Subset (3)

commercial · ~3.84M rows (showing the first 120k)

Split (1)

train · ~3.84M rows (showing the first 120k)

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PMC10788082	38222992	[ "<title>Introduction</title>", "<p>Thrombotic microangiopathy (TMA) is a serious pathological state where there is microvascular thrombosis leading to the mechanical destruction of red blood cells and consumption of platelets resulting in microangiopathic hemolytic anemia (MAHA) and thrombocytopenia, respectively...	[]	[]	[ "<title>Discussion</title>", "<p>TMA is a serious systemic illness with progressively life-threatening thrombocytopenia, MAHA, and renal dysfunction [##REF##34269998##5##]. TMA can be classified as primary, characterized by a complement mutation or complement autoantibodies, such as TTP and aHUS, or secondary due...	[ "<title>Conclusions</title>", "<p>TMA in pregnancy and the postpartum period is a complex and serious disorder that requires a high index of suspicion and a prompt course of action. Other coexisting elements such as autoimmune disorders or infections can make the diagnosis a real challenge. The natural history of...	[ "<p>Thrombotic microangiopathy (TMA) is a severe systemic disorder with multiorgan manifestations due to thrombosis of the microvasculature. Pregnancy and post-partum are particularly high-risk periods for many forms of TMA. The disease progression is rapid and can lead to organ failure and even death; therefore, u...	[ "<title>Case presentation</title>", "<p>A 27-year-old female, gravida 5, para 4, with no history of illness prior to her last pregnancy in 2021, presented in the third trimester with arthritis, headache, and generalized fatigue. The patient was found to have hypertension, renal impairment, and proteinuria. She wa...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>First kidney biopsy</title><p>(A) The glomerular vascular pole is showing fibrinoid necrosis. A thrombus is also seen in one capillary lumen. The glomerulus has fibrillary appearance with duplication of the glomerular c...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Summary of blood tests</title><p>C3: Complement 3; C4: Complement 4</p></caption><table frame=\"hsides\" rules=\"groups\"><tbody><tr style=\"background-color:#ccc\"><td rowspan=\"1\" colspan=\"1\">Test</td><td colspan=\"2\" rowspan=\"...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Basil Alnasrallah, Eman Alabbad, Mohammed M. Aljishi, Zainab A. Alkhuraidah, Sumayah Alsabaa</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Basil Alnasrallah, Eman A...	[ "<graphic xlink:href=\"cureus-0016-00000052248-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0016-00000052248-i02\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0016-00000052248-i03\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0016-00000052248-i04\" position=\"float\"/>" ]	[]	[{"label": ["1"], "article-title": ["Syndromes of thrombotic microangiopathy"], "source": ["N Engl J Med"], "person-group": ["\n"], "surname": ["Aviner", "Bibi"], "given-names": ["S", "H"], "fpage": ["1846"], "volume": ["371"], "year": ["2014"]}, {"label": ["6"], "article-title": ["Thrombotic microangiopathy in lupus n...	{ "acronym": [], "definition": [] }	16	CC BY	no	2024-01-15 23:43:49	Cureus.; 16(1):e52248	oa_package/2d/e2/PMC10788082.tar.gz
PMC10788087	38223752	[ "<title>Introduction</title>", "<p>Postural stability is defined as the ability to maintain the centre of mass of a body within the base of support with minimal postural sway through somatosensory information (##REF##31629327##Pino-Ortega et al., 2020##), and is commonly assessed through static and dynamic balanc...	[ "<title>Materials and Methods</title>", "<title>Study design</title>", "<p>A single-group pretest-posttest design was used, which involved repeated monopodal postural stability assessment of the dominant and non-dominant lower limb before and after a 4-week intervention (three weekly sessions) consisting of dom...	[ "<title>Results</title>", "<title>Changes associated with instability interventions</title>", "<p>##TAB##0##Table 1## shows the changes associated with an instability training programme measured with three monopodal postural stability tests. The dynamic balance for the dominant lower limb, as measured with the ...	[ "<title>Discussion</title>", "<p>To our knowledge, this is the first study that analyses the responsiveness of different monopodal stability tests in healthy participants after an instability training programme. We found that only EBT showed both internal and external responsiveness, while the mSEBT showed accept...	[ "<title>Conclusions</title>", "<p>According to the results, a positive responsiveness of the EBT to changes in monopodal stability after instability training in healthy participants can be concluded. In contrast, mSEBT only showed internal responsiveness, and none of the stabilometry platform measures were able t...	[ "<title>Background</title>", "<p>Stabilometry, the modified Star Excursion Balance Test (mSEBT) or the Emery balance test (EBT) are reported in the literature to reflect changes after an intervention in monopodal postural stability. Even so, the responsiveness of those tests has not been evaluated after an instab...	[ "<title>Supplemental Information</title>" ]	[ "<title>Additional Information and Declarations</title>" ]	[ "<fig position=\"float\" id=\"fig-1\"><object-id pub-id-type=\"doi\">10.7717/peerj.16765/fig-1</object-id><label>Figure 1</label><caption><title>Monopodal postural stability measured by (A) stabilometry, (B) modified Star Excursion Balance test, and (C) Emery balance test.</title></caption></fig>", "<fig position...	[ "<table-wrap position=\"float\" id=\"table-1\"><object-id pub-id-type=\"doi\">10.7717/peerj.16765/table-1</object-id><label>Table 1</label><caption><title>Differences in the dominant and non-dominant lower limb for the three monopodal stability tests after instability training.</title></caption><alternatives><table...	[]	[]	[]	[]	[]	[ "<supplementary-material id=\"supp-1\" position=\"float\" content-type=\"local-data\"><object-id pub-id-type=\"doi\">10.7717/peerj.16765/supp-1</object-id><label>Supplemental Information 1</label><caption><title>Raw data of all variables for each subject.</title></caption></supplementary-material>", "<supplementa...	[ "<table-wrap-foot><fn id=\"table-1fn\"><p>\n<bold>Notes:</bold>\n</p></fn><fn id=\"table-1fn1\" fn-type=\"other\"><p>M, mean; SD, standard deviation; mSEBT, modified Star Excursion Balance Test; EBT, Emery balance test; ANT, anterior; PM, posteromedial; PL, posterolateral.</p></fn><fn id=\"table-1fn2\" fn-type=\"ot...	[ "<graphic xlink:href=\"peerj-12-16765-g001\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-16765-g002\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-16765-g003\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-16765-g004\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-1676...	[ "<media xlink:href=\"peerj-12-16765-s001.sav\"><caption><p>Click here for additional data file.</p></caption></media>", "<media xlink:href=\"peerj-12-16765-s002.docx\"><caption><p>Click here for additional data file.</p></caption></media>", "<media xlink:href=\"peerj-12-16765-s003.pdf\"><caption><p>Click here f...	[{"label": ["Cain, Garceau & Linens (2017)"], "person-group": ["\n"], "surname": ["Cain", "Garceau", "Linens"], "given-names": ["MS", "SW", "SW"], "article-title": ["Effects of a 4-week biomechanical ankle platform system protocol on balance in high school athletes with chronic ankle instability"], "source": ["Journal ...	{ "acronym": [], "definition": [] }	42	CC BY	no	2024-01-15 23:43:49	PeerJ. 2024 Jan 11; 12:e16765	oa_package/65/2d/PMC10788087.tar.gz
PMC10788088	38223764	[ "<title>Introduction</title>", "<p>Birds, which encompass a remarkable diversity of over 11,000 species, are a captivating and highly valued part of the natural world (##UREF##2##BirdLife International, 2018##). Their intricate variety ranges from the tiniest to the largest, and the slowest to the swiftest flyers...	[ "<title>Materials and Methods</title>", "<title>Description of the study area</title>", "<title>Location</title>", "<p>The Dodola natural forest habitat is part of the Adaba Dodola Jalo forest which is one of the 61 National Forest Priority Areas (NFPA) of the country that covers approximately 530 km<sup>2</s...	[ "<title>Results</title>", "<title>Species composition</title>", "<p>Over the course of two distinct climatic periods (dry and wet), a total of 78 species of birds were recorded. Within the recorded species, the Abyssinian Catbird (<italic toggle=\"yes\">Parophasma galinieri</italic>), Ethiopian Siskin (<italic ...	[ "<title>Discussion</title>", "<title>Low detection frequencies and detection probabilities</title>", "<p>Some species, including the African Black Swift, Pied Crow, and Common Buzzard, exhibited low detection frequencies, falling below the standard recommended threshold of 60–80 observations. This could introdu...	[ "<title>Conclusion</title>", "<p>The study revealed the presence of three unique endemic bird species, constituting a notable 20% of Ethiopia’s endemic avian population. Moreover, within the study area, an impressive 71% of Ethiopia and Eritrea’s endemic bird species call this region home, highlighting the except...	[ "<title>Background</title>", "<p>Birds’ functional groups are useful for maintaining fundamental ecological processes, ecosystem services, and economic benefits. Negative consequences of loss of functional groups are substantial. Birds are usually found at a high trophic level in food webs and are relatively sens...	[ "<title>Supplemental Information</title>" ]	[ "<title>Additional Information and Declarations</title>" ]	[ "<fig position=\"float\" id=\"fig-1\"><object-id pub-id-type=\"doi\">10.7717/peerj.16775/fig-1</object-id><label>Figure 1</label><caption><title>Location map of the study area.</title><p>Map credit: Zenebe Ageru Yilma.</p></caption></fig>", "<fig position=\"float\" id=\"fig-2\"><object-id pub-id-type=\"doi\">10.7...	[ "<table-wrap position=\"float\" id=\"table-1\"><object-id pub-id-type=\"doi\">10.7717/peerj.16775/table-1</object-id><label>Table 1</label><caption><title>Encounter rates to provide a crude ordinal scale of abundance (##UREF##1##Bibby, Jones & Marsden, 1998##).</title></caption><alternatives><table frame=\"hsid...	[ "<disp-formula id=\"eqn-1\"><label>(1)</label><alternatives><tex-math id=\"tex-eqn-1\">\\documentclass[12pt]{minimal}\n\\usepackage{amsmath}\n\\usepackage{wasysym}\n\\usepackage{amsfonts}\n\\usepackage{amssymb}\n\\usepackage{amsbsy}\n\\usepackage{upgreek}\n\\usepackage{mathrsfs}\n\\setlength{\\oddsidemargin}{-69pt}...	[]	[]	[]	[]	[ "<supplementary-material id=\"supp-1\" position=\"float\" content-type=\"local-data\"><object-id pub-id-type=\"doi\">10.7717/peerj.16775/supp-1</object-id><label>Supplemental Information 1</label><caption><title>The study data and analysis in distance software</title></caption></supplementary-material>", "<supple...	[ "<table-wrap-foot><fn id=\"table-3fn\"><p>\n<bold>Notes.</bold>\n</p></fn><fn id=\"table-3fn1\" fn-type=\"other\"><p>\n</p></fn></table-wrap-foot>", "<table-wrap-foot><fn id=\"table-4fn\"><p>\n<bold>Notes.</bold>\n</p></fn><fn id=\"table-4fn1\" fn-type=\"other\"><p>\n</p></fn></table-wrap-foot>", "<table-wrap-f...	[ "<graphic xlink:href=\"peerj-12-16775-g001\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-16775-e001.jpg\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-16775-e002.jpg\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-16775-g002\" position=\"float\"/>", "<graphic xlink:href=\"peerj...	[ "<media xlink:href=\"peerj-12-16775-s001.zip\"><caption><p>Click here for additional data file.</p></caption></media>", "<media xlink:href=\"peerj-12-16775-s002.zip\"><caption><p>Click here for additional data file.</p></caption></media>", "<media xlink:href=\"peerj-12-16775-s003.csv\"><caption><p>Click here fo...	[{"label": ["Aynalem & Bekele (2008)"], "person-group": ["\n"], "surname": ["Aynalem", "Bekele"], "given-names": ["S", "A"], "year": ["2008"], "article-title": ["Species composition, relative abundance, and distribution of bird fauna of riverine and wetland habitats of Infranz and Yiganda at southern tip of Lake Tana, ...	{ "acronym": [ " n", " ER", " se.ER", " cv.ER" ], "definition": [ "total number of observations", "Encounter rate", "Standard error for ER", "coefficient variation of ER" ] }	44	CC BY	no	2024-01-15 23:43:49	PeerJ. 2024 Jan 11; 12:e16775	oa_package/c5/3e/PMC10788088.tar.gz
PMC10788089	38223754	[ "<title>Introduction</title>", "<p>The systematization of taxa of endemic wild mountain plant species is an urgent issue in the latest taxonomy of the Rosaceae Juss family; one of the most prominent examples is the systematization of representatives of endemic mountain shrubs of the almond subgenus. The almond is...	[ "<title>Materials & Methods</title>", "<title>Study of genetic structure using SSR</title>", "<p>This study investigated three isolated populations of <italic toggle=\"yes\">P. ledebouriana</italic> from two mountain geographic ranges (Altai and Tarbagatai) and one <italic toggle=\"yes\">P. tenella</italic>...	[ "<title>Results</title>", "<title>Variability of plant height among populations</title>", "<p>The samples of three <italic toggle=\"yes\">P. ledebouriana</italic> and one population of <italic toggle=\"yes\">P. tenella</italic> were assessed according to plant height (##FIG##0##Fig. 1##). The most significant p...	[ "<title>Discussion</title>", "<title>The phylogenetic relationship between <italic toggle=\"yes\">P. tenella</italic> and <italic toggle=\"yes\">P. ledebouriana</italic></title>", "<p>The phylogeny of the genus <italic toggle=\"yes\">Prunus</italic> is complex. Previous reports provided contradictory results on...	[ "<title>Conclusion</title>", "<p>Discriminating the endemic species <italic toggle=\"yes\">P. ledebouriana</italic> from wild almond <italic toggle=\"yes\">P. tenella</italic> has been a poorly studied issue for the genus <italic toggle=\"yes\">Prunus</italic>. In this work, two different approaches were conducte...	[ "<title>Background</title>", "<p>Genetic differences between isolated endemic populations of plant species and those with widely known twin species are relevant for conserving the biological diversity of our planet’s flora. <italic toggle=\"yes\">Prunus ledebouriana</italic> (Schlecht.) YY Yao is an endangered an...	[ "<title> Supplemental Information</title>" ]	[ "<p>The authors express their gratitude to the head of the Department of Science, Information, and Monitoring of the State National Natural Park, Tarbagatai Alemseitova Janylkan Kabikyzy, for organizing field scientific expeditions in the territory of the National Park.</p>", "<title>Additional Information and De...	[ "<fig position=\"float\" id=\"fig-1\"><object-id pub-id-type=\"doi\">10.7717/peerj.16735/fig-1</object-id><label>Figure 1</label><caption><title>Column diagram of plant heights in populations of <italic toggle=\"yes\">P. ledebouriana</italic> (A—Urdzhar, B—Kokpekty, C—Katon-Karagai-blue) and <italic toggle=\"yes\">...	[ "<table-wrap position=\"float\" id=\"table-1\"><object-id pub-id-type=\"doi\">10.7717/peerj.16735/table-1</object-id><label>Table 1</label><caption><title>The list of polymorphic SSR loci selected from ##UREF##25##Mnejja et al. (2005)## and analyzed in plants of <italic toggle=\"yes\">P. ledebouriana</italic> and <...	[]	[]	[]	[]	[]	[ "<supplementary-material id=\"supp-1\" position=\"float\" content-type=\"local-data\"><object-id pub-id-type=\"doi\">10.7717/peerj.16735/supp-1</object-id><label>Table S1</label><caption><title>Geographic locations of collected three populations of <italic toggle=\"yes\">P. ledebouriana</italic> and one population ...	[ "<table-wrap-foot><fn id=\"table-1fn\"><p>\n<bold>Notes.</bold>\n</p></fn><fn id=\"table-1fn1\" fn-type=\"other\"><p><sup>+</sup>—Optimized annealing temperature (°C).</p></fn></table-wrap-foot>", "<table-wrap-foot><fn id=\"table-2fn\"><p>\n<bold>Notes.</bold>\n</p></fn><fn id=\"table-2fn1\" fn-type=\"other\"><p>...	[ "<graphic xlink:href=\"peerj-12-16735-g001\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-16735-g002\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-16735-g006\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-16735-g007\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-1673...	[ "<media xlink:href=\"peerj-12-16735-s001.docx\"><caption><p>Click here for additional data file.</p></caption></media>", "<media xlink:href=\"peerj-12-16735-s002.xlsx\"><caption><p>Click here for additional data file.</p></caption></media>" ]	[{"label": ["Abdulina (1999)"], "person-group": ["\n"], "surname": ["Abdulina"], "given-names": ["SA"], "year": ["1999"], "source": ["Checklist of vascular plants in Kazakhstan"], "publisher-loc": ["Almaty"], "publisher-name": ["Ministry of Science, Academy of Sciences of the Republic of Kazakhstan, Institute of Botany...	{ "acronym": [ "n", " Na", " Ne", " uHe", " Fst", "HO", "HE", " FIS", " Rp", " MI" ], "definition": [ "number of plants studied in the population", "number of alleles per locus", "effective number of alleles", "Unbiased Expected Heterozygosity", "fixatio...	67	CC BY	no	2024-01-15 23:43:49	PeerJ. 2024 Jan 11; 12:e16735	oa_package/ed/f3/PMC10788089.tar.gz
PMC10788090	38223759	[ "<title>Introduction</title>", "<p>Faecal indicator bacteria (FIB) are a group of bacteria used to evaluate water faecal contamination. Ideally, FIB should be of faecal origin only and not grow in the extraintestinal environment (##REF##25941519##Rochelle-Newall et al., 2015##). Furthermore, the abundance of FIB ...	[ "<title>Materials & Methods</title>", "<title>Study sites and environmental variables</title>", "<p>A total of 35 water and 21 sediment samples were collected regularly at five independent urban lakes (Tasik Varsiti, Tasik Taman Jaya, Tasik Aman, Tasik Kelana and Tasik Central Park Bandar Utama), located 2–...	[ "<title>Results</title>", "<title>Environmental variables</title>", "<p>##TAB##0##Table 1## lists the size and land use of five lakes, and physico-chemical variables measured in the water samples collected at the five lakes in this study. Surface water temperature and pH varied little among the five lakes and r...	[ "<title>Discussion</title>", "<title>Environmental condition of the urban lakes</title>", "<p>The surface water temperatures recorded at the five lakes were relatively high with low variability, and is typical of tropical waters (##REF##29571392##Lim et al., 2018##). The DO concentrations measured at Tasik Vars...	[ "<title>Conclusions</title>", "<p>Sediments acted as a reservoir of <italic toggle=\"yes\">E. coli</italic> in tropical urban lakes with a higher abundance of <italic toggle=\"yes\">E. coli</italic> than in the water column. The habitat transition of <italic toggle=\"yes\">E. coli</italic> from sediment to the wa...	[ "<title>Background</title>", "<p><italic toggle=\"yes\">Escherichia coli</italic> is a commonly used faecal indicator bacterium to assess the level of faecal contamination in aquatic habitats. However, extensive studies have reported that sediment acts as a natural reservoir of <italic toggle=\"yes\">E. coli</ita...	[ "<title> Supplemental Information</title>" ]	[ "<p>We thank Yi You Wong, Kyle Young Low, Walter Aaron and Ee Lean Thiang for their assistance with sampling.</p>", "<title>Additional Information and Declarations</title>" ]	[ "<fig position=\"float\" id=\"fig-1\"><object-id pub-id-type=\"doi\">10.7717/peerj.16556/fig-1</object-id><label>Figure 1</label><caption><title>Map of the location of sampling stations.</title><p>Map showing the location of the tropical urban lakes (Tasik Varsiti, Tasik Taman Jaya, Tasik Aman, Tasik Kelana and Tas...	[ "<table-wrap position=\"float\" id=\"table-1\"><object-id pub-id-type=\"doi\">10.7717/peerj.16556/table-1</object-id><label>Table 1</label><caption><title>The size and land use of five lakes, and water physico-chemical variables (Mean ± SD) measured at five lakes in this study.</title></caption><alternatives><table...	[]	[]	[]	[]	[]	[ "<supplementary-material id=\"supp-1\" position=\"float\" content-type=\"local-data\"><object-id pub-id-type=\"doi\">10.7717/peerj.16556/supp-1</object-id><label>Supplemental Information 1</label><caption><title>List of lakes coordinates, sampling dates and experiments conducted in this study</title><p>The names of...	[ "<table-wrap-foot><fn id=\"table-1fn\"><p>\n<bold>Notes.</bold>\n</p></fn><fn id=\"table-1fn1\"><label>***</label><p>Showed significant differences in ANOVA at <italic toggle=\"yes\">p</italic> <0.001.</p></fn><fn id=\"table-1fn2\" fn-type=\"other\"><p>The same superscript letter of the alphabet indicates signif...	[ "<graphic xlink:href=\"peerj-12-16556-g001\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-16556-g002\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-16556-g013\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-16556-g014\" position=\"float\"/>", "<graphic xlink:href=\"peerj-12-1655...	[ "<media xlink:href=\"peerj-12-16556-s001.xlsx\"><caption><p>Click here for additional data file.</p></caption></media>", "<media xlink:href=\"peerj-12-16556-s002.xlsx\"><caption><p>Click here for additional data file.</p></caption></media>", "<media xlink:href=\"peerj-12-16556-s003.xlsx\"><caption><p>Click here...	[{"label": ["Bitton et al. (1983)"], "person-group": ["\n"], "surname": ["Bitton", "Farrah", "Ruskin", "Butner", "Chou"], "given-names": ["G", "SR", "RH", "J", "YJ"], "year": ["1983"], "article-title": ["Survival of pathogenic and indicator organisms in ground water"], "source": ["Ground Water"], "volume": ["21"], "fpa...	{ "acronym": [], "definition": [] }	52	CC BY	no	2024-01-15 23:43:49	PeerJ. 2024 Jan 11; 12:e16556	oa_package/fd/e6/PMC10788090.tar.gz
PMC10788091	38222249	[ "<title>1. Background</title>", "<p>For thousands of years, narcotics have been used for medicinal and palliative purposes and still have an important role in relieving pain, diarrhea, cough, and other symptoms. Narcotics abuse has risen dramatically in recent years. For instance, Golestan Cohort Study conducted ...	[ "<title>3. Methods</title>", "<p>This study was conducted in November 2019 at Imam Reza Hospital Rehab Center, Birjand, Iran. The patients were on methadone to ease quitting opium addiction. Our inclusion criteria were an addiction to opium for at least six months, not using corticosteroids in the past year, age ...	[ "<title>4. Results</title>", "<p>As shown in ##TAB##0##Table 1##, the mean age of the participants was 34.4 ± 5.2, and most were men (90.5%). Eight of them were cigarette smokers.</p>", "<p>Cortisol levels and response to the cosyntropin test had a normal distribution (P-value = 0.44 and 0.28, respectively).</p...	[ "<title>5. Discussion</title>", "<p>This study investigated changes in cortisol levels and the response to ACTH hormone in former opium addicts on methadone treatment. Considering adrenal insufficiency can affect the management of these patients. Fifty-five percent of our participants had cortisol levels lower th...	[]	[ "<title>Background</title>", "<p>Opium has been used for thousands of years for medical and analgesic purposes, and its misuse has also increased in recent years. Methadone, a synthetic opioid, has been used as an analgesic and to help patients quit opium addiction. However, some evidence suggests that long-term ...	[ "<title>2. Objectives</title>", "<p>Regarding the high prevalence of methadone use, we aimed to measure the changes in cortisol levels and the response to the cosyntropin test to determine the extent and prevalence of adrenal insufficiency in opium-addicted patients on methadone treatment.</p>" ]	[ "<p>We would like to thank Mr. Keivan Kalali, who contributed to writing the manuscript and analyzing the data.</p>", "<title>Authors' Contribution: </title>", "<p>Study concept and design: F. Z., M. G, and A. B; Acquisition of data: F. Z., A. K., and A. B; Analysis and interpretation of data: A. B, SA. E., and...	[ "<fig position=\"float\" id=\"A135206FIG1\" fig-type=\"inline\"><label>Figure 1.</label><caption><title>Changes in serum cortisol level in response to cosyntropin test</title></caption></fig>" ]	[ "<table-wrap position=\"float\" id=\"A135206TBL1\"><label>Table 1.</label><caption><title>Demographic and Clinical Characteristics of Study Participants <sup><xref rid=\"A135206TBL1FN1\" ref-type=\"table-fn\">a</xref></sup></title></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th style=\"text-align:...	[]	[]	[]	[]	[]	[]	[ "<table-wrap-foot><fn id=\"A135206TBL1FN1\"><p><sup>a</sup> Values are expressed as Mean ± SD or No. (%).</p></fn></table-wrap-foot>", "<table-wrap-foot><fn id=\"A135206TBL2FN1\"><p><sup>a</sup> By using one-way ANOVA</p></fn></table-wrap-foot>" ]	[ "<graphic xlink:href=\"aapm-13-3-135206-i001\" position=\"float\"/>" ]	[]	[{"label": ["10"], "surname": ["McPherson", "Pincus"], "given-names": ["RA", "MR"], "source": ["Henry's clinical diagnosis and management by laboratory methods."], "year": ["2021"], "isbn": ["0323755089"], "publisher-name": ["Elsevier Health Sciences"]}, {"label": ["11"], "surname": ["Melmed", "Polonsky", "Larsen", "Kr...	{ "acronym": [], "definition": [] }	27	CC BY	no	2024-01-15 23:43:49	Anesth Pain Med. 2023 Jun 3; 13(3):e135206	oa_package/46/9b/PMC10788091.tar.gz
PMC10788092	38222996	[ "<title>Introduction</title>", "<p><italic>Streptococcus pneumoniae</italic> (<italic>S. pneumoniae</italic>) is an aerobic gram-positive coccus that causes a broad variety of infections. Non-invasive pneumococcal infections include bronchitis, otitis media, and sinusitis. An infection in which <italic>S. pneumon...	[]	[]	[ "<title>Discussion</title>", "<p>The risk of infection, sepsis, and sepsis-related mortality appears to be approximately two to three times higher in asplenic patients when compared with the general population [##UREF##2##5##, ####UREF##3##6####3##6##]. Patients with impaired splenic function are at risk for seve...	[ "<title>Conclusions</title>", "<p>Fever in a patient with impaired splenic function is an emergency, and it should be promptly and adequately identified and managed as it may have a fulminant course.</p>", "<p>Despite the success of PCVs, with the reduction in PCV-serotype nasopharyngeal colonisation rates in c...	[ "<p>Invasive pneumococcal disease is a serious infection with an elevated case-fatality rate that can be even higher among patients with asplenia. Its impact has been blunted by the widespread use of vaccines; even recently, in 2021, two new pneumococcal conjugate vaccines emerged. The authors present a case of a 5...	[ "<title>Case presentation</title>", "<p>We report a case of a 58-year-old Caucasian male with a history of surgical splenectomy due to abdominal trauma at the age of 18. He had been previously hospitalised in July 2021 with pneumococcal shock with an unknown portal of entry; he was discharged after 18 days, makin...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Chest X-ray on the first admission showing no significant alteration</title></caption></fig>", "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG2\"><label>Figure 2</label><caption><title>Diffuse, exuberant erythe...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Comparison of laboratory values</title><p>aPTT: activated partial thromboplastin time; PT: prothrombin time</p></caption><table frame=\"hsides\" rules=\"groups\"><tbody><tr style=\"background-color:#ccc\"><td rowspan=\"2\" colspan=\"1...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Liliana Costa, Núria Jorge, Sofia Silva, André Silva-Pinto, José-Artur Paiva</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Liliana Costa, Sofia Silva</p><p><bold>Dr...	[ "<graphic xlink:href=\"cureus-0016-00000052255-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0016-00000052255-i02\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0016-00000052255-i03\" position=\"float\"/>" ]	[]	[{"label": ["2"], "article-title": ["Polysaccharide and conjugate vaccines to Streptococcus pneumoniae generate distinct humoral responses"], "source": ["Sci Transl Med"], "person-group": ["\n"], "surname": ["Davies", "Cizmeci", "Guo"], "given-names": ["LR", "D", "W"], "fpage": ["4065"], "volume": ["14"], "year": ["202...	{ "acronym": [], "definition": [] }	12	CC BY	no	2024-01-15 23:43:49	Cureus.; 16(1):e52255	oa_package/ab/9c/PMC10788092.tar.gz
PMC10788094	38222154	[ "<title>Introduction</title>", "<p>Tuberculosis (TB) is a major health problem. The World Health Organization has defined latent tuberculosis infection (LTBI) as a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens without evidence of clinically manifested active TB [##UREF#...	[ "<title>Materials and methods</title>", "<p>A single-center retrospective observational study was performed at Tawam Hospital, Abu Dhabi, UAE. Ethical approval for this study was obtained from the Tawam Human Research Ethics Committee. The department record system was searched to identify all patients on immunosu...	[ "<title>Results</title>", "<p>A total of 1,012 positive and 223 indeterminate LTBI tests were identified in the 12-year period, of which 39 indeterminate and 123 positive results met the inclusion criteria.</p>", "<p>Indeterminate IGRA results</p>", "<p>Thirty-nine rheumatologic patients had indeterminate IGR...	[ "<title>Discussion</title>", "<p>In this study, 123 positive and 39 indeterminate IGRA testing results were obtained in rheumatologic patients over a period of 12 years, with prevalence rates of 12.2% and 17.5%, respectively, across all subspecialties. These rates are much lower than the rate for the general popu...	[ "<title>Conclusions</title>", "<p>Long-term data on the risk of TB activation in positive and indeterminate IGRA results for rheumatological conditions are low. It is recommended to reassess the choice of using anti-TNF-α, with a positive IGRA result if no other feasible alternatives can be offered. Our findings ...	[ "<p>Introduction</p>", "<p>Prior to immunosuppression, rheumatology patients are routinely screened for latent tuberculosis (TB) infection using interferon-gamma release assays (IGRAs). Variability in the management of latent and indeterminate IGRA results across institutions limited long-term outcome data. A ret...	[]	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Post-IGRA screening of rheumatology patients in Tawam Hospital, 2010-2022</title><p>CT, computed tomography; CXR, chest x-ray; ID, infectious disease; IGRA, interferon-gamma release assay; TB, tuberculosis</p></caption>...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Characteristics of patients with positive and indeterminate interferon-gamma release assay (IGRA) testing</title><p>csDMARDs, conventional disease-modifying antirheumatic drugs; EGPA, eosinophilic granulomatosis with polyangiitis; FMF...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Shamma Al Nokhatha, Fatima AlKindi , Merna Abdelsalhen, Fatima AlKhyeli, Maryam Alfalasi</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Shamma Al Nokhatha, Fatima Al...	[ "<graphic xlink:href=\"cureus-0015-00000050581-i01\" position=\"float\"/>" ]	[]	[{"label": ["1"], "article-title": ["Latent Tuberculosis Infection: Updated and Consolidated Guidelines for Programmatic Management"], "publisher-loc": ["Geneva"], "publisher-name": ["World Health Organization"], "year": ["2018"], "uri": ["https://apps.who.int/iris/bitstream/handle/10665/260233/9789241550239-eng.pdf"]}...	{ "acronym": [], "definition": [] }	29	CC BY	no	2024-01-15 23:43:49	Cureus.; 15(12):e50581	oa_package/6f/6a/PMC10788094.tar.gz
PMC10788095	38222167	[ "<title>Introduction</title>", "<p>Lemierre syndrome is classically characterized by bacterial invasion of the pharyngeal mucosa, often preceded by a bacterial or viral pharyngeal infection [##REF##28698043##1##,##REF##32303484##2##], leading to the development of internal jugular vein (IJV) thrombophlebitis and ...	[]	[]	[ "<title>Discussion</title>", "<p>Here we report a case of Lemierre syndrome in an otherwise healthy male without obvious signs of oropharyngeal involvement on initial presentation and initial findings consistent with pneumonia rather than septic thrombophlebitis. Lemierre syndrome was first reported by French phy...	[ "<title>Conclusions</title>", "<p>In sum, we present a unique case of Lemierre syndrome with blood culture positive for <italic>S. constellatus</italic>. Clinicians should be cognizant of Lemierre syndrome as a cause of septic emboli in young, healthy adults and recognize that a variety of pathogens may be causat...	[ "<p>Lemierre syndrome is characterized by thrombophlebitis of the internal jugular vein (IJV) secondary to bacterial pharyngitis or tonsillitis. Though antibiotic use has made this a rarer syndrome, it can nevertheless manifest in patients presenting with pharyngitis. Herein, we describe a 20-year-old male patient ...	[ "<title>Case presentation</title>", "<p>A 20-year-old male with no significant past medical history presented to the emergency department with a four-day history of cough, shortness of breath, non-bloody diarrhea, non-bloody emesis, decreased appetite, body aches, sweats, fevers up to 103º F and significant fatig...	[ "<p>We would like to thank Dr. David C. Keyes for his assistance with radiological imaging interpretation.</p>" ]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>CT Chest with Pulmonary Septic Emboli</title><p>CT chest without contrast showing pulmonary septic emboli (arrows) and small bilateral pleural effusions. Scattered airspace opacities are most prominent in the lower lobe...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Selected Lab during Illness Course</title><p>ED = emergency department, ICU = intensive care unit, WBC = white blood cells, pro-BNP = pro-B-type natriuretic peptide</p></caption><table frame=\"hsides\" rules=\"groups\"><tbody><tr styl...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Christopher J. Peterson, Lauren N. Mazin, Miles Thomas</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Christopher J. Peterson, Lauren N. Mazin, Jonas Rawlins, Miles ...	[ "<graphic xlink:href=\"cureus-0015-00000050580-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050580-i02\" position=\"float\"/>" ]	[]	[{"label": ["4"], "article-title": ["Sur one septico-pyohemie de l'homme simulant la peste et cause par un streptobacile anaerobie"], "source": ["Arch Med Exp Anat Pathol"], "person-group": ["\n"], "surname": ["Courmont"], "given-names": ["P"], "fpage": ["393"], "lpage": ["418"], "volume": ["12"], "year": ["1900"]}, {"...	{ "acronym": [], "definition": [] }	20	CC BY	no	2024-01-15 23:43:49	Cureus.; 15(12):e50580	oa_package/d1/da/PMC10788095.tar.gz
PMC10788096	38222126	[ "<title>Introduction</title>", "<p>There is an increase in the burden of cancer globally due to population growth, aging, and an increase in risk factors such as obesity, smoking, and diet [##REF##26181261##1##]. Head and neck cancers most commonly occur in the oral cavity. Oral cancer's prognosis and survival ra...	[]	[]	[ "<title>Discussion</title>", "<p>Individuals who have undergone a maxillectomy often encounter recurring challenges in prosthodontic treatment related explicitly to insufficient support, retention, and stability. The extent of the defect, the number of remaining teeth, the amount of remaining bone structure, the ...	[ "<title>Conclusions</title>", "<p>The primary challenge in a maxillectomy patient's recovery is ensuring adequate retention, stability, and support. A thorough understanding of the patient's needs and extensive expertise is critical in effectively rehabilitating these individuals. The patient's masticatory abilit...	[ "<p>Maxillectomy defects can lead to oroantral communication, causing difficulties with chewing, swallowing, speech, and facial appearance. Prosthodontists play a crucial role in rehabilitating such defects using obturators. This case report presents the fabrication of a definitive obturator with a cast metal frame...	[ "<title>Case presentation</title>", "<p>A 70-year-old male patient was referred to the Department of Prosthodontics, Tabiah University Dental Hospital, Madina, Saudi Arbia, with a chief complaint regarding a previously ill-fitting acrylic maxillary obturator. The Research Ethical Committee of the College of Denti...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Intra-oral view of the maxillary defect</title></caption></fig>", "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG2\"><label>Figure 2</label><caption><title>Primary impression of the maxilla</title></caption></f...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Design for the removable cobalt-chrome partial obturator used in the case presented.</title></caption><table frame=\"hsides\" rules=\"groups\"><tbody><tr style=\"background-color:#ccc\"><td rowspan=\"1\" colspan=\"1\">\n \n</td><td ro...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Ahmad E. Farghal</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Ahmad E. Farghal</p><p><bold>Drafting of the manuscript:</bold> Ahmad E. Farghal</p><p><bold>Critica...	[ "<graphic xlink:href=\"cureus-0015-00000050578-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050578-i02\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050578-i03\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050578-i04\" position=\"float\"/>", "<gr...	[]	[{"label": ["6"], "article-title": ["Quality of life of maxillectomy patients using an obturator prosthesis"], "source": ["Jr Sci Spe Hea Nec"], "person-group": ["\n"], "surname": ["Kornblith", "Zlotolow", "Gooen"], "given-names": ["AB", "IM", "J"], "fpage": ["4"], "lpage": ["323"], "volume": ["18"], "year": ["1996"]},...	{ "acronym": [], "definition": [] }	27	CC BY	no	2024-01-15 23:43:49	Cureus.; 15(12):e50578	oa_package/a9/16/PMC10788096.tar.gz
