident size increase noted in the inf. lateral ventricle - no findings suggestive of enlargement are seen in the 3rd ventricle For the cerebral cortex: - no findings suggestive of atrophy are seen in the temporal lobe - parietal lobe maintains a normal appearance with no observable atrophic features - occipital lobe appears within normal limits without apparent atrophy - no findings suggestive of atrophy are seen in the limbic cortex - insular cortex demonstrates a healthy morphology without signs of atrophy - no clear atrophic alterations are visible in the frontal lobe For the subcortical structures: - amygdala appears preserved, with no observable tissue loss - pallidum appears within normal limits without apparent atrophy - putamen maintains a normal appearance with no observable atrophic features - thalamus maintains a normal appearance with no observable atrophic features - the caudate shows no notable changes suggestive of atrophy - hippocampus appears within normal limits without apparent atrophy - no observable atrophic changes in the accumbens	CN	We have the following subject's personal information: - The subject is a male of 79.0 years old. - Subject's current marrietal status is: married. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 3. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 14. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_024_S_6005_MR_Accelerated_Sagittal_MPRAGE__br_raw_20170313165704125_136_S544988_I828694	On a T1-weighted brain MRI we observed: For the cerebral cortex: - limbic cortex demonstrates a healthy morphology without signs of atrophy - frontal lobe maintains a normal appearance with no observable atrophic features - no appreciable degenerative or atrophic changes observed in the parietal lobe - mild bilateral atrophy of the occipital lobe; focal volume loss observed in the following subregions: calcarine cortex (mild atrophy both left and right) and sup. occipital gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) - no observable atrophic changes in the temporal lobe - no observable atrophic changes in the insular cortex For the subcortical structures: - no clear atrophic alterations are visible in the amygdala - no clear atrophic alterations are visible in the hippocampus - mild-to-moderate bilateral atrophy of the putamen - mild bilateral atrophy of the caudate - no findings suggestive of atrophy are seen in the accumbens - thalamus demonstrates a healthy morphology without signs of atrophy - pallidum appears preserved, with no observable tissue loss For the ventricles: - lateral ventricle maintains its expected proportions without signs of enlargement - mild enlargement of the external csf - no evident size increase noted in the 3rd ventricle - inf. lateral ventricle maintains its expected proportions without signs of enlargement - no observable enlargement of the 4th ventricle	CN	We have the following subject's personal information: - The subject is a female of 67.5 years old. We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 20 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, her total number of seconds to complete is 22. On the Trail Making Test Part B, her total number of seconds to complete is 52. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_036_S_6916_MR_Accelerated_Sagittal_MPRAGE_MSV21_br_raw_20250306201357951_1_I11142064	On a T1-weighted brain MRI we observed: For the subcortical structures: - no appreciable degenerative or atrophic changes observed in the thalamus - pallidum maintains a normal appearance with no observable atrophic features - mild bilateral atrophy of the accumbens - moderate bilateral atrophy of the amygdala - putamen appears within normal limits without apparent atrophy - caudate appears preserved, with no observable tissue loss - moderate atrophy of the left hippocampus, moderate atrophy of the right hippocampus For the ventricles: - external csf maintains a typical volume without observable enlargement - severe bilateral enlargement of the lateral ventricle - severe bilateral enlargement of the inf. lateral ventricle - the 4th ventricle shows no notable changes suggestive of enlargement - mild enlargement of the 3rd ventricle For the cerebral cortex: - mild bilateral atrophy of the parietal lobe; focal volume loss observed in the following subregions: angular gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), postcentral gyrus (mild atrophy on the left and normal on the right) and supramarginal gyrus (mild atrophy on the left) - mild-to-moderate bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: inf. temporal gyrus (mild atrophy both left and right) and temporal pole (mild atrophy on the left and normal-to-mild atrophy on the right) - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: entorhinal area (normal-to-mild atrophy on the left and mild atrophy on the right), anterior cingulate gyrus (normal on the left and mild atrophy on the right), middle cingulate gyrus (mild atrophy on the left and normal on the right) and posterior cingulate gyrus (mild atrophy on the left and normal on the right) - mild bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: medial orbital gyrus (mild atrophy both left and right), precentral gyrus medial segment (mild atrophy on the left and normal-to-mild atrophy on the right), gyrus rectus (normal on the left and mild atrophy on the right), medial frontal cortex (normal on the left and mild atrophy on the right), precentral gyrus (mild atrophy on the left and normal on the right) and sup. frontal gyrus (normal on the left and mild atrophy on the right) - mild-to-moderate bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: posterior insula (mild atrophy both left and right) and anterior insula (mild atrophy on the left and normal-to-mild atrophy on the right) - occipital lobe appears preserved, with no observable tissue loss	AD	We have the following subject's personal information: - The subject is a male of 80.5 years old. - Subject's current marrietal status is: married. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following subject's family history information: - His mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 22. In his MMSE test, he has an orientation to time score of 0. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - The subject has a 32-item Multilingual Naming Test (MINT) total score of 0. - On the semantic categorical fluency test, the subject named 12 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 0. - On the Functional Activities Questionnaire (FAQ), the subject has difficulity, but does by himself, for heating water, making a cup of coffee, turning off the stove. The subject requires assitance for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine. The subject is dependent for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for preparing a balanced meal, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 68. On the Trail Making Test Part B, his total number of seconds to complete is 164. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. His standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
FTLD_203494939_02939_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10178263	On a T1-weighted brain MRI we observed: For the cerebral cortex: - mild bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: middle temporal gyrus (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right) and temporal pole (mild atrophy on the left and normal-to-mild atrophy on the right) - the occipital lobe shows no notable changes suggestive of atrophy - no evident atrophy or tissue thinning seen in the parietal lobe - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild-to-moderate atrophy both left and right) - mild-to-moderate bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: anterior insula (moderate atrophy both left and right), frontal operculum (mild atrophy both left and right) and posterior insula (mild atrophy on the left and normal on the right) - atrophy of the frontal lobe with marked asymmetry (mild left, moderate right); focal volume loss observed in the following subregions: gyrus rectus (moderate atrophy both left and right), frontal pole (mild atrophy on the left and mild-to-moderate atrophy on the right), medial frontal cortex (mild atrophy on the left and mild-to-moderate atrophy on the right), medial orbital gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), posterior orbital gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), anterior orbital gyrus (mild atrophy both left and right), lateral orbital gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), sup. frontal gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), opercular inf. frontal gyrus (normal on the left and mild atrophy on the right), middle frontal gyrus (normal on the left and mild atrophy on the right), sup. frontal gyrus medial segment (normal on the left and mild atrophy on the right), orbital inf. frontal gyrus (normal on the left and mild atrophy on the right) and triangular inf. frontal gyrus (mild atrophy on the right) For the subcortical structures: - no appreciable degenerative or atrophic changes observed in the pallidum - caudate appears within normal limits without apparent atrophy - mild bilateral atrophy of the accumbens - mild bilateral atrophy of the putamen - no findings suggestive of atrophy are seen in the thalamus - mild-to-moderate bilateral atrophy of the amygdala - no observable atrophic changes in the hippocampus For the ventricles: - no clear enlargement or abnormal growth seen in the 3rd ventricle - inf. lateral ventricle maintains its expected proportions without signs of enlargement - moderate enlargement of the external csf - no findings suggestive of enlargement are seen in the lateral ventricle - no appreciable enlargement noted in the 4th ventricle	BV	We have the following subject's personal information: - The subject is a female of 59.0 years old. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 27. - On the semantic categorical fluency test, the subject named 9 animals in 60 seconds. She named 9 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 6. - On the Number Span forward test, her longest span forward was 5. On the Number Span backward test, her longest span backward was 4. - On the Trail Making Test Part A, her total number of seconds to complete is 45, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 300, her number of commission errors is 18, her number of correct lines is 1. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in agitation or aggression, irritability or lability, nighttime behaviors, a moderate (significant, but not dramatic) change in delusions, anxiety, elation or euphoria, apathy or indifference, appetite and eating, a mild (noticeable, but not significant) change in motor disturbance. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_035_S_6730_MR_Accelerated_Sagittal_MPRAGE__br_raw_20190618111229546_35_S833186_I1176653	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no clear atrophic alterations are visible in the temporal lobe - no findings suggestive of atrophy are seen in the limbic cortex - frontal lobe maintains a normal appearance with no observable atrophic features - occipital lobe demonstrates a healthy morphology without signs of atrophy - no clear atrophic alterations are visible in the insular cortex - mild bilateral atrophy of the parietal lobe; focal volume loss observed in the following subregions: postcentral gyrus (mild atrophy both left and right), precuneus (normal-to-mild atrophy on the left and mild atrophy on the right) and supramarginal gyrus (normal on the left and mild atrophy on the right) For the subcortical structures: - mild bilateral atrophy of the amygdala - thalamus appears within normal limits without apparent atrophy - hippocampus demonstrates a healthy morphology without signs of atrophy - no evident atrophy or tissue thinning seen in the accumbens - caudate appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the putamen - no clear atrophic alterations are visible in the pallidum For the ventricles: - no observable enlargement of the inf. lateral ventricle - no clear enlargement or abnormal growth seen in the 4th ventricle - no evident size increase noted in the 3rd ventricle - mild enlargement of the external csf - the lateral ventricle shows no notable changes suggestive of enlargement	CN	We have the following subject's personal information: - The subject is a male of 74.0 years old. We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 25 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 40. On the Trail Making Test Part B, his total number of seconds to complete is 81. From genetic data, APOE genotype is e3,e2 with no e4 allele.