PMC10788114	38222994	[ "<title>Introduction</title>", "<p>Schizophrenia symptoms are described as positive, such as hallucinations and delusions, and negative, like decreased emotional expression, lack of motivation, and cognitive decline. Over time, schizophrenia may interfere with an individual's social life, increase the likelihood ...	[ "<title>Materials and methods</title>", "<p>Participants</p>", "<p>The participants were selected from patients admitted to the psychiatric emergency unit of Showa University Northern Yokohama Hospital in Kanagawa, Japan, between January 2014 and December 2019. This hospital provides acute psychiatric inpatient...	[ "<title>Results</title>", "<p>We enrolled 262 inpatients diagnosed with schizophrenia, out of which 10 were excluded due to complications of infection and one was excluded due to death. Therefore, we analyzed 251 patients. Out of these patients, 102 were males and 139 were females. The mean±SD for NLR was 3.27±2....	[ "<title>Discussion</title>", "<p>This study examined potential biomarkers of imminent psychomotor arousal in patients with schizophrenia. Patients who refused oral antipsychotic drugs were offered IV haloperidol treatment. IV haloperidol was also used with patients who demonstrated extremely severe symptoms, incl...	[ "<title>Conclusions</title>", "<p>Herein, patients with severe psychosomatic schizophrenia who could not receive oral antipsychotics and required hospitalization for IV haloperidol had higher CGI-S and increased NLR and NAR compared with patients who could receive oral treatment. In the IV haloperidol group, pati...	[ "<p>Introduction</p>", "<p>Schizophrenia symptom severity is linked to neuroinflammation. Certain blood cell indexes such as neutrophil-lymphocyte ratio (NLR) and neutrophil-albumin ratio (NAR) have been used as biomarkers in various diseases, including schizophrenia. In acute clinical practice, it is challenging...	[]	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Classification of participants</title><p>Overall, 262 patients with schizophrenia requiring hospitalization were selected. Overall, one death and 10 patients with infectious complications were excluded. Hence, 251 patie...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Demographic and clinical data for the IV haloperidol (n=43) and oral antipsychotic groups (n=208)</title><p>Statistical analysis was performed using the Mann-Whitney U test (a) and chi-squared test (b).</p><p>NA: not applicable; SD: s...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Hiroi Tomioka, Shutaro Sugita, Akira Iwanami, Atsuko Inamoto, Kenji Sanada, Kensuke Mera</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Hiroi Tomioka, Shutaro Sugita...	[ "<graphic xlink:href=\"cureus-0016-00000052181-i01\" position=\"float\"/>" ]	[]	[{"label": ["4"], "article-title": ["Neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases"], "source": ["Int J Mol Sci"], "person-group": ["\n"], "surname": ["Buonacera", "Stancanelli", "Colaci", "Malatino"], "given-names": ["A", "B", "M", "L"], "volume": ["23"]...	{ "acronym": [], "definition": [] }	23	CC BY	no	2024-01-15 23:43:50	Cureus.; 16(1):e52181	oa_package/1f/b3/PMC10788114.tar.gz
PMC10788115	38222236	[ "<title>Introduction</title>", "<p>Arthritis robustus (rheumatoid robustus) commonly occurs in men over the age of 50, particularly those who are physically active and involved in manual labor. They do not complain of pain, stiffness, disability, or distress, though clinical signs of inflammation, deformity, and ...	[]	[]	[ "<title>Discussion</title>", "<p>Arthritis robustus primarily affects elderly males actively involved in physical labor. Despite the presence of an inflammatory joint disease that aligns with this patient’s clinical profile, the level of pain and stiffness is minimal. Also, a history of smoking was a risk factor ...	[ "<title>Conclusions</title>", "<p>The current case of arthritis robustus has associated tenosynovitis, which is rare. Apart from highlighting the existence of this syndrome, this discussion also underscores the need to spread awareness about this variant of RA while understanding its clinical presentation, differ...	[ "<p>Rheumatoid arthritis (RA) commonly presents as a chronic additive symmetric inflammatory polyarthritis involving the small and large joints. Rarely do patients present with few or no clinical symptoms, despite apparent signs of inflammation. This condition, known as arthritis robustus, typically occurs in elder...	[ "<title>Case presentation</title>", "<p>A 45-year-old male was referred to the rheumatology clinic for complaints of swelling in both wrists for a six-month duration. The swelling persisted without progressing, and there was no associated joint pain. However, the patient experienced 30 minutes of early morning st...	[ "<p>Vijay Karthik Bhogaraju and Arnav Kalra equally contributed to this work and should be considered co-first authors.</p>" ]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Both wrists of the patient</title><p>Note the left 3rd PIP swelling and left wrist tenosynovitis.</p><p>PIP: proximal interphalangeal</p></caption></fig>" ]	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Investigations at presentation</title><p>ESR: erythrocyte sedimentation rate; TLC: total leucocyte count; DLC: differential leucocyte count; CRP: C-reactive protein; ALT: alanine transaminase; AST: aspartate transferase; ALP: alkaline...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Human Ethics</title><fn fn-type=\"other\"><p>Consent was obtained or waived by all participants in this study</p></fn></fn-group>", "<fn-group content-type=\"competing-interests\"><fn fn-type=\"COI-statement\"><p>The authors have declared that no competing interests exist....	[ "<graphic xlink:href=\"cureus-0015-00000050583-i01\" position=\"float\"/>" ]	[]	[{"label": ["7"], "article-title": ["Pain in the rheumatic diseases"], "source": ["Ann Rheum Dis"], "person-group": ["\n"], "surname": ["Thompson", "Carr"], "given-names": ["PW", "AJ"], "fpage": ["395"], "volume": ["56"], "year": ["1997"]}, {"label": ["12"], "article-title": ["Bilateral Symmetric Polyarthritis with Def...	{ "acronym": [], "definition": [] }	16	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50583	oa_package/a1/dd/PMC10788115.tar.gz
PMC10788116	38222203	[ "<title>Introduction</title>", "<p>The symbiotic relationship between host and microorganisms is extremely complicated, and it is important to better understand these cellular interactions [##REF##36807754##1##]. Humans are colonized by the microbiota containing bacteria, archaea, fungi, and viruses; different bo...	[ "<title>Materials and methods</title>", "<p>Study design</p>", "<p>The study involved four commercial anaerobic probiotic bacterial products: Neuro Byome (NB), Metabo Byome (MB), Male/Female Byome (M/F), and Immuno Byome (IB) were obtained from Nutri-Biome (Ogden, Utah). The four probiotics were made by reconst...	[ "<title>Results</title>", "<p>It was our decision to study cellular viability and cytokine production after incubating PBMC with probiotic mixtures of anaerobic bacteria. With 70-80% of immune cells residing in the gut, it is important to understand the intricate interactions between the local microbiota and immu...	[ "<title>Discussion</title>", "<p>There was a minor difference in cell viability in the control cultures with no bacteria compared to the cultures with four probiotic mixtures as measured by the XTT assay (Figures ##FIG##0##1A##, ##FIG##0##1B##). This is not surprising, as bacteria have molecules on their surfaces...	[ "<title>Conclusions</title>", "<p>The data presented here clearly suggests that anaerobic bacteria do not grow rapidly in oxygen-containing conditions in the PBMC cell culture experiments. The presence of anaerobic bacteria in PBMC cultures stimulates a weak pro-inflammatory response in several cytokines. The add...	[ "<p>In the last couple of decades, much progress has been made in studying bacteria living in humans. However, there is much more to learn about bacteria immune cell interactions. Here, we show that anaerobic bacteria do not grow when cultured overnight with human cells under atmospheric air. Air contains about 18%...	[]	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Cell viability</title><p>A) XTT assay of PBMC after overnight culture. Control samples did not contain any bacteria. The cell viability of quadruplicate wells contained 2 x10<sup>5</sup> PBMC/well in 200 µl of CLT media...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Anaerobic bacteria strains in four probiotic products</title><p>Gram + and gram- are listed as + or -. The particular agar used to grow the specific strain is shown in the second column.</p></caption><table frame=\"hsides\" rules=\"gr...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Anthony R. Torres, Shayne Morris</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Anthony R. Torres, Shayne Morris, Michael Benson, Craig Wilkinson, Rachael Lyon</p><p...	[ "<graphic xlink:href=\"cureus-0015-00000050586-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050586-i02\" position=\"float\"/>" ]	[]	[{"label": ["5"], "article-title": ["Coevolution of the human host and gut microbiome: metagenomics of microbiota"], "source": ["Cureus"], "person-group": ["\n"], "surname": ["Shahab", "Shahab"], "given-names": ["M", "N"], "fpage": ["0"], "volume": ["14"], "year": ["2022"]}, {"label": ["13"], "article-title": ["Intesti...	{ "acronym": [], "definition": [] }	29	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50586	oa_package/6c/1a/PMC10788116.tar.gz
PMC10788117	38222989	[ "<title>Introduction</title>", "<p>Bisphosphonate (BP) is a drug similar to pyrophosphate that has been prescribed since 1960 to treat various bone diseases [##REF##28875143##1##, ####REF##26096687##2##, ##UREF##0##3##, ##REF##35300956##4####35300956##4##]. It has been shown that BP causes the inhibition of osteo...	[ "<title>Materials and methods</title>", "<p>An observational cross-sectional study was planned to collect data from dental students and dentists in the central region of Saudi Arabia. To collect information from participants, a valid and reliable questionnaire was used [##REF##33603544##22##] using a convenient n...	[ "<title>Results</title>", "<p>A total of 250 participants were enrolled in the study. Of them, 128 (51.2%) were women, and 122 (48.8%) were men. Marital status revealed that most participants were single (198 or 79.2%) and 47 (18.8%) were married. Most participants (149 or 59.6%) were between the ages of 18 and 2...	[ "<title>Discussion</title>", "<p>MRONJ is a significant and debilitating adverse medication reaction observed in individuals undergoing prolonged treatment with antiresorptive or antiangiogenic drugs, primarily impacting the mandible more commonly than the maxilla. Having a sufficient understanding of MRONJ is es...	[ "<title>Conclusions</title>", "<p>The implications of the findings in the present study warrant increased emphasis on the importance of educating students and dentists about this disease. It is highly recommended to attend continuing education courses that focus on treating and preventing this ailment in patients...	[ "<p>Background: Bisphosphonates (BPs) are often used in treating benign and malignant disorders. Medication-related osteonecrosis of the jaw (MRONJ) is a significant problem that arises from the long-term use of BPs.</p>", "<p>Objective: In this study, we assessed the knowledge of students and dentists about MRON...	[]	[ "<title>Appendices</title>" ]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Questionnaire (Section 1) </title></caption></fig>", "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG2\"><label>Figure 2</label><caption><title>Questionnaire (Section 2) </title></caption></fig>", "<fig positi...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Frequency distribution of demographic details of participants (n=250)</title></caption><table frame=\"hsides\" rules=\"groups\"><tbody><tr style=\"background-color:#ccc\"><td colspan=\"2\" rowspan=\"1\">Variable</td><td rowspan=\"1\" ...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Meshal M. Alghofaili, Syed Fareed Mohsin, Rayan Khaled Almazyad</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Meshal M. Alghofaili, Nada Mohammed Nahari, Tamim S. A...	[ "<graphic xlink:href=\"cureus-0016-00000052165-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0016-00000052165-i02\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0016-00000052165-i03\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0016-00000052165-i04\" position=\"float\"/>", "<gr...	[]	[{"label": ["3"], "article-title": ["Knowledge of bisphosphonate-related osteonecrosis of the jaws among Mexican dentists"], "source": ["Med Oral Patol Oral Cir Bucal"], "person-group": ["\n"], "surname": ["Vinitzky-Brener", "Ib\u00e1\u00f1ez-Mancera", "Aguilar-Rojas", "\u00c1lvarez-Jard\u00f3n"], "given-names": ["I", ...	{ "acronym": [], "definition": [] }	27	CC BY	no	2024-01-15 23:43:50	Cureus.; 16(1):e52165	oa_package/9d/7f/PMC10788117.tar.gz
PMC10788118	38222198	[ "<title>Introduction</title>", "<p>Leukemia is a malignancy of the bone marrow that arises from the abnormal proliferation and differentiation of hematopoietic stem cells. This results in the accumulation of immature or abnormal blood cells in the marrow and peripheral blood [##REF##27585213##1##]. Ocular manifes...	[]	[]	[ "<title>Discussion</title>", "<p>Leukemia is a systemic hematological disease, with retinal involvement as the most common ocular manifestation [##REF##2778482##2##, ####REF##14573980##3##, ##REF##30513404##4####30513404##4##]. Leukemic retinopathy may arise from direct infiltration of cancerous leukocytes. It ca...	[ "<title>Conclusions</title>", "<p>In cases of unexplained retinal hemorrhages, a high index of suspicion for blood dyscrasias should warrant hematologic evaluation. This patient's visual complaints resulted in a workup that led to the diagnosis of eosinophilic leukemia, with prompt treatment allowing for a favora...	[ "<p>Leukemia is a systemic malignancy that can compromise various physiological functions, including vision. We report a case of a 37-year-old male presenting with worsening bilateral central vision loss, fatigue, shortness of breath, and ankle edema. Ophthalmic examination revealed extensive retinal hemorrhages, R...	[ "<title>Case presentation</title>", "<p>A 37-year-old Hispanic male presented with a two-day history of progressively worsening central vision in both eyes. The patient’s past medical history was significant only for diet-controlled hyperlipidemia. There was no past ocular history and no relevant family history. ...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Color fundus photographs showing evidence of leukemic retinopathy</title><p>Color fundus photography of patient’s right (A) and left (B) eyes at initial presentation depicting Roth spots (solid white arrows), as well as...	[]	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Acquisition, analysis, or interpretation of data:</bold> Emanuel Mordechaev, Tatyana Beketova, Brian Murillo, Max D. Schlesinger</p><p><bold>Drafting of the manuscript:</bold> Emanuel Mordechaev, Tatyana Beketova, ...	[ "<graphic xlink:href=\"cureus-0015-00000050587-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050587-i02\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050587-i03\" position=\"float\"/>" ]	[]	[{"label": ["14"], "article-title": ["Leukemic retinopathy before and after chemotherapy"], "source": ["Ophthalmol Retina"], "person-group": ["\n"], "surname": ["Lezrek", "Daoudi", "Laghmari"], "given-names": ["O", "C", "M"], "fpage": ["561"], "volume": ["1"], "year": ["2017"]}]	{ "acronym": [], "definition": [] }	15	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50587	oa_package/69/f0/PMC10788118.tar.gz
PMC10788119	38222160	[ "<title>Introduction</title>", "<p>The term \"musculoskeletal disorders\" (MSDs) refers to a group of periarticular conditions that affect the musculoskeletal system and primarily cause functional discomfort and everyday pain [##REF##36589714##1##,##UREF##0##2##]. Musculoskeletal disorders (MSDs) are more prevale...	[ "<title>Materials and methods</title>", "<p>Study design and settings</p>", "<p>An analytic cross-sectional study was conducted for three months, from April 1 to June 30, 2023, in all schools in Buraydah City, Saudi Arabia, targeting all school teachers and other school workers in Buraydah City.</p>", "<p>Sam...	[ "<title>Results</title>", "<p>As indicated in Table ##TAB##0##1##, the total study participants were 787; among them, 648 were teachers, and the remaining 139 were other people working in school. The median age was 43 years, and the median years of experience were 16. The gender distribution shows 65.1% females a...	[ "<title>Discussion</title>", "<p>The study's findings shed light on the significant prevalence of MSD among teachers and other school staff and would also help educational institutions and policymakers take measures to promote safe and healthy working conditions for teachers to prevent the development of MSDs and...	[ "<title>Conclusions</title>", "<p>This study showed a high prevalence of MSD among teachers, highlighting the importance of addressing this issue for the well-being of educators. The study identifies key risk factors associated with MSD, including age and gender. MDD was also found to influence MSD. These finding...	[ "<p>Introduction: Musculoskeletal disorders (MSD) pose a significant challenge to the well-being and productivity of individuals and various occupational groups, including teachers. Among teachers, the prevalence of MSD has raised concerns globally, impacting their daily activities and overall quality of life. Bura...	[]	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Prevalence of pain in different body parts</title></caption></fig>", "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG2\"><label>Figure 2</label><caption><title>Treatment taken by teachers</title></caption></fig>...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Sociodemographic characteristics of study participants</title><p>IQR: Interquartile range, N: Frequency, %: Percentage</p></caption><table frame=\"hsides\" rules=\"groups\"><tbody><tr style=\"background-color:#ccc\"><td colspan=\"2\" ...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Tameem A. Alhomaid, Seham Alharbi, Nahla J. Alghafes, Yasmeen A. Alfouzan, Raghad I. Alhumaidan, Farah Alassaf, Abdullah Aldhuwyan </p><p><bold>Acquisition, analysis, or interpretation of ...	[ "<graphic xlink:href=\"cureus-0015-00000050584-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050584-i02\" position=\"float\"/>" ]	[]	[{"label": ["2"], "article-title": ["WHO: Musculoskeletal health"], "source": ["Published Online First"], "year": ["2022"], "uri": ["https://www.who.int/news-room/fact-sheets/detail/musculoskeletal-conditions"]}, {"label": ["3"], "article-title": ["Prevalence and factors associated with musculoskeletal disorders among ...	{ "acronym": [], "definition": [] }	21	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50584	oa_package/88/00/PMC10788119.tar.gz
PMC10788122	0	[ "<title>INTRODUCTION</title>", "<p>Transporters are transmembrane proteins that mediate selective uptake or export of solutes, metabolites, ions and drugs across the plasma membrane (PM) or other organellar membranes. Secondary active transporters of the PM couple the transport of substrates against their concent...	[ "<title>MATERIAL AND METHODS</title>", "<title>Media, strains and growth conditions</title>", "<p>Standard complete (CM) and minimal media (MM) for <italic>A. nidulans</italic> growth were used. Media and supplemented auxotrophies were used at the concentrations given in <ext-link xlink:href=\"http://www.fgsc.n...	[ "<title>RESULTS</title>", "<title>Most residues in TMS11 and TMS12 of FurE are not critical for PM localization and have a moderate role in transport</title>", "<p>Previous studies concerning NCS1 transporters failed to show a functional role of residues of the last two TMSs (TMS11-12) in transport kinetics or ...	[ "<title>DISCUSSION</title>", "<p>We showed that two specific aromatic residues in TMS12, namely Trp473 and Tyr484, are essential for ER-exit of FurE. In line with their functional importance, these residues are highly (Tyr484) or well (Trp473) conserved in FurE homologous proteins. Structural modelling and MD pro...	[]	[ "<p>Conflict of Interest: The authors declare no conflict of interest.</p>", "<p>Please cite this article as: Yiannis Pyrris, Georgia F. Papadaki, Emmanuel Mikros and George Diallinas (<bold>2024</bold>). The last two transmembrane helices in the APC-type FurE transporter act as an intramolecular chaperone essent...	[ "<title>SUPPLEMENTAL MATERIAL</title>", "<p>All supplemental data for this article are available online at <ext-link xlink:href=\"http://www.microbialcell.com/researcharticles/2023a-pyrris-microbial-cell/\" ext-link-type=\"uri\">www.microbialcell.com/researcharticles/2023a-pyrris-microbial-cell/</ext-link>.</p>" ...	[]	[ "<fig position=\"float\" id=\"fig1\"><label>Figure 1:</label><caption><title>FIGURE 1: TMS11-TMS12 form a distinct structural entity topologically distinct from the LeuT-fold.</title><p><bold>(A)</bold> Structural models of FurE in three conformations have been produced through homology modelling using the crystall...	[]	[]	[]	[]	[]	[]	[ "<supplementary-material id=\"mic-11-001-s01\" position=\"float\" content-type=\"local-data\"></supplementary-material>" ]	[]	[ "<graphic xlink:href=\"mic-11-001-g001\" position=\"float\"/>", "<graphic xlink:href=\"mic-11-001-g002\" position=\"float\"/>", "<graphic xlink:href=\"mic-11-001-g003\" position=\"float\"/>", "<graphic xlink:href=\"mic-11-001-g004\" position=\"float\"/>", "<graphic xlink:href=\"mic-11-001-g005\" position=\"...	[ "<media xlink:href=\"mic-11-001-s01.pdf\" id=\"d64e846\" position=\"anchor\"><caption><p>Click here for supplemental data file.</p></caption></media>" ]	[{"label": ["32."], "person-group": ["\n"], "surname": ["Witz", "Panwar", "Schober", "Deppe", "Pasha", "Lemieux", "M\u00f6hlmann"], "given-names": ["S", "P", "M", "J", "FA", "MJ", "T"], "year": ["2014"], "article-title": ["Structure-function relationship of a plant NCS1 member\u2013homology modeling and mutagenesis ide...	{ "acronym": [ "5FU", "APC", "BiF", "MD", "PM", "TMS", "wt" ], "definition": [ "– 5-fluorouracil,", "– amino acid-polyamine-oragnocation,", "– bifluorescence,", "– molecular dynamics,", "– plasma membrane,", "– transmembrane segment,", "– wild-type" ] }	57	CC BY	no	2024-01-15 23:43:50	Microb Cell.; 11:1-15	oa_package/33/68/PMC10788122.tar.gz
PMC10788123	38222150	[ "<title>Introduction</title>", "<p>Status epilepticus (SE) occurs within five minutes or more of continuous clinical and/or electrographic seizure activity or recurrent seizure activity without consciousness recovery between seizures. It is a common, life-threatening neurologic disorder with high morbidity and mo...	[ "<title>Materials and methods</title>", "<p>Study design</p>", "<p>We conducted a single-center retrospective study at the A1 intensive care unit at the Hassan II University Hospital of Fez in Morocco. Three-year study data were obtained from January 2019 to December 2021. We included patients with SE according...	[ "<title>Results</title>", "<p>Overall, 82 patients with SE were admitted to the ICU from January 2019 to December 2021 and were included in the study.</p>", "<p>Patient characteristics</p>", "<p>Patients were aged 18 to 95 years, with a mean of 39.5 years, including 50 males (61%) and 32 females (39%). Sevent...	[ "<title>Discussion</title>", "<p>Our study analyzed the clinical characteristics, etiologies, outcomes, and factors associated with mortality in patients with SE in a Moroccan center.</p>", "<p>Demographic and clinical characteristics</p>", "<p>The median age was 39.5 years, the incidence of SE was higher in ...	[ "<title>Conclusions</title>", "<p>This study elucidated the clinical characteristics, etiologies, management, and outcomes of SE in our hospital. The patients in our study were young, with a high rate of de-novo SE. While cerebrovascular events are the most common cause of known etiology, the major diagnosis in o...	[ "<p>Background</p>", "<p>Status epilepticus (SE) is a common neurologic emergency with high rates of mortality and morbidity.</p>", "<p>Objective</p>", "<p>To analyze the clinical characteristics, causes, management, and outcomes of patients with SE in a tertiary care hospital in Morocco.</p>", "<p>Methods<...	[]	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Proportion of status epilepticus etiologies</title></caption></fig>" ]	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Patient characteristics</title><p>SE: status epilepticus</p></caption><table frame=\"hsides\" rules=\"groups\"><tbody><tr style=\"background-color:#ccc\"><td rowspan=\"1\" colspan=\"1\">Items</td><td rowspan=\"1\" colspan=\"1\">Cases<...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Ibrahim Bechri, Abdelkrarim Shimi, Ali Derkaoui, Mohammed Khatouf</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Ibrahim Bechri, Abdelkrarim Shimi, Ali Derkaoui, Moh...	[ "<graphic xlink:href=\"cureus-0015-00000050591-i01\" position=\"float\"/>" ]	[]	[{"label": ["2"], "article-title": ["Status epilepticus management and mortality risk factors: a retrospective study"], "source": ["Neurologia (Engl Ed)"], "person-group": ["\n"], "surname": ["Hidalgo de la Cruz", "Miranda Acu\u00f1a", "Luque Buzo"], "given-names": ["M", "JA", "E"], "fpage": ["532"], "lpage": ["542"], ...	{ "acronym": [], "definition": [] }	22	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50591	oa_package/95/4a/PMC10788123.tar.gz
PMC10788124	38222196	[ "<title>Introduction and background</title>", "<p>Psoriasis is a chronic inflammatory skin illness characterized by a fast accumulation of skin cells, culminating in thick, scaly plaques [##REF##30909615##1##]. It can cause substantial physical and psychological anguish and impacts millions of individuals globall...	[]	[]	[]	[ "<title>Conclusions</title>", "<p>The systematic review assessed the performance of several biological drugs in the treatment of psoriasis offers significant insights into the treatment's success. Adalimumab, certolizumab, secukinumab, ustekinumab, and methotrexate had moderate efficacy, whereas guselkumab, ixeki...	[ "<p>Psoriasis is a chronic inflammatory skin illness that has the potential to manifest at any stage of life, it is most frequently observed in early adulthood. Biological drugs have significantly transformed the landscape of psoriasis treatment through the provision of focused therapy, which effectively mitigates ...	[ "<title>Review</title>", "<p>Methodology</p>", "<p>Study Design</p>", "<p>A comprehensive review was undertaken to evaluate and compare the effectiveness of diverse biological medicines utilised in the management of psoriasis. In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-An...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>The PRISMA figure showing the steps to choose the studies for systematic review</title><p>PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p></caption></fig>" ]	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title> RCT included in the systematic review focusing on the outcomes of GRAPPA domain</title><p>RCT: Randomized Controlled Trial, GRAPPA: Group for Research and Assessment of Psoriasis and Psoriatic Arthritis, PASI: Psoriasis Area and Seve...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Sattam A. Alzahrani , Abdulaziz M. Aljuhni, Norah Y. Alqahtani, Naif A. Al Thaqfan, Sara A. Alwarwari, Rakan A. Alzabadin, Abdullah A. Alhajlah, Fajer M. Alzamil, Reema A. Alzehairi</p><p>...	[ "<graphic xlink:href=\"cureus-0015-00000050588-i01\" position=\"float\"/>" ]	[]	[{"label": ["2"], "article-title": ["Psychological well-being of adult psoriasis patients: a narrative review"], "source": ["Cureus"], "person-group": ["\n"], "surname": ["Hepat", "Chakole", "Rannaware"], "given-names": ["A", "S", "A"], "fpage": ["0"], "volume": ["15"], "year": ["2023"]}, {"label": ["12"], "article-tit...	{ "acronym": [], "definition": [] }	66	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50588	oa_package/a0/1e/PMC10788124.tar.gz
PMC10788125	38222159	[ "<title>Introduction</title>", "<p>Diverticulitis, an inflammatory condition affecting colonic diverticula, is a relatively common gastrointestinal ailment in the general population [##REF##26416187##1##,##UREF##0##2##]. Its severity is broad but commonly presents with signs of inflammation and left lower quadran...	[]	[]	[ "<title>Discussion</title>", "<p>Early in training, diverticulitis is taught as a quintessential gastrointestinal diagnosis. However, when paired with other comorbid conditions and, in this case, several potential contraindications in management, it is important to realize the extent to which risk-benefit analysi...	[ "<title>Conclusions</title>", "<p>Although diagnosis and treatment of diverticular disease have been well documented and should serve as an initial guide when making initial considerations, management of complications of diverticulitis, such as abscesses and recurrent flares, should be managed with drainage when ...	[ "<p>The co-occurrence of diverticulitis with pregnancy is incredibly rare and the management of recurrent complicated diverticulitis may not be feasible in a pregnant patient. Adding cases to the incredibly sparse literature may highlight similarities and create potential recommendations for at-risk populations. We...	[ "<title>Case presentation</title>", "<p>The patient is a 30-year-old Caucasian female, 18 weeks’ gestation, with a history of diverticulosis. The patient initially reported a history of left lower quadrant pain and nausea. The pain was described as sharp/stabbing without radiation, severe, and sudden for 16 hours...	[ "<title>Appendices</title>" ]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Confirmatory CT Imaging without Contrast of Sigmoid Diverticular Abscess</title><p>CT scans used dose modulation, iterative reconstruction, and/or weight-based dosing to reduce radiation dose to as low as reasonably ach...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Abnormal Results of Initial Diagnostic Laboratory Tests</title><p>CRP - C-reactive protein</p></caption><table frame=\"hsides\" rules=\"groups\"><tbody><tr style=\"background-color:#ccc\"><td rowspan=\"1\" colspan=\"1\">Test</td><td r...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Nathan K. Louie</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Nathan K. Louie, Bradley Champagne</p><p><bold>Drafting of the manuscript:</bold> Nathan K. Louie</p>...	[ "<graphic xlink:href=\"cureus-0015-00000050590-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050590-i02\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050590-i03\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050590-i04\" position=\"float\"/>", "<gr...	[]	[{"label": ["2"], "article-title": ["Analysis of the epidemiological trends on inpatient diverticulosis admissions in the US: a longitudinal analysis from 1997-2018"], "source": ["Cureus"], "person-group": ["\n"], "surname": ["Fialho", "Fialho", "Shuja"], "given-names": ["A", "A", "A"], "fpage": ["0"], "volume": ["15"]...	{ "acronym": [], "definition": [] }	14	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50590	oa_package/c4/97/PMC10788125.tar.gz
PMC10788126	38222176	[ "<title>Introduction</title>", "<p>A tibial fracture is a common and serious lower extremity injury that is characterized by a break or crack in the shinbone. These fractures are frequently caused by high-energy trauma, but they can also result from overuse or underlying illnesses that weaken the bone [##REF##774...	[]	[]	[ "<title>Discussion</title>", "<p>This case study features a 45-year-old male patient who had a proximal tibial fracture managed surgically with ORIF. After three months, the patient visited the orthopaedic department for follow-up with complaints of stiffness, pain and restricted ROM, for the same he was referred...	[ "<title>Conclusions</title>", "<p>The results of this case study on physiotherapeutic therapies for postoperative stiffness in tibial fractures treated surgically demonstrate the important role that specialized physiotherapy plays in fostering functioning and flexibility. The case's comprehensive physiotherapy ap...	[ "<p>This case study explains the complete care of a 45-year-old male patient who had a high-impact road injury that resulted in a displaced proximal tibial fracture. Substantial soft tissue damage was discovered during the initial assessment, requiring careful thought before undergoing surgery. A customized physiot...	[ "<title>Case presentation</title>", "<p>A 45-year-old male patient reported he had been experiencing pain in his left knee joint over three months. He also reported stiffness in the same joint and difficulty walking. Three months prior, the patient underwent surgical management for a tibial fracture that was trea...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>The pre-operative radiograph of the left knee joint lateral and anteroposterior views</title></caption></fig>", "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG2\"><label>Figure 2</label><caption><title>The post...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Timeline of current episodes</title></caption><table frame=\"hsides\" rules=\"groups\"><tbody><tr style=\"background-color:#ccc\"><td rowspan=\"1\" colspan=\"1\">Events</td><td rowspan=\"1\" colspan=\"1\">Dates</td></tr><tr><td rowspa...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Krishnayani Shende, Nishigandha P. Deodhe, Grisha Ratnani, Khushi M. Gandhi</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Krishnayani Shende, Nishigandha P. Deodhe,...	[ "<graphic xlink:href=\"cureus-0015-00000050589-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050589-i02\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050589-i03\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050589-i04\" position=\"float\"/>", "<gr...	[]	[{"label": ["5"], "article-title": ["Fractures of the proximal tibia (shinbone)"], "date-in-citation": ["\n"], "month": ["10"], "year": ["2023", "2005"], "uri": ["https://www.orthoinfo.org/en/diseases--conditions/fractures-of-the-proximal-tibia-shinbone/"]}, {"label": ["7"], "article-title": ["Fracture and dislocation ...	{ "acronym": [], "definition": [] }	20	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50589	oa_package/08/a2/PMC10788126.tar.gz
PMC10788128	38222847	[ "<title>Introduction</title>", "<p>Simulation studies use computer-generated data to investigate research questions (##UREF##0##Beaujean, 2018##). Monte Carlo simulation is a commonly used procedure that uses repeated random number selections to solve modeling problems (##UREF##10##Gelfand and Smith, 1990##). It ...	[]	[ "<title>How will the missing null distribution of statistic conditions influence the result of a simulation study?</title>", "<p>In the following section, we will offer a general overview of the original study. We will specifically address the shortcomings of not including null distribution of the statistics cond...	[ "<title>Discussion</title>", "<p>Our study, alongside the original study by ##REF##27303333##Trizano-Hermosilla and Alvarado (2016)##, presents a new Monte Carlo simulation design within the confusion matrix paradigm. We have proposed new conditions, guided by the perspective of the confusion matrix, that should ...	[]	[ "<p>Edited by: Ioannis Tsaousis, National and Kapodistrian University of Athens, Greece</p>", "<p>Reviewed by: Jung Yeon Park, George Mason University, United States; Franca Crippa, University of Milano-Bicocca, Italy</p>", "<p>Monte Carlo simulation is a common method of providing empirical evidence to verify ...	[ "<title>The null distributions conditions included in the Monte Carlo simulation psychological studies</title>", "<p>We observed that the null distribution of statistics is generally included in existing Monte Carlo simulation studies in two ways: First, the null distribution of statistics is included to represen...	[ "<title>Conflict of interest</title>", "<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>", "<title>Publisher’s note</title>", "<p>All claims expressed in this article are solely t...	[]	[ "<table-wrap position=\"float\" id=\"tab1\"><label>Table 1</label><caption><p>The elements of a confusion matrix.</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th rowspan=\"1\" colspan=\"1\"/><th align=\"center\" valign=\"top\" rowspan=\"1\" colspan=\"1\">Predicted true result</th><th align=\"ce...	[ "<disp-formula id=\"EQ1\">\n<label>(1)</label>\n<mml:math id=\"M1\" overflow=\"scroll\"><mml:mi mathvariant=\"italic\">RMSE</mml:mi><mml:mo>=</mml:mo><mml:msqrt><mml:msup><mml:mfrac><mml:mrow><mml:mo stretchy=\"true\">∑</mml:mo><mml:mrow><mml:mfenced open=\"(\" close=\")\"><mml:mrow><mml:mover><mml:mi>p</mml:mi><mm...	[]	[]	[]	[]	[ "<supplementary-material id=\"SM1\" position=\"float\" content-type=\"local-data\"></supplementary-material>" ]	[ "<table-wrap-foot><p>True Positive (TP) is the proportion of results that correctly indicates the presence of a condition or characteristic in the population; True Negative (TN) is the proportion of results that correctly indicates the absence of a condition or characteristic in the population; False Positive (FP) ...	[]	[ "<media xlink:href=\"Data_Sheet_1.ZIP\"><caption><p>Click here for additional data file.</p></caption></media>" ]	[{"surname": ["Beaujean"], "given-names": ["A. A."], "year": ["2018"], "article-title": ["Simulating data for clinical research: a tutorial"], "source": ["J. Psychoeduc. Assess."], "volume": ["36"], "fpage": ["7"], "lpage": ["20"], "pub-id": ["10.1177/0734282917690302"]}, {"surname": ["Bernaards", "Jennrich"], "given-n...	{ "acronym": [], "definition": [] }	43	CC BY	no	2024-01-15 23:43:50	Front Psychol. 2023 Dec 27; 14:1298534	oa_package/e6/2f/PMC10788128.tar.gz
PMC10788129	38222846	[ "<title>Introduction</title>", "<p>The concept of autism has had a central role in cultural and clinical thinking throughout the twentieth and twenty-first centuries but has lacked a developed and representative phenomenology. Accounting for this will lead us to the heart of many current debates and dilemmas in t...	[]	[]	[ "<title>Discussion</title>", "<p>This study contains and juxtaposes several representations and expressions of autistic experience manifested over time and across across perspectives: (1) in the early years of phenomenological psychiatry, usually within the context of schizophrenia; (2) as conceptualised within e...	[]	[ "<p>Edited by: Valeria Bizzari, Husserl-Archives: Centre for Phenomenology and Continental Philosophy, Belgium</p>", "<p>Reviewed by: Nicolas Tajan, Kyoto University, Japan</p>", "<p>Janko Nešić, Institute of Social Sciences (IDN), Serbia</p>", "<p>We are now at a transition point in autism conceptualisation,...	[ "<title>The autistic concept in classical phenomenology</title>", "<p>Clinical descriptions are interested in both the <italic>content</italic> and <italic>form</italic> of another's experience to reach toward the empathic understanding of an individual, but also toward more general theories of mental function. T...	[ "<p>This is trans-disciplinary work, and the authors would like to acknowledge the generous input and advice in preparing our manuscript from many colleagues across philosophy, psychology, qualitative methodology, and data science, with particular thanks to Dr. Jo Bervoets, Dr. Bastian Greshake Tzovaras, Joan O'Raf...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><p>Derived phenomenological themes across autistic and non-autistic experience (reproduced with permission from Murray et al., ##REF##36183692##2023##, available at <ext-link xlink:href=\"https://doi.org/10.1159/000526213\" ext-link-type=\"uri\">htt...	[]	[]	[]	[]	[ "<disp-quote><p>“<italic>The jars of jams sang and talked to me… One</italic> of my favourite things to do was to watch flecks of dust floating in streaks of light or sunshine. … <italic>The door was made of vertical rows of boards, painted light yellow on the outside, like washed-out mustard, like saffron or daffo...	[]	[]	[ "<fn-group><fn id=\"fn0001\"><p><sup>1</sup>We begin by establishing our own positionally and perspectives as authors. The first author (Green) is non-autistic. He has worked clinically as a child psychiatrist with autistic children, young people, and families for 35 years and as a research professor in autism deve...	[ "<graphic xlink:href=\"fpsyg-14-1287209-g0001\" position=\"float\"/>" ]	[]	[{"surname": ["Barale", "Broglia", "De Vidovich", "di Nemi", "Rossi", "Monti"], "given-names": ["F.", "D.", "G. Z.", "S. U.", "M.", "M. R."], "year": ["2019"], "article-title": ["\u201cThe lifeworld of persons with autism,\u201d"], "source": ["Stanghellini 2019 The Oxford Handbook of Phenomenological Psychopathology"],...	{ "acronym": [], "definition": [] }	72	CC BY	no	2024-01-15 23:43:50	Front Psychol. 2023 Dec 27; 14:1287209	oa_package/e0/a5/PMC10788129.tar.gz
PMC10788130	38222184	[ "<title>Introduction</title>", "<p>Metabolic syndrome (MetS) is a collection of multiple metabolic abnormalities, such as hypertension, hyperglycemia, abdominal obesity, and atherogenic dyslipidemia. It remains one of the leading health challenges worldwide, affecting 25% of all adults according to the Internatio...	[ "<title>Materials and methods</title>", "<p>Study population</p>", "<p>Baseline data from the Prospective Epidemiological Research Studies in IrAN (PERSIAN) cohort study branch in Fasa city were used for this cross-sectional study. As part of the PERSIAN multicenter cohort study, the Fasa cohort study follows 1...	[ "<title>Results</title>", "<p>After eligibility was verified according to the inclusion criteria, data for 6356 participants (mean age: 46.58 ± 8.82 years, mean BMI: 25.02 ± 4.60 kg/m2) were included in the present analysis. MetS was prevalent in 777 (12.2%) participants.</p>", "<p>The general characteristics o...	[ "<title>Discussion</title>", "<p>In this cross-sectional study, even after adjusting for potential confounders, adherence to a diet with a high DAL was not associated with increased odds of MetS in Iranian adults. Among the components of MetS, a significant association was observed between higher DAL (PRAL and NE...	[ "<title>Conclusions</title>", "<p>Our findings suggest that a higher DAL was inversely associated with HDL-C and directly associated with serum TG levels in women. Moreover, there was a positive association between the fourth quintile of NEAP and FBS in men. However, even after adjusting for potential confounders...	[ "<p>Introduction</p>", "<p>Metabolic syndrome (MetS) remains one of the leading health challenges worldwide. A combination of genetic and environmental factors has been implicated in the etiology of MetS. Diet is a changeable environmental risk factor, and dietary modifications could significantly reduce the inci...	[]	[ "<p>We would like to thank the Research Council of the Nutrition and Food Security Research Center at Shahid Sadoughi University of Medical Sciences and the Noncommunicable Diseases Research Center at Fasa University of Medical Sciences for their support and funding. The authors thank all Fasa PERSIAN Cohort Study ...	[]	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Characteristics of the participants across quintiles of PRAL and NEAP</title><p>Note: Data are presented as mean ± standard error or absolute number (percentage).</p><p>Abbreviations: PRAL, potential renal acid load; NEAP, net endogen...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Seyede Hamide Rajaie, Sayyed Saeid Khayyatzadeh, Shiva Faghih, Yaser Mansoori, Mohammad Mehdi Naghizadeh, Mojtaba Farjam, Reza Homayounfar, Hassan Mozaffari-Khosravi</p><p><bold>Acquisitio...	[]	[]	[{"label": ["1"], "article-title": ["The definition and prevalence of obesity and metabolic syndrome"], "source": ["Obesity and Lipotoxicity"], "person-group": ["\n"], "surname": ["Engin"], "given-names": ["A"], "publisher-loc": ["Cham, Switzerland"], "publisher-name": ["Springer"], "year": ["2017"], "uri": ["https://d...	{ "acronym": [], "definition": [] }	38	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50593	oa_package/47/1b/PMC10788130.tar.gz
PMC10788131	38222174	[ "<title>Introduction</title>", "<p>Mucopolysaccharidoses (MPSs) are a subgroup of inherited lysosomal storage disorders caused by the deficiency of specific lysosomal enzymes on the glycosaminoglycans (GAG) catabolism pathway. The consequent storage of GAG in tissues leads to progressive multisystemic damage [##R...	[]	[]	[ "<title>Discussion</title>", "<p>MPS I has an estimated prevalence of 0.69 to 3.8 per 100,000 live births [##REF##16435194##7##]. At birth, the neonate can look healthy. Early symptoms include progressive coarse facial features, recurrent rhinitis, upper air obstruction, abdominal or inguinal hernias, thoracolumb...	[ "<title>Conclusions</title>", "<p>MPS I is an inherited autosomal recessive disorder with a multisystemic (including neurological) progressive course. Clinicians may suspect this diagnosis in children with coarse features, abdominal/inguinal hernias, recurrent upper respiratory infections, or dorsolumbar kyphosis...	[ "<p>Mucopolysaccharidoses are rare lysosomal storage disorders in which glycosaminoglycans accumulate in tissues, causing multiorgan dysfunction. Mucopolysaccharidosis type I is an autosomal recessive disease caused by a deficiency of the enzyme alpha-L-iduronidase, resulting in the accumulation of dermatan and hep...	[ "<title>Case presentation</title>", "<p>In 2017, a 15-month-old girl was referred to a neuropediatric consultation because of motor delay. She was the first child of healthy, non-consanguineous parents. The gestation was uneventful. Linea alba and umbilical and bilateral inguinal hernias were noticed at birth. Su...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Coarse facial features and thoracolumbar kyphosis at 15 months.</title></caption></fig>", "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG2\"><label>Figure 2</label><caption><title>Cranial computed tomography pe...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Clinical manifestations, complementary evaluations, and treatment during follow-up.</title><p>According to mucopolysaccharidosis type I guidelines for management and treatment [##REF##19117856##5##], patients should receive a comprehe...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Rui Diogo, Luísa Diogo, Alexandra Oliveira</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Rui Diogo, Luísa Diogo, Rute Serra, Joana Almeida, Alexandra Oliveira</p><p...	[ "<graphic xlink:href=\"cureus-0015-00000050595-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050595-i02\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050595-i03\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050595-i04\" position=\"float\"/>", "<gr...	[]	[{"label": ["6"], "article-title": ["Projecto FIND"], "date-in-citation": ["\n"], "month": ["9"], "year": ["2023", "2023"], "fpage": ["27"], "lpage": ["2023"], "uri": ["https://www.projetofind.pt/"]}, {"label": ["10"], "article-title": ["Orthopaedic aspects of mucopolysaccharidoses"], "source": ["Rheumatology (Oxford)"...	{ "acronym": [], "definition": [] }	20	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50595	oa_package/ef/7d/PMC10788131.tar.gz
PMC10788139	38222121	[ "<title>Introduction</title>", "<p>Tuberculosis is a major health problem, with 10.6 million new cases in 2021 according to the Global Tuberculosis Report 2022. Paradoxical deterioration upon tuberculosis chemotherapy, known as tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS), is a well-describe...	[]	[]	[ "<title>Discussion</title>", "<p>The patient was initially treated for acute miliary tuberculosis complicated by multiorgan system failure (i.e., shock, respiratory, and renal failure). The initial sites of involvement were the lungs, lymphatic system, liver, and urinary system. Brain extension was not explored a...	[ "<title>Conclusions</title>", "<p>PRs warrant close attention in patients presenting with neurological manifestations during tuberculosis treatment. Anti-TNF therapy has emerged as a promising salvage option in severe cases of PR. The potential benefits of utilizing anti-TNF therapy as a first-line treatment or a...	[ "<p>We report the case of a 42-year-old immunocompetent Indian patient presenting with miliary tuberculosis complicated by respiratory failure requiring intubation. Conventional quadritherapy was initiated for wild-type <italic>Mycobacterium tuberculosis</italic>. On day 29 of antibiotic treatment, persistent fever...	[ "<title>Case presentation</title>", "<p>A 42-year-old male of Indian origin, living in France since 2002, presented to our hospital with a one-month history of general status alteration. He reported asthenia and 19 kg of unintentional weight loss during an interval of less than six months. The patient sought medi...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Evolution of intracranial and thoracic findings: a year-long imaging assessment.</title><p>Imaging at baseline:</p><p>a. Chest X-ray reveals numerous bilateral small opacities resembling millet seeds.</p><p>b. Cerebral ...	[]	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Human Ethics</title><fn fn-type=\"other\"><p>Consent was obtained or waived by all participants in this study</p></fn></fn-group>", "<fn-group content-type=\"competing-interests\"><fn fn-type=\"COI-statement\"><p>The authors have declared that no competing interests exist....	[ "<graphic xlink:href=\"cureus-0015-00000050596-i01\" position=\"float\"/>" ]	[]	[]	{ "acronym": [], "definition": [] }	15	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50596	oa_package/88/1f/PMC10788139.tar.gz
PMC10788140	38222988	[ "<title>Introduction</title>", "<p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder characterized by recurrent, painful, and deep-seated abscesses, primarily in areas with apocrine sweat glands, such as the axillae, groin, buttocks, and infra-mammary regions [##REF##22236226##1##, ####REF##32...	[]	[]	[ "<title>Discussion</title>", "<p>Adalimumab is a fully human IgG1 monoclonal antibody that specifically targets TNF-α. It is currently approved for the treatment of various inflammatory diseases, including moderate to severe HS [##UREF##4##12##,##REF##27518661##13##]. While its ability to neutralize TNF-α contrib...	[ "<title>Conclusions</title>", "<p>This case of neurotuberculosis in a young individual following immunosuppressive treatment for HS underscores the critical importance of early screening for opportunistic diseases in patients undergoing immunosuppressive therapies. Notably, the initial unknown serological status ...	[ "<p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with limited therapeutic options. Adalimumab, an anti-tumor necrosis factor-alpha (TNF-α) monoclonal antibody, was the first biological agent approved for the treatment of moderate to severe HS. Tuberculosis (TB) is a highly prevalent global p...	[ "<title>Case presentation</title>", "<p>This case described a 23-year-old woman medical student in Portugal. She had a medical history dating back to the age of 12 years, marked by the presence of HS. In early 2019, she started adalimumab due to extensive suppurative lesions with fistulous tracts in various areas...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>(a) T2WI-FLAIR shows a subtle area of hyperintensity in the posterior region of the cerebellar vermis (arrow). There is no evidence of restricted diffusion, suggesting probable vasogenic edema. (b) Contrast-enhanced T1W...	[]	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Francisca Martins, Alexandra Rodrigues, João Fonseca Oliveira, Rui Malheiro, Luís Cerqueira</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Francisca Martins, Alexand...	[ "<graphic xlink:href=\"cureus-0016-00000052267-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0016-00000052267-i02\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0016-00000052267-i03\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0016-00000052267-i04\" position=\"float\"/>" ]	[]	[{"label": ["6"], "article-title": ["Therapies for hidradenitis suppurativa: a systematic review with a focus on Brazil"], "source": ["Drugs Context"], "person-group": ["\n"], "surname": ["Rivitti-Machado", "Ferreira Magalh\u00e3es", "Souto da Silva", "Duarte", "Bosnich", "Tunala", "Forestiero"], "given-names": ["MC", ...	{ "acronym": [], "definition": [] }	20	CC BY	no	2024-01-15 23:43:50	Cureus.; 16(1):e52267	oa_package/dd/14/PMC10788140.tar.gz
PMC10788143	38223407	[ "<title>Introduction</title>", "<p>Social determinants of health (SDoH) are non-medical factors that influence health outcomes, including the conditions in which people are born, grow, work, live, and age, as well as the wider set of forces and systems shaping daily life, such as economic policies, development ag...	[ "<title>Materials and methods</title>", "<title>Data sources and patient demographics</title>", "<p>This study uses the deidentified clinical notes at UCSF recorded between 2012 and 2021.##UREF##12##31## The study was approved by the Institutional Review Board (IRB) of the University of California, San Francisc...	[ "<title>Results</title>", "<p>We retrieved a total of 0.95 million de-identified clinical social work notes generated between 2012 and 2021 (see Materials and methods) from our UCSF Information Commons##UREF##12##31## (##FIG##0##Figure 1##). The majority of notes were classified as Progress Notes, Interdisciplina...	[ "<title>Discussion</title>", "<p>We used an unsupervised topic modeling method called LDA modeling on our corpus of 0.95 million de-identified clinical social work notes. We showed that topic modeling can be used to (1) extract the hidden themes from this huge corpus of clinical notes and identify the critical in...	[ "<title>Conclusion</title>", "<p>Social work notes contain rich and unique information about SDoH factors, frequently only recorded in text notes. SDoH factors are critical for analyzing health outcomes, and this study identified detailed categories of SDoH information covered by social work notes. Furthermore, t...	[ "<p>Drs Madhumita Sushil and Atul J. Butte contributed equally to this work.</p>", "<title>Abstract</title>", "<title>Objective</title>", "<p>Existing research on social determinants of health (SDoH) predominantly focuses on physician notes and structured data within electronic medical records. This study pos...	[ "<title>Background and significance</title>", "<p>Computational understanding of the free text in clinical notes is well known to be an open challenge, including the extraction of structured information from these documents.##REF##21233086##18## Some progress has been made in extracting SDoH factors from clinical...	[ "<title>Acknowledgments</title>", "<p>We thank all researchers, clinicians, and social workers who helped create and collect the deidentified clinical notes in our UCSF Information Commons. We thank everyone in Dr Atul J. Butte’s lab for the helpful discussion and feedback. We thank staff members in the Bakar Com...	[ "<fig position=\"float\" id=\"ooad112-F1\"><label>Figure 1.</label><caption><p>Retrieval of clinical social work notes for the study. The social work notes from the UCSF Information Commons between 2012 and 2021 were initially retrieved. Notes that were duplicated or extremely short were excluded, which resulted in...	[ "<table-wrap position=\"float\" id=\"ooad112-T1\"><label>Table 1.</label><caption><p>Topic modeling results for all social work notes.</p></caption><table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col valign=\"top\" align=\"left\" span=\"1\"/><col valign=\"top\" align=\"left\" span=\"1\"/></colgroup><...	[ "<inline-formula id=\"IE1\"><mml:math id=\"IM1\" display=\"inline\" overflow=\"scroll\"><mml:mo>∩</mml:mo></mml:math></inline-formula>", "<inline-formula id=\"IE2\"><mml:math id=\"IM2\" display=\"inline\" overflow=\"scroll\"><mml:mo>∪</mml:mo></mml:math></inline-formula>", "<inline-formula id=\"IE3\"><mml:math ...	[]	[]	[]	[]	[ "<supplementary-material id=\"sup1\" position=\"float\" content-type=\"local-data\"><label>ooad112_Supplementary_Data</label></supplementary-material>" ]	[ "<table-wrap-foot><fn id=\"tblfn2\"><p>Each row is an inferred topic, which is composed of 10 words.</p></fn></table-wrap-foot>", "<table-wrap-foot><fn id=\"tblfn1\"><p>The words in the <italic toggle=\"yes\">Keywords</italic> column are the representative words used to define the topics.</p></fn></table-wrap-foo...	[ "<graphic xlink:href=\"ooad112f1\" position=\"float\"/>", "<graphic xlink:href=\"ooad112f2\" position=\"float\"/>", "<graphic xlink:href=\"ooad112f3\" position=\"float\"/>" ]	[ "<media xlink:href=\"ooad112_supplementary_data.docx\"><caption><p>Click here for additional data file.</p></caption></media>" ]	[{"label": ["2"], "mixed-citation": ["\n"], "collab": ["World Health Organization"], "italic": ["Social Determinants of Health"], "year": ["2008"]}, {"label": ["3"], "mixed-citation": ["World Health Organization. "], "italic": ["A Conceptual Framework for Action on the Social Determinants of Health"], "ext-link": ["htt...	{ "acronym": [], "definition": [] }	47	CC BY	no	2024-01-15 23:43:50	JAMIA Open. 2024 Jan 14; 7(1):ooad112	oa_package/d7/43/PMC10788143.tar.gz
PMC10788145	38222240	[ "<title>Introduction</title>", "<p>To achieve a precise and prompt diagnosis, physicians should meticulously consider the interplay between patient history, thorough physical examination, and diagnostic imaging. This comprehensive approach frequently unveils distinctive and intriguing cases. The presence of odyno...	[]	[]	[ "<title>Discussion</title>", "<p>Acute calcific tendinitis of the longus colli muscle (ACTLC) is characterized by the deposition of calcium hydroxyapatite and subsequent inflammation in the longus colli muscle, primarily affecting its superior oblique portion [##REF##14239862##1##,##REF##32720813##2##]. Common sy...	[ "<title>Conclusions</title>", "<p>A typical history of preceding neck strain, symptoms including odynophagia and limited motion of the neck, and a CT finding of retropharyngeal calcification may indicate ACTLC. It is imperative for physicians to recognize the clinical characteristics of ACTLC and conduct thorough...	[ "<p>A man in his 40s complained of posterior neck pain and headache after a local festival. The patient also developed mild fever, odynophagia, and difficulty opening his mouth widely. Physical examination revealed mild rightward torticollis and limited ranges of neck motion. A neck computed tomography (CT) reveale...	[ "<title>Case presentation</title>", "<p>A previously healthy man at age 42 presented to our emergency department with complaints of posterior neck pain and headache. He reported participating in a local festival two days prior, during which he carried a Mikoshi, or portable shrine, by placing the carrying pole be...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>(A) A horizontal view of the neck CT. An arrow indicates the calcification of the longus colli muscle. (B) A sagittal view. An arrow indicates the calcification</title><p>CT, computed tomography</p></caption></fig>" ]	[]	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Junki Mizumoto</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Junki Mizumoto</p><p><bold>Drafting of the manuscript:</bold> Junki Mizumoto</p><p><bold>Critical revi...	[ "<graphic xlink:href=\"cureus-0015-00000050599-i01\" position=\"float\"/>" ]	[]	[{"label": ["4"], "article-title": ["Acute calcific tendinitis of the longus colli muscle: case report and review of the literature"], "source": ["Eur Spine J"], "person-group": ["\n"], "surname": ["Zibis", "Giannis", "Malizos", "Kitsioulis", "Arvanitis"], "given-names": ["AH", "D", "KN", "P", "DL"], "fpage": ["434"], ...	{ "acronym": [], "definition": [] }	10	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50599	oa_package/cf/26/PMC10788145.tar.gz
PMC10788146	38222162	[ "<title>Introduction</title>", "<p>Situs inversus (SI) is an autosomal recessive congenital abnormality characterized by a complete mirror reversal of both the abdominal and the thoracic organs [##REF##31181389##1##]. The normal human body’s composition is termed situs solitus with the classic external human body...	[]	[]	[ "<title>Discussion</title>", "<p>SI is a rare autosomal recessive congenital abnormality characterized by a complete mirror reversal arrangement of the internal organs along the left-right axis [##REF##32111882##2##]. While it is difficult to estimate the real frequency of this abnormality, a systematic review fr...	[ "<title>Conclusions</title>", "<p>This case represents a rare example of surgical management of cholecystitis in a patient with SI. Accurate diagnosis of cholecystitis can be made with a thorough understanding of anatomy as well as the utilization of imaging such as ultrasound and plain films. Once a diagnosis is...	[ "<p>Situs inversus (SI) is an autosomal recessive congenital abnormality in which there is a complete mirror reversal of visceral organs. In this article, we present the case of a 26-year-old male with a past medical history of suicidal ideations, gallstones, and SI who complained of left upper quadrant pain for tw...	[ "<title>Case presentation</title>", "<p>A 26-year-old male presented to the emergency department with left upper quadrant and epigastric abdominal pain for two weeks. He had been diagnosed with gallstones two years prior but never pursued surgery. His medical history was significant for SI and gallstones with a p...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>CT scan of the patient with SI. Stones in the gallbladder can be seen</title><p>The surgeon was on the patient's right side and the assistant on the patient's left side</p></caption></fig>", "<fig position=\"anchor\" ...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Labs at the time of presentation</title><p>WBC: white blood cells, ALT: alanine transaminase, AST: aspartate transaminase</p></caption><table frame=\"hsides\" rules=\"groups\"><tbody><tr style=\"background-color:#ccc\"><td rowspan=\"1...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Human Ethics</title><fn fn-type=\"other\"><p>Consent was obtained or waived by all participants in this study</p></fn></fn-group>", "<fn-group content-type=\"competing-interests\"><fn fn-type=\"COI-statement\"><p>The authors have declared that no competing interests exist....	[ "<graphic xlink:href=\"cureus-0015-00000050598-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050598-i02\" position=\"float\"/>" ]	[]	[{"label": ["4"], "article-title": ["Situs inversus totalis and disease of the biliary tract: survey of the literature and report of a case"], "source": ["Arch Surg"], "person-group": ["\n"], "surname": ["Wood", "Blalock"], "given-names": ["GO", "A"], "fpage": ["885"], "lpage": ["896"], "volume": ["40"], "year": ["1940...	{ "acronym": [], "definition": [] }	5	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50598	oa_package/32/24/PMC10788146.tar.gz
PMC10788148	38222117	[ "<title>Introduction and background</title>", "<p>Fatty liver disease, characterized by fat accumulation in the liver, has two primary variants: alcoholic fatty liver disease, or steatohepatitis, and non-alcoholic fatty liver disease (NAFLD). The latter, which is unrelated to excessive alcohol consumption, can be...	[]	[]	[]	[ "<title>Conclusions</title>", "<p>In synthesis, this systematic review underscores the promise of AI-assisted diagnosis for various types of fatty liver disease, including NAFLD, through the integration of imaging data and diverse diagnostic methods. Across a diverse range of studies with varying sample sizes, AI...	[ "<p>Fatty liver disease, also known as hepatic steatosis, poses a significant global health concern due to the excessive accumulation of fat within the liver. If left untreated, this condition can give rise to severe complications. Recent advances in artificial intelligence (AI, specifically AI-based ultrasound ima...	[ "<title>Review</title>", "<p>Methodology</p>", "<p>Search Strategy</p>", "<p>We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework for our study's methodology. Our goal was to find research studies that used AI to diagnose and categorize fatty liver disease usin...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>PRISMA study selection flow diagram</title></caption></fig>" ]	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Comprehensive search strategy for identifying studies on AI-assisted diagnosis and categorization of fatty liver disease using imaging data</title></caption><table frame=\"hsides\" rules=\"groups\"><tbody><tr style=\"background-color:...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Acquisition, analysis, or interpretation of data:</bold> Yazan A. Al-Ajlouni, Basil N. Nduma</p><p><bold>Critical review of the manuscript for important intellectual content:</bold> Yazan A. Al-Ajlouni, Basile Njei...	[ "<graphic xlink:href=\"cureus-0015-00000050601-i01\" position=\"float\"/>" ]	[]	[{"label": ["15"], "article-title": ["An integrated index for identification of fatty liver disease using radon transform and discrete cosine transform features in ultrasound images"], "source": ["Inf Fusion"], "person-group": ["\n"], "surname": ["Acharya", "Fujita", "Sudarshan"], "given-names": ["UR", "H", "VK"], "fpa...	{ "acronym": [], "definition": [] }	26	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50601	oa_package/cc/8f/PMC10788148.tar.gz
PMC10788149	38222189	[ "<title>Introduction</title>", "<p>Ulnar collateral ligament (UCL) tear is a common injury sustained by overhead athletes that results from repetitive valgus stresses on the elbow joint [##REF##32112818##1##]. It’s becoming a more prevalent injury as baseball pitching velocity has increased, especially among yout...	[]	[]	[ "<title>Discussion</title>", "<p>The presented case illustrates an intriguing instance of a high-grade partial UCL tear in a young baseball pitcher managed successfully through non-operative means. UCL tears are a considerable concern among throwing athletes, primarily due to the high valgus stresses imposed on t...	[ "<title>Conclusions</title>", "<p>This case report sheds light on the potentially successful opportunity for non-operative management of a high-grade partial UCL tear in a competitive baseball pitcher. The patient's significant improvement in pain, coupled with objective findings of structural healing and joint w...	[ "<p>Ulnar collateral ligament (UCL) tears of the elbow are prevalent injuries among throwing athletes and are associated with excessive or repeated valgus forces at the elbow. We present the case of an 18-year-old male baseball pitcher with an 18-month history of progressive right elbow pain, notably worsened durin...	[ "<title>Case presentation</title>", "<p>Case history</p>", "<p>An 18-year-old right-hand-dominant competitive high school baseball pitcher presented for evaluation of right elbow pain. Over the course of the past 18 months, the pain had progressively worsened. Notably, the pain's intensity varied based on the t...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Magnetic Resonance Imaging and Ultrasound of the right elbow. </title><p>Magnetic resonance imaging (MRI) demonstrates a near full-thickness, at least high-grade partial, tearing of the anterior bundle proximal portion ...	[]	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Rock P. Vomer II, Emma York, George G. A. Pujalte, Sara Memon, Daniel P. Montero, Shane Shapiro, Chris Fungwe</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Rock P. ...	[ "<graphic xlink:href=\"cureus-0015-00000050600-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050600-i02\" position=\"float\"/>" ]	[]	[{"label": ["8"], "article-title": ["Molecular and biologic effects of platelet-rich plasma (PRP) in ligament and tendon healing and regeneration: a systematic review"], "source": ["Int J Mol Sci"], "person-group": ["\n"], "surname": ["Chalidis", "Givissis", "Papadopoulos", "Pitsilos"], "given-names": ["B", "P", "P", "...	{ "acronym": [], "definition": [] }	10	CC BY	no	2024-01-15 23:43:50	Cureus.; 15(12):e50600	oa_package/f4/ce/PMC10788149.tar.gz
PMC10788151	37910419	[ "<title>Introduction</title>", "<p id=\"P3\">Photoacoustic (PA) imaging combines optical contrast with ultrasound (US) image formation. It exploits the PA effect in which time-modulated light is absorbed in chromophores within biological tissue, inducing differential thermoelastic expansion forming acoustic waves...	[]	[]	[ "<title>Conclusion and Discussion</title>", "<title>PAUS Imaging</title>", "<p id=\"P50\">PAUS imaging systems integrate a fiber-optic delivery system within a conventional clinical US transducer, enabling simultaneous PA and US imaging with flexible physical manipulation for human subject scanning. They can po...	[ "<title>Conclusion and Discussion</title>", "<title>PAUS Imaging</title>", "<p id=\"P50\">PAUS imaging systems integrate a fiber-optic delivery system within a conventional clinical US transducer, enabling simultaneous PA and US imaging with flexible physical manipulation for human subject scanning. They can po...	[ "<p id=\"P1\">Photoacoustic (PA) imaging provides optical contrast at relatively large depths within the human body, compared to other optical methods, at ultrasound (US) spatial resolution. By integrating real-time PA and US (PAUS) modalities, PAUS imaging has the potential to become a routine clinical modality br...	[ "<title>Photoacoustic Imaging</title>", "<p id=\"P14\">This section briefly describes the fundamentals of PA imaging. Further details can be found in [##UREF##24##59##], [##UREF##25##60##], and [##REF##22734732##61##]. ##FIG##1##Fig. 2## illustrates PA signal generation and acquisition through two distinct proces...	[ "<p id=\"P68\">This work was supported in part by the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MSIT) under Grant 2021R1A2C2094778; in part by the Institute of Information and Communications Technology Planning and Evaluation (IITP) under the Artificial Intelligence Converge...	[ "<fig position=\"float\" id=\"F1\"><label>Fig. 1.</label><caption><p id=\"P78\">(a) One example of a commercial PAUS platform Vevo LAZR-X, Visualsonics). (b) Optical fibers are located at/near the surface of the clinical US transducer to deliver laser energy into tissue (linear transducer). The PA signal is acquire...	[ "<table-wrap position=\"float\" id=\"T1\" orientation=\"landscape\"><label>TABLE I</label><caption><p id=\"P92\">Data Acquisition Conditions and Reconstruction Models in Reviewed Papers</p></caption><table frame=\"box\" rules=\"all\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\"/><col align=...	[ "<inline-formula><mml:math id=\"M1\" display=\"inline\"><mml:mi>λ</mml:mi></mml:math></inline-formula>", "<disp-formula id=\"FD1\">\n<label>(1)</label>\n<mml:math id=\"M2\" display=\"block\"><mml:mrow><mml:msub><mml:mi>μ</mml:mi><mml:mi>a</mml:mi></mml:msub><mml:mrow><mml:mo>(</mml:mo><mml:mrow><mml:mi mathvarian...	[ "<boxed-text id=\"BX1\" position=\"float\"><caption><title>Highlights</title></caption><list list-type=\"bullet\" id=\"L1\"><list-item><p id=\"P95\">Integrated PA and US (PAUS) imaging holds promise for disease detection and interventions, yet clinical adoption is hindered by poor image quality from handheld US arr...	[]	[]	[]	[]	[ "<table-wrap-foot><fn id=\"TFN1\"><label>*</label><p id=\"P93\">Improvement in PSNR/SNR with respect to the standard method in simulation/in-vitro tests</p></fn></table-wrap-foot>" ]	[ "<graphic xlink:href=\"nihms-1952312-f0001.jpg\" position=\"anchor\"/>", "<graphic xlink:href=\"nihms-1952312-b0002.gif\" position=\"float\"/>", "<graphic xlink:href=\"nihms-1952312-b0003.gif\" position=\"float\"/>", "<graphic xlink:href=\"nihms-1952312-b0004.gif\" position=\"float\"/>", "<graphic xlink:hre...	[]	[{"label": ["[1]"], "surname": ["McDonald", "Wetsel"], "given-names": ["FA", "GC"], "suffix": ["Jr."], "article-title": ["Generalized theory of the photoacoustic effect"], "source": ["J. Appl. Phys"], "volume": ["49"], "issue": ["4"], "fpage": ["2313"], "lpage": ["2322"], "month": ["Apr."], "year": ["1978"]}, {"label":...	{ "acronym": [], "definition": [] }	133	CC BY	no	2024-01-15 23:43:50	IEEE Trans Ultrason Ferroelectr Freq Control. 2023 Dec 14; 70(12):1591-1606	oa_package/0f/af/PMC10788151.tar.gz