ADNI_129_S_6704_MR_Accelerated_Sag_IR-FSPGR___br_raw_20190401061925402_196_S811320_I1149034	On a T1-weighted brain MRI we observed: For the ventricles: - 3rd ventricle appears to be of normal dimensions, with no observable increase in size - inf. lateral ventricle maintains a typical volume without observable enlargement - no observable enlargement of the external csf - no evident size increase noted in the 4th ventricle - no evident size increase noted in the lateral ventricle For the subcortical structures: - no evident atrophy or tissue thinning seen in the amygdala - no appreciable degenerative or atrophic changes observed in the thalamus - accumbens appears within normal limits without apparent atrophy - the putamen shows no notable changes suggestive of atrophy - caudate demonstrates a healthy morphology without signs of atrophy - pallidum appears within normal limits without apparent atrophy - no observable atrophic changes in the hippocampus For the cerebral cortex: - no observable atrophic changes in the temporal lobe - the frontal lobe shows no notable changes suggestive of atrophy - insular cortex appears within normal limits without apparent atrophy - occipital lobe maintains a normal appearance with no observable atrophic features - limbic cortex maintains a normal appearance with no observable atrophic features - the parietal lobe shows no notable changes suggestive of atrophy	CN	We have the following subject's personal information: - The subject is a female of 65.4 years old. - Subject's current marrietal status is: married. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following subject's family history information: - Both of her parents are reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 28. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 9. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_013_S_4579_MR_MPRAGE_br_raw_20120410165848520_140_S146815_I296776	On a T1-weighted brain MRI we observed: For the subcortical structures: - no findings suggestive of atrophy are seen in the amygdala - pallidum maintains a normal appearance with no observable atrophic features - putamen appears within normal limits without apparent atrophy - hippocampus maintains a normal appearance with no observable atrophic features - caudate appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the thalamus - no observable atrophic changes in the accumbens For the cerebral cortex: - frontal lobe appears preserved, with no observable tissue loss - the temporal lobe shows no notable changes suggestive of atrophy - no clear atrophic alterations are visible in the parietal lobe - occipital lobe appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the limbic cortex - the insular cortex shows no notable changes suggestive of atrophy For the ventricles: - no observable enlargement of the lateral ventricle - no clear enlargement or abnormal growth seen in the 4th ventricle - moderate bilateral enlargement of the inf. lateral ventricle - 3rd ventricle appears within normal size limits with no apparent enlargement - no evident size increase noted in the external csf	CN	We have the following subject's personal information: - The subject is a male of 85.1 years old. - Subject's current marrietal status is: divorced. - He has 12.0 years of education (equivalent to high school or GRE) - The subject is left-handed We have the following subject's health history information: - He has quit smoking at the age of 45.He smoked a pack to a pack and a half a day. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 13. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_032_S_0400_MR_MPR____N3__Scaled_Br_20070118000329335_S13238_I36459	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild bilateral atrophy of the putamen - thalamus appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the pallidum - mild bilateral atrophy of the caudate - the accumbens shows no notable changes suggestive of atrophy - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - the amygdala shows no notable changes suggestive of atrophy For the cerebral cortex: - frontal lobe appears preserved, with no observable tissue loss - mild bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: transverse temporal gyrus (normal on the left and mild atrophy on the right) - insular cortex demonstrates a healthy morphology without signs of atrophy - mild bilateral atrophy of the parietal lobe; focal volume loss observed in the following subregions: angular gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: parahippocampal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) - no observable atrophic changes in the occipital lobe For the ventricles: - mild-to-moderate bilateral enlargement of the lateral ventricle - severe bilateral enlargement of the inf. lateral ventricle - mild enlargement of the external csf - mild-to-moderate enlargement of the 3rd ventricle - the 4th ventricle shows no notable changes suggestive of enlargement	AD	We have the following subject's personal information: - The subject is a male of 69.2 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 27. - On the semantic categorical fluency test, the subject named 15 animals in 60 seconds. He named 5 vegetables in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for shopping alone for clothes, household necessities, or groceries, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject has difficulity, but does by himself, for writing checks, paying bills, or balancing a checkbook, for paying attention to and understanding a TV program, book, or magazine. The subject requires assitance for assembling tax records, business affairs, or other paper, for playing a game of skill such as bridge or chess, working on a hobby, for remembering appointments, family occasions, holidays, medications. - On the Digit Span test of the Wechsler Memory Scale-Revised, his digit span forward length is 6, his digit span forward trials correct is 8, his digit span backward length is 4., his digit span forward trials correct is 4. - On the Trail Making Test Part A, his total number of seconds to complete is 132. On the Trail Making Test Part B, his total number of seconds to complete is 300. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in appetite and eating, a mild (noticeable, but not significant) change in depression or dysphoria, nighttime behaviors. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_116_S_4199_MR_Accelerated_Sagittal_MPRAGE__br_raw_20180411154509057_81_S675706_I984486	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no clear atrophic alterations are visible in the limbic cortex - no evident atrophy or tissue thinning seen in the temporal lobe - frontal lobe appears preserved, with no observable tissue loss - mild bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: posterior insula (mild atrophy both left and right) and anterior insula (mild atrophy on the left and normal on the right) - no appreciable degenerative or atrophic changes observed in the occipital lobe - no appreciable degenerative or atrophic changes observed in the parietal lobe For the subcortical structures: - no clear atrophic alterations are visible in the amygdala - the pallidum shows no notable changes suggestive of atrophy - mild bilateral atrophy of the putamen - mild bilateral atrophy of the thalamus - mild bilateral atrophy of the caudate - hippocampus appears preserved, with no observable tissue loss - accumbens demonstrates a healthy morphology without signs of atrophy For the ventricles: - inf. lateral ventricle maintains a typical volume without observable enlargement - no appreciable enlargement noted in the 4th ventricle - lateral ventricle appears to be of normal dimensions, with no observable increase in size - no appreciable enlargement noted in the 3rd ventricle - mild enlargement of the external csf	CN	We have the following subject's personal information: - The subject is a male of 65.7 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 26. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 8. - On the semantic categorical fluency test, the subject named 24 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 10. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 25. On the Trail Making Test Part B, his total number of seconds to complete is 44. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_177_S_6448_MR_Accelerated_Sagittal_MPRAGE__br_raw_20200919075020024_1_S961026_I1340855	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no clear atrophic alterations are visible in the frontal lobe - limbic cortex maintains a normal appearance with no observable atrophic features - temporal lobe maintains a normal appearance with no observable atrophic features - mild bilateral atrophy of the parietal lobe; focal volume loss observed in the following subregions: postcentral gyrus (mild atrophy on the right) - no evident atrophy or tissue thinning seen in the insular cortex - mild bilateral atrophy of the occipital lobe; focal volume loss observed in the following subregions: calcarine cortex (mild-to-moderate atrophy on the left and mild atrophy on the right) For the ventricles: - mild enlargement of the external csf - no findings suggestive of enlargement are seen in the inf. lateral ventricle - lateral ventricle appears to be of normal dimensions, with no observable increase in size - 4th ventricle maintains a typical volume without observable enlargement - no appreciable enlargement noted in the 3rd ventricle For the subcortical structures: - pallidum demonstrates a healthy morphology without signs of atrophy - no evident atrophy or tissue thinning seen in the amygdala - mild bilateral atrophy of the caudate - no findings suggestive of atrophy are seen in the accumbens - hippocampus appears within normal limits without apparent atrophy - thalamus demonstrates a healthy morphology without signs of atrophy - no clear atrophic alterations are visible in the putamen	CN	We have the following subject's personal information: - The subject is a male of 70.0 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - The subject has a 32-item Multilingual Naming Test (MINT) total score of 0. - On the semantic categorical fluency test, the subject named 18 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 12. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 30. On the Trail Making Test Part B, his total number of seconds to complete is 55. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
FTLD_203260125_02526_MR_Sagittal_MP-Rage_br_raw_20230206161248652_I10181566	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild bilateral atrophy of the thalamus - mild bilateral atrophy of the accumbens - mild bilateral atrophy of the caudate - pallidum appears within normal limits without apparent atrophy - putamen appears preserved, with no observable tissue loss - amygdala maintains a normal appearance with no observable atrophic features - no evident atrophy or tissue thinning seen in the hippocampus For the ventricles: - moderate enlargement of the 3rd ventricle - mild-to-moderate bilateral enlargement of the lateral ventricle - moderate bilateral enlargement of the inf. lateral ventricle - mild-to-moderate enlargement of the external csf - mild enlargement of the 4th ventricle For the cerebral cortex: - moderate bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: sup. frontal gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), precentral gyrus medial segment (mild atrophy both left and right), precentral gyrus (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right), supplementary motor cortex (mild atrophy on the left and normal-to-mild atrophy on the right), gyrus rectus (mild atrophy on the left and normal on the right) and sup. frontal gyrus medial segment (normal on the left and mild atrophy on the right) - no findings suggestive of atrophy are seen in the parietal lobe - mild bilateral atrophy of the insular cortex - temporal lobe appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the occipital lobe - no findings suggestive of atrophy are seen in the limbic cortex	PNFA	We have the following subject's personal information: - The subject is a female of 78.0 years old. - She has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 24. - On the semantic categorical fluency test, the subject named 5 animals in 60 seconds. She named 7 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 7. - On the Number Span forward test, her longest span forward was 4. On the Number Span backward test, her longest span backward was 3. - On the Trail Making Test Part A, her total number of seconds to complete is 150, her number of commission errors is 3, her number of correct lines is 2. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in depression or dysphoria, apathy or indifference, a mild (noticeable, but not significant) change in disinhibition, irritability or lability, appetite and eating. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 9.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 2.0 (moderate impairment). Description: No pretense of independent function outside the home; appears well enough to be taken to functions outside the family home. * Home and hobbies: Score 3.0 (severe impairment). Description: No significant function in the home. * Personal care: Score 2.0 (moderate impairment). Description: Requires much help with personal care; frequent incontinence. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