PMC10788155	0	[]	[]	[]	[]	[]	[ "<p>Note: this Editorial is published in both <italic toggle=\"yes\">Philosophical Transactions A</italic> and <italic toggle=\"yes\">Philosophical Transactions B</italic>.</p>" ]	[ "<p>Earlier in 2023, the Committee on Publication Ethics (COPE) published a discussion document entitled ‘Best Practices for Editing Collections' [##UREF##0##1##]. The document was written in response to concerns that have been raised about the quality of content in themed collections, highlighted by the fact that ...	[ "<title>Data accessibility</title>", "<p>This article has no additional data.</p>", "<title>Declaration of AI use</title>", "<p>We have not used AI-assisted technologies in creating this article.</p>", "<title>Authors' contributions</title>", "<p>J.D.: writing—original draft; R.A.D.: writing—original draf...	[]	[]	[]	[]	[]	[]	[]	[]	[]	[]	[]	[{"label": ["1"], "x": [". "], "collab": ["COPE"], "year": ["2023"], "source": ["Discussion document: best practices for guest edited collections. The committee on publication ethics"], "publisher-loc": ["Hampshire, UK"], "publisher-name": ["Chandler's Ford"], "pub-id": ["10.24318/7cKLAia0"]}, {"label": ["2"], "x": ["....	{ "acronym": [], "definition": [] }	2	CC BY	no	2024-01-15 23:43:50	Philos Trans A Math Phys Eng Sci.; 382(2267):20230374	oa_package/e2/2e/PMC10788155.tar.gz
PMC10788156	0	[ "<title>Introduction</title>", "<p>When he first introduced the notion of a conformal boundary into the study of asymptotically empty space–times [##UREF##0##1##,##UREF##1##2##] Penrose noted that the boundary would be null, space-like or time-like according as the cosmological constant was zero, positive or neg...	[]	[]	[]	[]	[ "<p>One contribution of 13 to a discussion meeting issue ‘<ext-link xlink:href=\"http://dx.doi.org/10.1098/rsta/382/2267\" ext-link-type=\"uri\">At the interface of asymptotics, conformal methods and analysis in general relativity</ext-link>’.</p>", "<p>When he first introduced the notion of a conformal boundary ...	[ "<title>Conformal rescaling</title>", "<p>This section is included to fix conventions, which do vary across the literature, though the content should be familiar.</p>", "<p>Following [##UREF##1##2##] and assuming the space–time signature is and the Riemann tensor is defined by\nwe need to impose Penrose’s <ita...	[ "<title>Data accessibility</title>", "<p>This article has no additional data.</p>", "<title>Declaration of AI use</title>", "<p>I have not used AI-assisted technologies in creating this article.</p>", "<title>Authors' contributions</title>", "<p>P.T.: writing—original draft, writing—review and editing.</p...	[]	[]	[ "<inline-formula><mml:math id=\"IM1\"><mml:mi>Λ</mml:mi></mml:math></inline-formula>", "<inline-formula><mml:math id=\"IM2\"><mml:mi>Λ</mml:mi></mml:math></inline-formula>", "<inline-formula><mml:math id=\"IM3\"><mml:mi>Λ</mml:mi></mml:math></inline-formula>", "<inline-formula><mml:math id=\"IM4\"><mml:mi>Λ</...	[]	[]	[]	[]	[]	[ "<fn-group><fn id=\"FN1\"><label>1</label><p>With the conventions we are using, the Einstein equations are .</p></fn><fn id=\"FN2\"><label>2</label><p>Now in abstract indices.</p></fn><fn id=\"FN3\"><label>3</label><p>We will assume that or and , to avoid recollapse.</p></fn><fn id=\"FN4\"><label>4</label><p>The ...	[]	[]	[{"label": ["1"], "x": [". "], "surname": ["Penrose"], "given-names": ["R"], "year": ["1964"], "comment": ["Conformal treatment of infinity. Relativit\u00e9, Groupes et Topologie (Lectures, Les Houches, 1963 Summer School of Theoret. Phys., Univ. Grenoble), pp. 565\u2013584. New York, NY: Gordon and Breach"]}, {"label"...	{ "acronym": [], "definition": [] }	43	CC BY	no	2024-01-15 23:43:50	Philos Trans A Math Phys Eng Sci.; 382(2267):20230043	oa_package/31/07/PMC10788156.tar.gz
PMC10788157	0	[ "<title>Introduction</title>", "<p>Roger Penrose suggested to discuss the asymptotic behaviour of space–times in terms of extensions of their conformal structure [##UREF##0##1##,##UREF##1##2##]. The idea is that a <italic toggle=\"yes\">physical space–time</italic>\n may admit a smooth extension where is a smoo...	[]	[ "<title>Conformal field equations, stability results</title>", "<p>Finding initial data which develop into solutions to the Einstein equations that admit smooth conformal boundaries poses subtle problems when the cosmological constant vanishes or is negative. Because the initial slices are not compact choices ha...	[]	[]	[ "<p>One contribution of 13 to a discussion meeting issue ‘<ext-link xlink:href=\"http://dx.doi.org/10.1098/rsta/382/2267\" ext-link-type=\"uri\">At the interface of asymptotics, conformal methods and analysis in general relativity</ext-link>’.</p>", "<p>Smooth Cauchy data on for the Einstein--vacuum field equati...	[ "<title>Conformally non-covariant matter fields</title>", "<p>Finding such a mechanism, if something like it exists at all, requires among other things a sufficiently general and deep understanding of the behaviour of matter and the field equations at future time-like infinity. A number of authors analysed the fu...	[ "<title>Data accessibility</title>", "<p>This article has no additional data.</p>", "<title>Declaration of AI use</title>", "<p>I have not used AI-assisted technologies in creating this article.</p>", "<title>Authors' contributions</title>", "<p>H.F.: conceptualization, formal analysis, methodology, writi...	[]	[]	[ "<inline-formula><mml:math id=\"IM1\"><mml:msup><mml:mrow><mml:mi mathvariant=\"double-struck\">S</mml:mi></mml:mrow><mml:mn>3</mml:mn></mml:msup></mml:math></inline-formula>", "<inline-formula><mml:math id=\"IM2\"><mml:mi>λ</mml:mi></mml:math></inline-formula>", "<inline-formula><mml:math id=\"IM3\"><mml:mi>λ<...	[]	[]	[]	[]	[]	[]	[]	[]	[{"label": ["1"], "x": ["."], "surname": ["Penrose"], "given-names": ["R"], "year": ["1963"], "article-title": ["Asymptotic properties of fields and space-time"], "source": ["Phys. Rev. Lett."], "bold": ["10"], "fpage": ["66"], "lpage": ["68"], "pub-id": ["10.1103/PhysRevLett.10.66"]}, {"label": ["2"], "x": ["."], "sur...	{ "acronym": [], "definition": [] }	35	CC BY	no	2024-01-15 23:43:50	Philos Trans A Math Phys Eng Sci.; 382(2267):20230044	oa_package/61/8e/PMC10788157.tar.gz
PMC10788158	0	[ "<title>Introduction</title>", "<p>Roger Penrose’s seminal idea [##UREF##0##1##,##UREF##1##2##] of using techniques from conformal geometry to study global questions in general relativity has been vastly influential. Today, these ideas permeate a number of current research programmes in mathematical physics, part...	[]	[]	[]	[]	[ "<p>One contribution of 13 to a discussion meeting issue ‘<ext-link xlink:href=\"http://dx.doi.org/10.1098/rsta/382/2267\" ext-link-type=\"uri\">At the interface of asymptotics, conformal methods and analysis in general relativity</ext-link>’.</p>", "<p>This is an introductory article for the proceedings associat...	[ "<title>Penrose’s conformal compactification</title>", "<p>Robert Geroch’s description in the proceedings [##UREF##2##3##] of the 1976 Cincinnati Symposium on Asymptotic Structure of Space-Time captures well an essential reason why general relativity (henceforth GR) is distinct from many other physical theories: ...	[ "<title>Acknowledgements</title>", "<p>An attempt has been made here to cover the most important historical aspects of the subject. However, due to the very large number of researchers who have contributed to the broad area of asymptotics in general relativity, some omissions have no doubt crept in. All such inst...	[]	[]	[ "<inline-formula><mml:math id=\"IM1\"><mml:mi>ϕ</mml:mi></mml:math></inline-formula>", "<inline-formula><mml:math id=\"IM2\"><mml:mi>ϕ</mml:mi></mml:math></inline-formula>", "<inline-formula><mml:math id=\"IM3\"><mml:msub><mml:mrow><mml:mover><mml:mi>g</mml:mi><mml:mo stretchy=\"false\">~</mml:mo></mml:mover></...	[]	[]	[]	[]	[]	[ "<fn-group><fn id=\"FN1\"><label>1</label><p>A similar strategy was used by Y. Choquet-Bruhat and D. Christodoulou to show the global existence of solutions to the Yang–Mills equations [##UREF##44##47##].</p></fn></fn-group>" ]	[]	[]	[{"label": ["1"], "x": ["."], "surname": ["Penrose"], "given-names": ["R"], "year": ["1963"], "article-title": ["Asymptotic properties of fields and space-times"], "source": ["Phys. Rev. Lett."], "bold": ["10"], "fpage": ["66"], "lpage": ["68"], "pub-id": ["10.1103/PhysRevLett.10.66"]}, {"label": ["2"], "x": ["."], "su...	{ "acronym": [], "definition": [] }	74	CC BY	no	2024-01-15 23:43:50	Philos Trans A Math Phys Eng Sci.; 382(2267):20230048	oa_package/33/6b/PMC10788158.tar.gz
PMC10788159	0	[]	[]	[]	[]	[]	[ "<p>One contribution of 13 to a discussion meeting issue ‘<ext-link xlink:href=\"http://dx.doi.org/10.1098/rsta/382/2267\" ext-link-type=\"uri\">At the interface of asymptotics, conformal methods and analysis in general relativity</ext-link>’.</p>", "<p>This paper describes conservation laws in general relativity...	[ "<title>Early work on gravitational radiation</title>", "<p>The late 1950s and early 1960s saw the beginnings of our current understanding of gravitational radiation, according to general relativity (GR), and how gravitational waves carry energy away from a system of accelerating gravitating bodies. Already in 19...	[ "<title>Data accessibility</title>", "<p>This article has no additional data.</p>", "<title>Declaration of AI use</title>", "<p>I have not used AI-assisted technologies in creating this article.</p>", "<title>Authors' contributions</title>", "<p>R.P.: conceptualization, writing—original draft, writing—rev...	[ "<fig position=\"float\" id=\"RSTA20230041F1\"><label>Figure 1<x xml:space=\"preserve\">. </x></label><caption><p>A spin-vector, pictured as a future-null vector ‘flagpole', determining a point on the future-celestial (Riemann) sphere with a null half-plane ‘flag' attached, to describe (up to sign) the spinor's pha...	[]	[ "<disp-formula id=\"RSTA20230041M1.1\"><label>1.1</label><mml:math id=\"DM1\" display=\"block\"><mml:mrow><mml:msup><mml:mi>g</mml:mi><mml:mrow><mml:mi>a</mml:mi><mml:mi>b</mml:mi></mml:mrow></mml:msup></mml:mrow><mml:mrow><mml:mo> </mml:mo></mml:mrow><mml:mrow><mml:msub><mml:mi mathvariant=\"normal\">∇</mml:mi><mm...	[]	[]	[]	[]	[]	[]	[ "<graphic xlink:href=\"rsta20230041f01\" position=\"float\"/>", "<graphic xlink:href=\"rsta20230041f02\" position=\"float\"/>", "<graphic xlink:href=\"rsta20230041f03\" position=\"float\"/>", "<graphic xlink:href=\"rsta20230041f04\" position=\"float\"/>", "<graphic xlink:href=\"rsta20230041f05\" position=\"...	[]	[{"label": ["1"], "x": ["."], "surname": ["Brinkmann"], "given-names": ["HW"], "year": ["1925"], "article-title": ["Einstein spaces which are mapped conformally on one another"], "source": ["Mathematische Annalen"], "bold": ["94"], "fpage": ["119"], "lpage": ["145"], "pub-id": ["10.1007/BF01208647"]}, {"label": ["2"], ...	{ "acronym": [], "definition": [] }	59	CC BY	no	2024-01-15 23:43:50	Philos Trans A Math Phys Eng Sci.; 382(2267):20230041	oa_package/44/63/PMC10788159.tar.gz
PMC10788160	0	[ "<title>Introduction</title>", "<p>One of the main open problems in Mathematical General Relativity is that of the nonlinear stability of spacetimes. In 1986, Friedrich provided the first result concerning the global stability of the de Sitter spacetime and a semi-global stability result for the Minkowski spaceti...	[]	[ "<title>Standard results for symmetric hyperbolic systems</title>", "<p>The nature of the conformal Einstein field equations requires the <italic toggle=\"yes\">hyperbolic reduction</italic> of the conformal evolution equations to discuss the existence and asymptotic properties of their solutions. In this case, t...	[]	[ "<title>Conclusion</title>", "<p>This review article provides a discussion based on [##UREF##14##15##,##UREF##15##16##] describing how the extended conformal Einstein field equations and a gauge adapted to the conformal geodesics can be used to study the evolution of vacuum spacetimes with positive Cosmological c...	[ "<p>One contribution of 13 to a discussion meeting issue ‘<ext-link xlink:href=\"http://dx.doi.org/10.1098/rsta/382/2267\" ext-link-type=\"uri\">At the interface of asymptotics, conformal methods and analysis in general relativity</ext-link>’.</p>", "<p>This article provides a discussion on the construction of co...	[ "<title>Tools of conformal geometry</title>", "<p>The purpose of this section is to provide a brief summary of the technical tools of conformal geometry that will be used in the analysis of the evolution of the spacetimes under consideration.</p>", "<p>Let be a vacuum spacetime satisfying the Einstein field eq...	[ "<title>Data accessibility</title>", "<p>This article has no additional data.</p>", "<title>Declaration of AI use</title>", "<p>We have not used AI-assisted technologies in creating this article.</p>", "<title>Authors' contributions</title>", "<p>M.M.: conceptualization, formal analysis, investigation, wr...	[ "<fig position=\"float\" id=\"RSTA20230040F1\"><label>Figure 1<x xml:space=\"preserve\">. </x></label><caption><p>Penrose–Carter diagram of the background solution. The conformal representation discussed in the main text has compact spatial sections of negative scalar curvature. The vertical lines and correspond ...	[]	[ "<inline-formula><mml:math id=\"IM1\"><mml:mo stretchy=\"false\">(</mml:mo><mml:mrow><mml:mi mathvariant=\"script\">M</mml:mi></mml:mrow><mml:mo>,</mml:mo><mml:mrow><mml:mi mathvariant=\"bold-italic\">g</mml:mi></mml:mrow><mml:mo stretchy=\"false\">)</mml:mo></mml:math></inline-formula>", "<inline-formula><mml:ma...	[]	[]	[]	[]	[]	[ "<fn-group><fn id=\"FN1\"><label>1</label><p>The value for the Cosmological constant is conventional and set for convenience. This analysis can be carried out for any other positive value of .</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"rsta20230040f01\" position=\"float\"/>", "<graphic xlink:href=\"rsta20230040f02\" position=\"float\"/>", "<graphic xlink:href=\"rsta20230040f03\" position=\"float\"/>", "<graphic xlink:href=\"rsta20230040f04\" position=\"float\"/>" ]	[]	[{"label": ["1"], "x": ["."], "surname": ["Friedrich"], "given-names": ["H"], "year": ["1986"], "article-title": ["On the existence of "], "{http://www.w3.org/1998/Math/MathML}mi": ["n"], "source": ["Commun. Math. Phys."], "bold": ["107"], "fpage": ["587"], "lpage": ["609"], "pub-id": ["10.1007/BF01205488"]}, {"label":...	{ "acronym": [], "definition": [] }	26	CC BY	no	2024-01-15 23:43:51	Philos Trans A Math Phys Eng Sci.; 382(2267):20230040	oa_package/3e/8b/PMC10788160.tar.gz
PMC10788161	0	[ "<title>Introduction</title>", "<p>In this paper, we physically motivate and give an overview of mathematical constructions of solutions to the linearized Einstein vacuum equations around Schwarzschild with the following features:\n<list list-type=\"simple\"><list-item><label>(i)<x xml:space=\"preserve\"> </x></l...	[]	[ "<title>The main result</title>", "<p>We already formulate a rough version of one of the main results of Kehrberger & Masaood [##UREF##1##2##].</p>", "<title>Theorem 3.3.</title>", "<p><italic toggle=\"yes\">There exists a unique solution to</italic>\n<bold>LGS</bold>\n<italic toggle=\"yes\">attaining the...	[]	[ "<title>Conclusion</title>", "<p>Clearly, the results (##FORMU##318##3.6##) and (##FORMU##438##5.8##), which show that near (in complete agreement with [##UREF##26##27##]), violate the peeling property (##FORMU##25##1.3##) for (recall that is equivalent to ). As opposed to the violation of peeling near , whic...	[ "<p>One contribution of 13 to a discussion meeting issue ‘<ext-link xlink:href=\"http://dx.doi.org/10.1098/rsta/382/2267\" ext-link-type=\"uri\">At the interface of asymptotics, conformal methods and analysis in general relativity</ext-link>’.</p>", "<p>This paper is the fourth in a series dedicated to the mathem...	[ "<title>The physical set-up for the generation problem</title>", "<p>We here sketch the physical set-up that will inform our mathematical construction. This section does not aim or claim to be rigorous, instead, we want to give a ‘quick and dirty’ justification for the assumptions we will make for our mathematica...	[ "<title>Data accessibility</title>", "<p>This article has no additional data.</p>", "<title>Declaration of AI use</title>", "<p>We have not used AI-assisted technologies in creating this article.</p>", "<title>Authors' contributions</title>", "<p>L.K.: writing—original draft.</p>", "<title>Conflict of i...	[ "<fig position=\"float\" id=\"RSTA20230039F1\"><label>Figure 1<x xml:space=\"preserve\">. </x></label><caption><p>Depiction of a ‘Bondi bomb’ spacetime, i.e. a spacetime that is stationary in the past. The often made assumption of compactly supported initial data corresponds to precisely such a scenario.</p></capti...	[]	[ "<inline-formula><mml:math id=\"IM1\"><mml:mi>N</mml:mi></mml:math></inline-formula>", "<inline-formula><mml:math id=\"IM2\"><mml:msup><mml:mrow><mml:mi mathvariant=\"script\">I</mml:mi></mml:mrow><mml:mo>−</mml:mo></mml:msup></mml:math></inline-formula>", "<inline-formula><mml:math id=\"IM3\"><mml:msup><mml:mi...	[]	[]	[]	[]	[]	[ "<fn-group><fn id=\"FN1\"><label>1</label><p>For an overview over the field before the advent of the ideas discussed in the present section, we refer to the lecture notes [##UREF##11##12##] (from 1958) and references therein.</p></fn><fn id=\"FN2\"><label>2</label><p>We note in passing that, owing to another condit...	[ "<graphic xlink:href=\"rsta20230039f01\" position=\"float\"/>", "<graphic xlink:href=\"rsta20230039f02\" position=\"float\"/>", "<graphic xlink:href=\"rsta20230039f03\" position=\"float\"/>", "<graphic xlink:href=\"rsta20230039f04\" position=\"float\"/>", "<graphic xlink:href=\"rsta20230039f05\" position=\"...	[]	[{"label": ["1"], "x": [". "], "surname": ["Christodoulou", "Klainerman"], "given-names": ["D", "S"], "year": ["1993"], "source": ["The global nonlinear stability of the Minkowski space"], "series": ["Princeton Mathematical Series"], "publisher-name": ["Princeton, New Jersey, USA: Princeton University Press"]}, {"label...	{ "acronym": [], "definition": [] }	77	CC BY	no	2024-01-15 23:43:51	Philos Trans A Math Phys Eng Sci.; 382(2267):20230039	oa_package/f4/90/PMC10788161.tar.gz
PMC9481603	36124059	[ "<title>Introduction</title>", "<p id=\"Par7\">Vaccines are the most powerful pharmaceutical tool to prevent infections with SARS-CoV-2 and combat the COVID-19 pandemic. Fast vaccine uptake by as many individuals as possible saves lives, people’s health, and livelihoods. Despite large-scale vaccine roll-out campa...	[ "<title>Methods</title>", "<title>Mathematical framework</title>", "<p id=\"Par13\">We use a population-structured compartmental infectious disease model that captures a variety of aspects regarding vaccination against COVID-19 (see Supplementary Methods, Sec. ##SUPPL##1##1.1.1##). The model’s dynamics are full...	[ "<title>Results</title>", "<p id=\"Par23\">As a first model validation we find that for the high efficacy scenario the relative size of breakthrough infections within age groups eligible for vaccination is in good agreement with the share of reported symptomatic breakthrough cases (Table ##TAB##0##1##), albeit be...	[ "<title>Discussion</title>", "<p id=\"Par32\">After vaccine rollout programs in Germany have slowed down in late summer, incidences were rising to unprecedented levels in the fall of 2021, with hospitals and ICUs having reached maximum capacity. As about 41% of reported cases aged 12 or above were recorded as bre...	[]	[ "<title>Background</title>", "<p id=\"Par1\">While the majority of the German population was fully vaccinated at the time (about 65%), COVID-19 incidence started growing exponentially in October 2021 with about 41% of recorded new symptomatic cases aged twelve or above being symptomatic breakthrough infections, p...	[ "<title>Supplementary information</title>", "<p>\n\n\n\n\n</p>" ]	[ "<title>Supplementary information</title>", "<p>The online version contains supplementary material available at 10.1038/s43856-022-00176-7.</p>", "<title>Acknowledgements</title>", "<p>We thank L. E. Sander for valuable comments. B. F. M. is financially supported by the Joachim Herz Stiftung as an <italic>Add...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>Estimated contributions of infection pathways towards new cases within vaccinated and unvaccinated subpopulations.</title><p>Estimated contributions of infection pathways to in the (<bold>a</bold>) “high efficacy”, (<bold>b</bold>) “medium efficacy”, and (<bol...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Share of breakthrough infections in the age groups eligible for vaccination according to official estimates by the Robert Koch Institute (RKI)<sup>##UREF##6##11##</sup> and the model for “low efficacy”, “medium efficacy”, and “high efficacy” scenarios.</p><...	[ "<inline-formula id=\"IEq1\"><alternatives><tex-math id=\"M1\">\\documentclass[12pt]{minimal}\n\t\t\t\t\\usepackage{amsmath}\n\t\t\t\t\\usepackage{wasysym} \n\t\t\t\t\\usepackage{amsfonts} \n\t\t\t\t\\usepackage{amssymb} \n\t\t\t\t\\usepackage{amsbsy}\n\t\t\t\t\\usepackage{mathrsfs}\n\t\t\t\t\\usepackage{upgreek}\n...	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM3\"></supplementary-material>", "<supplementary-material ...	[ "<fn-group><fn><p><bold>Publisher’s note</bold> Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn><fn><p><bold>Change history</bold></p><p>1/12/2024</p><p>A Correction to this paper has been published: 10.1038/s43856-024-00432-y</p></fn></...	[ "<inline-graphic xlink:href=\"43856_2022_176_Article_IEq1.gif\"/>", "<inline-graphic xlink:href=\"43856_2022_176_Article_IEq2.gif\"/>", "<inline-graphic xlink:href=\"43856_2022_176_Article_IEq3.gif\"/>", "<inline-graphic xlink:href=\"43856_2022_176_Article_IEq4.gif\"/>", "<inline-graphic xlink:href=\"43856_...	[ "<media xlink:href=\"43856_2022_176_MOESM1_ESM.pdf\"><caption><p>Description of Additional Supplementary Files</p></caption></media>", "<media xlink:href=\"43856_2022_176_MOESM2_ESM.pdf\"><caption><p>Supplementary Information</p></caption></media>", "<media xlink:href=\"43856_2022_176_MOESM3_ESM.xlsx\"><caption...	[{"label": ["1."], "mixed-citation": ["World Health Organisation. WHO Coronavirus (COVID-19) Dashboard (2021). "], "ext-link": ["https://covid19.who.int"]}, {"label": ["2."], "mixed-citation": ["Keeling, M. J. & Rohani, P. Modeling infectious diseases in humans and animals (Princeton University Press, 2011). 10.2307/j....	{ "acronym": [], "definition": [] }	58	CC BY	no	2024-01-14 23:35:02	Commun Med (Lond). 2022 Sep 16; 2:116	oa_package/d7/d6/PMC9481603.tar.gz
PMC9808557	36577523	[ "<title>INTRODUCTION</title>", "<p>Since the discovery of oncogenic driver mutations, the therapeutic landscape of non-small-cell lung cancer (NSCLC) has evolved exponentially. Genomic profiling has set the stage for personalized cancer therapy. NSCLC is known to demonstrate somatic alterations in the <italic>BRC...	[ "<title>METHODS</title>", "<p>The specimen obtained from the epigastric lump was sent for <italic>EGFR</italic> mutation analysis by direct Sanger sequencing. Genomic DNA was extracted from the tissue sample. The extracted DNA then undergoes polymerase chain reaction (PCR) amplification for exons 18, 19, 20, and ...	[]	[ "<title>DISCUSSION</title>", "<p>In this case report, we showed the clinical efficacy of olaparib in a patient with metastatic NSCLC harboring a somatic <italic>BRCA2</italic> PV and germline <italic>BRCA2</italic> wild type. The patient's PFS of 8 mo with olaparib was superior to pembrolizumab and pemetrexed-car...	[]	[ "<p>Poly (ADP-ribose) polymerase (PARP) inhibitors have been approved in malignancies associated with germline <italic>BRCA1</italic> or <italic>BRCA2</italic> pathogenic variants, such as breast, ovarian, prostate, and pancreatic cancer. In malignancies not associated with germline <italic>BRCA1</italic> or <itali...	[ "<title>CLINICAL PRESENTATION</title>", "<p>The patient was a 64-yr-old Chinese gentleman with a smoking history of forty pack-years and hypertension who presented with a skin lump over the epigastrium in March 2019. Significant family history included his sister who was diagnosed with breast cancer in her 40s an...	[]	[ "<fig position=\"float\" id=\"MCS006223SOOF1\"><label>Figure 1.</label><caption><p>Metastatic non-small-cell lung cancer (NSCLC) treatment using different regimens and results of next-generation sequencing (NGS). (BSC) Best supportive care, (PD) progression of disease, (PDL-1 TPS) programmed death-ligand 1 tumor pr...	[ "<table-wrap position=\"float\" id=\"MCS006223SOOTB1\"><label>Table 1.</label><caption><p>Genomic findings and their variant interpretation identified on somatic sequencing of lung primary</p></caption><table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" span=\"1\"/><col align=\"center\...	[]	[]	[]	[]	[]	[ "<supplementary-material id=\"PMC_1\" content-type=\"local-data\">\n<caption>\n<title>Supplemental Material</title>\n</caption>\n\n\n</supplementary-material>" ]	[ "<table-wrap-foot><fn><p>(HGVS) Human Genome Variation Society.</p></fn></table-wrap-foot>", "<table-wrap-foot><fn><p>(HGVS) Human Genome Variation Society.</p></fn></table-wrap-foot>", "<fn-group><fn fn-type=\"supplementary-material\"><p>[Supplemental material is available for this article.]</p></fn></fn-group...	[ "<graphic xlink:href=\"MCS006223Soo_F1\" position=\"float\"/>", "<graphic xlink:href=\"MCS006223Soo_F2\" position=\"float\"/>" ]	[ "<media mimetype=\"text\" mime-subtype=\"html\" xlink:href=\"supp_8_7_a006223__DC1.html\"/>", "<media xlink:role=\"associated-file\" mimetype=\"application\" mime-subtype=\"pdf\" xlink:href=\"supp_mcs.a006223_Supplemental_Material.pdf\"/>" ]	[{"surname": ["Fennell", "Lester", "Danson", "Blackhall", "Nicolson", "Nixon", "Porter", "Gardner", "White", "Griffiths"], "given-names": ["DA", "JF", "S", "FH", "M", "LS", "C", "GM", "A", "GO"], "year": ["2020"], "article-title": ["A randomized phase II trial of olaparib maintenance versus placebo monotherapy in patie...	{ "acronym": [], "definition": [] }	20	CC BY	no	2024-01-14 23:36:37	Cold Spring Harb Mol Case Stud. 2022 Dec; 8(7):a006223	oa_package/34/75/PMC9808557.tar.gz
PMC9885904	36715720	[]	[ "<title>Methodik</title>", "<p>Um die Entwicklung der Fahrradunfälle in Münster zu analysieren, wurden 4 Studien des UKM mit der offiziellen Verkehrsunfallstatistik der Polizei Münster verglichen. Alle Daten wurden mittels eines Patientenfragebogens und des Krankenhausinformationssystems erhoben. Die erste Studie...	[]	[]	[]	[ "<p>Carl Neuerburg, München</p>", "<p>Ben Ockert, München</p>", "<p>Hans Polzer, München</p>", "<title>Hintergrund</title>", "<p>Fahrräder sind seit vielen Jahren ein beliebtes Verkehrsmittel. Gerade in Zeiten der verstärkten Klimadiskussion ist das Fahrrad als umweltfreundliches und kostengünstiges Verkehr...	[ "<p>Fahrräder sind seit Jahren ein beliebtes Transportmittel. Sie bieten Vorteile für Umwelt und Gesundheit, dennoch sind Fahrradunfälle im Straßenverkehr häufig folgenschwer. Mit dem Wandel der Fahrradnutzung hin zur E‑Mobilität müssen sich die Bedingungen für Radfahrer im Sinne der Unfallverhütung weiterentwickel...	[ "<title>Funding</title>", "<p>Open Access funding enabled and organized by Projekt DEAL.</p>", "<title>Einhaltung ethischer Richtlinien</title>", "<title>Interessenkonflikt</title>", "<p>Die Autoren D. Schlautmann, M. Raschke, U. Weiss, B. Wieskötter, J. Ueberberg und C. Juhra erklären, dass sie keinen Inte...	[ "<fig id=\"Fig1\"></fig>", "<fig id=\"Fig2\"></fig>", "<fig id=\"Fig3\"></fig>", "<fig id=\"Fig4\"></fig>", "<fig id=\"Fig5\"></fig>", "<fig id=\"Fig6\"></fig>" ]	[ "<table-wrap id=\"Tab1\"><table frame=\"hsides\" rules=\"groups\"><thead><tr><th>Studien</th><th>Studienzeitraum</th><th>Fahrradtypen</th><th><italic>n</italic></th><th>Pedelecs, absolut</th><th>Pedelecs, prozentual (%)</th></tr></thead><tbody><tr><td>Studie 1</td><td>01.02.2009–31.01.2010</td><td>Alle</td><td>452<...	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn id=\"Fn1\"><label>1</label><p>Ethikantragsnummern: Studie 1: Die Ethiksantragsnummer ist nach 10-jähriger Archivierung verfallen. Studie 2: 2012-171-f‑S Studie 3: Az.: 2017-281-b‑S; Studie 4: Az.: 2018-198-f‑S.</p></fn><fn><p>\n\n</p><p>QR-Code scannen & Beitrag online lesen</p></fn></fn-group>" ...	[ "<graphic xlink:href=\"113_2022_1287_Fig1_HTML\" id=\"d32e466\"/>", "<graphic xlink:href=\"113_2022_1287_Fig2_HTML\" id=\"d32e499\"/>", "<graphic xlink:href=\"113_2022_1287_Fig3_HTML\" id=\"d32e554\"/>", "<graphic xlink:href=\"113_2022_1287_Fig4_HTML\" id=\"d32e583\"/>", "<graphic xlink:href=\"113_2022_1287...	[]	[{"label": ["1."], "mixed-citation": ["Allgemeiner Deutscher Fahrrad-Club EV Rechtliche Rahmenbedingungen. "], "ext-link": ["https://www.adfc.de/artikel/rechtliche-rahmenbedingungen"]}, {"label": ["2."], "mixed-citation": ["Allgemeiner Deutscher Fahrrad-Club Nordrhein-Westfalen-Kreisverband Bottrop E.\u202fV. Was ist b...	{ "acronym": [], "definition": [] }	24	CC BY	no	2024-01-14 23:35:01	Unfallchirurgie (Heidelb). 2024 Jan 30; 127(1):54-61	oa_package/07/0e/PMC9885904.tar.gz
PMC10034899	36952068	[ "<title>Introduction</title>", "<p id=\"Par2\">Since the beginning of the twentieth century, cardiovascular diseases (CVD) have remained the most common cause of death, taking significant hold, especially in industrialized countries in Western Europe and North America [##REF##23902484##1##]. CVD contributed to 17...	[]	[]	[]	[ "<title>Conclusion</title>", "<p id=\"Par27\">Regulation of vascular function is dependent on the balance between the adaptive inflammatory mechanisms in the body that are meant to produce fibrosis, wound healing, scarring, and maladaptive infiltration by pro-inflammatory cytokines. Factors such as diabetes, high...	[ "<p id=\"Par1\">Atherosclerosis is characterized by the development of intimal plaque, thrombosis, and stenosis of the vessel lumen causing decreased blood flow and hypoxia precipitating angina. Chronic inflammation in the stable plaque renders it unstable and rupture of unstable plaques results in the formation of...	[ "<title>Oxidative stress and sirtuins</title>", "<p id=\"Par6\">Intimal injury, the predisposing factor for plaque formation and progression, and vascular inflammation induce local upregulation of the renin-angiotensin system [##REF##26260307##14##, ##REF##22479397##15##]. Renin–angiotensin–aldosterone system (RA...	[ "<title>Acknowledgements</title>", "<p>VR is thankful to WesternU for the startup funds and DKA thanks the National Institutes of Health, USA for funding.</p>", "<title>Author contribution</title>", "<p>VP: literature search; design; critical review and interpretation of the published reports; preparation of ...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><p>Inflammatory pathway leading to cascade resulting in plaque vulnerability and the effect of Sirtuins attenuating pro-inflammatory mediators<bold>.</bold> Intimal injury during vascular intervention or during atherogenesis induce release of DAMPs which stimulate inf...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Summary of the studies investigating the role of sirtuins (SIRTs) in atherosclerosis</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th align=\"left\">Aim of the study</th><th align=\"left\">Experimental model</th><th align=\"left\">Strate...	[]	[]	[]	[]	[]	[]	[ "<table-wrap-foot><p>Abbreviations: Ang, Angiotensin; CAD, coronary artery disease; CVD, cardiovascular disease; ECs, endothelial cells; KO, knockout; LDLr, low density lipoprotein receptor; TNFSF4, TNF Superfamily Member 4</p></table-wrap-foot>", "<fn-group><fn><p><bold>Publisher's Note</bold></p><p>Springer Nat...	[ "<graphic xlink:href=\"11010_2023_4714_Fig1_HTML\" id=\"MO1\"/>", "<graphic xlink:href=\"11010_2023_4714_Fig2_HTML\" id=\"MO2\"/>", "<graphic xlink:href=\"11010_2023_4714_Fig3_HTML\" id=\"MO3\"/>" ]	[]	[{"label": ["2."], "mixed-citation": ["Organization WH. Cardiovascular diseases (CVDs). Fact sheet. Reviewed June 2016. cited 2016-08-26. "], "ext-link": ["http://www.who.int/mediacentre/factsheets/fs317/en"]}, {"label": ["3."], "surname": ["Herrington", "Lacey", "Sherilkar", "Armitage", "Lewington"], "given-names": ["...	{ "acronym": [], "definition": [] }	103	CC BY	no	2024-01-14 23:35:01	Mol Cell Biochem. 2024 Mar 23; 479(1):51-62	oa_package/2a/23/PMC10034899.tar.gz
PMC10463284	37633903	[ "<title>Introduction</title>", "<p id=\"Par13\">Health-related stigma refers to a social process by which people devalue or exclude others on the basis of their perceived health condition or features associated with that health condition [##REF##17130065##1##]. Hepatitis B virus (HBV) is a blood-borne virus, with...	[ "<title>Methods</title>", "<p id=\"Par18\">This paper reports on qualitative data, drawn from a broader mixed-methods evaluation of the DLM program, conducted by the Centre for Social Research in Health at UNSW Sydney [##UREF##11##31##]. The broader evaluation aimed to evaluate the effectiveness of the DLM progra...	[ "<title>Results and discussion</title>", "<p id=\"Par25\">The sample consisted of five Aboriginal and Torres Strait Islander and six non-Aboriginal or Torres Strait Islander health workers and key informants involved in the DLM program. Health workers were involved in varying aspects of the DLM program, from the ...	[ "<title>Results and discussion</title>", "<p id=\"Par25\">The sample consisted of five Aboriginal and Torres Strait Islander and six non-Aboriginal or Torres Strait Islander health workers and key informants involved in the DLM program. Health workers were involved in varying aspects of the DLM program, from the ...	[ "<title>Conclusions</title>", "<p id=\"Par64\">Health workers in this research perceived that HBV was not a priority in Aboriginal and Torres Strait Islander communities, and this was partly due to the focus of health promotion programs on screening and treatment for HCV and the conflation among health workers an...	[ "<title>Background</title>", "<p id=\"Par1\">Experiences of stigma and discrimination can act as a significant barrier to testing, monitoring, and treatment for hepatitis B virus (HBV). Aboriginal and Torres Strait Islander Australians are a population disproportionately impacted by HBV and yet limited research h...	[]	[ "<title>Acknowledgements</title>", "<p>This research was funded by a National Health and Medical Research Council Partnership Grant and by the NSW Ministry of Health. Funding and in-kind contributions were also provided by participating sites. The authors wish to acknowledge the contributions of everyone who was ...	[]	[]	[]	[]	[]	[ "<disp-quote><p id=\"Par27\">I mean there are so many forms of stigma that conflate into and comes down upon an individual’s head and on a community shoulders, that being able to unpick … Being treated shabbily by health care workers or community members or family members and peers, because of an individual kind of...	[]	[]	[ "<fn-group><fn><p>The original online version of this article was revised: reference number 31 has been added \n</p></fn><fn><p><bold>Publisher's Note</bold></p><p>Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn><fn><p><bold>Change histo...	[]	[]	[{"label": ["11."], "mixed-citation": ["World Health Organization. Global hepatitis report 2017. 2017."]}, {"label": ["13."], "surname": ["Ringelhan", "McKeating", "Protzer"], "given-names": ["M", "JA", "U"], "article-title": ["Viral hepatitis and liver cancer"], "source": ["Philos Trans R Soc Lond B Biol Sci"], "year"...	{ "acronym": [ "BBV", "DLM", "HARP", "HBV", "HCV", "LHD", "NSW", "STI" ], "definition": [ "Blood-borne virus", "Deadly Liver Mob", "HIV and Related Programs", "Hepatitis B", "Hepatitis C", "Local Health District", "New South Wales", "Sexually transmi...	53	CC BY	no	2024-01-14 23:35:04	Harm Reduct J. 2023 Aug 26; 20:116	oa_package/7f/2e/PMC10463284.tar.gz
PMC10509603	37736290	[ "<title>Introduction</title>", "<p>The impact of the digital turn on our culture is undeniable. It has changed the way we consume and create content, breaking down geographical barriers, and empowering individuals to participate in cultural expression on a global scale. With the rise of social media, digital medi...	[]	[]	[]	[ "<title>Conclusion</title>", "<p>The digital revolution has had a significant impact on collective memory, resulting in notable changes. Archives, which were once static repositories, have undergone a transformation and now function as dynamic entities. This shift challenges traditional storage methods and promot...	[ "<p>No competing interests were disclosed.</p>", "<p>This article explores the configuration of collective memory under the impact of the digital turn. In recent debates, there has been a marked tendency to interpret ‘digital memory’ as a new type of memory, which is radically different from the traditional conce...	[ "<title>Rethinking the social</title>", "<p>In 1925, Maurice Halbwachs published\n<italic toggle=\"yes\">Social Frameworks of Memory</italic> (\n<italic toggle=\"yes\">Les cadres sociaux de la mémoire</italic>), a book in which he advanced the concept of ‘collective memory’. While Halbwachs was not the only one t...	[ "<title>Data availability</title>", "<p>No data associated with this article.</p>" ]	[]	[]	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"pub-status\"><fn><p>[version 2; peer review: 1 approved, 2 approved with reservations]</p></fn></fn-group>", "<fn-group><fn><p id=\"FN1\">\n<sup>1</sup> In fact, reflection on memory is as old as humanity itself. It not only has a long history predating the 'memory boom,' but often, by c...	[]	[]	[{"mixed-citation": ["\n"], "person-group": ["\n"], "surname": ["Assmann"], "given-names": ["A"], "article-title": ["Canon and Archive."], "italic": ["Cultural Memory Studies: An International and Interdisciplinary Handbook."], "year": ["2008"], "fpage": ["97"], "lpage": ["107"], "ext-link": ["Reference Source"]}, {"mi...	{ "acronym": [], "definition": [] }	56	CC BY	no	2024-01-14 23:35:01	Open Res Eur. 2024 Jan 12; 3:123	oa_package/fd/7d/PMC10509603.tar.gz
PMC10547664	37800097	[ "<title>Introduction</title>", "<p id=\"Par2\">The <italic>Domb numbers</italic>\n, defined byfor non-negative integers <italic>n</italic>, first appeared in an extensive study by Domb [##UREF##3##4##] on interacting particles on crystal lattices. In particular, Domb showed that counts the number of 2<italic>n<...	[]	[]	[]	[]	[ "<p id=\"Par1\">In this paper, we prove two recently conjectured supercongruences (modulo , where <italic>p</italic> is any prime greater than 3) of Zhi-Hong Sun on truncated sums involving the Domb numbers. Our proofs involve a number of ingredients such as congruences involving specialized Bernoulli polynomials, ...	[ "<title>Preliminary lemmas</title>", "<p id=\"Par9\">Recall that the Bernoulli polynomials are given bywhere, as before, are the Bernoulli numbers. We will also use the classical Legendre symbol (for integer <italic>a</italic> and odd prime <italic>q</italic>). The following lemma involving the (generalized) h...	[ "<title>Acknowledgements</title>", "<p>The authors would like to thank the anonymous referees for helpful comments.</p>", "<title>Funding</title>", "<p>Open access funding provided by Austrian Science Fund (FWF).</p>", "<title>Data availability</title>", "<p>Data sharing is not applicable to this article ...	[]	[]	[ "<inline-formula id=\"IEq1\"><alternatives><tex-math id=\"M1\">\\documentclass[12pt]{minimal}\n\t\t\t\t\\usepackage{amsmath}\n\t\t\t\t\\usepackage{wasysym} \n\t\t\t\t\\usepackage{amsfonts} \n\t\t\t\t\\usepackage{amssymb} \n\t\t\t\t\\usepackage{amsbsy}\n\t\t\t\t\\usepackage{mathrsfs}\n\t\t\t\t\\usepackage{upgreek}\n...	[]	[]	[]	[]	[]	[ "<fn-group><fn><p>Guo-Shuai Mao was supported by the National Natural Science Foundation of China (grant nos. 12001288 and 12071208) and China Scholarship Council (grant no. 202008320187). Michael J. Schlosser was partially supported by FWF Austrian Science Fund grant P 32305.</p></fn><fn><p><bold>Publisher's Note<...	[ "<inline-graphic xlink:href=\"13398_2023_1509_Article_IEq1.gif\"/>", "<inline-graphic xlink:href=\"13398_2023_1509_Article_IEq2.gif\"/>", "<graphic xlink:href=\"13398_2023_1509_Article_Equ12.gif\" position=\"anchor\"/>", "<inline-graphic xlink:href=\"13398_2023_1509_Article_IEq3.gif\"/>", "<inline-graphic x...	[]	[{"label": ["1."], "surname": ["Chan", "Zudilin"], "given-names": ["HH", "W"], "article-title": ["New representations for Ap\u00e9ry-like sequences"], "source": ["Mathematika"], "year": ["2010"], "volume": ["56"], "fpage": ["107"], "lpage": ["117"], "pub-id": ["10.1112/S0025579309000436"]}, {"label": ["2."], "surname":...	{ "acronym": [], "definition": [] }	23	CC BY	no	2024-01-14 23:35:01	Rev R Acad Cienc Exactas Fis Nat A Mat. 2024 Oct 3; 118(1):11	oa_package/6f/52/PMC10547664.tar.gz
PMC10624743	37921996	[ "<title>Introduction</title>", "<p id=\"Par5\">Neutropenia is a risk factor for certain infections that may appear as a frequent and severe complication in oncological patients; its only typical symptom is fever [##REF##16925575##1##].</p>", "<p id=\"Par6\">This entity has classically been treated through hospi...	[ "<title>Methods</title>", "<title>Design and search strategy</title>", "<p id=\"Par8\">Using the MEDLINE (PubMed), Embase, and Cochrane Library databases, a search was undertaken of all meta-analyses, clinical trials, and observational studies published up to February 2021. We also performed backward reference ...	[ "<title>Results</title>", "<p id=\"Par13\">The results of the search and the study flow chart are presented in Fig. ##FIG##0##1##.</p>", "<title>Description of included studies</title>", "<p id=\"Par14\">The criteria for defining the concepts of fever and neutropenia in different studies are presented in anne...	[ "<title>Discussion</title>", "<p id=\"Par28\">Since at least the early 1990s, with Rubenstein et al. [##REF##8490912##10##], and possibly even before then, there has been recognition that the risk of complications is heterogeneous in populations with febrile neutropenia. The few studies available on this topic ha...	[]	[ "<title>Purpose</title>", "<p id=\"Par1\">Recent clinical practice guidelines have recommended ambulatory management of febrile neutropenia in patients with low risk of complications. Although some centers have begun developing management protocols for these patients, there appears to be a certain reluctance to i...	[ "<title>Supplementary information</title>", "<p>\n</p>" ]	[ "<title>Author contribution</title>", "<p>All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by EF-Q. The first draft of the manuscript was written by EF-Q, DO-B, and CL-Q. All authors commented on previous versions of the manuscript. All...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><p>Study flow chart</p></caption></fig>" ]	[ "<table-wrap id=\"Tab1\"><label>Table 1.</label><caption><p>Exclusion criteria for low-risk treatment group, by organ, organ system, or medical specialty</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th>Criteria</th><th>Studies</th></tr></thead><tbody><tr><td><italic>Cardiovascular system</itali...	[]	[]	[]	[ "<disp-quote><p id=\"Par10\">“Febrile neutropenia,” “low risk febrile neutropenia,” and “Low risk Neutropenic fever” in three search strings, each combined with the following terms using the Boolean operator AND: “Hospital admission,” “inpatient management,” “outpatient management,” “Home admission,” “Ambulatory ma...	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>" ]	[ "<table-wrap-foot><p><italic>AST</italic> aspartate transaminase, <italic>ALT</italic> alanine aminotransferase, <italic>eGFR</italic> estimated glomerular filtration rate</p></table-wrap-foot>", "<fn-group><fn><p><bold>Publisher’s Note</bold></p><p>Springer Nature remains neutral with regard to jurisdictional cl...	[ "<graphic xlink:href=\"520_2023_8065_Fig1_HTML\" id=\"MO1\"/>" ]	[ "<media xlink:href=\"520_2023_8065_MOESM1_ESM.pdf\"><label>ESM 1</label><caption><p>(PDF 344 kb)</p></caption></media>" ]	[]	{ "acronym": [], "definition": [] }	37	CC BY	no	2024-01-14 23:35:02	Support Care Cancer. 2023 Dec 13; 31(11):665	oa_package/31/9b/PMC10624743.tar.gz
PMC10632307	37970590	[ "<title>Introduction and main results</title>", "<p id=\"Par2\">In many cases, completeness properties of various objects of General Topology or Topological Algebra can be characterized externally as closedness in ambient objects. For example, a metric space <italic>X</italic> is complete if and only if <italic>X...	[]	[ "<title>Introduction and main results</title>", "<p id=\"Par2\">In many cases, completeness properties of various objects of General Topology or Topological Algebra can be characterized externally as closedness in ambient objects. For example, a metric space <italic>X</italic> is complete if and only if <italic>X...	[]	[]	[ "<p id=\"Par1\">Let be a class of topological semigroups. A semigroup <italic>X</italic> is called <italic>absolutely </italic><italic>-closed</italic> if for any homomorphism to a topological semigroup , the image <italic>h</italic>[<italic>X</italic>] is closed in <italic>Y</italic>. Let , , and be the classes...	[ "<title>Preliminaries</title>", "<p id=\"Par115\">In this section we collect some auxiliary results and notions that will be used in the remaining part of the paper.</p>", "<p id=\"Par116\">We denote by the set of finite ordinals and by the set of positive integers. Each ordinal is identified with the set o...	[ "<title>Funding</title>", "<p>Open access funding provided by The Ministry of Education, Science, Research and Sport of the Slovak Republic in cooperation with Centre for Scientific and Technical Information of the Slovak Republic.</p>", "<title>Data Availability</title>", "<p>Not applicable.</p>" ]	[]	[]	[ "<inline-formula id=\"IEq1\"><alternatives><tex-math id=\"M1\">\\documentclass[12pt]{minimal}\n\t\t\t\t\\usepackage{amsmath}\n\t\t\t\t\\usepackage{wasysym} \n\t\t\t\t\\usepackage{amsfonts} \n\t\t\t\t\\usepackage{amssymb} \n\t\t\t\t\\usepackage{amsbsy}\n\t\t\t\t\\usepackage{mathrsfs}\n\t\t\t\t\\usepackage{upgreek}\n...	[]	[]	[]	[]	[]	[ "<fn-group><fn><p>Serhii Bardyla was supported by the Slovak Research and Development Agency under the Contract no. APVV-21-0468 and by the Austrian Science Fund FWF (Grant I 5930).</p></fn><fn><p><bold>Publisher's Note</bold></p><p>Springer Nature remains neutral with regard to jurisdictional claims in published m...	[ "<inline-graphic xlink:href=\"13398_2023_1519_Article_IEq1.gif\"/>", "<inline-graphic xlink:href=\"13398_2023_1519_Article_IEq2.gif\"/>", "<inline-graphic xlink:href=\"13398_2023_1519_Article_IEq3.gif\"/>", "<inline-graphic xlink:href=\"13398_2023_1519_Article_IEq4.gif\"/>", "<inline-graphic xlink:href=\"13...	[]	[{"label": ["1."], "mixed-citation": ["Arhangelskii, A., Choban, M.: Completeness type properties of semitopological groups, and the theorems of Montgomery and Ellis. In: Topology Proceedings, vol. 37, pp. 33\u201360 (2011)"]}, {"label": ["2."], "mixed-citation": ["Bader, U., Leibtag, E.: Homomorhic Images of Algebraic...	{ "acronym": [], "definition": [] }	73	CC BY	no	2024-01-14 23:35:02	Rev R Acad Cienc Exactas Fis Nat A Mat. 2024 Nov 9; 118(1):23	oa_package/f3/ba/PMC10632307.tar.gz
PMC10725581	38104056	[ "<title>Background</title>", "<p id=\"Par27\">Erectile dysfunction (ED) is a vascular disease, which is estimated to affect 322 million men worldwide by 2025, and 30–75% of men experience ED, especially diabetes-related ED [##REF##10444124##1##]. Oral phosphodiesterase 5 (PDE5) inhibitors, which rely on endogenou...	[ "<title>Methods</title>", "<title>Ethics statement and study design</title>", "<p id=\"Par30\">This animal model study included 75 adult male C57BL/6 J mice (8 weeks old; Orient Bio, Inc.): 15 for the MCPs primary culture, MCPs-EVs isolation, and small-RNA sequencing analysis; 20 for in vitro studies; and 40 fo...	[ "<title>Results</title>", "<title>MCPs-EV characterization and tracking analysis in MCECs</title>", "<p id=\"Par50\">Based on the TEM images, the MCPs-EVs exhibited a unique cup-shaped morphology (diameter ~ 30 nm; Fig. ##FIG##0##1##a). Western blotting showed that positive EVs surface markers, such as CD9, CD6...	[ "<title>Discussion</title>", "<p id=\"Par55\">Increasingly, evidence has suggested that miRNAs are widely involved in physiological and pathological processes, including in cancer, diabetes mellitus, and neurological disorders [##UREF##2##12##, ##REF##27326409##24##, ##REF##25714967##25##]. However, the detailed ...	[ "<title>Conclusions</title>", "<p id=\"Par59\">Our study shows that miR-148a-3p, which is highly expressed in MCPs-EVs, plays an important role in enhancing neurovascular regeneration and ultimately improving erectile function by inhibiting PDK4 expression in diabetic mice.</p>" ]	[ "<title>Background</title>", "<p id=\"Par1\">To investigate the regulatory role of microRNA (miR)-148a-3p in mouse corpus cavernous pericyte (MCPs)-derived extracellular vesicles (EVs) in the treatment of diabetes-induced erectile dysfunction (ED).</p>", "<title>Methods</title>", "<p id=\"Par2\">Mouse corpus ...	[ "<title>Supplementary Information</title>", "<p>\n</p>" ]	[ "<title>Acknowledgements</title>", "<p>The manuscript is edited by a professional, native English-speaking editor at Wordvice (edit@wordvice.com; Kevin Heintz, Managing Editor, Wordvice).</p>", "<title>Authors’ contributions</title>", "<p>JO and GNY conceived and designed the experiments. JO, FYL, FRF, LN, MN...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><p>MCP-derived extracellular vesicle (MCPs-EV) characterization and tracking analysis in MCECs. <bold>a</bold> Representative transmission electron micrograph (TEM) phase images for detecting isolated MCPs-EVs as indicated by the arrows. Scale bar = 100 nm. <bold>b</b...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Small RNA sequencing analysis of Mouse cavernous pericytes (MCPs)-derived extracellular vesicles (EVs)</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th>Gene symbol</th><th>MCPs-EVs Raw data (RC)</th><th>Sequence</th></tr></thead><tbody><...	[]	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>" ]	[ "<table-wrap-foot><p>Values are the mean ± SEM for <italic>n</italic> = 5 animals per group. <italic>RC</italic> regent control; <italic>miR</italic>-148a-3p i miR-148a-3p inhibitor; <italic>STZ</italic> streptozotocin; <italic>MSBP</italic> Mean systolic blood pressure; *<italic>P</italic> < 0.05 vs. Control gr...	[ "<graphic xlink:href=\"12894_2023_1378_Fig1_HTML\" id=\"MO1\"/>", "<graphic xlink:href=\"12894_2023_1378_Fig2_HTML\" id=\"MO2\"/>", "<graphic xlink:href=\"12894_2023_1378_Fig3_HTML\" id=\"MO3\"/>", "<graphic xlink:href=\"12894_2023_1378_Fig4_HTML\" id=\"MO4\"/>", "<graphic xlink:href=\"12894_2023_1378_Fig5_...	[ "<media xlink:href=\"12894_2023_1378_MOESM1_ESM.pdf\"><caption><p><bold>Additional file 1.</bold>\n</p></caption></media>" ]	[{"label": ["7."], "surname": ["Hu", "Qi", "Zhang", "Fu"], "given-names": ["L", "S", "K", "Q"], "article-title": ["Essential role of brain-derived neurotrophic factor (bdnf) in diabetic erectile dysfunction"], "source": ["Andrologia"], "year": ["2018"], "volume": ["50"], "fpage": ["3"], "pub-id": ["10.1111/and.12924"]}...	{ "acronym": [ "MCP", "EVs", "ED", "MCECs", "PDK4", "PDE5", "NO", "DM", "mRNAs", "miRNAs", "NV", "CNI", "TUNEL", "DAPI", "ICP", "MSBP", "PH3", "FITC", "TRITC", "NG", "HG", "STZ" ], "definition": [ "Mouse corpus cavernous p...	29	CC BY	no	2024-01-14 23:35:04	BMC Urol. 2023 Dec 16; 23:209	oa_package/c7/ca/PMC10725581.tar.gz
PMC10729446	38114976	[ "<title>Background</title>", "<p id=\"Par7\">Unplanned pregnancies and the prevalence of sexually transmitted diseases are significant concerns in Sub-Saharan Africa, where approximately half of all pregnancies among young women in low-income areas occur without planning [##REF##25080352##1##–##REF##30727995##3##...	[ "<title>Methods</title>", "<title>Derivation of the used measurements</title>", "<p id=\"Par13\">Technology Acceptance Models, like UTAUT, aim to explain effects of acceptability and intention to use of new technologies. The UTAUT model, developed by Venkatesh [##UREF##7##18##], unifies eight established resear...	[ "<title>Results</title>", "<title>Descriptive analysis</title>", "<p id=\"Par38\">A total of 96 people took part in the survey. About N = 77 responses were assessed as complete and consequently included in the analysis. The descriptive characteristics of the participants are shown in Table ##TAB##2##3##.</p>", ...	[ "<title>Discussion</title>", "<p id=\"Par70\">This study investigated the acceptance to use and usability of a newly developed digital tool for sexual health education of young adults in Kenya, concerning the utilization of a modified UTAUT model. The analysis and a comparison of the results with prior studies co...	[ "<title>Conclusions</title>", "<p id=\"Par85\">This research study describes a validated approach assessing acceptance and usability of a newly developed digital tool designed for sexual health education in Kenya. The study adopted the Unified Theory of Acceptance and Use of Technology (UTAUT) and the System Usab...	[ "<title>Background</title>", "<p id=\"Par1\">Unplanned pregnancies and sexually transmitted diseases are a concern in Sub-Saharan Africa, particularly in low-income areas. Access to sexual health information is limited, partly due to the absence of comprehensive sex education in the national school curriculum and...	[]	[ "<title>Acknowledgements</title>", "<p>We would like to acknowledge the support given in the community centers in Eldoret, Kisumu, Lodwar and Nairobi for contributing and welcoming us. Additional we would like to thank all volunteers for participating in the study.</p>", "<title>Author contributions</title>", ...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><p>Prototype screenshot</p></caption></fig>", "<fig id=\"Fig2\"><label>Fig. 2</label><caption><p>UTAUT: Research model of this study</p></caption></fig>", "<fig id=\"Fig3\"><label>Fig. 3</label><caption><p>Final respecified factor model</p></caption></fig>", "<f...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Questionnaire of the survey</p></caption><table frame=\"hsides\" rules=\"groups\"><tbody><tr><td align=\"left\" colspan=\"4\">\n<bold>Section A</bold>\n</td></tr><tr><td align=\"left\" colspan=\"3\">\n<bold>Question English</bold>\n</td><td align=\"left\">\...	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn><p><bold>Publisher’s Note</bold></p><p>Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"12905_2023_2839_Fig1_HTML\" id=\"d32e315\"/>", "<graphic xlink:href=\"12905_2023_2839_Fig2_HTML\" id=\"d32e412\"/>", "<graphic xlink:href=\"12905_2023_2839_Fig3_HTML\" id=\"d32e1904\"/>", "<graphic xlink:href=\"12905_2023_2839_Fig4_HTML\" id=\"d32e2577\"/>", "<graphic xlink:href=\"129...	[]	[{"label": ["5."], "mixed-citation": ["Makinde OA, Olamijuwon E, Ichegbo NK, Onyemelukwe C, Ilesanmi MG. The nature of technology-facilitated violence and abuse among young adults in sub-Saharan Africa. In: Bailey J, Flynn A, Henry N, editors. The Emerald international handbook of technology-facilitated violence and ab...	{ "acronym": [], "definition": [] }	44	CC BY	no	2024-01-14 23:35:04	BMC Womens Health. 2023 Dec 19; 23:676	oa_package/5b/b7/PMC10729446.tar.gz
PMC10739219	37955684	[ "<title>Introduction</title>", "<p id=\"Par5\">Trigeminal neuralgia (TN) is a clinical diagnosis defined as recurrent unilateral brief electric shock-like pain, with abrupt onset and termination, limited to the distribution of the trigeminal nerve, and triggered by innocuous stimuli [##REF##23771276##16##]. The c...	[ "<title>Methods</title>", "<p id=\"Par9\">All patients with a diagnosis of TN who underwent microsurgical posterior fossa re-exploration over a 10-year period at the Department of Neurosurgery, Hannover Medical School, were screened for the present study. Inclusion criteria were a clinical diagnosis of classical ...	[ "<title>Results</title>", "<title>Patients and pain characteristics</title>", "<p id=\"Par14\">There were 13 women (50%) and 13 men (50%). Mean age at the time of surgery for recurrent TN was 59.1 years. The mean intervals between the initial surgery and microsurgical posterior fossa re-exploration are shown in...	[ "<title>Discussion</title>", "<p id=\"Par23\">There is no standard treatment for recurrent TN after a previously successful MVD procedure [##REF##31045760##9##]. There are few studies advocating repeat posterior fossa re-exploration in such a scenario; however, these studies are characterized by marked discrepanc...	[ "<title>Conclusions</title>", "<p id=\"Par35\">In the present study, we show that microsurgical posterior fossa re-exploration is a useful treatment option for recurrent TN. There were no serious side effects, and the frequency of postoperative hypaesthesia was relatively low. We conclude that microsurgical poste...	[ "<title>Objective</title>", "<p id=\"Par1\">Microvascular decompression (MVD) is a well-accepted treatment modality for trigeminal neuralgia (TN) with high initial success rates. The causes for recurrence of TN after previously successful MVD have not been fully clarified, and its treatment is still a matter of d...	[]	[ "<title>Author contributions</title>", "<p>Conceptualization: GHM, FWF, and JKK. Formal analysis and full investigation: GHM, FWF, HE, and SAA. Writing original draft preparation: GHM, FWF, and JKK. Writing—review and editing: FWF, GHM, HE, SAA, and JKK.</p>", "<title>Funding</title>", "<p>Open Access funding...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><p>Graphical demonstration of the “piston effect” defined as transmission of pulsations to the trigeminal nerve from systole to diastole from an arterial vessel via the interposed and hardened Teflon</p></caption></fig>", "<fig id=\"Fig2\"><label>Fig. 2</label><capt...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Demographic and clinical data of 26 patients with recurrent trigeminal neuralgia undergoing posterior fossa re-exploration after previous microvascular decompression</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th>Patient characteristic...	[]	[]	[]	[]	[]	[]	[ "<table-wrap-foot><p>Comparison of the individual preoperative, early postoperative (first postoperative day), 3-month, 12-month, 24-month, and the last available follow-up BNI pain intensity scores. Follow-up periods are given as months. Barrow Neurological Institute (BNI) pain intensity score (adapted from Przyby...	[ "<graphic xlink:href=\"701_2023_5877_Fig1_HTML\" id=\"MO1\"/>", "<graphic xlink:href=\"701_2023_5877_Fig2_HTML\" id=\"MO2\"/>" ]	[]	[{"label": ["8."], "surname": ["Chen", "Yu", "Du", "Jiang", "Dong", "Cao"], "given-names": ["JN", "WH", "HG", "L", "XQ", "J"], "article-title": ["Prospective comparison of redo microvascular decompression and percutaneous balloon compression as primary surgery for recurrent trigeminal neuralgia"], "source": ["J Korean ...	{ "acronym": [], "definition": [] }	49	CC BY	no	2024-01-14 23:35:02	Acta Neurochir (Wien). 2023 Nov 13; 165(12):3877-3885	oa_package/e6/b7/PMC10739219.tar.gz
PMC10760223	38168324	[ "<title>Introduction</title>", "<p id=\"P2\">Targeted therapies have emerged as a promising therapeutic option in the management of metastatic colorectal cancer (mCRC) when used in combination with chemotherapy [##UREF##0##1##, ##UREF##1##2##]. However, the efficacy of targeted therapies can vary significantly am...	[ "<title>Materials and methods</title>", "<title>Data</title>", "<p id=\"P28\">Patients in this study were drawn from the Cancer and Leukemia Group B (CALGB; now a part of the Alliance for Clinical Trials in Oncology) and SWOG 80405 (Alliance) trial. The trial was initiated in September 2005 with a total of 2,32...	[ "<title>Results</title>", "<p id=\"P5\">This study is conducted on a subset of Caucasian samples from CRC patients enrolled in a randomized phase III trial CALGB/SWOG 80405 due to the limited sample size from other ethnicities. Germline genotyped data was extracted from the peripheral blood of 1,165 patients (Fig...	[ "<title>Discussion</title>", "<p id=\"P23\">Prognostic gene expression signatures can help to improve treatment assignments and provide guidance for a personalized treatment-decision. To improve, the interpretability and reproducibility of the gene signatures for patient stratification, we integrated the intercon...	[]	[ "<p id=\"P1\">Predictive and prognostic gene signatures derived from interconnectivity among genes can tailor clinical care to patients in cancer treatment. We identified gene interconnectivity as the transcriptomic-causal network by integrating germline genotyping and tumor RNA-seq data from 1,165 patients with me...	[ "<title>Methods</title>", "<title>Data preprocessing</title>", "<p id=\"P32\">Among the 584 samples with RNA-seq data, the majority (86%) were Caucasian, with 9% being African American and 5% from other ethnicities. Due to the small sample size of other ethnicities, our analysis focused specifically on primary ...	[ "<title>Acknowledgements.</title>", "<p id=\"P50\">Research reported in this publication was supported by the NCI of the NIH under Award Numbers U10CA180821, U10CA180882, and U24CA196171 (to the Alliance for Clinical Trials in Oncology). Also supported in part by funds from Bristol-Myers Squibb, Genentech, Pfizer...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><title>Overall workflow.</title><p id=\"P55\">Gene interactions were revealed as transcriptomic-causal-network and integrated into OS analysis to account for confounding genes and identify gene sets that each collectively impact OS as a gene signatu...	[ "<table-wrap position=\"float\" id=\"T1\"><label>Table 1</label><caption><p id=\"P61\">Replication of gene interactions in the identified signatures using the STRING database. The confidence scores greater than 0.5 indicate promising evidence for potential physical interactions of proteins encoded by the genes in t...	[ "<inline-formula><mml:math id=\"M1\" display=\"inline\"><mml:msub><mml:mrow><mml:mi>α</mml:mi></mml:mrow><mml:mrow><mml:mi>i</mml:mi></mml:mrow></mml:msub><mml:mo>=</mml:mo><mml:mfenced open=\"{\" close=\"}\" separators=\"\|\"><mml:mrow><mml:msup><mml:mrow><mml:mn>10</mml:mn></mml:mrow><mml:mrow><mml:mo>−</mml:mo><m...	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN1\"><p id=\"P51\">Competing interests.</p><p id=\"P52\">The authors declare no competing interests.</p></fn><fn id=\"FN2\"><p id=\"P53\">Declarations</p><p id=\"P54\">A statement of ethics approval: This study has been approved by the Alliance for Clinical Trials in O...	[ "<graphic xlink:href=\"nihpp-rs3673588v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3673588v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3673588v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3673588v1-f0004\" position=\"float\"/>", "<graphic xlink:href...	[]	[{"label": ["1."], "surname": ["Kabbinavar", "Schulz", "McCleod"], "given-names": ["FF", "J", "M"], "article-title": ["Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer"], "source": ["Journal of Clinical Oncology"], "ye...	{ "acronym": [], "definition": [] }	52	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 15;:rs.3.rs-3673588	oa_package/7b/38/PMC10760223.tar.gz
PMC10769295	38187722	[ "<title>Introduction</title>", "<p id=\"P5\">Inflammatory and glucolipotoxic (GLT) stress causing β-cell failure and destruction <italic toggle=\"yes\">in vitro</italic> differentially regulates hundreds of β-cell transcripts (##REF##32894309##1##, ##REF##32398822##2##). The upregulation of splicing factors and o...	[ "<title>Materials and Methods</title>", "<title>Cell culture, human islet dispersion and treatment</title>", "<p id=\"P9\">INS1(832/13) (##REF##1370150##12##), EndoC-βH3 (##REF##21865645##13##) or dispersed human islet cells were cultured and manipulated according to the protocols and procedures described in ##...	[ "<title>Results</title>", "<title>Cytokines suppress, whereas glucolipotoxicity increases, NMD activity in β-cells.</title>", "<p id=\"P20\">We previously reported that cytokines and glucolipotoxicity differentially up or down-regulate NMD component transcripts in pancreatic β-cells (##REF##30065031##11##). How...	[ "<title>Discussion</title>", "<p id=\"P41\">In this study, we demonstrate that cytokines decrease nonsense-mediated RNA decay (NMD) in INS1(832/13), EndoC-βH3 cells and dispersed human islets and. In contrast, glucolipotoxicity (GLT) increased the NMD activity in EndoC-βH3 cells. We also showed that the cytokine-...	[]	[ "<p id=\"P1\">Lead investigator: <email>ghiasi@sund.ku.dk</email>, <email>mghiasi@sbpdiscovery.org</email></p>", "<p id=\"P2\">Author contributions</p>", "<p id=\"P3\">S.M.G. was lead investigator and grant holder (grant number: 9034-00001B) and principally designed and performed all experiments, analysed data,...	[ "<title>Supplementary Material</title>" ]	[ "<title>Acknowledgments</title>", "<p id=\"P53\">Our special thanks to Dr. Gabriele Neu-Yilik, Professor Andreas E. Kulozik and Professor Matthias W. Hentze (Heidelberg University, Germany) for providing the plasmids <italic toggle=\"yes\">Renilla</italic> (<italic toggle=\"yes\">RLuc)</italic>-HBB (NS39), <itali...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1.</label><caption><title>Cytokines suppress, whereas glucolipotoxicity increases, NMD activity in β-cells</title><p id=\"P57\">A-B. EndoC-βH3 cells (A) and dispersed human islet cells (B) were co-transfected with <italic toggle=\"yes\">Renilla</italic>-HBB(WT) and o...	[]	[]	[]	[]	[]	[]	[ "<supplementary-material id=\"SD1\" position=\"float\" content-type=\"local-data\"><label>Supplement 1</label></supplementary-material>" ]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN3\"><p id=\"P55\">Conflict of interest</p><p id=\"P56\">G.A.R. is a consultant for, and has received grant funding from Sun Pharmaceuticals Inc.</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"nihpp-2023.12.20.572623v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-2023.12.20.572623v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-2023.12.20.572623v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-2023.12.20.572623v1-f0004\" position=\"fl...	[ "<media xlink:href=\"media-1.pdf\" id=\"d64e919\" position=\"anchor\"/>" ]	[{"label": ["3."], "surname": ["Alvelos", "Juan-Mateu", "Colli", "Turatsinze", "Eizirik"], "given-names": ["MI", "J", "ML", "JV", "DL"], "article-title": ["When one becomes many-Alternative splicing in beta-cell function and failure"], "source": ["Diabetes Obes Metab"], "year": ["2018"], "volume": ["20 Suppl 2"], "issu...	{ "acronym": [], "definition": [] }	34	CC BY	no	2024-01-14 23:43:50	bioRxiv. 2023 Dec 21;:2023.12.20.572623	oa_package/93/d4/PMC10769295.tar.gz
PMC10769296	38187717	[]	[]	[]	[]	[]	[ "<p id=\"P1\">Author Contributions</p>", "<p id=\"P2\">The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript.</p>", "<p id=\"P3\">A modified protein fragment complementation assay has been designed and validated as a gain-of-signa...	[ "<p id=\"P5\">Proteins whose function can be turned on and off experimentally enable biosensing applications and provide valuable reagents to probe complex biological pathways. Temperature sensitive phenotypes, for example, are possible with destabilized mutant proteins that aggregate or fail to fold above some thr...	[]	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1.</label><caption><title>Extraneous peptide sequences or self-labeling domains that remain on the selected bioconjugate product cover a wide range.</title><p id=\"P35\"><italic toggle=\"yes\">Drosophila</italic> Hedgehog HhC (DHhC) catalyzed protein-nucleic acid con...	[ "<table-wrap position=\"float\" id=\"T1\" orientation=\"landscape\"><label>Table 1.</label><caption><p id=\"P40\">Sequences of steramer 1 and 2 and nucleic acid targets evaluated here for potential hybridization-driven protein fragment complementation</p></caption><table frame=\"void\" rules=\"none\"><colgroup span...	[]	[]	[]	[]	[]	[ "<supplementary-material id=\"SD1\" position=\"float\" content-type=\"local-data\"><label>Supplement 1</label></supplementary-material>" ]	[ "<fn-group><fn id=\"FN2\"><p id=\"P23\">ASSOCIATED CONTENT</p><p id=\"P24\"><bold>Supporting Information</bold>. vector construction, protein expression, steramer kinetic assays, chemical synthesis, NMR and MALDI-TOF. This material is available free of charge via the Internet at <ext-link xlink:href=\"http://pubs.a...	[ "<graphic xlink:href=\"nihpp-2023.12.19.572427v1-f0001.jpg\" position=\"anchor\"/>", "<graphic xlink:href=\"nihpp-2023.12.19.572427v1-f0002.jpg\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-2023.12.19.572427v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-2023.12.19.572427v1-f0004\" posi...	[ "<media xlink:href=\"media-1.pdf\" id=\"d64e456\" position=\"anchor\"/>" ]	[{"label": ["21."], "surname": ["Sekhon", "Loh"], "given-names": ["H.", "S.N."], "article-title": ["Engineering protein activity into off-the-shelf DNA devices."], "source": ["Cell Reports Methods"], "year": ["2022"], "volume": ["2"], "issue": ["4"]}, {"label": ["35."], "surname": ["Zhou"], "given-names": ["L."], "arti...	{ "acronym": [ "DHhC", "SUMO", "MW", "ssDNA", "dsDNA", "NSP10", "Ni-NTA", "S1", "S2", "NSP" ], "definition": [ "Drosophila hedgehog C-terminal domain", "small ubiquitin modifier protein", "molecular weight", "single stranded DNA", "double stranded DNA", ...	43	CC BY-ND	no	2024-01-14 23:43:50	bioRxiv. 2023 Dec 19;:2023.12.19.572427	oa_package/a0/89/PMC10769296.tar.gz