ADNI_022_S_0219_MR_MPR__GradWarp__B1_Correction__N3__Scaled_Br_20070712154620604_S12375_I59533	On a T1-weighted brain MRI we observed: For the subcortical structures: - atrophy of the amygdala with marked asymmetry (normal-to-mild left, moderate right) - mild bilateral atrophy of the accumbens - caudate maintains a normal appearance with no observable atrophic features - mild-to-moderate atrophy of the left hippocampus, mild atrophy of the right hippocampus (marked asymmetry favoring the left) - mild bilateral atrophy of the thalamus - mild bilateral atrophy of the pallidum - no clear atrophic alterations are visible in the putamen For the ventricles: - 4th ventricle appears to be of normal dimensions, with no observable increase in size - mild enlargement of the 3rd ventricle - no evident size increase noted in the external csf - severe bilateral enlargement of the inf. lateral ventricle - lateral ventricle maintains a typical volume without observable enlargement For the cerebral cortex: - mild bilateral atrophy of the temporal lobe - occipital lobe maintains a normal appearance with no observable atrophic features - no clear atrophic alterations are visible in the parietal lobe - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: entorhinal area (normal on the left and mild-to-moderate atrophy on the right) and anterior cingulate gyrus (mild atrophy on the right) - no clear atrophic alterations are visible in the insular cortex - frontal lobe appears within normal limits without apparent atrophy	AD	We have the following subject's personal information: - The subject is a male of 74.5 years old. We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 18 animals in 60 seconds. He named 13 vegetables in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject has difficulity, but does by himself, for preparing a balanced meal, for remembering appointments, family occasions, holidays, medications. - On the Digit Span test of the Wechsler Memory Scale-Revised, his digit span forward length is 4, his digit span forward trials correct is 4, his digit span backward length is 3., his digit span forward trials correct is 4. - On the Trail Making Test Part A, his total number of seconds to complete is 30. On the Trail Making Test Part B, his total number of seconds to complete is 261. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in anxiety, irritability or lability, a mild (noticeable, but not significant) change in hallucinations, agitation or aggression. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_067_S_2301_MR_MPRAGE_br_raw_20140226111214774_170_S213307_I415424	On a T1-weighted brain MRI we observed: For the ventricles: - external csf appears to be of normal dimensions, with no observable increase in size - 3rd ventricle appears to be of normal dimensions, with no observable increase in size - no findings suggestive of enlargement are seen in the lateral ventricle - the 4th ventricle shows no notable changes suggestive of enlargement - no observable enlargement of the inf. lateral ventricle For the subcortical structures: - accumbens maintains a normal appearance with no observable atrophic features - no observable atrophic changes in the thalamus - hippocampus appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the caudate - amygdala appears preserved, with no observable tissue loss - pallidum appears preserved, with no observable tissue loss - no observable atrophic changes in the putamen For the cerebral cortex: - no clear atrophic alterations are visible in the frontal lobe - parietal lobe appears preserved, with no observable tissue loss - limbic cortex demonstrates a healthy morphology without signs of atrophy - no appreciable degenerative or atrophic changes observed in the insular cortex - occipital lobe demonstrates a healthy morphology without signs of atrophy - temporal lobe appears preserved, with no observable tissue loss	CN	We have the following subject's personal information: - The subject is a male of 68.8 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - The subject has a Boston Naming Test (BNT) total score of 29. - On the semantic categorical fluency test, the subject named 38 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 12. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject has difficulity, but does by himself, for paying attention to and understanding a TV program, book, or magazine. - On the Trail Making Test Part A, his total number of seconds to complete is 26. On the Trail Making Test Part B, his total number of seconds to complete is 63. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_023_S_4020_MR_MPRAGE_br_raw_20110503145535673_39_S107436_I232428	On a T1-weighted brain MRI we observed: For the ventricles: - 4th ventricle maintains a typical volume without observable enlargement - no observable enlargement of the 3rd ventricle - external csf maintains a typical volume without observable enlargement - no observable enlargement of the lateral ventricle - inf. lateral ventricle appears within normal size limits with no apparent enlargement For the subcortical structures: - thalamus appears within normal limits without apparent atrophy - no observable atrophic changes in the accumbens - no evident atrophy or tissue thinning seen in the amygdala - no clear atrophic alterations are visible in the hippocampus - putamen appears preserved, with no observable tissue loss - no evident atrophy or tissue thinning seen in the pallidum - no findings suggestive of atrophy are seen in the caudate For the cerebral cortex: - parietal lobe appears preserved, with no observable tissue loss - no clear atrophic alterations are visible in the occipital lobe - no clear atrophic alterations are visible in the temporal lobe - no findings suggestive of atrophy are seen in the insular cortex - limbic cortex appears within normal limits without apparent atrophy - frontal lobe appears preserved, with no observable tissue loss	CN	We have the following subject's personal information: - The subject is a male of 66.5 years old. - Subject's current marrietal status is: married. - He has 16.0 years of education (equivalent to bachelor’s degree) - The subject is left-handed We have the following subject's health history information: - He has quit smoking at the age of 51.He smoked a pack to a pack and a half a day. - He has a remote/inactive history of alcool abuse. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 12. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e2 with no e4 allele.
FTLD_203426391_02192_MR_Sagittal_MP-Rage_br_raw_20230209095858883_I10183320	On a T1-weighted brain MRI we observed: For the cerebral cortex: - insular cortex appears within normal limits without apparent atrophy - mild bilateral atrophy of the parietal lobe; focal volume loss observed in the following subregions: precuneus (mild atrophy both left and right), sup. parietal lobule (mild atrophy both left and right) and supramarginal gyrus (mild atrophy on the right) - no evident atrophy or tissue thinning seen in the temporal lobe - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: parahippocampal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) and entorhinal area (mild atrophy on the left and normal on the right) - mild-to-moderate bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: middle frontal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), precentral gyrus (mild atrophy on the left and normal on the right), sup. frontal gyrus (mild atrophy on the left and normal on the right) and supplementary motor cortex (mild atrophy on the left and normal on the right) - no clear atrophic alterations are visible in the occipital lobe For the subcortical structures: - mild bilateral atrophy of the caudate - mild-to-moderate atrophy of the left hippocampus, normal-to-mild atrophy of the right hippocampus (marked asymmetry favoring the left) - no appreciable degenerative or atrophic changes observed in the pallidum - mild-to-moderate bilateral atrophy of the amygdala - no findings suggestive of atrophy are seen in the accumbens - mild bilateral atrophy of the putamen - thalamus maintains a normal appearance with no observable atrophic features For the ventricles: - 3rd ventricle appears within normal size limits with no apparent enlargement - no appreciable enlargement noted in the 4th ventricle - moderate enlargement of the external csf - inf. lateral ventricle appears to be of normal dimensions, with no observable increase in size - lateral ventricle maintains a typical volume without observable enlargement	PNFA	We have the following subject's personal information: - The subject is a male of 71.0 years old. - He has 20.0 years of education (equivalent to doctorate) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 30. - On the semantic categorical fluency test, the subject named 8 animals in 60 seconds. He named 2 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 6. - On the Number Span forward test, his longest span forward was 4. On the Number Span backward test, his longest span backward was 3. - On the Trail Making Test Part A, his total number of seconds to complete is 77, his number of commission errors is 1, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 300, his number of commission errors is 2, his number of correct lines is 16. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in agitation or aggression, irritability or lability, a mild (noticeable, but not significant) change in depression or dysphoria, nighttime behaviors. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 2.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
ADNI_301_S_10769_MR_Accelerated_Sagittal_MPRAGE_MSV21_br_raw_20250519191453242_1_I11282437	On a T1-weighted brain MRI we observed: For the ventricles: - no clear enlargement or abnormal growth seen in the external csf - no appreciable enlargement noted in the 4th ventricle - mild-to-moderate bilateral enlargement of the lateral ventricle - no findings suggestive of enlargement are seen in the inf. lateral ventricle - 3rd ventricle appears to be of normal dimensions, with no observable increase in size For the subcortical structures: - caudate demonstrates a healthy morphology without signs of atrophy - putamen appears within normal limits without apparent atrophy - no observable atrophic changes in the amygdala - no appreciable degenerative or atrophic changes observed in the thalamus - the accumbens shows no notable changes suggestive of atrophy - the hippocampus shows no notable changes suggestive of atrophy - pallidum appears preserved, with no observable tissue loss For the cerebral cortex: - mild bilateral atrophy of the occipital lobe; focal volume loss observed in the following subregions: calcarine cortex (mild atrophy both left and right) and occipital fusiform gyrus (mild atrophy on the left and normal on the right) - no findings suggestive of atrophy are seen in the limbic cortex - no evident atrophy or tissue thinning seen in the insular cortex - temporal lobe appears preserved, with no observable tissue loss - frontal lobe appears within normal limits without apparent atrophy - the parietal lobe shows no notable changes suggestive of atrophy	CN	We have the following subject's personal information: - The subject is a female of 63.5 years old. - Subject's current marrietal status is: married. - She has 15.0 years of education - The subject is right-handed We have the following subject's family history information: - Her mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 9. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_126_S_10166_MR_Accelerated_Sagittal_IR-FSPGR_MSV21_br_raw_20240724183952474_1_I10888803	On a T1-weighted brain MRI we observed: For the ventricles: - inf. lateral ventricle appears to be of normal dimensions, with no observable increase in size - 3rd ventricle maintains its expected proportions without signs of enlargement - mild enlargement of the 4th ventricle - mild enlargement of the external csf - no findings suggestive of enlargement are seen in the lateral ventricle For the subcortical structures: - no observable atrophic changes in the pallidum - the hippocampus shows no notable changes suggestive of atrophy - no findings suggestive of atrophy are seen in the amygdala - caudate appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the putamen - no appreciable degenerative or atrophic changes observed in the accumbens - no findings suggestive of atrophy are seen in the thalamus For the cerebral cortex: - no appreciable degenerative or atrophic changes observed in the occipital lobe - no clear atrophic alterations are visible in the parietal lobe - insular cortex demonstrates a healthy morphology without signs of atrophy - the temporal lobe shows no notable changes suggestive of atrophy - no clear atrophic alterations are visible in the limbic cortex - no clear atrophic alterations are visible in the frontal lobe	CN	We have the following subject's personal information: - The subject is a female of 60.4 years old. - Subject's current marrietal status is: married. - She has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 19. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
FTLD_203383767_03768_MR_Accelerated_Sagittal_MPRAGE_br_raw_20240_I10451140	On a T1-weighted brain MRI we observed: For the cerebral cortex: - moderate bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: middle frontal gyrus (moderate atrophy on the left and mild-to-moderate atrophy on the right), gyrus rectus (mild atrophy on the left and mild-to-moderate atrophy on the right), frontal pole (mild atrophy both left and right), anterior orbital gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), medial orbital gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), posterior orbital gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), opercular inf. frontal gyrus (mild atrophy on the left and normal on the right), medial frontal cortex (normal on the left and mild atrophy on the right), supplementary motor cortex (mild atrophy on the left and normal on the right) and sup. frontal gyrus (normal on the left and mild atrophy on the right) - mild-to-moderate bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right) and entorhinal area (mild atrophy on the right) - mild-to-moderate bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: temporal pole (mild atrophy on the left and mild-to-moderate atrophy on the right), fusiform gyrus (mild atrophy both left and right) and middle temporal gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) - mild-to-moderate bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: anterior insula (mild atrophy both left and right) and central operculum (normal on the left and mild atrophy on the right) - no findings suggestive of atrophy are seen in the occipital lobe - mild bilateral atrophy of the parietal lobe; focal volume loss observed in the following subregions: angular gyrus (mild atrophy both left and right) and precuneus (normal on the left and mild atrophy on the right) For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - the 4th ventricle shows no notable changes suggestive of enlargement - severe bilateral enlargement of the lateral ventricle - mild-to-moderate enlargement of the 3rd ventricle - mild-to-moderate enlargement of the external csf For the subcortical structures: - moderate-to-severe bilateral atrophy of the caudate - pallidum appears within normal limits without apparent atrophy - mild bilateral atrophy of the thalamus - normal-to-mild atrophy of the left hippocampus, normal-to-mild atrophy of the right hippocampus - mild bilateral atrophy of the amygdala - mild-to-moderate bilateral atrophy of the accumbens - mild-to-moderate bilateral atrophy of the putamen	BV	We have the following subject's personal information: - The subject is a male of 59.0 years old. - He has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 16. - On the Number Span forward test, his longest span forward was 4. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in disinhibition, a moderate (significant, but not dramatic) change in apathy or indifference, irritability or lability, nighttime behaviors, a mild (noticeable, but not significant) change in agitation or aggression, depression or dysphoria, anxiety, elation or euphoria, motor disturbance, appetite and eating. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 2.0, corresponding to moderate impairment. His standard CDR Sum of Boxes score is 12.0. --- ## 📋 Detailed Domain Scores * Memory: Score 2.0 (moderate impairment). Description: Severe memory loss; only highly learned material retained; new material rapidly lost. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 3.0 (severe impairment). Description: Unable to make judgments or solve problems. * Community affairs: Score 2.0 (moderate impairment). Description: No pretense of independent function outside the home; appears well enough to be taken to functions outside the family home. * Home and hobbies: Score 2.0 (moderate impairment). Description: Only simple chores preserved; very restricted interests, poorly maintained. * Personal care: Score 2.0 (moderate impairment). Description: Requires much help with personal care; frequent incontinence. * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 1.0 (mild impairment). Description: Moderate word-finding difficulty in speech; cannot name objects in environment; reduced phrase length and/or agrammatical speech and/or reduced comprehension in conversation and reading.
ADNI_023_S_6400_MR_Accelerated_Sagittal_MPRAGE__br_raw_20180530163448275_138_S690769_I1004030	On a T1-weighted brain MRI we observed: For the subcortical structures: - the amygdala shows no notable changes suggestive of atrophy - thalamus maintains a normal appearance with no observable atrophic features - accumbens maintains a normal appearance with no observable atrophic features - no evident atrophy or tissue thinning seen in the pallidum - caudate appears within normal limits without apparent atrophy - hippocampus demonstrates a healthy morphology without signs of atrophy - putamen maintains a normal appearance with no observable atrophic features For the ventricles: - no evident size increase noted in the 4th ventricle - lateral ventricle maintains its expected proportions without signs of enlargement - no clear enlargement or abnormal growth seen in the 3rd ventricle - no findings suggestive of enlargement are seen in the external csf - no observable enlargement of the inf. lateral ventricle For the cerebral cortex: - the parietal lobe shows no notable changes suggestive of atrophy - no clear atrophic alterations are visible in the frontal lobe - no evident atrophy or tissue thinning seen in the occipital lobe - temporal lobe maintains a normal appearance with no observable atrophic features - no clear atrophic alterations are visible in the limbic cortex - no observable atrophic changes in the insular cortex	CN	We have the following subject's personal information: - The subject is a female of 64.3 years old. - Subject's current marrietal status is: married. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following subject's family history information: - Her mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 18. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_052_S_4959_MR_Accelerated_Sag_IR-FSPGR_br_raw_20130304164859456_143_S183633_I361953	On a T1-weighted brain MRI we observed: For the ventricles: - moderate bilateral enlargement of the inf. lateral ventricle - mild bilateral enlargement of the lateral ventricle - no findings suggestive of enlargement are seen in the external csf - 3rd ventricle maintains its expected proportions without signs of enlargement - 4th ventricle appears to be of normal dimensions, with no observable increase in size For the subcortical structures: - the thalamus shows no notable changes suggestive of atrophy - no evident atrophy or tissue thinning seen in the pallidum - no findings suggestive of atrophy are seen in the hippocampus - no clear atrophic alterations are visible in the caudate - no observable atrophic changes in the amygdala - no findings suggestive of atrophy are seen in the accumbens - putamen appears within normal limits without apparent atrophy For the cerebral cortex: - no evident atrophy or tissue thinning seen in the temporal lobe - insular cortex maintains a normal appearance with no observable atrophic features - no appreciable degenerative or atrophic changes observed in the parietal lobe - no clear atrophic alterations are visible in the occipital lobe - limbic cortex appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the frontal lobe	AD	We have the following subject's personal information: - The subject is a male of 77.5 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 30. - On the semantic categorical fluency test, the subject named 9 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for heating water, making a cup of coffee, turning off the stove. The subject has difficulity, but does by himself, for preparing a balanced meal, for paying attention to and understanding a TV program, book, or magazine. The subject requires assitance for playing a game of skill such as bridge or chess, working on a hobby, for keeping track of current events. The subject is dependent for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 26. On the Trail Making Test Part B, his total number of seconds to complete is 126. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
NIFD_1_S_0147_MR_T1_mprage_S3_DIS3D_br_raw_20140612224636364_53_S222067_I430635	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no findings suggestive of atrophy are seen in the limbic cortex - no evident atrophy or tissue thinning seen in the temporal lobe - no appreciable degenerative or atrophic changes observed in the insular cortex - mild bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: middle frontal gyrus (mild atrophy both left and right) and precentral gyrus (normal on the left and mild atrophy on the right) - no observable atrophic changes in the parietal lobe - occipital lobe appears preserved, with no observable tissue loss For the subcortical structures: - amygdala appears within normal limits without apparent atrophy - no appreciable degenerative or atrophic changes observed in the caudate - no clear atrophic alterations are visible in the thalamus - hippocampus maintains a normal appearance with no observable atrophic features - mild bilateral atrophy of the pallidum - mild bilateral atrophy of the accumbens - putamen maintains a normal appearance with no observable atrophic features For the ventricles: - 3rd ventricle appears within normal size limits with no apparent enlargement - no clear enlargement or abnormal growth seen in the inf. lateral ventricle - 4th ventricle maintains a typical volume without observable enlargement - no findings suggestive of enlargement are seen in the lateral ventricle - no clear enlargement or abnormal growth seen in the external csf	PNFA	We have the following subject's personal information: - The subject is a female of 68.0 years old. - She has 14.0 years of education We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 16. - The subject has a Montreal Cognitive Assessment (MoCA) total score, corrected for education, of 10. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 3. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
ADNI_041_S_5141_MR_MPRAGE_br_raw_20130419091107601_66_S187377_I367903	On a T1-weighted brain MRI we observed: For the subcortical structures: - accumbens appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the thalamus - no clear atrophic alterations are visible in the caudate - no evident atrophy or tissue thinning seen in the putamen - no clear atrophic alterations are visible in the pallidum - no evident atrophy or tissue thinning seen in the hippocampus - no observable atrophic changes in the amygdala For the cerebral cortex: - no clear atrophic alterations are visible in the temporal lobe - limbic cortex demonstrates a healthy morphology without signs of atrophy - parietal lobe appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the frontal lobe - insular cortex demonstrates a healthy morphology without signs of atrophy - no clear atrophic alterations are visible in the occipital lobe For the ventricles: - no clear enlargement or abnormal growth seen in the 4th ventricle - no observable enlargement of the external csf - no appreciable enlargement noted in the 3rd ventricle - the lateral ventricle shows no notable changes suggestive of enlargement - inf. lateral ventricle appears to be of normal dimensions, with no observable increase in size	CN	We have the following subject's personal information: - The subject is a male of 76.8 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 28. - On the semantic categorical fluency test, the subject named 19 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject has difficulity, but does by himself, for remembering appointments, family occasions, holidays, medications. - On the Trail Making Test Part A, his total number of seconds to complete is 22. On the Trail Making Test Part B, his total number of seconds to complete is 90. From genetic data, APOE genotype is e3,e2 with no e4 allele.