PMC10769377	38187691	[ "<title>Introduction</title>", "<p id=\"P4\">The circulating thyroxine (T4) and triiodothyronine (T3) levels are robustly regulated to stay within narrow (about 2-3 fold) physiological ranges (##UREF##5##Jain 2015##, ##REF##27737898##Welsh and Soldin 2016##). Deviations of the thyroid hormones (THs) from the norm...	[ "<title>Methods</title>", "<title>The nonspatial human PBK model of THs</title>", "<p id=\"P8\">The details of the nonspatial human PBK model of THs, including its construction and parameterization, were described in our recently published paper (##REF##37305053##Bagga et al. 2023##). The model was rigorously p...	[ "<title>Results</title>", "<p id=\"P12\">Among the three THBPs, it has been argued that ALB and/or TTR play a larger role than TBG in supplying THs to tissues because of their lower binding affinity for THs and/or shorter residence time of T4 and T3 on these proteins (##REF##2673754##Mendel 1989##, ##REF##1071855...	[ "<title>Discussion</title>", "<title>Contribution of THBPs to TH tissue delivery</title>", "<title>Uniform TH tissue delivery</title>", "<p id=\"P31\">One of the most prominent functions of THBPs is to transport THs from the thyroid gland through the blood circulation to various target tissues and ensure unif...	[ "<title>Conclusion</title>", "<p id=\"P48\">In summary, we have constructed a spatial PBK model with explicit considerations of TH and THBP interactions and explored their differential contributions in supplying TH to tissues. While it remains to be experimentally validated, the model provides novel insights into...	[ "<p id=\"P1\">Author Contributions</p>", "<p id=\"P2\">QZ conceived the model structure, ADB constructed and simulated the model in MATLAB, ADB and QZ conducted the parameter justification and estimation, and formal analysis of simulation results, ADB and QZ wrote the initial draft and revised the manuscript. BPJ...	[ "<title>Supplementary Material</title>" ]	[ "<title>Funding Acknowledgements</title>", "<p id=\"P49\">This research was supported in part by NIEHS Superfund Research grant P42ES04911 and NIEHS HERCULES grant P30ES019776.</p>" ]	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1.</label><caption><title>Schematic illustrations of the human PBK model for T4 and T3.</title><p id=\"P53\"><bold>(A)</bold> The overall structure of the PBK model (##REF##37305053##Bagga et al. 2023##). <italic toggle=\"yes\">RB</italic>: rest-of-body. QC: cardiac ...	[ "<table-wrap position=\"float\" id=\"T1\"><label>Table 1.</label><caption><p id=\"P66\">Loading and unloading of THs in tissues by THBPs in nonspatial PBK model</p></caption><table frame=\"hsides\" rules=\"groups\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\"/><col align=\"left\" valign=\"m...	[]	[]	[]	[]	[]	[ "<supplementary-material id=\"SD1\" position=\"float\" content-type=\"local-data\"><label>Supplement 1</label></supplementary-material>", "<supplementary-material id=\"SD2\" position=\"float\" content-type=\"local-data\"><label>Supplement 2</label></supplementary-material>" ]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN2\"><p id=\"P50\">Conflict of Interest</p><p id=\"P51\">The authors declare no conflict of interest.</p></fn></fn-group>", "<table-wrap-foot><fn id=\"TFN1\"><p id=\"P67\">Note: na, not applicable. CA: arterial concentration, CV: venous concentration, % change = (CV-...	[ "<graphic xlink:href=\"nihpp-2023.12.20.572629v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-2023.12.20.572629v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-2023.12.20.572629v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-2023.12.20.572629v1-f0004\" position=\"fl...	[ "<media xlink:href=\"media-1.pdf\" id=\"d64e2240\" position=\"anchor\"/>", "<media xlink:href=\"media-2.pdf\" id=\"d64e2243\" position=\"anchor\"/>" ]	[{"surname": ["Benvenga"], "given-names": ["S"], "year": ["2013"], "part-title": ["Thyroid Hormone Transport Proteins and the Physiology of Hormone Binding"], "source": ["Werner & Ingbar's the thyroid: a fundamental and clinical text"], "publisher-name": ["L. E. Braverman and D. Cooper. Philadelphia, Lippincott William...	{ "acronym": [], "definition": [] }	77	CC BY-ND	no	2024-01-14 23:43:50	bioRxiv. 2023 Dec 22;:2023.12.20.572629	oa_package/13/91/PMC10769377.tar.gz
PMC10775353	38196654	[ "<title>Introduction</title>", "<p id=\"P2\">The microgravity environment induces a plethora of pathophysiological changes that resemble accelerated aging including wasting of skeletal muscle,<sup>##REF##35171699##1##</sup> bone demineralization<sup>##REF##35383182##2##</sup>, and metabolic and cardiovascular dys...	[ "<title>Methods</title>", "<title>Tissue Acquisition & Cell Culture:</title>", "<p id=\"P20\">Whole human kidneys that were not suited for human transplantation were obtained from Novabiosis, Inc. (Research Triangle Park, NC) with all patient identifiers removed in accordance with a biospecimens procurement...	[ "<title>Results</title>", "<title>Kidney Chip Perfusion Platform System Overview</title>", "<p id=\"P6\">In partnership with BioServe Space Technologies, we developed the KCPP hardware, addressed NASA safety and regulatory requirements, and facilitated the transition to a spaceflight certified and capable syste...	[ "<title>Discussion</title>", "<p id=\"P19\">KCPP is an integrated, automated, piston-based perfusion platform and enclosed cell culture environment designed to support MPS-based life sciences experimentation on board the ISSNL. Its compact design enables a significant reduction in the logistical challenges and sp...	[]	[ "<p id=\"P1\">Study of the physiological effects of microgravity on humans is limited to non-invasive testing of astronauts. Microphysiological models of human organs recapitulate many functions and disease states. Here we describe the development of an advanced, semi-autonomous hardware platform to support kidney ...	[]	[ "<title>Acknowledgements:</title>", "<p id=\"P24\">This work was supported by the National Center for Advancing Translational Sciences (UH3TR000504, UG3TR002158 and UH3TR002178), jointly by the National Center for Advancing Translational Sciences and the Center for the Advancement of Science in Space (UG3TR002178...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><p id=\"P28\">Schematic (A) and real life (B) view of the novel KCPP programmable perfusion platform designed by BioServe Space Technologies showing six Triplex chips (1) situated within a housing unit after integration into the adapter unit (2) and...	[]	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN1\"><p id=\"P25\"><bold>Competing interests statement:</bold> All authors declare no financial or non-financial competing interests.</p></fn><fn id=\"FN2\"><p id=\"P26\">Tables</p><p id=\"P27\">Tables 1 to 5 are available in the Supplementary Files section.</p></fn></...	[ "<graphic xlink:href=\"nihpp-rs3750478v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3750478v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3750478v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3750478v1-f0004\" position=\"float\"/>", "<graphic xlink:href...	[]	[{"label": ["5."], "surname": ["Mao"], "given-names": ["X. W."], "article-title": ["Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis"], "source": ["Int J Mol Sci"], "volume": ["19"], "year": ["2018"], "pub-id": ["10.3390/ijms19092546"]}, {"label": ["7."], "surname": [...	{ "acronym": [], "definition": [] }	19	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 22;:rs.3.rs-3750478	oa_package/f6/c0/PMC10775353.tar.gz
PMC10775362	38196660	[ "<title>INTRODUCTION</title>", "<p id=\"P4\">The blood vasculature is topologically organized as branched trees or a hybrid combination of trees and connecting vessels between branches, which effectively create loops<sup>##REF##15681697##1##,##REF##10820900##3##</sup>. Most vessel networks, including the skeletal...	[ "<title>METHODS</title>", "<title>Experimental model</title>", "<title>Animal models.</title>", "<p id=\"P39\">The protocol for the animal experiments was reviewed and approved by the Institutional Animal Care and Use Committee of the Massachusetts General Hospital. The procedures were performed in accordance...	[ "<title>RESULTS</title>", "<title>Laser ablation of the dorsal skinfold chamber (DSFC) microcirculation</title>", "<p id=\"P9\">The general patterns of skin microvascular remodeling were similar in all five mice studied (Supplementary Figure 1, sFig. 1 and Supplementary Tables 1–6, sTables 1–6). sFig.1 provides...	[ "<title>DISCUSSION</title>", "<p id=\"P31\">In this study, we analyzed flow redistribution and remodeling in vessel networks after laser ablations of vascular segments. Laser ablation cauterizes vessels and causes acute temporary vasoconstriction lasting only a few minutes after ablation. This was observed in the...	[]	[ "<p id=\"P1\">AUTHOR’S CONTRIBUTIONS</p>", "<p id=\"P2\">G.G., J.B., B.J.V., T.P.P. and L.L.M. conceived the experiment(s), G.G., S.M., D.B., L.G.G. and M.O.L. conducted the experiment(s), G.G., J.B., B.J.V., T.P.P. and L.L.M. analyzed the results, L.G.G, B.J.V and L.L.M. secured the funding. All authors reviewed...	[]	[ "<title>ACKNOWLEDGEMENTS</title>", "<p id=\"P47\">Research reported in this publication was supported by the Center for Biomedical OCT Research and Translation through Grant Number P41EB015903, awarded by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health, and the...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1.</label><caption><p id=\"P51\">Vascular laser ablation. A, B: Bright field (BF) microscopy images of the skin vasculature before (A) and at four hours after ablation (B) of specific large vessels. The major and minor artery-vein pairs are indicated by solid and ope...	[]	[ "<inline-formula><mml:math id=\"M1\" display=\"inline\"><mml:mi>i</mml:mi></mml:math></inline-formula>", "<inline-formula><mml:math id=\"M2\" display=\"inline\"><mml:mi>j</mml:mi></mml:math></inline-formula>", "<inline-formula><mml:math id=\"M3\" display=\"inline\"><mml:msub><mml:mrow><mml:mi>Q</mml:mi></mml:mr...	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN2\"><p id=\"P49\">COMPETING INTERESTS</p><p id=\"P50\">The author(s) declare no competing interests.</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"nihpp-rs3754775v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3754775v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3754775v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3754775v1-f0004\" position=\"float\"/>", "<graphic xlink:href...	[]	[{"label": ["2"], "surname": ["Gruionu", "Hoying", "Pries", "Secomb"], "given-names": ["G", "JB", "AR", "TW"], "article-title": ["Structural remodeling of the mouse gracilis artery: coordinated changes in diameter and medial area maintain circumferential stress"], "source": ["Microcirc N Y N 1994"], "year": ["2012"], "...	{ "acronym": [], "definition": [] }	37	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 18;:rs.3.rs-3754775	oa_package/92/14/PMC10775362.tar.gz
PMC10775364	38196647	[ "<title>Introduction</title>", "<p id=\"P4\">There has been a long appreciation of the relationship between aging and a loss of mitochondrial function, including bioenergetic, biophysical, and replicative properties <sup>##REF##23746838##1##</sup>. In addition to being considered a “hallmark of aging” <sup>##REF#...	[ "<title>Methods</title>", "<title>Animal Usage and Ethical Procedures</title>", "<p id=\"P7\">All animal experiments were approved by the Institutional Animal Care and Use Committees and UTHSA (Animal Protocol 20170190AR), and have been reported following ARRIVE guidelines. All methods were conducted in accorda...	[ "<title>Results</title>", "<p id=\"P15\">For isolated mitochondria studies, liver and kidney were processed immediately following collection from MR-treated mice and controls. Oxygen consumption rate (OCR) measured in isolated kidney mitochondria indicated that State 2 respiration (respiration in the presence of ...	[ "<title>Discussion</title>", "<p id=\"P20\">Previous studies have shown MR to have a variety of impacts on mitochondrial function <sup>##REF##25773352##8##,##REF##26278039##13##–##REF##16770005##18##,##REF##25273919##41##,##REF##31472257##42##</sup>. Here we expand on these findings and point to sex- and tissue-s...	[]	[ "<p id=\"P1\">Author Contributions</p>", "<p id=\"P2\">Study was formulated by ABS and KMT. Data was collected and analyzed by KMT and RC. Figures and manuscript drafts were prepared by KMT. ABS, RC, and KMT reviewed, edited, and approved the manuscript.</p>", "<p id=\"P3\">Methionine restriction (MR) has been ...	[]	[ "<title>Acknowledgements</title>", "<p id=\"P24\">We would also like to acknowledge the experimental assistance of Yuhong Liu throughout this study, and Dr. Jonathan Dorigatti and Dr. Kennedy Mdaki for experimental assistance and helpful discussions. This research was funded in part by R01 AG050797, R01 AG057431,...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><title>Kidney Isolated Mitochondria Oxygen Consumption Rate</title><p id=\"P29\">Oxygen Consumption Rate (OCR) was measured via Oxytherm Clark electrode. Isolated mitochondria were allowed to stabilize oxygen consumption in the presence of rotenone....	[]	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn id=\"FN2\"><p id=\"P26\">Declarations</p><p id=\"P27\">Competing Interests</p><p id=\"P28\">The authors declare no competing interests.</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"nihpp-rs3755231v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3755231v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3755231v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3755231v1-f0004\" position=\"float\"/>", "<graphic xlink:href...	[]	[{"label": ["7."], "surname": ["Ruetenik", "Barrientos"], "given-names": ["A.", "A."], "article-title": ["Dietary restriction, mitochondrial function and aging: from yeast to humans"], "source": ["Biochim. Biophys. Acta BBA - Bioenerg"], "volume": ["1847"], "fpage": ["1434"], "lpage": ["1447"], "year": ["2015"]}, {"lab...	{ "acronym": [], "definition": [] }	46	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 21;:rs.3.rs-3755231	oa_package/15/e9/PMC10775364.tar.gz
PMC10775367	38196656	[ "<title>Background</title>", "<p id=\"P7\">Promoting sustained engagement in antiretroviral therapy (ART) services is a major focus of HIV programs throughout sub-Saharan Africa [##UREF##0##1##]. New or returning ART clients (defined as those on ART < 3 months) are at increased risk of treatment interruption [...	[ "<title>Methods</title>", "<title>Study Design</title>", "<p id=\"P12\">We conducted in-depth interviews with internationally based stakeholders (from foundations, multilateral organizations, and NGOs) and Malawi-based stakeholders (from the Ministry of Health and local implementing partners) to explore perspec...	[ "<title>Results</title>", "<title>Participant characteristics</title>", "<p id=\"P21\">We conducted 22 interviews between October 2021 and March 2022—thirteen with internationally based stakeholders and nine with nationally based stakeholders (##TAB##0##Table 1##). Participants had varied levels of experience w...	[ "<title>Discussion</title>", "<p id=\"P60\">In resource-constrained settings, stakeholders make difficult trade-offs across multiple criteria (such as effectiveness, equity, budgetary and practical constraints, and political considerations) when deciding which interventions to implement and scale up. In this stud...	[ "<title>Conclusions</title>", "<p id=\"P66\">We found that the top priorities of international and Malawi national stakeholders regarding DSD interventions for new or returning ART clients are effectiveness, feasibility, sustainability, and client acceptability. International stakeholders should recognize and act...	[ "<p id=\"P1\">Authors’ contributions</p>", "<p id=\"P2\">KD and SH conceptualized and designed the study. SH, KP, and MT conducted qualitative data collection. KP coded the qualitative data. KD, SH, KH, and KP reviewed the coded transcripts, discussed discrepancies, and refined the codebook. SH conducted the prel...	[]	[ "<title>Acknowledgements</title>", "<p id=\"P67\">We acknowledge and thank the individuals who took the time to participate in the study. Their honest and generous engagement made this study possible.</p>", "<title>Funding</title>", "<p id=\"P68\">This work was supported by the Bill and Melinda Gates Foundati...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><p id=\"P78\">Ratings of decision-making criteria by national and international stakeholders</p></caption></fig>", "<fig position=\"float\" id=\"F2\"><label>Figure 2</label><caption><p id=\"P79\">DSD intervention ratings by national and internatio...	[ "<table-wrap position=\"float\" id=\"T1\"><label>Table 1</label><caption><p id=\"P80\">Participant characteristics</p></caption><table frame=\"box\" rules=\"rows\"><colgroup span=\"1\"><col align=\"left\" valign=\"top\" span=\"1\"/><col align=\"left\" valign=\"top\" span=\"1\"/></colgroup><thead><tr><th align=\"lef...	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN2\"><p id=\"P70\">Competing interests</p><p id=\"P71\">The authors declare that they have no competing interests.</p></fn><fn fn-type=\"COI-statement\" id=\"FN3\"><p id=\"P72\"><bold>Additional Declarations:</bold> No competing interests reported.</p></fn><fn id=\"FN4...	[ "<graphic xlink:href=\"nihpp-rs3725505v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3725505v1-f0002\" position=\"float\"/>" ]	[]	[{"label": ["1."], "surname": ["Rosen", "Grimsrud", "Ehrenkranz", "Katz"], "given-names": ["S", "A", "P", "I"], "article-title": ["Models of service delivery for optimizing a patient\u2019s first six months on antiretroviral therapy for HIV: an applied research agenda [Internet]"], "source": ["Gates Open Research"], "y...	{ "acronym": [], "definition": [] }	50	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 21;:rs.3.rs-3725505	oa_package/b0/59/PMC10775367.tar.gz
PMC10775368	38196614	[ "<title>Introduction</title>", "<p id=\"P3\">Adipose tissue is comprised of two major cell types- white and brown adipocytes-that have opposing energetic functions. White adipocytes primarily function to store excess lipid and an over-abundance of white adipose tissue (WAT) leads to unfavorable outcomes due to di...	[ "<title>Methods</title>", "<title>Animals</title>", "<p id=\"P22\">GRAF1 gene trap mice were generated and obtained from the Texas A&M Institute for Genomic Medicine (College Station, TX) and were described previously <sup>##REF##25019370##28##</sup>. ES cells carrying Arhgap26 targeted knockout first condi...	[ "<title>Results</title>", "<title>GRAF1 expression correlates with BAT maturation in mouse and human cells.</title>", "<p id=\"P9\">We previously reported that GRAF1 was transiently upregulated during skeletal muscle development (E17-P4) and again following adult muscle injury and that, in these contexts, GRAF1...	[ "<title>Discussion</title>", "<p id=\"P17\">Adipose tissue in mammals is a vital component of the energy regulation system and consists of two primary types: white adipocytes and brown adipocytes. White adipocytes are characterized by their large central lipid droplets, serving as reservoirs for storing excess en...	[]	[ "<p id=\"P1\"><bold>Author contributions:</bold> conceived and performed experiments, data analysis and preliminary manuscript writing XB, final manuscript writing and data analysis, QZ. Data analysis, MEC, development of SBGS cell line, distribution and guidance of usage, MW. Conceptual development of studies and ...	[]	[ "<title>Acknowledgments</title>", "<p id=\"P34\">This research is based in part upon work conducted at the Microscopy Services Laboratory, Department of Pathology and Laboratory Medicine, which are supported in part by a National Cancer Institute Cancer Center Core Support Grant to the University of North Carolin...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><title>GRAF1 expression closely correlates with BAT maturation.</title><p id=\"P37\"><bold>a.</bold> GRAF1 protein levels in 3 week postnatal mouse tissue detected by Western blotting. scWAT, sub-cutaneous white adipose tissue; iBAT and sBAT, inter-...	[]	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN2\"><p id=\"P36\"><bold>Competing interests:</bold> The authors declare that they have no competing interests.</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"nihpp-rs3740465v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3740465v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3740465v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3740465v1-f0004\" position=\"float\"/>", "<graphic xlink:href...	[]	[{"label": ["5."], "surname": ["Zhou", "Yon Toh", "Chen", "Guo", "Ng", "Ponniah", "Lin", "Hong", "Li"], "given-names": ["Z", "S", "Z", "K", "CP", "S", "SC", "W", "P"], "article-title": ["Cidea-deficient mice have lean phenotype and are resistant to obesity"], "source": ["Nature genetics"], "year": ["2003"], "volume": [...	{ "acronym": [], "definition": [] }	50	CC BY	no	2024-01-14 23:35:04	Res Sq. 2023 Dec 19;:rs.3.rs-3740465	oa_package/c4/fa/PMC10775368.tar.gz
PMC10775369	38196620	[ "<title>INTRODUCTION</title>", "<p id=\"P2\">With improved microscopy instrumentation, researchers increasingly produce a wealth of biological data from imaging experiments. Either by mechanical scanning or computational post-processing (e.g., Fourier ptychography, diffraction microscopy), millimeter-scale fields...	[ "<title>METHODS AND MATERIALS</title>", "<title>Human tumor biopsy dataset and image acquisition</title>", "<p id=\"P17\">FNA samples from HNSCC patients were collected, stained, and imaged as previously reported<sup>##REF##34233961##19##</sup>. The study protocol was reviewed and approved by the Institutional ...	[ "<title>RESULTS AND DISCUSSIONS</title>", "<title>CycloNET pipeline</title>", "<p id=\"P5\">##FIG##0##Figure 1A## shows CycloNET’s overall workflow. The input data are raw fluorescent images obtained through cyclic immunofluorescent microscopy. The computational pipeline collates acquired multichannel images, p...	[ "<title>RESULTS AND DISCUSSIONS</title>", "<title>CycloNET pipeline</title>", "<p id=\"P5\">##FIG##0##Figure 1A## shows CycloNET’s overall workflow. The input data are raw fluorescent images obtained through cyclic immunofluorescent microscopy. The computational pipeline collates acquired multichannel images, p...	[ "<title>CONCLUSIONS</title>", "<p id=\"P15\">High-throughput, multiplexed microscopy generates expansive data (>giga bytes) that are often beyond manual inspection. The developed CycloNET can simplify large-scale dataset analysis and extract biological information. CycloNET integrated three key modules: i) a c...	[ "<p id=\"P1\">Recent advances in microscopy allow scientists to generate vast amounts of biological data from a single biopsy sample. Cyclic fluorescence microscopy, in particular, enables multiple targets to be detected simultaneously. This, in turn, has deepened our understanding of tissue composition, cell-to-ce...	[]	[ "<title>Funding:</title>", "<p id=\"P22\">NIH R01CA264363 (H.L.), R01CA239078 (H.L.), R01CA237500 (H.L.), R21CA267222 (H.L.), U01CA284982 (H.L.), R01HL163513 (H.L.), U01CA279858 (H.L.).</p>", "<title>Data availability</title>", "<p id=\"P23\">Imaging data that support the findings of this study are available ...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1.</label><caption><title>Overview of CycloNET analysis pipeline.</title><p id=\"P26\"><bold>(A)</bold> Schematic for computationally assisted biopsy analysis. After immunofluorescent images are collected via cyclic staining, CycloNET automatically aligns images from...	[ "<table-wrap position=\"float\" id=\"T1\"><label>Table 1.</label><caption><p id=\"P31\">Marker combinations for immune cell phenotyping</p></caption><table frame=\"hsides\" rules=\"none\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\"/><col align=\"left\" valign=\"middle\" span=\"1\"/><col al...	[ "<disp-formula id=\"FD1\">\n<mml:math id=\"M1\" display=\"block\"><mml:mi>L</mml:mi><mml:mo>=</mml:mo><mml:msub><mml:mrow><mml:mi>L</mml:mi></mml:mrow><mml:mrow><mml:mi>s</mml:mi><mml:mi>e</mml:mi><mml:mi>g</mml:mi></mml:mrow></mml:msub><mml:mo>+</mml:mo><mml:msub><mml:mrow><mml:mi>λ</mml:mi></mml:mrow><mml:mrow><m...	[]	[]	[]	[]	[]	[ "<fn-group><fn id=\"FN1\"><p id=\"P24\">Competing interests</p><p id=\"P25\">The authors declare no competing interests.</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"nihpp-rs3745061v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3745061v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3745061v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3745061v1-f0004\" position=\"float\"/>", "<graphic xlink:href...	[]	[{"label": ["(1)"], "surname": ["Zheng", "Shen", "Jiang", "Song", "Yang"], "given-names": ["G.", "C.", "S.", "P.", "C."], "article-title": ["Concept, Implementations and Applications of Fourier Ptychography"], "source": ["Nature Reviews Physics"], "year": ["2021"], "volume": ["3"], "issue": ["3"], "fpage": ["207"], "lp...	{ "acronym": [], "definition": [] }	25	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 18;:rs.3.rs-3745061	oa_package/03/55/PMC10775369.tar.gz
PMC10775375	38196621	[ "<title>Background</title>", "<p id=\"P7\">Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease characterized by the progressive loss of upper motor neurons in the cortex and lower motor neurons of the brainstem and spinal cord. Even with FDA-approved disease modifying medication and palliation...	[ "<title>Methods</title>", "<title>Study population</title>", "<p id=\"P9\">All samples and data came from participants that provided written, informed consent for genetic studies that had been IRB-approved at each contributing center. The study cohort includes participants from the Genomic Translation for ALS C...	[ "<title>Results</title>", "<title>Rare variant burden testing</title>", "<p id=\"P20\">Collapsing analysis of all rare functional variants (missense and protein truncating variants) (<underline><bold>Supplemental Table 2</bold></underline>) found genome-wide and study-wide significant (p < 4.9 × 10<sup>−7</s...	[ "<title>Discussion</title>", "<title>Burden testing.</title>", "<p id=\"P24\">Conducting genic and intolerant domain based rare variant burden testing in a large multi-ethnic population provides insight into novel and established biological mechanisms in disease manifestations. Additionally, analyzing specific ...	[ "<title>Conclusions</title>", "<p id=\"P28\">In summary, we performed the largest rare variant analyses of a multi-ethnic population of patients with ALS to date. Our analysis did not identify new ALS risk genes but demonstrated that collapsing models informed by regions of intolerance can be useful for identifyi...	[ "<p id=\"P1\">AUTHORS’ CONTRIBUTIONS</p>", "<p id=\"P2\">Conception and design: T.D.P., J.E.M., D.B.G., and M.B.H. Data acquisition: C.A.M.M., H.P., T.J.A., J.S.L, H.M., D.B.G., and M.B.H. Analysis: T.D.P. and M.B.H. Interpretation, draft and review, and final approval: all authors. T.D.P. and M.B.H. had full acc...	[]	[ "<title>ACKNOWLEDGEMENTS:</title>", "<p id=\"P30\">We thank the following groups for contributing ALS/PLS samples, sequencing, or clinical data:</p>", "<p id=\"P31\"><underline><bold><italic toggle=\"yes\">New York Genome Center ALS Consortium:</italic></bold></underline> J. Kwan, D. Sareen, J.R. Broach, Z. Sim...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1.</label><caption><title>Q-Q plots of gene- and domain-level collapsing of ALL functional coding variants in ALS cohort.</title><p id=\"P47\">(A) The results for a standard gene-level collapsing of 6,970 ALS cases and 22,524 controls. P-values were generated using a...	[ "<table-wrap position=\"float\" id=\"T1\"><label>Table 1.</label><caption><p id=\"P52\">ALS gene association strength</p></caption><table frame=\"box\" rules=\"rows\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\"/><col align=\"left\" valign=\"middle\" span=\"1\"/><col align=\"left\" valign=\...	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN2\"><p id=\"P40\">COMPETING INTERESTS</p><p id=\"P41\">The authors declare that they have no competing interests</p></fn><fn fn-type=\"COI-statement\" id=\"FN3\"><p id=\"P42\"><bold>Additional Declarations:</bold> No competing interests reported.</p></fn><fn id=\"FN4\...	[ "<graphic xlink:href=\"nihpp-rs3721598v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3721598v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3721598v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3721598v1-f0004\" position=\"float\"/>", "<graphic xlink:href...	[]	[{"label": ["21."], "surname": ["Gregory", "Fagegaltier", "Phatnani", "Harms"], "given-names": ["JM", "D", "H", "MB"], "article-title": ["Genetics of Amyotrophic Lateral Sclerosis"], "source": ["Current Genetic Medicine Reports"], "year": ["2020"], "volume": ["8"], "issue": ["4"], "fpage": ["121"], "lpage": ["31"]}]	{ "acronym": [], "definition": [] }	37	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 21;:rs.3.rs-3721598	oa_package/70/ae/PMC10775375.tar.gz
PMC10775379	38196650	[ "<title>Introduction</title>", "<p id=\"P7\">A growing body of literature documents the high prevalence of trauma exposure and PTSD among individuals with substance use disorders (SUD) (##REF##30180003##1##, ##REF##15769558##2##), with rates of co-occurring post-traumatic stress disorder (PTSD) ranging from 33–50...	[ "<title>Methods</title>", "<title>Study Design and Enrollment</title>", "<p id=\"P13\">A NCCIH-funded randomized controlled trial to examine mindful body awareness training in individuals engaged in MOUD treatment provided the opportunity to examine the prevalence of self-reported lifetime trauma exposure and d...	[ "<title>Results</title>", "<title>Participants</title>", "<p id=\"P22\">This sample (N = 303) had a median age of 40, with ages ranging from 21–73. Self-report gender in the sample was 144 male, 157 female, and two non-binary. The majority (79%) of the sample identified as White, 9% as mixed-race, 5% as Black, ...	[ "<title>Discussion</title>", "<p id=\"P28\">This is the first study to examine lifetime trauma experiences among a large sample of individuals in MOUD. The results highlight the high prevalence of trauma in both childhood and in adulthood, as well as both interpersonal and non-interpersonal traumatic events in bo...	[ "<title>Conclusions</title>", "<p id=\"P36\">In conclusion, the findings highlight the complex connection between trauma exposure, OUD, gender, PTSD symptoms, and chronic pain. This study provides valuable insights into the prevalence of trauma across genders and points to the potential impact on individuals enga...	[ "<p id=\"P1\"><bold>Authors’ contributions:</bold> CJP and JOM obtained funding and oversaw data collection; CJP and MNR conceptualized the manuscript; KP was responsible for data analysis; MNR, DDC, SL, and CJP wrote the article; JOM manuscript review. All authors read and approved the final manuscript.</p>", "<...	[]	[ "<title>Funding:</title>", "<p id=\"P37\">This research was made possible by Grant Numbers R33AT009932 from the National Center for Complementary and Integrative Health (NCCIH) and R01 AT010742 from the National Center for Complementary and Integrative Health (NCCIH) and the National Institute of Neurological Dis...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><p id=\"P50\">Legend not included with this version.</p></caption></fig>", "<fig position=\"float\" id=\"F2\"><label>Figure 2</label><caption><p id=\"P51\">Legend not included with this version.</p></caption></fig>" ]	[ "<table-wrap position=\"float\" id=\"T1\"><label>Table 1</label><caption><p id=\"P52\">Trauma Categories and Corresponding TLEQ Items</p></caption><table frame=\"box\" rules=\"rows\"><colgroup span=\"1\"><col align=\"left\" valign=\"top\" span=\"1\"/></colgroup><thead><tr><th align=\"left\" valign=\"top\" rowspan=\...	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN3\"><p id=\"P38\"><bold>Competing interests:</bold> The authors declare that they have no competing interests.</p></fn><fn id=\"FN4\"><p id=\"P39\"><bold>Ethics approval and consent to participate.</bold> This study received Human Subjects Institutional Review Board a...	[ "<graphic xlink:href=\"nihpp-rs3750143v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3750143v1-f0002\" position=\"float\"/>" ]	[]	[{"label": ["3."], "source": ["Trauma and substance abuse: Causes, consequences, and treatment of comorbid disorders"], "edition": ["2nd"], "publisher-loc": ["Washington, DC, US"], "publisher-name": ["American Psychological Association"], "year": ["2014"], "volume": ["xiv"], "fpage": ["350"], "comment": ["(Ouimette P, ...	{ "acronym": [ "SUD", "PTSD", "OUD", "MOUD", "TLFB", "TLEQ", "PCL 5", "BPI", "IPV" ], "definition": [ "Substance use disorder", "Post–traumatic stress disorder", "Opioid use disorder", "Medication for opioid use disorder", "Timeline Follow–Back Interview", ...	64	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 19;:rs.3.rs-3750143	oa_package/25/a6/PMC10775379.tar.gz
PMC10775381	38196594	[ "<title>INTRODUCTION</title>", "<p id=\"P11\">Prostate cancer (<bold>PC</bold>) ranks as the second leading cause of cancer-related deaths among American men, claiming over 34,700 lives annually <sup>##REF##36633525##1##</sup>. While androgen deprivation therapy (<bold>ADT</bold>) is initially effective in most m...	[ "<title>MATERIALS AND METHODS</title>", "<title>Human tissue samples</title>", "<p id=\"P36\">This study was approved by the Institutional Review Board of the University of Washington (protocol no. 2341). Formalin-fixed, paraffin-embedded tissues from 52 patients were used to construct tissue microarrays as des...	[ "<title>RESULTS</title>", "<title>Patterns of DLL3, CEACAM5, PSMA and TROP2 protein expression across molecular subtypes of mCRPC</title>", "<p id=\"P18\">To contextualize the expression patterns of cell surface antigens in mCRPC, we utilized a recently published molecular subgrouping framework based on AR sign...	[ "<title>DISCUSSION</title>", "<p id=\"P26\">Targeting cell-surface proteins has opened novel avenues for cancer therapy <sup>##REF##32243795##12##–##REF##35318309##17##</sup>. In advanced metastatic PC, PSMA-directed agents have demonstrated encouraging clinical activity, which culminated in the recent approval o...	[]	[ "<p id=\"P1\">These authors contributed equally</p>", "<p id=\"P2\"><bold><italic toggle=\"yes\">Corresponding Author:</italic></bold> Michael C. Haffner, Fred Hutchinson Cancer Center, 1100 Fairview Avenue, Seattle, WA 98109; (206) 667-6769 (phone), <email>mhaffner@fredhutch.org</email>.</p>", "<p id=\"P3\">AU...	[]	[ "<title>ACKNOWLEDGEMENTS</title>", "<p id=\"P40\">We are grateful to the patients and their families, and the rapid autopsy teams and Dr’s. Andrew Hsieh, Jonathan Wright, Funda Vakar-Lopez, Daniel Lin, and Celestia Higano for their contributions to the University of Washington Medical Center Prostate Cancer Donor...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1.</label><caption><title>Distribution and co-expression patterns of DLL3, CEACAM5, PSMA, and TROP2 expressions across different molecular subtypes of mCRPC.</title><p id=\"P43\"><bold>A.</bold> Representative images of cell surface antigen expressions (determined by...	[]	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN4\"><p id=\"P41\">Conflict of interest statement:</p><p id=\"P42\">J. Zhao is currently an employee at Astra Zeneca. L.D. True is a co-founder and has equity in Alpenglow Biosciences. H.H. Cheng was a paid consultant to AstraZeneca in the past and has received researc...	[ "<graphic xlink:href=\"nihpp-rs3745991v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3745991v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3745991v1-f0003\" position=\"float\"/>" ]	[]	[{"label": ["2."], "surname": ["Sartor", "Bono"], "given-names": ["O.", "J. S. de"], "article-title": ["Metastatic Prostate Cancer"], "source": ["New Engl J Medicine"], "volume": ["378"], "fpage": ["1653"], "lpage": ["1654"], "year": ["2018"]}, {"label": ["9."], "surname": ["Kulac", "Roudier", "Haffner"], "given-names"...	{ "acronym": [], "definition": [] }	55	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 19;:rs.3.rs-3745991	oa_package/6d/25/PMC10775381.tar.gz
PMC10775386	38196577	[ "<title>Introduction</title>", "<p id=\"P7\">Hepatitis B virus (HBV) and HIV are the leading cause of chronic viral infection globally and it’s among the infections with prominence in the clinical evaluation of pregnancy [##UREF##0##1##]. HBV infection in pregnancy poses serious implications such as the risk of d...	[ "<title>Methods</title>", "<title>Study setting</title>", "<p id=\"P15\">A cross-sectional grounded theory qualitative approach was employed in an institutional setting to obtain data on facilitators and barriers of integrated viral hepatitis B, C and HIV screening among pregnant mothers and their newborns in s...	[ "<title>Results</title>", "<p id=\"P23\">A total of (20 KIs) participated in this study; (12) were male, while (8) were female. Similarly, (10) respondents were aged 25 to 30 years while the remaining (10) were aged 31 to 45 years and above. In terms of the cadre (2) of the study participants were enrolled midwiv...	[ "<title>Discussion</title>", "<title>Facilitators of integrated HBC, HCV and HIV in health facilities</title>", "<p id=\"P65\">The West Nile region in Uganda has a high burden of HBV and HIV [##REF##23297754##13##]. This study revealed that health workers were aware of integrated health service delivery but rep...	[ "<title>Conclusion</title>", "<p id=\"P76\">The facilitators to integrated viral diseases (HBV, HCV, and HIV) were; high prevalence of hepatitis B infection in West Nile region, team spirit from health workers perspective, reduced long waiting time, availability of medical products such as HBV and HCV test kits, ...	[ "<p id=\"P1\">Authors’ Contributions</p>", "<p id=\"P2\">John Bosco Alege conceptualized the study, collected data, and wrote the first draft research report, including the draft manuscript with substantial guidance and mentorship from; Orago, Oyore, and Musoke (supervisors). Nanyonga reviewed the draft manuscrip...	[]	[ "<title>Acknowledgments</title>", "<p id=\"P77\">The authors would like to acknowledge Lugei Foundation, Clarke International University, the School of Public Health and Applied Human Sciences, Kenyatta University, Nairobi, Kenya, to which the authors are affiliated, and their support in this implementation resea...	[]	[]	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN2\"><p id=\"P80\">Declarations</p><p id=\"P81\">Competing Interests</p><p id=\"P82\">All authors declared that they had no competing interests</p></fn><fn fn-type=\"COI-statement\" id=\"FN3\"><p id=\"P83\"><bold>Additional Declarations:</bold> No competing interests r...	[]	[]	[{"label": ["1."], "collab": ["WHO"], "source": ["Global hepatitis report 2017. WHO"], "year": ["2017"]}, {"label": ["11."], "surname": ["Hill", "Nath", "Simmons"], "given-names": ["AM", "S", "B"], "article-title": ["The road to elimination of hepatitis C: analysis of cures versus new infections in 91 countries"], "sou...	{ "acronym": [ "ANC", "CHB", "GHSS", "HBsAg", "HBV", "HCC", "MoH", "REC", "UNCST" ], "definition": [ "Antenatal Clinic", "Chronic hepatitis B", "Global health sector strategy", "Hepatitis B surface antigen", "Hepatitis B virus", "Hepatocellular carcinoma...	41	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 18;:rs.3.rs-3739602	oa_package/61/c8/PMC10775386.tar.gz