FTLD_203037518_01813_MR_Sagittal_MP-Rage_br_raw_20230124205507143_I10178441	On a T1-weighted brain MRI we observed: For the ventricles: - no findings suggestive of enlargement are seen in the 3rd ventricle - lateral ventricle maintains its expected proportions without signs of enlargement - no observable enlargement of the inf. lateral ventricle - external csf appears within normal size limits with no apparent enlargement - mild-to-moderate enlargement of the 4th ventricle For the subcortical structures: - no evident atrophy or tissue thinning seen in the hippocampus - no clear atrophic alterations are visible in the thalamus - no appreciable degenerative or atrophic changes observed in the caudate - no findings suggestive of atrophy are seen in the putamen - no findings suggestive of atrophy are seen in the accumbens - pallidum demonstrates a healthy morphology without signs of atrophy - no observable atrophic changes in the amygdala For the cerebral cortex: - the frontal lobe shows no notable changes suggestive of atrophy - no evident atrophy or tissue thinning seen in the insular cortex - temporal lobe appears preserved, with no observable tissue loss - limbic cortex appears within normal limits without apparent atrophy - the occipital lobe shows no notable changes suggestive of atrophy - the parietal lobe shows no notable changes suggestive of atrophy	CN	We have the following subject's personal information: - The subject is a male of 42.0 years old. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 25 animals in 60 seconds. He named 14 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 17. - On the Number Span forward test, his longest span forward was 9. On the Number Span backward test, his longest span backward was 8. - On the Trail Making Test Part A, his total number of seconds to complete is 16, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 56, his number of commission errors is 0, his number of correct lines is 24. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
FTLD_203011813_02311_MR_Sagittal_MP-Rage_br_raw_20230124212826247_I10178654	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no clear atrophic alterations are visible in the parietal lobe - no findings suggestive of atrophy are seen in the occipital lobe - no evident atrophy or tissue thinning seen in the temporal lobe - frontal lobe demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the insular cortex - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild atrophy on the left and normal on the right) and middle cingulate gyrus (mild atrophy on the left and normal on the right) For the ventricles: - no observable enlargement of the external csf - 3rd ventricle maintains its expected proportions without signs of enlargement - 4th ventricle appears to be of normal dimensions, with no observable increase in size - lateral ventricle maintains its expected proportions without signs of enlargement - no clear enlargement or abnormal growth seen in the inf. lateral ventricle For the subcortical structures: - accumbens appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the pallidum - the thalamus shows no notable changes suggestive of atrophy - putamen demonstrates a healthy morphology without signs of atrophy - hippocampus demonstrates a healthy morphology without signs of atrophy - no observable atrophic changes in the amygdala - caudate maintains a normal appearance with no observable atrophic features	CN	We have the following subject's personal information: - The subject is a male of 53.0 years old. - He has 20.0 years of education (equivalent to doctorate) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 37 animals in 60 seconds. He named 17 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 14. - On the Number Span forward test, his longest span forward was 6. On the Number Span backward test, his longest span backward was 7. - On the Trail Making Test Part A, his total number of seconds to complete is 21, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 40, his number of commission errors is 0, his number of correct lines is 24. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_067_S_5205_MR_MPRAGE_br_raw_20130617123032185_46_S192528_I376818	On a T1-weighted brain MRI we observed: For the subcortical structures: - no clear atrophic alterations are visible in the thalamus - no findings suggestive of atrophy are seen in the pallidum - no clear atrophic alterations are visible in the putamen - hippocampus appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the accumbens - mild bilateral atrophy of the amygdala - caudate demonstrates a healthy morphology without signs of atrophy For the cerebral cortex: - no evident atrophy or tissue thinning seen in the insular cortex - limbic cortex demonstrates a healthy morphology without signs of atrophy - mild bilateral atrophy of the parietal lobe; focal volume loss observed in the following subregions: supramarginal gyrus (mild atrophy both left and right), angular gyrus (normal on the left and mild atrophy on the right) and precuneus (mild atrophy on the left and normal on the right) - no appreciable degenerative or atrophic changes observed in the occipital lobe - mild bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: fusiform gyrus (mild atrophy on the right) and planum temporale (mild atrophy on the left) - mild bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: middle frontal gyrus (mild-to-moderate atrophy both left and right), medial frontal cortex (mild atrophy on the left and normal-to-mild atrophy on the right), anterior orbital gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) and sup. frontal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) For the ventricles: - no clear enlargement or abnormal growth seen in the 4th ventricle - mild bilateral enlargement of the lateral ventricle - mild-to-moderate bilateral enlargement of the inf. lateral ventricle - no observable enlargement of the 3rd ventricle - mild-to-moderate enlargement of the external csf	AD	We have the following subject's personal information: - The subject is a female of 59.3 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 24. - On the semantic categorical fluency test, the subject named 6 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for paying attention to and understanding a TV program, book, or magazine. The subject has difficulity, but does by himself, for writing checks, paying bills, or balancing a checkbook. The subject requires assitance for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, her total number of seconds to complete is 150. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_036_S_0672_MR_MPR__GradWarp__B1_Correction__N3__Scaled_Br_20070119235831844_S17131_I36938	On a T1-weighted brain MRI we observed: For the ventricles: - 3rd ventricle appears within normal size limits with no apparent enlargement - no findings suggestive of enlargement are seen in the external csf - 4th ventricle maintains its expected proportions without signs of enlargement - no findings suggestive of enlargement are seen in the inf. lateral ventricle - lateral ventricle appears within normal size limits with no apparent enlargement For the cerebral cortex: - limbic cortex appears preserved, with no observable tissue loss - no evident atrophy or tissue thinning seen in the insular cortex - no findings suggestive of atrophy are seen in the parietal lobe - the temporal lobe shows no notable changes suggestive of atrophy - no observable atrophic changes in the frontal lobe - occipital lobe appears preserved, with no observable tissue loss For the subcortical structures: - no findings suggestive of atrophy are seen in the thalamus - pallidum demonstrates a healthy morphology without signs of atrophy - mild bilateral atrophy of the caudate - amygdala demonstrates a healthy morphology without signs of atrophy - putamen appears preserved, with no observable tissue loss - the hippocampus shows no notable changes suggestive of atrophy - the accumbens shows no notable changes suggestive of atrophy	CN	We have the following subject's personal information: - The subject is a female of 62.1 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 28. - On the semantic categorical fluency test, the subject named 11 animals in 60 seconds. She named 15 vegetables in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Digit Span test of the Wechsler Memory Scale-Revised, her digit span forward length is 7, her digit span forward trials correct is 9, her digit span backward length is 6., her digit span forward trials correct is 9. - On the Trail Making Test Part A, her total number of seconds to complete is 35. On the Trail Making Test Part B, her total number of seconds to complete is 97. From genetic data, APOE genotype is e3,e2 with no e4 allele.
ADNI_016_S_4887_MR_Accelerated_SAG_IR-SPGR__br_raw_20120822093912566_54_S162209_I325642	On a T1-weighted brain MRI we observed: For the ventricles: - no evident size increase noted in the external csf - mild bilateral enlargement of the lateral ventricle - no findings suggestive of enlargement are seen in the 4th ventricle - moderate bilateral enlargement of the inf. lateral ventricle - mild enlargement of the 3rd ventricle For the cerebral cortex: - no clear atrophic alterations are visible in the insular cortex - no appreciable degenerative or atrophic changes observed in the parietal lobe - limbic cortex maintains a normal appearance with no observable atrophic features - occipital lobe appears within normal limits without apparent atrophy - frontal lobe demonstrates a healthy morphology without signs of atrophy - no observable atrophic changes in the temporal lobe For the subcortical structures: - mild bilateral atrophy of the amygdala - putamen appears preserved, with no observable tissue loss - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - the caudate shows no notable changes suggestive of atrophy - no appreciable degenerative or atrophic changes observed in the pallidum - no clear atrophic alterations are visible in the accumbens - thalamus appears within normal limits without apparent atrophy	AD	We have the following subject's personal information: - The subject is a male of 73.8 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 15. - On the semantic categorical fluency test, the subject named 17 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has difficulity, but does by himself, for playing a game of skill such as bridge or chess, working on a hobby, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject requires assitance for shopping alone for clothes, household necessities, or groceries, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for remembering appointments, family occasions, holidays, medications. The subject is dependent for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper. - On the Trail Making Test Part A, his total number of seconds to complete is 42. On the Trail Making Test Part B, his total number of seconds to complete is 300. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
FTLD_203765060_03066_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10178114	On a T1-weighted brain MRI we observed: For the subcortical structures: - severe atrophy of the left amygdala - mild atrophy of the left thalamus - the hippocampus shows no notable changes suggestive of atrophy - atrophy of the caudate with marked asymmetry (mild left, normal right) - mild-to-moderate bilateral atrophy of the accumbens - mild-to-moderate atrophy of the left pallidum; the right pallidum is normal - atrophy of the putamen with marked asymmetry (mild-to-moderate left, normal right) For the cerebral cortex: - no evident atrophy or tissue thinning seen in the occipital lobe - no evident atrophy or tissue thinning seen in the parietal lobe - mild atrophy of the left insular cortex; focal volume loss observed in the following subregions: frontal operculum (mild atrophy on the left and normal on the right) and anterior insula (mild atrophy on the left) - no appreciable degenerative or atrophic changes observed in the frontal lobe - atrophy of the temporal lobe with marked asymmetry (severe left, normal-to-mild right); focal volume loss observed in the following subregions: middle temporal gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), temporal pole (moderate atrophy on the left and normal-to-mild atrophy on the right), planum temporale (mild atrophy on the left), inf. temporal gyrus (mild atrophy on the left and normal on the right), sup. temporal gyrus (mild atrophy on the left and normal on the right) and fusiform gyrus (mild atrophy on the left) - mild-to-moderate bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: entorhinal area (mild atrophy on the left and normal on the right), anterior cingulate gyrus (mild atrophy on the left and normal on the right) and middle cingulate gyrus (mild atrophy on the left) For the ventricles: - moderate enlargement of the 3rd ventricle - mild enlargement of the external csf - moderate-to-severe bilateral enlargement of the inf. lateral ventricle - moderate bilateral enlargement of the lateral ventricle - mild enlargement of the 4th ventricle	BV	We have the following subject's personal information: - The subject is a male of 67.0 years old. - He has 14.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 8. - On the semantic categorical fluency test, the subject named 2 animals in 60 seconds. He named 1 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 0. - On the Number Span forward test, his longest span forward was 5. On the Number Span backward test, his longest span backward was 4. - On the Trail Making Test Part A, his total number of seconds to complete is 33, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 77, his number of commission errors is 0, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in apathy or indifference, disinhibition, irritability or lability. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. His standard CDR Sum of Boxes score is 8.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 2.0 (moderate impairment). Description: Severely impaired in handling problems, similarities, and differences; social judgment usually impaired. * Community affairs: Score 2.0 (moderate impairment). Description: No pretense of independent function outside the home; appears well enough to be taken to functions outside the family home. * Home and hobbies: Score 2.0 (moderate impairment). Description: Only simple chores preserved; very restricted interests, poorly maintained. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
NIFD_1_S_0096_MR_T1_mprage_S3_DIS3D_br_raw_20170817133934845_74_S598211_I891811	On a T1-weighted brain MRI we observed: For the ventricles: - mild enlargement of the external csf - no appreciable enlargement noted in the inf. lateral ventricle - no clear enlargement or abnormal growth seen in the 4th ventricle - mild bilateral enlargement of the lateral ventricle - mild enlargement of the 3rd ventricle For the subcortical structures: - no clear atrophic alterations are visible in the accumbens - hippocampus demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the amygdala - no clear atrophic alterations are visible in the caudate - no observable atrophic changes in the pallidum - no findings suggestive of atrophy are seen in the putamen - atrophy of the thalamus with marked asymmetry (normal left, mild-to-moderate right) For the cerebral cortex: - limbic cortex maintains a normal appearance with no observable atrophic features - no findings suggestive of atrophy are seen in the parietal lobe - insular cortex appears preserved, with no observable tissue loss - no clear atrophic alterations are visible in the temporal lobe - frontal lobe appears preserved, with no observable tissue loss - no clear atrophic alterations are visible in the occipital lobe	BV	We have the following subject's personal information: - The subject is a male of 69.0 years old. - He has 18.0 years of education (equivalent to master’s degree) We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 23. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Functional Activities Questionnaire (FAQ), the subject requires assitance for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject is dependent for preparing a balanced meal, for remembering appointments, family occasions, holidays, medications. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in apathy or indifference, appetite and eating, a moderate (significant, but not dramatic) change in agitation or aggression, irritability or lability, motor disturbance. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 2.0, corresponding to moderate impairment. His standard CDR Sum of Boxes score is 8.5. --- ## 📋 Detailed Domain Scores * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 0.5 (questionnable impairment). Description: Consistent mild word-finding difficulties; simplification of word choice; circumlocution; decreased phrase length; and/or mild comprehension difficulties.
ADNI_005_S_0221_MR_MPR__GradWarp__B1_Correction__N3__Scaled_Br_20070910164745994_S11958_I72128	On a T1-weighted brain MRI we observed: For the ventricles: - mild-to-moderate bilateral enlargement of the lateral ventricle - moderate bilateral enlargement of the inf. lateral ventricle - no findings suggestive of enlargement are seen in the 4th ventricle - no clear enlargement or abnormal growth seen in the 3rd ventricle - no observable enlargement of the external csf For the cerebral cortex: - limbic cortex maintains a normal appearance with no observable atrophic features - occipital lobe maintains a normal appearance with no observable atrophic features - no appreciable degenerative or atrophic changes observed in the insular cortex - mild atrophy of the right parietal lobe; focal volume loss observed in the following subregions: sup. parietal lobule (normal on the left and mild atrophy on the right) and angular gyrus (normal on the left and mild atrophy on the right) - no appreciable degenerative or atrophic changes observed in the frontal lobe - the temporal lobe shows no notable changes suggestive of atrophy For the subcortical structures: - mild bilateral atrophy of the putamen - mild bilateral atrophy of the thalamus - mild-to-moderate atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus - mild bilateral atrophy of the pallidum - moderate bilateral atrophy of the amygdala - mild bilateral atrophy of the caudate - no appreciable degenerative or atrophic changes observed in the accumbens	AD	We have the following subject's personal information: - The subject is a male of 67.5 years old. - Subject's current marrietal status is: married. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following subject's health history information: - He has a remote/inactive history of substance abuse (drug). We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 20. In his MMSE test, he has an orientation to time score of 1. In his MMSE test, he has an orientation to place score of 3.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 0. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. His standard CDR Sum of Boxes score is 7.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 2.0 (moderate impairment). Description: Only simple chores preserved; very restricted interests, poorly maintained. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. From genetic data, APOE genotype is e4,e4 with 2 copies of e4 allele.
FTLD_203551893_02395_MR_Sagittal_MP-Rage_br_raw_20230124212843779_I10178656	On a T1-weighted brain MRI we observed: For the subcortical structures: - the thalamus shows no notable changes suggestive of atrophy - pallidum demonstrates a healthy morphology without signs of atrophy - amygdala maintains a normal appearance with no observable atrophic features - hippocampus appears preserved, with no observable tissue loss - no evident atrophy or tissue thinning seen in the accumbens - the putamen shows no notable changes suggestive of atrophy - no evident atrophy or tissue thinning seen in the caudate For the cerebral cortex: - limbic cortex appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the insular cortex - no clear atrophic alterations are visible in the frontal lobe - parietal lobe appears within normal limits without apparent atrophy - no findings suggestive of atrophy are seen in the occipital lobe - the temporal lobe shows no notable changes suggestive of atrophy For the ventricles: - no observable enlargement of the inf. lateral ventricle - no clear enlargement or abnormal growth seen in the lateral ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - no findings suggestive of enlargement are seen in the external csf - 3rd ventricle maintains its expected proportions without signs of enlargement	CN	We have the following subject's personal information: - The subject is a male of 38.0 years old. - He has 16.0 years of education (equivalent to bachelor’s degree) - The subject is left-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 28. - On the semantic categorical fluency test, the subject named 17 animals in 60 seconds. He named 12 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 10. - On the Number Span forward test, his longest span forward was 4. On the Number Span backward test, his longest span backward was 3. - On the Trail Making Test Part A, his total number of seconds to complete is 22, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 71, his number of commission errors is 0, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in depression or dysphoria, anxiety, apathy or indifference, motor disturbance. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_141_S_6116_MR_Accelerated_Sagittal_MPRAGE__br_raw_20190102161901176_24_S635865_I935952	On a T1-weighted brain MRI we observed: For the subcortical structures: - the putamen shows no notable changes suggestive of atrophy - hippocampus demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the accumbens - no observable atrophic changes in the pallidum - thalamus appears within normal limits without apparent atrophy - caudate maintains a normal appearance with no observable atrophic features - no appreciable degenerative or atrophic changes observed in the amygdala For the ventricles: - the 3rd ventricle shows no notable changes suggestive of enlargement - lateral ventricle appears to be of normal dimensions, with no observable increase in size - external csf maintains its expected proportions without signs of enlargement - no findings suggestive of enlargement are seen in the inf. lateral ventricle - 4th ventricle appears to be of normal dimensions, with no observable increase in size For the cerebral cortex: - temporal lobe appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the parietal lobe - no clear atrophic alterations are visible in the insular cortex - no observable atrophic changes in the limbic cortex - frontal lobe appears preserved, with no observable tissue loss - no observable atrophic changes in the occipital lobe	CN	We have the following subject's personal information: - The subject is a female of 69.6 years old. - Subject's current marrietal status is: married. - She has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following subject's family history information: - Her mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 16. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_141_S_0790_MR_MPR__GradWarp__B1_Correction__N3__Scaled_Br_20080220165919265_S18766_I91253	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no clear atrophic alterations are visible in the parietal lobe - limbic cortex appears within normal limits without apparent atrophy - occipital lobe maintains a normal appearance with no observable atrophic features - no findings suggestive of atrophy are seen in the insular cortex - temporal lobe appears preserved, with no observable tissue loss - no observable atrophic changes in the frontal lobe For the subcortical structures: - no findings suggestive of atrophy are seen in the amygdala - no observable atrophic changes in the thalamus - caudate maintains a normal appearance with no observable atrophic features - no findings suggestive of atrophy are seen in the hippocampus - no clear atrophic alterations are visible in the putamen - the accumbens shows no notable changes suggestive of atrophy - pallidum maintains a normal appearance with no observable atrophic features For the ventricles: - 3rd ventricle maintains a typical volume without observable enlargement - mild enlargement of the 4th ventricle - mild bilateral enlargement of the inf. lateral ventricle - mild bilateral enlargement of the lateral ventricle - no evident size increase noted in the external csf	AD	We have the following subject's personal information: - The subject is a female of 83.4 years old. - Subject's current marrietal status is: married. - She has 14.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 26. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 3. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. Her standard CDR Sum of Boxes score is 3.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
FTLD_203437634_03433_MR_Accelerated_Sagittal_MPRAGE_br_raw_20240_I10450733	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no evident atrophy or tissue thinning seen in the insular cortex - occipital lobe appears within normal limits without apparent atrophy - no observable atrophic changes in the limbic cortex - mild bilateral atrophy of the parietal lobe; focal volume loss observed in the following subregions: supramarginal gyrus (mild atrophy both left and right) and postcentral gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) - no evident atrophy or tissue thinning seen in the temporal lobe - mild bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: middle frontal gyrus (mild atrophy both left and right), precentral gyrus (mild atrophy both left and right), sup. frontal gyrus (normal on the left and mild atrophy on the right) and opercular inf. frontal gyrus (mild atrophy on the left) For the subcortical structures: - no appreciable degenerative or atrophic changes observed in the amygdala - mild bilateral atrophy of the putamen - no evident atrophy or tissue thinning seen in the accumbens - the thalamus shows no notable changes suggestive of atrophy - mild bilateral atrophy of the pallidum - hippocampus maintains a normal appearance with no observable atrophic features - mild bilateral atrophy of the caudate For the ventricles: - no evident size increase noted in the 4th ventricle - no observable enlargement of the inf. lateral ventricle - mild enlargement of the 3rd ventricle - mild bilateral enlargement of the lateral ventricle - mild-to-moderate enlargement of the external csf	PNFA	We have the following subject's personal information: - The subject is a female of 81.0 years old. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 30. - On the semantic categorical fluency test, the subject named 9 animals in 60 seconds. She named 2 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 20. - On the Number Span forward test, her longest span forward was 6. On the Number Span backward test, her longest span backward was 3. - On the Trail Making Test Part A, her total number of seconds to complete is 91, her number of commission errors is 0, her number of correct lines is 24. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. Her standard CDR Sum of Boxes score is 1.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 1.0 (mild impairment). Description: Moderate word-finding difficulty in speech; cannot name objects in environment; reduced phrase length and/or agrammatical speech and/or reduced comprehension in conversation and reading.