PMC10775387	38196595	[ "<title>INTRODUCTION</title>", "<p id=\"P2\">Ebola virus (EBOV; family <italic toggle=\"yes\">Filoviridae</italic>: species <italic toggle=\"yes\">Orthoebolavirus zairense</italic>) causes severe and frequently fatal acute human disease in outbreaks that can cause thousands of deaths. Complicating containment eff...	[ "<title>Methods</title>", "<title>Cell lines</title>", "<p id=\"P20\">Human embryonic kidney (HEK) epithelial Expi293F cells (Thermo Fisher Scientific, Waltham, MA, USA) were cultured on orbital shakers in Expi293 expression medium (Thermo Fisher Scientific) at 37°C in a humidified atmosphere containing 8% CO<s...	[ "<title>RESULTS</title>", "<title>Crystal structures of unbound human mAb 3A6 Fab bound to the Ebola virus glycoprotein stalk–MPER</title>", "<p id=\"P5\">mAb 9.6.3A6 (henceforth abbreviated as “3A6 IgG”) was isolated from a human survivor of the 2013–2016 Western African EVD outbreak 6 months after hospital di...	[ "<title>Discussion</title>", "<p id=\"P16\">Vaccines are currently only approved for prevention of EBOV infection <sup>##UREF##1##25##</sup>, but not for infections caused by other filoviruses. Antibody therapeutics that can be used at a low dose to reverse advanced disease are urgently needed to treat people wit...	[]	[ "<p id=\"P1\">Monoclonal antibodies (mAbs) against Ebola virus (EBOV) glycoprotein (GP<sub>1,2</sub>) are the standard of care for Ebola virus disease (EVD). Anti-GP<sub>1,2</sub> mAbs targeting the stalk and membrane proximal external region (MPER) potently neutralize EBOV <italic toggle=\"yes\">in vitro</italic>....	[]	[ "<title>Acknowledgements</title>", "<p id=\"P45\">We are grateful to Dustin Morado, Kun Qu, and Joaquin Oton (Medical Research Council Laboratory of Molecular Biology) for support in collecting and/or processing cryogenic electron tomography data and to Stanford Synchrotron Light Source (SSRL) and Advanced Photon...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><p id=\"P62\">Crystal structures of unbound human mAb 3A6 Fab and mAb 3A6 Fab bound to the Ebola virus glycoprotein stalk–MPER (A) Top: Schematic of proteolytically processed mature EBOV GP<sub>1,2</sub> using the amino acid residue numbering of its...	[]	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN1\"><p id=\"P51\">Competing interests</p><p id=\"P52\">A.G., E.D., and B.J.D. are employees of Integral Molecular, and B.J.D.is a shareholder in that company.</p></fn><fn fn-type=\"COI-statement\" id=\"FN2\"><p id=\"P53\"><bold>Additional Declarations:</bold> There is...	[ "<graphic xlink:href=\"nihpp-rs3722563v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3722563v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3722563v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3722563v1-f0004\" position=\"float\"/>", "<graphic xlink:href...	[]	[{"label": ["1."], "surname": ["Kuhn", "Amarasinghe", "Perry", "Howley", "Knipe", "Whelan"], "given-names": ["J.H.", "G.K.", "D.L.", "P.M.", "D.M.", "S.P.J."], "part-title": ["Filoviridae"], "source": ["Fields Virology Vol. 1 (Emerging Viruses)"], "fpage": ["449"], "lpage": ["503"], "publisher-name": ["Wolters Kluwer/L...	{ "acronym": [], "definition": [] }	56	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 22;:rs.3.rs-3722563	oa_package/a5/45/PMC10775387.tar.gz
PMC10775389	38196624	[ "<title>Introduction</title>", "<p id=\"P4\">Currently, over 100,000 individuals anxiously await a lifesaving organ transplant, yet thousands of these will die every year while on the waitlist due to a severe organ shortage. Current clinical standards for organ handling for transplantation include a period of col...	[ "<title>MATERIALS AND METHODS</title>", "<title>Liver procurement and storage</title>", "<p id=\"P21\">All animals for the experiments were maintained in accordance with National Research Council guidelines and were approved by the Institutional Animal Care and Use Committee (IACUC) at Massachusetts General Hos...	[ "<title>Results</title>", "<title>RRS allows quantification of mitochondrial redox state with different perfusate compositions.</title>", "<p id=\"P9\">RRS allows accurate quantification of the redox state of mitochondria as well as hemoglobin in the perfusate since both mitochondrial complexes and hemoglobin m...	[ "<title>Discussion</title>", "<p id=\"P15\">Solid organ transplantation is a lifesaving procedure, yet severely limited in its capacity to save lives due to ischemia-reperfusion injury (IRI) related complications. Machine perfusion (MP) allows minimization of and recovery from IRI when compared to the current cli...	[]	[ "<p id=\"P1\">Author Contribution</p>", "<p id=\"P2\">R.J. - Planning and execution of the experiments, data analysis, making figures and writing the manuscript.E.O.A. - Planning and execution of the experiments, manuscript editing.P.R. - Design and optimization of the Raman spectroscopy device, critical analysis...	[]	[ "<title>Acknowledgements</title>", "<p id=\"P31\">This work was supported by generous funding to S.N.T. from the US National Institutes of Health (R01DK134590). We also gratefully acknowledge funding from the US National Institute of Health (K99/R00 HL1431149; R01HL157803; R24OD034189), National Science Foundatio...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><title>Resonance Raman Spectroscopy predicts functional oxygenation of liver tissue during machine perfusion.</title><p id=\"P35\"><bold>a</bold>, schematic of machine perfusion of livers where a perfusate(I) with or without red blood cells as oxyge...	[]	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN2\"><p id=\"P33\">Competing Interests</p><p id=\"P34\">The authors declare competing interests. Dr. Tessier and Mr. Romfh have provisional patent applications relevant to this study. P.R. is an employee and shareholder of Pendar Technologies. S.N.T.’s competing intere...	[ "<graphic xlink:href=\"nihpp-rs3740098v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3740098v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3740098v1-f0003\" position=\"float\"/>" ]	[]	[{"label": ["1."], "article-title": ["Organ preservation: from the past to the future"], "source": ["Acta Pharmacologica Sinica"], "ext-link": ["https://www.nature.com/articles/aps2017182"]}, {"label": ["5."], "article-title": ["Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm is...	{ "acronym": [], "definition": [] }	43	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 21;:rs.3.rs-3740098	oa_package/63/eb/PMC10775389.tar.gz
PMC10775395	38196574	[ "<title>Background</title>", "<p id=\"P15\">Myocarditis is an inflammation of the myocardium, or muscle tissue of the heart, and a leading cause of sudden cardiac death in persons under 50 years of age [##REF##30638108##1##, ##REF##33309175##2##]. The Global Burden of Disease (GBD) study from 2019 reported 1.8 mi...	[ "<title>Methods</title>", "<title>Myocarditis Model</title>", "<p id=\"P46\">Male and female 6–8 week-old BALB/cJ mice (stock# 651) were obtained from Jackson Laboratory (Bar Harbor, ME). Mice were inoculated with sterile phosphate buffered saline (PBS) (vehicle control) or 10<sup>3</sup> plaque forming units (...	[ "<title>Results</title>", "<title>Myocardial inflammation is increased in males compared to females</title>", "<p id=\"P17\">We first examined inflammation in males versus females and uninfected PBS vehicle controls to confirm sex differences and to select samples for RNA sequencing. As we have shown previously...	[ "<title>Discussion</title>", "<p id=\"P35\">In this study we show for the first time that male mice with CVB3 myocarditis have reduced mitochondrial transcription compared to females using an autoimmune model of CVB3 myocarditis that is highly translational to human disease [##REF##34042389##36##]. We show that f...	[ "<title>Conclusion</title>", "<p id=\"P45\">In this study we show for the first time that males with CVB3 myocarditis have reduced mitochondrial gene expression of nuclear-encoded electron transport chain genes compared to females. Females had higher levels of global regulators of mitochondrial function compared ...	[ "<p id=\"P1\">Contributions</p>", "<p id=\"P2\">Conceptualization: DND, KAB, DF</p>", "<p id=\"P3\">Data Acquisition: DND, KAB, DF</p>", "<p id=\"P4\">Sample Acquisition: DND, KAB, DF</p>", "<p id=\"P5\">Methodology: DND, DJG, EJM, IC, KAS, AJ, KAB, GRS, DJB, PGG, SK, NEB-H, ERW, VB, GJW, JAF, SCK, CJM, EA-...	[]	[ "<title>Acknowledgements</title>", "<p id=\"P58\">We thank the Dickson Histology Group for their work embedding and staining slides for this project. This group includes Dr. Dennis W. Dickson, Linda Rousseau, Virginia Phillips, Ariston Libraro, and Monica Castanedes. We thank Dr. Laura Lewis-Tuffin and the Mayo M...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><title>Myocardial inflammation is increased in males compared to females</title><p id=\"P72\"><bold>a,</bold> Myocarditis severity (% inflammation) between female controls (F-CON, <italic toggle=\"yes\">n</italic>= 27), females with myocarditis (F-M...	[]	[]	[ "<boxed-text id=\"BX1\" position=\"float\"><caption><title>Highlights</title></caption><list list-type=\"bullet\" id=\"L1\"><list-item><p id=\"P84\">Viral myocarditis is more severe in males than females.</p></list-item><list-item><p id=\"P85\">ERRa and mitochondrial gene expression increased in females with myocar...	[]	[]	[]	[]	[ "<fn-group><fn id=\"FN2\" fn-type=\"COI-statement\"><p id=\"P62\">Competing Interests</p><p id=\"P63\">The authors declare that they have no competing interests.</p></fn><fn id=\"FN3\"><p id=\"P64\">Ethics Approval and Consent to participate</p><p id=\"P65\">No humans were researched as a part of this study.</p></f...	[ "<graphic xlink:href=\"nihpp-rs3716881v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3716881v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3716881v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3716881v1-f0004\" position=\"float\"/>", "<graphic xlink:href...	[]	[{"label": ["6."], "surname": ["Myers", "Cooper", "Kem", "Stavrakis", "Kosanke", "Shevach", "Fairweather", "Stoner", "Cox", "Cunningham"], "given-names": ["JM", "LT", "DC", "S", "SD", "EM", "D", "JA", "CJ", "MW"], "article-title": ["Cardiac myosin-Th17 responses promote heart failure in human myocarditis"], "source": [...	{ "acronym": [], "definition": [] }	81	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 19;:rs.3.rs-3716881	oa_package/5c/bb/PMC10775395.tar.gz
PMC10775396	38196585	[ "<title>Background</title>", "<p id=\"P8\">Medical students are essential to the development of a socially accountable medical school (##UREF##0##1##, ##UREF##1##2##). Social accountability for medical schools is defined as the obligation of the medical school to direct education, research, and service activities...	[ "<title>Methods</title>", "<title>Study design and questionnaire:</title>", "<p id=\"P12\">A cross-sectional online questionnaire-based survey was conducted between September 2022 and October 2023 using Google Forms. This study collected responses from medical students from the Makerere University School of Med...	[ "<title>Results</title>", "<p id=\"P16\">This study involved 426 medical students in their fourth or fifth year of study at the Makerere University School of Medicine. The mean age of the students was 25.24 ± 4.4 years. Most of the participants were in their fourth year of study, as the link was available over tw...	[ "<title>Discussion</title>", "<p id=\"P21\">We evaluated the perceptions and experiences of medical students at the Makerere University School of Medicine regarding social accountability. Our study findings suggest that medical students at the Makerere University School of Medicine have varied perceptions and exp...	[ "<title>Conclusions</title>", "<p id=\"P26\">Medical students at the Makerere University School of Medicine have varied perceptions and experiences of social accountability. Most students felt moderately prepared for COBERS and evaluated medical school positively for social accountability. Regarding individual it...	[ "<p id=\"P1\">Authors’ contributions</p>", "<p id=\"P2\">LO conception of the study, acquisition and analysis of data, drafting the paper and writing the final version.</p>", "<p id=\"P3\">IGM, SK and AGM-refined the study concept, reviewed the results, drafted the paper and approved its final version.</p>", ...	[]	[ "<title>Funding</title>", "<p id=\"P28\">The research reported in this publication was supported by the Fogarty International Center of the National Institutes of Health, U.S. Department of State’s Office of the U.S. Global AIDS Coordinator and Health Diplomacy (S/GAC) and the President’s Emergency Plan for AIDS ...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><p id=\"P36\">Level of Preparedness for Last Community-Based Education Research and Service Experience</p></caption></fig>", "<fig position=\"float\" id=\"F2\"><label>Figure 2</label><caption><p id=\"P37\">Evaluation categories of social accountab...	[ "<table-wrap position=\"float\" id=\"T1\"><label>Table 1</label><caption><p id=\"P38\">Characteristics of the study participants</p></caption><table frame=\"box\" rules=\"rows\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\"/><col align=\"left\" valign=\"middle\" span=\"1\"/><col align=\"left...	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN2\"><p id=\"P30\">Declarations</p><p id=\"P31\">Competing interests</p><p id=\"P32\">AGM is a member of the BMC Medical Education editorial board. The other authors declare that they have no competing interests.</p></fn><fn id=\"FN3\"><p id=\"P33\">Ethical approval an...	[ "<graphic xlink:href=\"nihpp-rs3756902v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3756902v1-f0002\" position=\"float\"/>" ]	[]	[{"label": ["1."], "surname": ["Dijk", "P\u00e1lsd\u00f3ttir", "Ross", "Bhiri", "Ramalho", "Glasner"], "given-names": ["S", "B", "SJ", "M", "R", "J"], "article-title": ["Students\u2019 Toolkit on Social Accountability in Medical Schools"], "source": ["Amst IFMSA"], "year": ["2017"]}, {"label": ["2."], "surname": ["Rour...	{ "acronym": [ "COBERS" ], "definition": [ "Community-Based Education Research and Service" ] }	15	CC BY	no	2024-01-14 23:35:02	Res Sq. 2023 Dec 19;:rs.3.rs-3756902	oa_package/05/ee/PMC10775396.tar.gz
PMC10775399	38196579	[ "<title>Introduction</title>", "<p id=\"P3\">Glaucoma is the second leading cause of irreversible blindness worldwide affecting about 70 million people<sup>##REF##16488940##1##–##REF##24974815##3##</sup>. Primary open angle glaucoma (POAG), the most common form of glaucoma is associated with progressive loss of r...	[ "<title>Methods</title>", "<title>Viral Vector Constructs:</title>", "<p id=\"P7\">AAV 2, self-complementary AAV2 (scAAV2) and Trp-Mutant scAAV2 (scAAV2<sup>Trp-Mut</sup>) were selected for the study based on previous studies that show tropism toward the trabecular outflow pathway <sup>##REF##31611639##58##</su...	[ "<title>Results</title>", "<title>Ocular transduction patterns of various AAV2 serotypes and lentiviral particles in mouse eyes:</title>", "<p id=\"P20\">Selective AAV serotypes were shown to have tropism towards the TM of mice, rats, and monkeys in previous studies <sup>##REF##26052939##72##–##REF##28763501##7...	[ "<title>Discussion</title>", "<p id=\"P25\">Recent advances in genome editing technologies allow investigators to directly alter the genes associated with disease pathology. The gain-of-function mutation of the <italic toggle=\"yes\">MYOC</italic> gene serves as a direct target for gene editing without the need f...	[]	[ "<p id=\"P1\"><bold>Authors Contributions:</bold> GSZ, VCS and AFC designed research studies. SVP, BK, SR, YS, JCM, QZ, and CCS. performed experiments and analyzed data. SVP, and GSZ wrote the manuscript. VCS, AFC, TES, and QZ assisted in conducting key experiments, provided reagents, and assisted in manuscript pre...	[]	[ "<title>Acknowledgments.</title>", "<p id=\"P31\">These studies were supported by the National Institutes of Health (EY026177 and EY030366) and facilitated by an NIH/NEI Center Support Grant to the University of Iowa (P30 EY025580). The authors acknowledge support from NIH grant P30EY034070 and from an unrestrict...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><title>AAV2-mediated GFP transduction in ocular tissues of C57BL/6J mice.</title><p id=\"P33\">ssAAV2, scAAV2 and scAAV2<sup>Trp-Mut</sup> expressing GFP (2 × 10<sup>10</sup> GC/eye) were injected in mouse eyes via IVT or IC bolus injections or slow...	[]	[]	[]	[]	[]	[]	[]	[]	[ "<graphic xlink:href=\"nihpp-rs3740880v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3740880v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3740880v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3740880v1-f0004\" position=\"float\"/>", "<graphic xlink:href...	[]	[{"label": ["23."], "surname": ["Lohano", "Su", "Ruochen", "Basnet", "Naveed", "Khemani", "Khooharo"], "given-names": ["MK", "L", "W", "BB", "H", "VD", "AA"], "article-title": ["Myocilin and Glaucoma its Risk Factors"], "source": ["Int J Pure App Biosci"], "year": ["2016"], "volume": ["4"], "issue": ["1"], "fpage": ["1...	{ "acronym": [], "definition": [] }	98	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 19;:rs.3.rs-3740880	oa_package/78/4b/PMC10775399.tar.gz
PMC10775401	38196610	[ "<title>INTRODUCTION</title>", "<p id=\"P2\">Post-acute sequelae of SARS-CoV-2 infection (i.e., long COVID) is a growing public health crisis globally.<sup>##UREF##0##1##</sup> There have been over 769 million confirmed COVID-19 cases worldwide, and more than 200 million individuals infected have had or will deve...	[ "<title>METHODS</title>", "<title>Data Source and Cohort</title>", "<p id=\"P23\">Data for this study were derived from the AoU data enclave (version 7) available in the preproduction environment,<sup>##REF##31412182##9##</sup> which consist of EHRs, survey-based information, genotyping data, and lifestyle data...	[ "<title>RESULTS</title>", "<title>Study population</title>", "<p id=\"P7\">Our final cohort included 17,755 AoU participants out of which 976 had long COVID. The data availability for the cohort is represented in ##FIG##2##Fig. 3##. Our genetic model was trained on a total of 3,145 participants with 55 long COV...	[ "<title>DISCUSSION</title>", "<p id=\"P16\">Our findings show that combining multiple data sources using a weighted averaging method can increase the overall accuracy of the existing predictive N3C predictive algorithm. The inclusion of different data types in AoU led to a direct increase in the AUC ROC score of ...	[]	[ "<p id=\"P1\">Over 200 million SARS-CoV-2 patients have or will develop persistent symptoms (long COVID). Given this pressing research priority, the National COVID Cohort Collaborative (N3C) developed a machine learning model using only electronic health record data to identify potential patients with long COVID. W...	[]	[ "<title>Acknowledgements:</title>", "<p id=\"P43\">This study was supported under award numbers R01 GM139891, R01AG069900, and U01 HG011181.</p>", "<title>Data Availability</title>", "<p id=\"P44\">The All of Us dataset can be accessed through the Researcher Workbench by following the detailed data applicatio...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><title>Training, Testing, and Validation Set Parameters.</title><p id=\"P49\">Flowchart describing how the AoU data was divided into sets based on data availability.</p></caption></fig>", "<fig position=\"float\" id=\"F2\"><label>Figure 2</label><...	[ "<table-wrap position=\"float\" id=\"T1\"><label>Table 1</label><caption><p id=\"P54\">Predictive Model Results</p></caption><table frame=\"box\" rules=\"rows\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\"/><col align=\"left\" valign=\"middle\" span=\"1\"/><col align=\"left\" valign=\"middl...	[ "<disp-formula id=\"FD1\">\n<mml:math id=\"M1\" display=\"block\"><mml:mo>[</mml:mo><mml:mi mathvariant=\"normal\">α</mml:mi><mml:mo>,</mml:mo><mml:mi mathvariant=\"normal\">β</mml:mi><mml:mo>,</mml:mo><mml:mi mathvariant=\"normal\">γ</mml:mi><mml:mo>]</mml:mo><mml:mo>=</mml:mo><mml:mo>[</mml:mo><mml:mn>0.58</mml:m...	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN2\"><p id=\"P45\">Declarations</p><p id=\"P46\">The authors declared no competing interests for this work.</p></fn><fn id=\"FN3\"><p id=\"P47\">Code Availability</p><p id=\"P48\">The source code associated with this study is publicly available at: <ext-link xlink:href...	[ "<graphic xlink:href=\"nihpp-rs3749510v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3749510v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3749510v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3749510v1-f0004\" position=\"float\"/>", "<graphic xlink:href...	[]	[{"label": ["1."], "surname": ["Yang", "Tebbutt"], "given-names": ["C.", "S. J."], "article-title": ["Long COVID: the next public health crisis is already on its way"], "source": ["The Lancet Regional Health \u2013 Europe"], "volume": ["28"], "year": ["2023"]}, {"label": ["2."], "source": ["WHO Coronavirus (COVID-19) D...	{ "acronym": [], "definition": [] }	14	CC BY	no	2024-01-14 23:35:02	Res Sq. 2023 Dec 19;:rs.3.rs-3749510	oa_package/0b/02/PMC10775401.tar.gz
PMC10775402	38196635	[ "<title>Background</title>", "<p id=\"P5\">Ensuring access to high-quality maternal health care across each stage of the perinatal continuum of care is critical for reducing maternal morbidity and mortality and improving pregnancy and postpartum experiences. India has made dramatic progress in reducing maternal m...	[ "<title>Methods</title>", "<p id=\"P10\">The <italic toggle=\"yes\">MeSSSSage</italic> mHealth educational and social support intervention pilot study occurred within Boothgarh district, Punjab state, northern India. Eligibility criteria for participation included age 18 or above, 28–32 weeks pregnant, living in ...	[ "<title>Results</title>", "<title>Sociodemographic characteristics</title>", "<p id=\"P20\">At enrollment, study participants were mean age 26.8 years (mean 26.8, SD 3.9) and almost all were married (99.3%; ##TAB##1##Table 2##). Most women had either completed a high school education (44.8%) or higher (44.3%). ...	[ "<title>Discussion</title>", "<p id=\"P28\">Our preliminary effectiveness assessment of the <italic toggle=\"yes\">MeSSSSage</italic> mHealth education and social support intervention found our group call modality had a positive impact on change in knowledge of maternal danger signs at pregnancy and childbirth, i...	[ "<title>Conclusion</title>", "<p id=\"P34\">Expansion of the evidence base for interventions to improve postpartum care and support are needed to overcome deficits in postpartum care seen across multiple settings. MHealth interventions such as <italic toggle=\"yes\">MeSSSSage</italic> which combine education, soc...	[ "<title>Background.</title>", "<p id=\"P1\">Significant disruptions in the perinatal continuum of care occur postpartum in India, despite it being a critical time to optimize maternal health and wellbeing. Group-oriented mHealth approaches may help mitigate the impact of limited access to care and the lack of soc...	[]	[ "<title>Acknowledgements:</title>", "<p id=\"P35\">We greatly appreciate our research participants who shared their time and experiences with us. We also appreciate our intervention moderators, field teams, and community health professionals who facilitated our research. This paper is dedicated to Dr. Vijay Kumar...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><title>Conceptual Framework of Intervention Context, <italic toggle=\"yes\">MeSSSSage</italic> Intervention Targets, Outcomes and Anticipated Long-Term Impacts</title><p id=\"P40\">MeSSSSage intervention targets include knowledge, social support, an...	[ "<table-wrap position=\"float\" id=\"T1\"><label>Table 1</label><caption><p id=\"P41\"><italic toggle=\"yes\">MeSSSSage</italic> intervention modalities</p></caption><table frame=\"box\" rules=\"rows\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\"/><col align=\"left\" valign=\"middle\" span=...	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn fn-type=\"COI-statement\" id=\"FN1\"><p id=\"P37\"><bold>Competing interests:</bold> No potential competing interest was reported by the authors.</p></fn><fn id=\"FN2\"><p id=\"P38\"><bold>Ethics approval and consent to participate</bold>: This study received ethical approval from Institute Ethics co...	[ "<graphic xlink:href=\"nihpp-rs3746241v1-f0001\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3746241v1-f0002\" position=\"float\"/>" ]	[]	[{"label": ["1."], "collab": ["Office of the Registrar General, India"], "source": ["Special Bulletin on Maternal Mortality in India 2016\u20132018"], "publisher-name": ["Office of the Registrar General, India; Vital Statistics Division"]}, {"label": ["2."], "collab": ["World Bank Group, and United Nations Population D...	{ "acronym": [], "definition": [] }	42	CC BY	no	2024-01-14 23:35:03	Res Sq. 2023 Dec 22;:rs.3.rs-3746241	oa_package/e8/d0/PMC10775402.tar.gz
PMC10775858	38196615	[ "<title>Introduction</title>", "<p id=\"P3\">Chronic kidney disease (CKD) is a major health epidemic that affects 37 million adults in the United States and many more worldwide.<sup>##REF##17986697##1##,##REF##27383068##2##</sup> Patients with CKD face significantly higher risks of cardiovascular disease and subs...	[ "<title>Methods</title>", "<title>Antibodies, recombinant proteins and heparin</title>", "<p id=\"P6\">Carrier-free recombinant mouse FGF23 (2629FG025/CF) from R&D systems was used at 25 ng/mL and 100 ng/mL. The isoform specific FGFR4 small molecule inhibitor BLU9931 from Selleck Chemicals (Cat. No S7819, T...	[ "<title>Results</title>", "<title>CKD alters cardiac mitochondrial structure prior to onset of LVH</title>", "<p id=\"P25\">To investigate cardiac metabolic remodeling in heart failure due to CKD, we analyzed cardiac structure and function in wild-type mice fed 0.2% adenine diet to induce CKD.<sup>##REF##315759...	[ "<title>Discussion</title>", "<p id=\"P43\">In this report, we demonstrate that cardiac mitochondrial dysfunction and metabolic remodeling are complications of CKD that precede structural remodeling of the heart that eventually culminates in LVH. Using bioengineered cardio-bundles, primary culture of NRVM, gain-o...	[]	[ "<p id=\"P1\">Chronic kidney disease (CKD) is a global health epidemic that significantly increases mortality due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiac injury in CKD. High serum levels of fibroblast growth factor (FGF) 23 in patients with CKD may contribu...	[]	[ "<title>Acknowledgment</title>", "<p id=\"P48\">We would like to acknowledge the excellent and expert technical support provided to this project by: The Animal Clinical Laboratory Services Core of the University on North Carolina (Chapel Hill), Duke Cardiovascular Physiology Core, Duke Center for Genomics and Com...	[ "<fig position=\"float\" id=\"F1\"><label>Figure 1</label><caption><title>Cardiac function, remodeling and changes to cardiac mitochondria in CKD.</title><p id=\"P71\">Cardiac function of control and adenine fed mice was evaluated at the outset of the experiment at 8 weeks and at study termination at 16 weeks.</p><...	[ "<table-wrap position=\"float\" id=\"T1\"><label>Table 1 :</label><caption><p id=\"P87\">Taq-man probes used for RNA quantification</p></caption><table frame=\"box\" rules=\"all\"><colgroup span=\"1\"><col align=\"left\" valign=\"middle\" span=\"1\"/><col align=\"left\" valign=\"middle\" span=\"1\"/></colgroup><the...	[]	[]	[]	[]	[]	[]	[ "<fn-group><fn id=\"FN1\"><p id=\"P52\">Disclosure statement</p><p id=\"P53\">MW has equity interests in Akebia, Unicycive, and Walden and has served as a consultant for Bayer, Enyo, Jnana, Kissei, Launch, Pharmacosmos and Reata.</p></fn><fn id=\"FN2\"><p id=\"P54\">Supplemental figure S1: cardiac functional parame...	[ "<graphic xlink:href=\"nihpp-rs3705543v1-f0001.jpg\" position=\"anchor\"/>", "<graphic xlink:href=\"nihpp-rs3705543v1-f0002\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3705543v1-f0003\" position=\"float\"/>", "<graphic xlink:href=\"nihpp-rs3705543v1-f0004\" position=\"float\"/>", "<graphic xlink...	[]	[{"label": ["20."], "surname": ["Parker", "Packer", "Schneider"], "given-names": ["T. G.", "S. E.", "M. D."], "source": ["Peptide growth factors can provoke \u2018fetal\u2019 contractile protein gene expression in rat cardiac myocytes"], "ext-link": ["https://www.jci.org/articles/view/114466/pdf"], "year": ["1990"], "p...	{ "acronym": [], "definition": [] }	55	CC BY	no	2024-01-14 23:35:04	Res Sq. 2023 Dec 23;:rs.3.rs-3705543	oa_package/ea/e6/PMC10775858.tar.gz
PMC10776967	38204923	[ "<title>Introduction</title>", "<p>The service sectors are growing faster as compared to other sectors in developing nations (\n##UREF##60##Mukherjee, 2015##;\n##UREF##47##Latha, 2016##;\n##UREF##76##Service sectors in India, 2021##). The services industry not only accounts for the bulk of India’s Gross Domestic ...	[ "<title>Methods</title>", "<title>Study design</title>", "<p>This research work is highly focused on patient satisfaction in a healthcare setting to empirically validate the hypotheses framed. This study has adopted a quantitative approach. A cross-sectional research design was applied in the study. The relatio...	[ "<title>Results</title>", "<p>Descriptive statistics are estimated and the output is presented in\n##TAB##0##Tables 1## &\n##TAB##1##2##. The full dataset can be found in the\n<italic toggle=\"yes\">Underlying data</italic> (\n##UREF##4##Akthar\net al., 2022##).</p>", "<p>The measurement model was estimated...	[ "<title>Conclusions/Discussion</title>", "<p>In this research endeavor, we intended to explore the role of emotions in adverse services. We proposed to explore if mood mediates the relationship between happiness and service quality perception which had a direct bearing on patient satisfaction. Happiness was explo...	[ "<title>Conclusions/Discussion</title>", "<p>In this research endeavor, we intended to explore the role of emotions in adverse services. We proposed to explore if mood mediates the relationship between happiness and service quality perception which had a direct bearing on patient satisfaction. Happiness was explo...	[ "<p>No competing interests were disclosed.</p>", "<title>Background</title>", "<p>Managing emotions during hospital visits is important to enhance patient satisfaction. The purpose of this paper is to explore the relationship between patients’ happiness and satisfaction through patients’ mood and perceived serv...	[ "<title>Literature review</title>", "<title>Theoretical background</title>", "<p>\n##REF##10467897##Ashby and Isen (1999)## proposed that positive affect has a consistent impact on a variety of cognitive activities. Many of these effects are explained by the neuropsychological theory, which claims that the plea...	[]	[ "<fig position=\"float\" fig-type=\"figure\" id=\"f1\"><label>Figure 1. </label><caption><title>Proposed hypotheses.</title></caption></fig>", "<fig position=\"float\" fig-type=\"figure\" id=\"f2\"><label>Figure 2. </label><caption><title>Structural model.</title></caption></fig>", "<fig position=\"float\" fig-...	[ "<table-wrap position=\"float\" id=\"T1\"><label>Table 1. </label><caption><title>Demographic characteristics (N=227).</title></caption><table frame=\"hsides\" rules=\"groups\" content-type=\"article-table\"><thead><tr><th align=\"left\" colspan=\"1\" rowspan=\"1\" valign=\"top\">Characteristics</th><th align=\"lef...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"pub-status\"><fn><p>[version 2; peer review: 2 approved]</p></fn></fn-group>", "<table-wrap-foot><fn id=\"tfn1\"><label>*</label><p>p<0.01.</p></fn><fn id=\"tfn2\"><label></label><p>p<0.05.</p></fn><fn id=\"tfn3\"><label>*</label><p>p<0.1.</p></fn></table-wrap-foot>", "<ta...	[ "<graphic xlink:href=\"f1000research-11-161254-g0000\" id=\"gr1\" position=\"float\"/>", "<graphic xlink:href=\"f1000research-11-161254-g0001\" id=\"gr2\" position=\"float\"/>", "<graphic xlink:href=\"f1000research-11-161254-g0002\" id=\"gr3\" position=\"float\"/>", "<graphic xlink:href=\"f1000research-11-161...	[]	[{"mixed-citation": ["\n"], "person-group": ["\n"], "surname": ["Aagja", "Garg"], "given-names": ["JP", "R"], "article-title": ["Measuring perceived service quality for public hospitals (PubHosQual) in the Indian context."], "source": ["\n"], "italic": ["Int. J. Pharm. Healthc. Mark."], "year": ["2010"], "volume": ["4"...	{ "acronym": [], "definition": [] }	114	CC BY	no	2024-01-14 23:35:01	F1000Res. 2024 Jan 12; 11:347	oa_package/bb/3f/PMC10776967.tar.gz
PMC10786709	0	[ "<title>Introduction</title>", "<p>Biliary tract cancer (BTC) is a malignant tumor originating from the differentiation of bile ducts or gallbladder epithelial cells. It encompasses intrahepatic cholangiocarcinoma (ICC), hilar cholangiocarcinoma (HCCA), extrahepatic cholangiocarcinoma (eCCA) and gallbladder carci...	[ "<title>Methods</title>", "<title>Experimental procedure</title>", "<title>Study design and patients</title>", "<p>This is a single‐centre, prospective, single‐arm, exploratory clinical study to assess the safety and efficacy of anlotinib hydrochloride in combination with toripalimab for the treatment of unre...	[ "<title>Results</title>", "<title>Effective</title>", "<p>From May 2020 to September 2021, a total of 15 eligible patients were enrolled to a combination therapy of anlotinib and toripalimab. Among these patients, there were nine with ICC, three with HCCA and three with GBC. Out of the 15 patients, four (26.7%)...	[ "<title>Discussion</title>", "<p>Biliary tract cancer constitutes approximately 3% of all gastrointestinal malignancies and ranks as the second most prevalent hepatobiliary cancer.##REF##34626563##\n18\n## Because of its high malignancy and aggressive nature, effective systemic treatment options for advanced BTC ...	[]	[ "<title>Abstract</title>", "<title>Objectives</title>", "<p>To assess the safety and efficacy of anlotinib (a multi‐targeted tyrosine kinase inhibitor) combined with toripalimab (a PD‐1 monoclonal antibody) in the treatment of unresectable biliary tract cancer (BTC).</p>", "<title>Methods</title>", "<p>In t...	[ "<title>Ethical approval</title>", "<p>This study protocol was reviewed and approved by ethics committee of Comprehensive Cancer Center of Drum Tower Hospital of Nanjing University and Drum Tower Hospital of Nanjing University. The patients/participants provided their written informed consent to participate in th...	[ "<title>Data availability statement</title>", "<p>All data generated or analysed during this study are included in this published article.</p>" ]	[ "<fig position=\"float\" fig-type=\"Figure\" id=\"cti21483-fig-0001\"><label>Figure 1</label><caption><p>Kaplan–Meier progression‐free survival curves of all patients <bold>(a)</bold> and second‐line treatment patients <bold>(b)</bold>; Kaplan–Meier overall survival curves of all patients <bold>(c)</bold> and the s...	[ "<table-wrap position=\"float\" id=\"cti21483-tbl-0001\" content-type=\"Table\"><label>Table 1</label><caption><p>Demographic and disease characteristics at baseline</p></caption><table frame=\"hsides\" rules=\"all\"><col align=\"left\" span=\"1\"/><col align=\"left\" span=\"1\"/><thead valign=\"bottom\"><tr style=...	[]	[ "<boxed-text position=\"anchor\" content-type=\"graphic\" id=\"cti21483-blkfxd-0001\"></boxed-text>" ]	[]	[]	[]	[ "<supplementary-material id=\"cti21483-supitem-0001\" position=\"float\" content-type=\"local-data\"><caption><p>\nSupplementary table 1\n</p><p>\nSupplementary table 2\n</p></caption></supplementary-material>" ]	[ "<fn-group id=\"cti21483-ntgp-0001\"><fn id=\"cti21483-note-0001\"><p>Trial registration: ChiCTR2000037847.</p></fn></fn-group>", "<table-wrap-foot id=\"cti21483-ntgp-0002\"><fn id=\"cti21483-note-0002\"><p>Data are median (IQR) or <italic toggle=\"yes\">N</italic> (%).</p></fn><fn id=\"cti21483-note-0003\"><p>EC...	[ "<graphic xlink:href=\"CTI2-13-e1483-g005.jpg\" position=\"anchor\" id=\"jats-graphic-1\"/>", "<graphic xlink:href=\"CTI2-13-e1483-g004\" position=\"anchor\" id=\"jats-graphic-3\"/>", "<graphic xlink:href=\"CTI2-13-e1483-g003\" position=\"anchor\" id=\"jats-graphic-5\"/>", "<graphic xlink:href=\"CTI2-13-e1483...	[ "<media xlink:href=\"CTI2-13-e1483-s001.docx\"><caption><p>Click here for additional data file.</p></caption></media>" ]	[{"label": ["4"], "mixed-citation": ["\n"], "string-name": ["\n", "\n", "\n", "\n", "\n"], "surname": ["Morizane", "Okusaka", "Mizusawa", "Katayama", "Ueno"], "given-names": ["C", "T", "J", "H", "M"], "article-title": ["Combination gemcitabine plus S\u20101 versus gemcitabine plus cisplatin for advanced/recurrent bilia...	{ "acronym": [], "definition": [] }	27	CC BY	no	2024-01-14 23:40:08	Clin Transl Immunology. 2024 Jan 12; 13(1):e1483	oa_package/7f/2e/PMC10786709.tar.gz