ADNI_072_S_4103_MR_MPRAGE_br_raw_20110721105250665_38_S115543_I245969	On a T1-weighted brain MRI we observed: For the subcortical structures: - putamen demonstrates a healthy morphology without signs of atrophy - no appreciable degenerative or atrophic changes observed in the thalamus - no findings suggestive of atrophy are seen in the amygdala - pallidum appears within normal limits without apparent atrophy - the hippocampus shows no notable changes suggestive of atrophy - no findings suggestive of atrophy are seen in the caudate - mild bilateral atrophy of the accumbens For the ventricles: - no evident size increase noted in the external csf - the 3rd ventricle shows no notable changes suggestive of enlargement - no appreciable enlargement noted in the 4th ventricle - lateral ventricle appears within normal size limits with no apparent enlargement - inf. lateral ventricle appears within normal size limits with no apparent enlargement For the cerebral cortex: - no observable atrophic changes in the limbic cortex - no findings suggestive of atrophy are seen in the parietal lobe - no clear atrophic alterations are visible in the temporal lobe - frontal lobe demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the insular cortex - no observable atrophic changes in the occipital lobe	CN	We have the following subject's personal information: - The subject is a male of 71.0 years old. - Subject's current marrietal status is: married. - He has 20.0 years of education (equivalent to doctorate) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 13. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_123_S_6891_MR_Sagittal_3D_Accelerated_MPRAGE_br_raw_20201027113931193_204_S970515_I1353817	On a T1-weighted brain MRI we observed: For the subcortical structures: - moderate atrophy of the left hippocampus, moderate atrophy of the right hippocampus - mild-to-moderate bilateral atrophy of the putamen - moderate bilateral atrophy of the amygdala - mild bilateral atrophy of the caudate - mild bilateral atrophy of the thalamus - mild bilateral atrophy of the pallidum - mild-to-moderate bilateral atrophy of the accumbens For the ventricles: - 4th ventricle appears to be of normal dimensions, with no observable increase in size - mild-to-moderate enlargement of the external csf - mild-to-moderate bilateral enlargement of the inf. lateral ventricle - moderate bilateral enlargement of the lateral ventricle - mild enlargement of the 3rd ventricle For the cerebral cortex: - mild bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: frontal pole (mild atrophy both left and right), gyrus rectus (mild atrophy on the left and normal-to-mild atrophy on the right), middle frontal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), supplementary motor cortex (normal-to-mild atrophy on the left and mild atrophy on the right), orbital inf. frontal gyrus (mild atrophy on the left and normal on the right), posterior orbital gyrus (mild atrophy on the left and normal on the right) and medial orbital gyrus (mild atrophy on the left) - mild bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: anterior insula (mild atrophy both left and right), posterior insula (mild atrophy both left and right) and central operculum (mild atrophy on the left) - occipital lobe maintains a normal appearance with no observable atrophic features - limbic cortex appears preserved, with no observable tissue loss - moderate bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: temporal pole (mild atrophy both left and right), fusiform gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), transverse temporal gyrus (mild-to-moderate atrophy on the left and normal on the right), planum temporale (mild atrophy on the left and normal on the right) and middle temporal gyrus (mild atrophy on the left) - parietal lobe demonstrates a healthy morphology without signs of atrophy	AD	We have the following subject's personal information: - The subject is a male of 78.4 years old. - Subject's current marrietal status is: married. - He has 15.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 22. In his MMSE test, he has an orientation to time score of 2. In his MMSE test, he has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 0. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. His standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
FTLD_203116846_02641_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10177758	On a T1-weighted brain MRI we observed: For the cerebral cortex: - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild atrophy both left and right) - no evident atrophy or tissue thinning seen in the insular cortex - mild atrophy of the left parietal lobe - mild atrophy of the left temporal lobe; focal volume loss observed in the following subregions: temporal pole (mild-to-moderate atrophy on the left) and sup. temporal gyrus (mild atrophy on the left and normal on the right) - atrophy of the frontal lobe with marked asymmetry (moderate left, normal right); focal volume loss observed in the following subregions: sup. frontal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), sup. frontal gyrus medial segment (mild-to-moderate atrophy on the left and normal on the right), middle frontal gyrus (mild atrophy on the left and normal on the right), lateral orbital gyrus (mild atrophy on the left and normal on the right), medial orbital gyrus (mild atrophy on the left and normal on the right), frontal pole (mild atrophy on the left and normal on the right), posterior orbital gyrus (mild atrophy on the left and normal on the right) and opercular inf. frontal gyrus (mild atrophy on the left) - the occipital lobe shows no notable changes suggestive of atrophy For the subcortical structures: - the thalamus shows no notable changes suggestive of atrophy - mild atrophy of the left putamen - mild-to-moderate bilateral atrophy of the accumbens - mild atrophy of the left amygdala - no evident atrophy or tissue thinning seen in the hippocampus - no findings suggestive of atrophy are seen in the pallidum - atrophy of the caudate with marked asymmetry (moderate left, mild right) For the ventricles: - 3rd ventricle appears to be of normal dimensions, with no observable increase in size - inf. lateral ventricle appears to be of normal dimensions, with no observable increase in size - the lateral ventricle shows no notable changes suggestive of enlargement - no observable enlargement of the 4th ventricle - moderate enlargement of the external csf	BV	We have the following subject's personal information: - The subject is a male of 68.0 years old. - He has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 28. - On the semantic categorical fluency test, the subject named 12 animals in 60 seconds. He named 7 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 0. - On the Number Span forward test, his longest span forward was 6. On the Number Span backward test, his longest span backward was 3. - On the Trail Making Test Part A, his total number of seconds to complete is 51, his number of commission errors is 0, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in apathy or indifference, appetite and eating, a mild (noticeable, but not significant) change in elation or euphoria, disinhibition, irritability or lability, nighttime behaviors. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 2.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 1.0 (mild impairment). Description: Moderate word-finding difficulty in speech; cannot name objects in environment; reduced phrase length and/or agrammatical speech and/or reduced comprehension in conversation and reading.
ADNI_019_S_10106_MR_Sagittal_3D_Accelerated_MPRAGE_MSV21_br_raw_20240517083810931_1_I10460278	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no observable atrophic changes in the insular cortex - temporal lobe demonstrates a healthy morphology without signs of atrophy - no appreciable degenerative or atrophic changes observed in the occipital lobe - frontal lobe appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the parietal lobe - limbic cortex demonstrates a healthy morphology without signs of atrophy For the ventricles: - mild enlargement of the 3rd ventricle - the 4th ventricle shows no notable changes suggestive of enlargement - the external csf shows no notable changes suggestive of enlargement - no clear enlargement or abnormal growth seen in the inf. lateral ventricle - moderate bilateral enlargement of the lateral ventricle For the subcortical structures: - hippocampus maintains a normal appearance with no observable atrophic features - no evident atrophy or tissue thinning seen in the putamen - mild bilateral atrophy of the accumbens - mild bilateral atrophy of the caudate - thalamus appears within normal limits without apparent atrophy - no findings suggestive of atrophy are seen in the amygdala - mild bilateral atrophy of the pallidum	CN	We have the following subject's personal information: - The subject is a female of 61.6 years old. We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 28 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, her total number of seconds to complete is 21. On the Trail Making Test Part B, her total number of seconds to complete is 60. From genetic data, APOE genotype is e3,e2 with no e4 allele.
FTLD_203807114_03410_MR_Sagittal_3D_Accelerated_MPRAGE_br_raw_202_I10450687	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild bilateral atrophy of the caudate - thalamus appears preserved, with no observable tissue loss - pallidum maintains a normal appearance with no observable atrophic features - putamen appears preserved, with no observable tissue loss - no observable atrophic changes in the accumbens - amygdala appears within normal limits without apparent atrophy - hippocampus demonstrates a healthy morphology without signs of atrophy For the ventricles: - no findings suggestive of enlargement are seen in the 4th ventricle - inf. lateral ventricle appears to be of normal dimensions, with no observable increase in size - external csf appears to be of normal dimensions, with no observable increase in size - no findings suggestive of enlargement are seen in the lateral ventricle - no appreciable enlargement noted in the 3rd ventricle For the cerebral cortex: - no observable atrophic changes in the occipital lobe - parietal lobe appears within normal limits without apparent atrophy - no appreciable degenerative or atrophic changes observed in the temporal lobe - no evident atrophy or tissue thinning seen in the insular cortex - no appreciable degenerative or atrophic changes observed in the frontal lobe - no evident atrophy or tissue thinning seen in the limbic cortex	CN	We have the following subject's personal information: - The subject is a female of 53.0 years old. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 28. - On the semantic categorical fluency test, the subject named 28 animals in 60 seconds. She named 17 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 20. - On the Number Span forward test, her longest span forward was 8. On the Number Span backward test, her longest span backward was 4. - On the Trail Making Test Part A, her total number of seconds to complete is 13, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 31, her number of commission errors is 0, her number of correct lines is 24. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_021_S_4718_MR_Accelerated_Sag_IR-SPGR__br_raw_20120516162344538_10_S150673_I304759	On a T1-weighted brain MRI we observed: For the ventricles: - mild enlargement of the external csf - severe bilateral enlargement of the inf. lateral ventricle - mild-to-moderate bilateral enlargement of the lateral ventricle - no evident size increase noted in the 4th ventricle - mild enlargement of the 3rd ventricle For the cerebral cortex: - no observable atrophic changes in the frontal lobe - limbic cortex appears preserved, with no observable tissue loss - occipital lobe maintains a normal appearance with no observable atrophic features - mild-to-moderate bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: middle temporal gyrus (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right), fusiform gyrus (mild-to-moderate atrophy on the left and normal on the right) and inf. temporal gyrus (normal on the left and mild atrophy on the right) - no appreciable degenerative or atrophic changes observed in the insular cortex - moderate bilateral atrophy of the parietal lobe; focal volume loss observed in the following subregions: angular gyrus (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right), precuneus (normal-to-mild atrophy on the left and mild atrophy on the right) and postcentral gyrus (normal on the left and mild atrophy on the right) For the subcortical structures: - moderate bilateral atrophy of the amygdala - mild bilateral atrophy of the accumbens - early/mild-grade volumetric reduction of the left hippocampus, mild-to-moderate atrophy of the right hippocampus (marked asymmetry favoring the right) - mild bilateral atrophy of the caudate - mild bilateral atrophy of the thalamus - no clear atrophic alterations are visible in the putamen - pallidum appears within normal limits without apparent atrophy	AD	We have the following subject's personal information: - The subject is a male of 78.6 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 22. - On the semantic categorical fluency test, the subject named 8 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has difficulity, but does by himself, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events. The subject requires assitance for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications. The subject is dependent for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 70. On the Trail Making Test Part B, his total number of seconds to complete is 293. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_051_S_1296_MR_MPR__GradWarp__B1_Correction__N3__Scaled_Br_20070628165536504_S26431_I58022	On a T1-weighted brain MRI we observed: For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - moderate-to-severe bilateral enlargement of the lateral ventricle - mild-to-moderate enlargement of the 3rd ventricle - no appreciable enlargement noted in the 4th ventricle - external csf appears to be of normal dimensions, with no observable increase in size For the subcortical structures: - mild bilateral atrophy of the thalamus - mild-to-moderate bilateral atrophy of the accumbens - early/mild-grade volumetric reduction of the left hippocampus, early/mild-grade volumetric reduction of the right hippocampus - mild bilateral atrophy of the pallidum - mild-to-moderate bilateral atrophy of the amygdala - mild bilateral atrophy of the putamen - mild bilateral atrophy of the caudate For the cerebral cortex: - the parietal lobe shows no notable changes suggestive of atrophy - temporal lobe demonstrates a healthy morphology without signs of atrophy - limbic cortex appears preserved, with no observable tissue loss - no observable atrophic changes in the insular cortex - frontal lobe demonstrates a healthy morphology without signs of atrophy - occipital lobe appears within normal limits without apparent atrophy	AD	We have the following subject's personal information: - The subject is a male of 77.0 years old. - Subject's current marrietal status is: married. - He has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 25. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 2. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 4.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e4,e4 with 2 copies of e4 allele.
FTLD_203661911_02116_MR_Sagittal_MP-Rage_br_raw_20230206154039408_I10181429	On a T1-weighted brain MRI we observed: For the ventricles: - 4th ventricle maintains its expected proportions without signs of enlargement - mild-to-moderate enlargement of the 3rd ventricle - mild bilateral enlargement of the lateral ventricle - mild-to-moderate enlargement of the external csf - severe bilateral enlargement of the inf. lateral ventricle For the cerebral cortex: - occipital lobe appears preserved, with no observable tissue loss - parietal lobe appears within normal limits without apparent atrophy - mild-to-moderate bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: anterior insula (moderate atrophy on the left and mild-to-moderate atrophy on the right) and posterior insula (mild atrophy on the left) - the frontal lobe shows no notable changes suggestive of atrophy - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: entorhinal area (mild-to-moderate atrophy on the left and mild atrophy on the right) and anterior cingulate gyrus (mild atrophy both left and right) - atrophy of the temporal lobe with marked asymmetry (moderate-to-severe left, normal right); focal volume loss observed in the following subregions: temporal pole (moderate atrophy on the left and mild-to-moderate atrophy on the right), fusiform gyrus (mild-to-moderate atrophy on the left and normal on the right), inf. temporal gyrus (mild atrophy on the left and normal on the right) and middle temporal gyrus (mild atrophy on the left) For the subcortical structures: - atrophy of the thalamus with marked asymmetry (mild left, normal right) - mild bilateral atrophy of the pallidum - atrophy of the caudate with marked asymmetry (mild-to-moderate left, normal right) - atrophy of the accumbens with marked asymmetry (moderate left, mild right) - atrophy of the putamen with marked asymmetry (moderate left, mild right) - atrophy of the amygdala with marked asymmetry (severe left, mild-to-moderate right) - moderate atrophy of the left hippocampus, normal-to-mild atrophy of the right hippocampus (marked asymmetry favoring the left)	SV	We have the following subject's personal information: - The subject is a male of 73.0 years old. - He has 14.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 13. - On the semantic categorical fluency test, the subject named 7 animals in 60 seconds. He named 1 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 0. - On the Number Span forward test, his longest span forward was 8. On the Number Span backward test, his longest span backward was 7. - On the Trail Making Test Part A, his total number of seconds to complete is 45, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 146, his number of commission errors is 1, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in agitation or aggression, depression or dysphoria, anxiety, elation or euphoria, apathy or indifference, disinhibition, irritability or lability, motor disturbance, nighttime behaviors. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. His standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 1.0 (mild impairment). Description: Moderate word-finding difficulty in speech; cannot name objects in environment; reduced phrase length and/or agrammatical speech and/or reduced comprehension in conversation and reading.
FTLD_203735377_03773_MR_Accelerated_Sagittal_MPRAGE_br_raw_20240_I10451145	On a T1-weighted brain MRI we observed: For the subcortical structures: - no evident atrophy or tissue thinning seen in the putamen - atrophy of the amygdala with marked asymmetry (severe left, mild right) - thalamus demonstrates a healthy morphology without signs of atrophy - mild bilateral atrophy of the accumbens - mild-to-moderate atrophy of the left hippocampus, normal-to-mild atrophy of the right hippocampus (marked asymmetry favoring the left) - pallidum appears within normal limits without apparent atrophy - caudate appears within normal limits without apparent atrophy For the cerebral cortex: - no evident atrophy or tissue thinning seen in the occipital lobe - atrophy of the temporal lobe with marked asymmetry (moderate left, mild right); focal volume loss observed in the following subregions: temporal pole (moderate atrophy on the left and mild atrophy on the right), inf. temporal gyrus (moderate atrophy on the left), middle temporal gyrus (mild atrophy on the left and normal on the right) and fusiform gyrus (mild atrophy on the left and normal on the right) - parietal lobe appears within normal limits without apparent atrophy - insular cortex maintains a normal appearance with no observable atrophic features - no clear atrophic alterations are visible in the limbic cortex - frontal lobe maintains a normal appearance with no observable atrophic features For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - mild-to-moderate bilateral enlargement of the lateral ventricle - no evident size increase noted in the external csf - no findings suggestive of enlargement are seen in the 3rd ventricle - no findings suggestive of enlargement are seen in the 4th ventricle	SV	We have the following subject's personal information: - The subject is a female of 75.0 years old. - She has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 4. - On the semantic categorical fluency test, the subject named 6 animals in 60 seconds. She named 4 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 13. - On the Number Span forward test, her longest span forward was 6. On the Number Span backward test, her longest span backward was 6. - On the Trail Making Test Part A, her total number of seconds to complete is 65, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 134, her number of commission errors is 0, her number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in disinhibition, nighttime behaviors, appetite and eating. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. Her standard CDR Sum of Boxes score is 3.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 1.0 (mild impairment). Description: Moderate word-finding difficulty in speech; cannot name objects in environment; reduced phrase length and/or agrammatical speech and/or reduced comprehension in conversation and reading.

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