PMC10786710	0	[ "<title>Introduction</title>", "<p>Myasthenia gravis (MG) is an autoimmune disease that results in impaired signal transmission due to the presence of pathogenic autoantibodies to several target antigens on the postsynaptic membrane of the neuromuscular junction. Antibodies against acetylcholine receptor (AChR) a...	[]	[]	[ "<title>Discussion</title>", "<p>MG is the most common neuromuscular disorder, characterized by fluctuating muscle weakness that worsens with use and improves with rest [##REF##28029925##1##]. Its symptoms vary depending on the age of onset and the antibodies involved [##REF##28029925##1##].</p>", "<p>MG can pr...	[ "<title>Conclusions</title>", "<p>In conclusion, this case underscores the atypical presentation of MuSK-positive MG in an elderly patient, initially manifested as type 2 respiratory failure. Some patients with MG do not exhibit the typical ocular or limb symptoms and, instead, develop respiratory failure. In the...	[ "<p>Myasthenia gravis (MG) is an autoimmune disease and represents one of the most common disorders associated with neuromuscular transmission defects. Within MG, the anti-muscle-specific kinase antibody-positive subtype (MuSK-positive MG) is rare. While it shares similarities with the common form of MG by presenti...	[ "<title>Case presentation</title>", "<p>An 84-year-old female presented to the emergency department with a three-day history of worsening respiratory distress. Her medical problems included reflux esophagitis, insomnia, and Alzheimer's disease. She had no history of obstructive lung pathology and no history of to...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>Chest x-ray showed no remarkable findings.</title></caption></fig>" ]	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Results of blood cell count, biochemistry, arterial blood gas analysis, and autoantibody tests.</title></caption><table frame=\"hsides\" rules=\"groups\"><tbody><tr style=\"background-color:#ccc\"><td rowspan=\"1\" colspan=\"1\">Blood...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Tadaharu Shiozumi, Tasuku Matsuyama, Nobunaga Okada, Yoshihiro Yamahata, Bon Ohta</p><p><bold>Acquisition, analysis, or interpretation of data:</bold> Tadaharu Shiozumi, Tasuku Matsuyama,...	[ "<graphic xlink:href=\"cureus-0015-00000050480-i01\" position=\"float\"/>" ]	[]	[{"label": ["3"], "article-title": ["MuSK-associated myasthenia gravis: clinical features and management"], "source": ["Front Neurol"], "person-group": ["\n"], "surname": ["Rodolico", "Bonanno", "Toscano", "Vita"], "given-names": ["C", "C", "A", "G"], "volume": ["11"], "year": ["2020"]}, {"label": ["7"], "article-title...	{ "acronym": [], "definition": [] }	10	CC BY	no	2024-01-14 23:40:08	Cureus.; 15(12):e50480	oa_package/aa/d8/PMC10786710.tar.gz
PMC10786711	0	[ "<title>Introduction and background</title>", "<p>Tricuspid regurgitation (TR), also known as tricuspid insufficiency, is a heart condition where blood flows backward through the tricuspid valve [##UREF##0##1##]. It can be categorized as primary, caused by intrinsic valve abnormalities, or secondary, often due to...	[]	[]	[]	[ "<title>Conclusions</title>", "<p>Our comprehensive meta-analysis sheds light on sex-based disparities in TR, revealing distinct baseline characteristics and treatment outcomes between male and female patients. While males generally exhibited higher baseline cardiac function, they required more PPM across various...	[ "<p>Tricuspid regurgitation (TR) is a heart condition where blood flows backward through the tricuspid valve. Tricuspid valve disease constitutes a major valvular heart condition that is receiving heightened attention due to tailored treatment options and sex-specific differences in treatment outcomes. The study ai...	[ "<title>Review</title>", "<p>Materials and methods</p>", "<p>Literature Searches</p>", "<p>The Population, Intervention, Comparator, and Outcome (PICO) standard was used in the development of search terms to detect studies that provide comparisons of sex-specific treatment outcome comparisons in adult patient...	[]	[ "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG1\"><label>Figure 1</label><caption><title>PRISMA chart</title><p>The flowchart represents the methodology of the article on sex differences in tricuspid valve disease</p></caption></fig>", "<fig position=\"anchor\" fig-type=\"figure\" id=\"FIG2\"><label>Figur...	[ "<table-wrap position=\"float\" id=\"TAB1\"><label>Table 1</label><caption><title>Risk-of-bias assessment using the NOS</title><p>Scotti et al. 2022 [##REF##36445158##17##]; Veen et al. 2018 [##REF##30517619##18##]; Chandrashekar et al. 2018 [##UREF##5##19##]; Dietz et al. 2021 [##REF##33640367##20##]; Gual-Capllon...	[]	[]	[]	[]	[]	[]	[ "<fn-group content-type=\"other\"><title>Author Contributions</title><fn fn-type=\"other\"><p><bold>Concept and design:</bold> Ayesha Islam Khan, Tahoora N. Surve, Virushnee Senthilkumar, Nishant Kumar, Abdul Haseeb, Shinto Bosco, Soujanya Tirupati, Asem M. Thaher, Saya Alasaadi, Rajeswari Ramalingame, Umer Sulema...	[ "<graphic xlink:href=\"cureus-0015-00000050478-i01\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050478-i02\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050478-i03\" position=\"float\"/>", "<graphic xlink:href=\"cureus-0015-00000050478-i04\" position=\"float\"/>", "<gr...	[]	[{"label": ["1"], "article-title": ["Problem: tricuspid valve regurgitation"], "date-in-citation": ["\n"], "month": ["10"], "year": ["2023", "2023"], "uri": ["https://www.heart.org/en/health-topics/heart-valve-problems-and-disease/heart-valve-problems-and-causes/problem-tricuspid-valve-regurgitation"]}, {"label": ["9"]...	{ "acronym": [], "definition": [] }	36	CC BY	no	2024-01-14 23:40:08	Cureus.; 15(12):e50478	oa_package/26/c5/PMC10786711.tar.gz
PMC10786713	37996700	[ "<title>Introduction</title>", "<p id=\"Par3\">The process of cancer progression is supported by replacement of normal tissue matrix with tumor-associated matrix which is primarily produced by cancer-associated fibroblasts (CAFs). A major structural component of the tumor extracellular matrix (ECM) is fibrillar c...	[ "<title>Materials and methods</title>", "<title>Cell lines and culture</title>", "<p id=\"Par34\">ES2 cells were obtained from NCI and maintained in McCoy’s 5A (modified) medium (Gibco 16600082) supplemented with 10% heat inactivated fetal bovine serum (FBS) and 1% penicillin and streptomycin (Penstrep) (Gibco ...	[ "<title>Results</title>", "<title>DDR2-null mice have decreased ovarian tumor burden</title>", "<p id=\"Par6\">Immunohistochemical evaluation of advanced stage, human ovarian cancer specimens demonstrate that high expression of DDR2 in tumors is associated with poor survival [##UREF##0##22##]. Since DDR2 is pre...	[ "<title>Discussion</title>", "<p id=\"Par27\">DDR2 signaling in multiple preclinical tumor models has been shown to impact tumor progression and metastasis, and high DDR2 expression in human tumor specimens has been associated with worse clinical outcomes [##REF##18023033##12##–##REF##22328973##14##, ##REF##26362...	[]	[ "<p id=\"Par1\">Ovarian cancer has poor survival outcomes particularly for advanced stage, metastatic disease. Metastasis is promoted by interactions of stromal cells, such as cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME), with tumor cells. CAFs play a key role in tumor progression by rem...	[ "<title>Supplementary information</title>", "<p>\n\n\n\n\n\n\n\n\n\n</p>" ]	[ "<title>Supplementary information</title>", "<p>The online version contains supplementary material available at 10.1038/s41388-023-02884-3.</p>", "<title>Acknowledgements</title>", "<p>Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health R01...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>Deletion of host DDR2 leads to decrease in tumor burden.</title><p><bold>A</bold> DDR2-positive ID8 <italic>Trp53</italic><sup>−/−</sup>\n<italic>Brca2</italic><sup>−/−</sup> (ID8TB<sup>−/−</sup>) mouse ovarian surface epithelium cell (MOSEC) tumor line was int...	[]	[]	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM3\"></supplementary-material>", "<supplementary-material ...	[ "<fn-group><fn><p><bold>Publisher’s note</bold> Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn><fn><p>These authors contributed equally: Gregory D. Longmore, Katherine C. Fuh.</p></fn></fn-group>" ]	[ "<graphic position=\"anchor\" xlink:href=\"41388_2023_2884_Figa_HTML\" id=\"d32e339\"/>", "<graphic xlink:href=\"41388_2023_2884_Fig1_HTML\" id=\"d32e545\"/>", "<graphic xlink:href=\"41388_2023_2884_Fig2_HTML\" id=\"d32e695\"/>", "<graphic xlink:href=\"41388_2023_2884_Fig3_HTML\" id=\"d32e790\"/>", "<graphi...	[ "<media xlink:href=\"41388_2023_2884_MOESM1_ESM.docx\"><caption><p>Supplemental methods</p></caption></media>", "<media xlink:href=\"41388_2023_2884_MOESM2_ESM.pptx\"><caption><p>Supplemental Figures and Legends</p></caption></media>", "<media xlink:href=\"41388_2023_2884_MOESM3_ESM.xlsx\"><caption><p>Supplemen...	[{"label": ["22."], "mixed-citation": ["Schab AM, Greenwade MM, Stock E, Lomonosova E, Cho K, Grither WR, et al. Stromal DDR2 Promotes Ovarian Cancer Metastasis through Regulation of Metabolism and Secretion of Extracellular Matrix Proteins. Mol Cancer Res. 2023;21:1234\u201348."]}, {"label": ["36."], "surname": ["Kivi...	{ "acronym": [], "definition": [] }	55	CC BY	no	2024-01-14 23:40:09	Oncogene. 2024 Nov 23; 43(3):189-201	oa_package/49/49/PMC10786713.tar.gz
PMC10786714	38123640	[]	[ "<title>Methods</title>", "<title>Ethics</title>", "<p id=\"Par31\">No new aDNA data were generated for this study and we only analysed previously published and publicly available aDNA data. Identifying biological kin is a standard analysis in the aDNA field. Permission for aDNA work on the archaeological sampl...	[ "<title>Results</title>", "<title>Identifying IBD with ancIBD</title>", "<p id=\"Par5\">Our method consists of two computational steps (Fig. ##FIG##0##1b##). In a preprocessing step, the aDNA data are first computationally imputed and phased using a modern reference haplotype panel. In the main step, we apply a...	[ "<title>Discussion</title>", "<p id=\"Par23\">We have introduced ancIBD, a method to detect IBD segments optimized for aDNA data. The algorithm follows a long line of work using probabilistic HMMs to screen for IBD segments<sup>##REF##20529903##40##–##REF##34718411##44##</sup>. When compared to other methods to d...	[]	[ "<p id=\"Par1\">Long DNA segments shared between two individuals, known as identity-by-descent (IBD), reveal recent genealogical connections. Here we introduce ancIBD, a method for identifying IBD segments in ancient human DNA (aDNA) using a hidden Markov model and imputed genotype probabilities. We demonstrate tha...	[ "<title>Main</title>", "<p id=\"Par3\">Some pairs of individuals share long, nearly identical genomic segments, so-called IBD segments, that must be co-inherited from a recent common ancestor because recombination during each meiosis leads to the rapid break-up of these segments. Consequently, long IBD segments p...	[ "<title>Extended data</title>", "<p id=\"Par67\">\n\n</p>", "<p id=\"Par68\">\n\n</p>", "<p id=\"Par69\">\n\n</p>", "<p id=\"Par70\">\n\n</p>", "<p id=\"Par71\">\n\n</p>", "<p id=\"Par72\">\n\n</p>", "<p id=\"Par73\">\n\n</p>", "<p id=\"Par74\">\n\n</p>", "<title>Extended data</title>", "<p id=\...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>Overview of the ancIBD algorithm.</title><p><bold>a</bold>, Sketch of the ancIBD HHM. The HMM has five states: one background state of no allele sharing and four states modelling the four possible IBD-sharing states between two phased diploid genomes. We model ...	[ "<table-wrap id=\"Tab1\"><label>Extended Data Table 1</label><caption><p>Inferred segment length in simulated WGS-like data</p></caption></table-wrap>", "<table-wrap id=\"Tab2\"><label>Extended Data Table 2</label><caption><p>Inferred segment length in simulated 1240k-like data</p></caption></table-wrap>", "<ta...	[ "<inline-formula id=\"IEq1\"><alternatives><tex-math id=\"M1\">\\documentclass[12pt]{minimal}\n\t\t\t\t\\usepackage{amsmath}\n\t\t\t\t\\usepackage{wasysym} \n\t\t\t\t\\usepackage{amsfonts} \n\t\t\t\t\\usepackage{amssymb} \n\t\t\t\t\\usepackage{amsbsy}\n\t\t\t\t\\usepackage{mathrsfs}\n\t\t\t\t\\usepackage{upgreek}\n...	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM3\"></supplementary-material>", "<supplementary-material ...	[ "<table-wrap-foot><p>For each of the simulated IBD lengths (4cM, 8cM, 12cM, 16cM, 20cM) with WGS-like data quality at various coverages, the table shows the inferred segment length averaged over 500 independent replicates.</p></table-wrap-foot>", "<table-wrap-foot><p>For each of the simulated IBD lengths (4cM, 8c...	[ "<graphic xlink:href=\"41588_2023_1582_Fig1_HTML\" id=\"d32e347\"/>", "<graphic xlink:href=\"41588_2023_1582_Fig2_HTML\" id=\"d32e456\"/>", "<graphic xlink:href=\"41588_2023_1582_Fig3_HTML\" id=\"d32e575\"/>", "<inline-graphic xlink:href=\"41588_2023_1582_Article_IEq1.gif\"/>", "<graphic xlink:href=\"41588_...	[ "<media xlink:href=\"41588_2023_1582_MOESM1_ESM.pdf\"><label>Supplementary Information</label><caption><p>Supplementary Notes 1–11.</p></caption></media>", "<media xlink:href=\"41588_2023_1582_MOESM2_ESM.pdf\"><caption><p>Reporting Summary</p></caption></media>", "<media xlink:href=\"41588_2023_1582_MOESM3_ESM....	[{"label": ["8."], "mixed-citation": ["Ferrando-Bernal, M. et al. Mapping co-ancestry connections between the genome of a medieval individual and modern Europeans. "], "italic": ["Sci. Rep."], "bold": ["10"]}, {"label": ["10."], "mixed-citation": ["Allentoft, M. E. et al. Population genomics of Stone Age Eurasia. Prepr...	{ "acronym": [], "definition": [] }	61	CC BY	no	2024-01-14 23:40:09	Nat Genet. 2024 Dec 20; 56(1):143-151	oa_package/a5/54/PMC10786714.tar.gz
PMC10786715	38049662	[]	[ "<title>Methods</title>", "<title>Human study participants</title>", "<p id=\"Par34\">Study participants were recruited in accordance with IRB 2019P003155 from multiple phlebotomy clinics in the MGB hospital system. Sample sizes of measured blood profiles and genotyped subjects per perturbation condition are li...	[ "<title>Results</title>", "<title>Chemical perturbations expand the phenotypic space of blood profiles</title>", "<p id=\"Par7\">In clinical settings, whole blood cytometry is used to quantify circulating cells as part of standardized diagnostic tests. We adapted a widely-used whole-blood cytometry analyzer (Sy...	[ "<title>Discussion</title>", "<p id=\"Par27\">Over 3,300 traits have been investigated using GWAS in more than 1 million participants, with current studies continuing to increase sample sizes to improve statistical power. While the techniques are robust, it remains difficult to identify underlying biological effe...	[]	[ "<p id=\"Par1\">Although genome-wide association studies (GWAS) have successfully linked genetic risk loci to various disorders, identifying underlying cellular biological mechanisms remains challenging due to the complex nature of common diseases. We established a framework using human peripheral blood cells, phys...	[ "<title>Main</title>", "<p id=\"Par3\">Precision medicine strives to reclassify complex heterogeneous diseases into distinct biologically defined groups, thereby enabling targeted therapies and improved outcomes. Examples include the subdivision of common cancers by somatic driver mutations<sup>##REF##32778778##1...	[ "<title>Extended data</title>", "<p id=\"Par68\">\n\n</p>", "<p id=\"Par69\">\n\n</p>", "<p id=\"Par70\">\n\n</p>", "<p id=\"Par71\">\n\n</p>", "<p id=\"Par72\">\n\n</p>", "<p id=\"Par73\">\n\n</p>", "<title>Extended data</title>", "<p id=\"Par64\">is available for this paper at 10.1038/s41588-023-0...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>Chemical perturbations expand the phenotypic space of quantitative blood profiles, and blood cell responses are associated with clinical phenotypes and genetic variants.</title><p><bold>a</bold>, Recruitment setting and application of a standard hematological a...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Genetic regions associated with whole-blood perturbation response traits</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th>Lead SNP</th><th>rsID</th><th><italic>P</italic> value</th><th>Candidate genes</th><th>CADD consequence</th><th>Top...	[]	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM3\"></supplementary-material>", "<supplementary-material ...	[ "<table-wrap-foot><p>Associations for blood traits and perturbation conditions were clumped to produce unique genomic regions across multiple conditions. Two-sided <italic>P</italic> values are based on <italic>t</italic> tests in linear regression models and are not adjusted for multiple testing. Variants with the...	[ "<graphic xlink:href=\"41588_2023_1600_Fig1_HTML\" id=\"d32e482\"/>", "<graphic xlink:href=\"41588_2023_1600_Fig2_HTML\" id=\"d32e641\"/>", "<graphic xlink:href=\"41588_2023_1600_Fig3_HTML\" id=\"d32e1963\"/>", "<graphic xlink:href=\"41588_2023_1600_Fig4_HTML\" id=\"d32e2194\"/>", "<graphic xlink:href=\"415...	[ "<media xlink:href=\"41588_2023_1600_MOESM1_ESM.pdf\"><label>Supplementary Information</label><caption><p>Supplementary Notes, Supplementary Figs. 1–7 and Supplementary Tables 1–6.</p></caption></media>", "<media xlink:href=\"41588_2023_1600_MOESM2_ESM.pdf\"><caption><p>Reporting Summary</p></caption></media>", ...	[{"label": ["6."], "surname": ["Uffelmann"], "given-names": ["E"], "article-title": ["Genome-wide association studies"], "source": ["Nat. Rev. Methods Prim."], "year": ["2021"], "volume": ["1"], "fpage": ["59"]}, {"label": ["50."], "mixed-citation": ["Meyer, H. V. meyer-lab-cshl/plinkQC: plinkQC 0.3.2 (v0.3.2). Zenodo....	{ "acronym": [], "definition": [] }	54	CC BY	no	2024-01-14 23:40:09	Nat Genet. 2024 Dec 4; 56(1):37-50	oa_package/d3/69/PMC10786715.tar.gz
PMC10786716	38123642	[]	[ "<title>Methods</title>", "<title>The BridgePRS model</title>", "<p id=\"Par29\">All modeling is performed at the locus-level, and each locus is assumed to be independent of all others. A locus is defined as a genomic region that captures all variants with <italic>r</italic><sup>2</sup> > 0.01 within 1 Mb of...	[ "<title>Results</title>", "<title>Overview of BridgePRS method</title>", "<p id=\"Par7\">An overview of the BridgePRS modeling employed here is shown in Fig. ##FIG##0##1##. The key modeling (model 1 in Fig. ##FIG##0##1##; <xref rid=\"Sec7\" ref-type=\"sec\">Methods</xref>) can be broken into two stages: (1) a P...	[ "<title>Discussion</title>", "<p id=\"Par24\">We have introduced a trans-ancestry PRS method, BridgePRS, that leverages shared genetic effects across ancestries to increase the accuracy of PRS in non-European populations. We benchmarked BridgePRS and the leading trans-ancestry PRS method PRS-CSx, as well as singl...	[]	[ "<p id=\"Par1\">Here we present BridgePRS, a novel Bayesian polygenic risk score (PRS) method that leverages shared genetic effects across ancestries to increase PRS portability. We evaluate BridgePRS via simulations and real UK Biobank data across 19 traits in individuals of African, South Asian and East Asian anc...	[ "<title>Main</title>", "<p id=\"Par3\">PRSs have typically been derived using European ancestry genome-wide association study (GWAS) data, resulting in substantially lower predictive power when applied to non-European samples, in particular those of African ancestry<sup>##REF##28366442##1##,##REF##31346163##2##</...	[ "<title>Extended data</title>", "<p id=\"Par60\">\n\n</p>", "<p id=\"Par61\">\n\n</p>", "<p id=\"Par62\">\n\n</p>", "<p id=\"Par63\">\n\n</p>", "<p id=\"Par64\">\n\n</p>", "<p id=\"Par65\">\n\n</p>", "<p id=\"Par66\">\n\n</p>", "<title>Extended data</title>", "<p id=\"Par56\">is available for this...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>Flow diagram describing the modeling of BridgePRS.</title><p><bold>a</bold>, Two-stage approach to combine GWASs from two populations. <bold>b</bold>, BridgePRS combining three different PRS models to determine the final PRS. <italic>β</italic>, SNP effect size...	[ "<table-wrap id=\"Tab1\"><label>Extended Data Table 1</label><caption><p>GWAS and UK Biobank test and validation sample sizes</p></caption></table-wrap>", "<table-wrap id=\"Tab2\"><label>Extended Data Table 2</label><caption><p><italic>Bio</italic>Me Biobank sample sizes for individuals of African, South Asian an...	[ "<inline-formula id=\"IEq1\"><alternatives><tex-math id=\"M1\">\\documentclass[12pt]{minimal}\n\t\t\t\t\\usepackage{amsmath}\n\t\t\t\t\\usepackage{wasysym} \n\t\t\t\t\\usepackage{amsfonts} \n\t\t\t\t\\usepackage{amssymb} \n\t\t\t\t\\usepackage{amsbsy}\n\t\t\t\t\\usepackage{mathrsfs}\n\t\t\t\t\\usepackage{upgreek}\n...	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM3\"></supplementary-material>" ]	[ "<table-wrap-foot><p>African and South Asian GWASs used UK Biobank samples, Biobank Japan was used for East Asian GWAS summary data, for East Asians numbers are only shown for those traits with overlapping BBJ summary statistics. Across all traits 10,000 European samples were used as test data. Height - Standing he...	[ "<inline-graphic xlink:href=\"41588_2023_1583_Article_IEq1.gif\"/>", "<graphic xlink:href=\"41588_2023_1583_Fig1_HTML\" id=\"d32e434\"/>", "<inline-graphic xlink:href=\"41588_2023_1583_Article_IEq2.gif\"/>", "<inline-graphic xlink:href=\"41588_2023_1583_Article_IEq3.gif\"/>", "<graphic xlink:href=\"41588_20...	[ "<media xlink:href=\"41588_2023_1583_MOESM1_ESM.pdf\"><label>Supplementary Information</label><caption><p>Supplementary Table 1 and Figs. 1–4.</p></caption></media>", "<media xlink:href=\"41588_2023_1583_MOESM2_ESM.pdf\"><caption><p>Reporting Summary</p></caption></media>", "<media xlink:href=\"41588_2023_1583_...	[{"label": ["4."], "mixed-citation": ["Hu, S. et al. Leveraging fine-scale population structure reveals conservation in genetic effect sizes between human populations across a range of human phenotypes. Preprint at "], "italic": ["bioRxiv"]}, {"label": ["14."], "mixed-citation": ["Choi, S. W. & O\u2019Reilly, P. F. PRS...	{ "acronym": [], "definition": [] }	32	CC BY	no	2024-01-14 23:40:09	Nat Genet. 2024 Dec 20; 56(1):180-186	oa_package/f5/56/PMC10786716.tar.gz
PMC10786717	37989866	[ "<title>Introduction</title>", "<p id=\"Par2\">The propensity of an organ to foster metastatic lesions is variable, with the lung, liver, ovarian, peritoneum, and bone being common metastatic sites in gastric cancer [##REF##31695791##1##, ##REF##31273177##2##]. Primary gastric cancers (GCs) tend to metastasize to...	[ "<title>Materials and methods</title>", "<title>Cell lines</title>", "<p id=\"Par23\">The gastric cancer cell NCI-N87 and MGC-803 were purchased from ATCC, the human peritoneal mesothelial cell line HMrSV5 and gastric cancer cell SGC-7901 was obtained from the cell bank of the Chinese Academy of Sciences (Shang...	[ "<title>Results</title>", "<title>HOXA11 over-expressed gastric cancer cells strongly propelled mesothelial fibrosis in vivo and in vitro</title>", "<p id=\"Par7\">Based on our previous work showing that HOXA11 overexpression could accelerate peritoneal dissemination of gastric cancer (GC) cells [##REF##3169579...	[ "<title>Discussion</title>", "<p id=\"Par14\">Our work offers a promise for the understanding of a formerly ambiguous mechanism for peritoneal dissemination of GC that is related with HOXA11-PDGF BB/TGF β1-miR-181a-5p-Egr1 feedforward amplifier circuity (Fig. ##FIG##7##8S##).</p>", "<p id=\"Par15\">Our work pro...	[ "<title>Conclusions</title>", "<p id=\"Par22\">In conclusion, our study shed new light on Egr1 as a key driver that activates mesothelial fibrosis and prompts migration of GC cells, on the basis of our findings and works from other researchers, HOXA11-PDGF BB/TGF β1-miR-181a-5p-Egr1 feedforward amplifier circuity...	[ "<p id=\"Par1\">A proportion of gastric cancer (GC) patients suffer from peritoneal metastasis (PM) in the late stage of tumor and these patients have a poor prognosis. To provide more care for GC patient with PM, a deeper exploration of the molecular characteristics of GC-PM is needed. Here we performed the in vit...	[ "<title>Supplementary information</title>", "<p>\n\n</p>" ]	[ "<title>Supplementary information</title>", "<p>The online version contains supplementary material available at 10.1038/s41388-023-02891-4.</p>", "<title>Author contributions</title>", "<p>CW, CZ and JZ, designed and performed the experiments; JJ and YJ, provided the human samples; CW and YJ, wrote the manusc...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>HOXA11 which expressed in gastric cancer cells could modulate the fibrosis of peritoneal mesothelial cells.</title><p><bold>A</bold> H&E images of peritoneal metastatic foci sections derived from BALB/c mice of NCI-N87-Vecotr and NCI-N87-HOXA11 gastric canc...	[]	[]	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>" ]	[ "<fn-group><fn><p><bold>Publisher’s note</bold> Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn><fn><p>These authors contributed equally: Chao Wang, Jun Ji, Yangbing Jin.</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"41388_2023_2891_Fig1_HTML\" id=\"d32e400\"/>", "<graphic xlink:href=\"41388_2023_2891_Fig2_HTML\" id=\"d32e534\"/>", "<graphic xlink:href=\"41388_2023_2891_Fig3_HTML\" id=\"d32e662\"/>", "<graphic xlink:href=\"41388_2023_2891_Fig4_HTML\" id=\"d32e730\"/>", "<graphic xlink:href=\"41388...	[ "<media xlink:href=\"41388_2023_2891_MOESM1_ESM.docx\"><caption><p>Supplementary information</p></caption></media>" ]	[{"label": ["5."], "mixed-citation": ["Aguirre-Ghiso JA. Sosa MSJARoCB. Emerging Topics on Disseminated Cancer Cell Dormancy and the Paradigm of Metastasis. Annu Rev Cancer Biol. 2018;2:377\u201393."]}, {"label": ["13."], "surname": ["Zhu"], "given-names": ["Z"], "article-title": ["[Clinical significance and practice p...	{ "acronym": [], "definition": [] }	51	CC BY	no	2024-01-14 23:40:10	Oncogene. 2024 Nov 21; 43(3):171-188	oa_package/8c/b7/PMC10786717.tar.gz
PMC10786718	38155330	[]	[ "<title>Methods</title>", "<title>Study design and cohort descriptions</title>", "<p id=\"Par18\">We used a single joint meta-analysis study design to maximize statistical power<sup>##REF##16415888##40##</sup>. We used datasets representing four different ancestry groups: European, East Asian, Latin American an...	[]	[ "<title>Discussion</title>", "<p id=\"Par12\">This study is a large-scale GWAS meta-analysis of PD that incorporates multiple diverse ancestry populations. From the joint cohort analysis, we identified 66 independent risk loci near previously known PD risk regions and 12 potentially novel risk loci. Of the putati...	[]	[ "<p id=\"Par1\">Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,...	[ "<title>Main</title>", "<p id=\"Par3\">Parkinson’s disease (PD) is a neurodegenerative disease pathologically defined by Lewy body inclusions in the brain and the death of dopaminergic neurons in the midbrain. The identification of genetic risk factors is imperative for mitigating the global burden of PD, one of ...	[ "<title>Supplementary information</title>", "<p>The online version contains supplementary material available at 10.1038/s41588-023-01584-8.</p>", "<title>Acknowledgements</title>", "<p>This work was supported by the following grants and institutions: Intramural Research Program of the National Institutes of H...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>MAMA study design.</title><p>Top panel: four ancestry groups used in the meta-analysis. Middle panel: MAMA and the two methods used. Random-effect (top) is better suited for risk variants with homogeneous effect direction across different ancestries, whereas MR...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Cohort descriptions</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th>Study</th><th>Ancestral population</th><th>Cases/proxy/controls</th></tr></thead><tbody><tr><td>Nalls et al.<sup>##REF##31701892##1##</sup></td><td>European (EUR)</td><...	[ "<disp-formula id=\"Equa\"><alternatives><tex-math id=\"M1\">\\documentclass[12pt]{minimal}\n\t\t\t\t\\usepackage{amsmath}\n\t\t\t\t\\usepackage{wasysym} \n\t\t\t\t\\usepackage{amsfonts} \n\t\t\t\t\\usepackage{amssymb} \n\t\t\t\t\\usepackage{amsbsy}\n\t\t\t\t\\usepackage{mathrsfs}\n\t\t\t\t\\usepackage{upgreek}\n\t...	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM3\"></supplementary-material>", "<supplementary-material ...	[ "<table-wrap-foot><p>MR-MEGA could not be run for the lead SNP of the <italic>FASN</italic> locus, as it was missing in more than three cohorts: Foo et al.<sup>##REF##32310270##2##</sup>, 23andMe East Asian and 23andMe Latino. No <italic>P</italic> values were corrected for multiple tests. CHR, chromosome; BP, base...	[ "<graphic xlink:href=\"41588_2023_1584_Fig1_HTML\" id=\"d32e3640\"/>", "<graphic xlink:href=\"41588_2023_1584_Fig2_HTML\" id=\"d32e4484\"/>", "<graphic xlink:href=\"41588_2023_1584_Fig3_HTML\" id=\"d32e4506\"/>", "<graphic xlink:href=\"41588_2023_1584_Article_Equa.gif\" position=\"anchor\"/>" ]	[ "<media xlink:href=\"41588_2023_1584_MOESM1_ESM.pdf\"><label>Supplementary Information</label><caption><p>Supplementary Figs. 1–12.</p></caption></media>", "<media xlink:href=\"41588_2023_1584_MOESM2_ESM.pdf\"><caption><p>Reporting Summary</p></caption></media>", "<media xlink:href=\"41588_2023_1584_MOESM3_ESM....	[{"label": ["5."], "mixed-citation": ["Global Parkinson\u2019s Genetics Program. GP2: The Global Parkinson\u2019s Genetics Program. "], "italic": ["Mov. Disord"], "bold": ["36"]}, {"label": ["9."], "mixed-citation": ["Smeland, O. B. et al. Genome-wide association analysis of Parkinson\u2019s disease and schizophrenia r...	{ "acronym": [], "definition": [] }	59	CC BY	no	2024-01-14 23:40:10	Nat Genet. 2024 Dec 28; 56(1):27-36	oa_package/56/12/PMC10786718.tar.gz
PMC10786719	38036782	[]	[ "<title>Methods</title>", "<title>Cell culture</title>", "<p id=\"Par14\">The generation of hTERT-RPE1 <italic>ΔTP53, ΔBRCA1</italic> and <italic>ΔBRCA2</italic> cells has been described elsewhere<sup>##REF##29973717##20##,##REF##35107878##21##</sup>. They were gifts from M. Tarsounas (University of Oxford) and...	[]	[]	[]	[ "<p id=\"Par1\">The chemotherapeutic agent CX-5461, or pidnarulex, has been fast-tracked by the United States Food and Drug Administration for early-stage clinical studies of <italic>BRCA1-</italic>, <italic>BRCA2-</italic> and <italic>PALB2</italic>-mutated cancers. It is under investigation in phase I and II tria...	[ "<title>Main</title>", "<p id=\"Par3\">CX-5461 was initially characterized as a selective inhibitor of RNA polymerase I-dependent RNA synthesis, with application in hematological malignancies<sup>##REF##21159662##1##–##REF##33196044##3##</sup>. More recently, CX-5461 was reported to exhibit synthetic lethal prope...	[ "<title>Extended data</title>", "<p id=\"Par36\">\n\n</p>", "<p id=\"Par37\">\n\n</p>", "<p id=\"Par38\">\n\n</p>", "<title>Extended data</title>", "<p id=\"Par32\">is available for this paper at 10.1038/s41588-023-01602-9.</p>", "<title>Supplementary information</title>", "<p id=\"Par33\">The online ...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>CX-5461 induces heavy mutagenesis, leaving distinctive mutational signatures in hTERT-immortalized RPE1 cells.</title><p><bold>a</bold>, Mutation accumulation experiment in which isogenic RPE1-<italic>BRCA1</italic><sup>–/–</sup>, <italic>-BRCA2</italic><sup>–/...	[]	[]	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM3\"></supplementary-material>" ]	[ "<fn-group><fn><p><bold>Publisher’s note</bold> Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"41588_2023_1602_Fig1_HTML\" id=\"d32e404\"/>", "<graphic xlink:href=\"41588_2023_1602_Fig2_HTML\" id=\"d32e553\"/>", "<graphic position=\"anchor\" xlink:href=\"41588_2023_1602_Fig3_ESM\" id=\"d32e977\"/>", "<graphic position=\"anchor\" xlink:href=\"41588_2023_1602_Fig4_ESM\" id=\"d32e10...	[ "<media xlink:href=\"41588_2023_1602_MOESM1_ESM.pdf\"><caption><p>Reporting Summary</p></caption></media>", "<media xlink:href=\"41588_2023_1602_MOESM2_ESM.pdf\"><caption><p>Peer Review File</p></caption></media>", "<media xlink:href=\"41588_2023_1602_MOESM3_ESM.xlsx\"><label>Supplementary Tables</label><captio...	[{"label": ["7."], "surname": ["Alqaisi"], "given-names": ["H"], "article-title": ["OZM-114: phase Ib expansion study of CX-5461in patients with solid tumors and BRCA2 and/or PALB2 mutation"], "source": ["J. Clin. Oncol."], "year": ["2022"], "volume": ["40"], "fpage": ["TPS5621"], "lpage": ["TPS5621"], "pub-id": ["10.1...	{ "acronym": [], "definition": [] }	30	CC BY	no	2024-01-14 23:40:10	Nat Genet. 2024 Nov 30; 56(1):23-26	oa_package/1b/4f/PMC10786719.tar.gz
PMC10786720	38177344	[]	[ "<title>Methods</title>", "<title>Ethics</title>", "<p id=\"Par22\">It is not applicable because no biological samples were collected and no animal handling was performed for this study.</p>", "<title>RNA-seq data analysis and molecular phenotype quantification</title>", "<p id=\"Par23\">In total, we gather...	[ "<title>Results</title>", "<title>Data summary</title>", "<p id=\"Par6\">After filtering out the low-quality samples from the initial set of 9,530, we retained 7,095 RNA-seq profiles for downstream analysis (Supplementary Fig. ##SUPPL##0##1## and ##SUPPL##0##Supplementary Note##). We quantified expression level...	[ "<title>Discussion</title>", "<p id=\"Par20\">The pilot PigGTEx offers a deep survey of genetic regulatory effects across a wide range of tissues, representing a substantial advance in the understanding of the gene regulation landscape in pigs. This multi-tissue catalog of regulatory variants further advances our...	[]	[ "<p id=\"Par1\">The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biological discovery and exploitation in a...	[ "<title>Main</title>", "<p id=\"Par3\">Genome-wide association studies (GWAS) reveal genomic variants associated with complex phenotypes at an unprecedented speed and scale in both plants<sup>##REF##33442955##1##</sup> and animals<sup>##REF##34850103##2##</sup>, but particularly in humans<sup>##REF##33214558##3##...	[ "<title>Extended data</title>", "<p id=\"Par45\">\n\n</p>", "<p id=\"Par46\">\n\n</p>", "<p id=\"Par47\">\n\n</p>", "<p id=\"Par48\">\n\n</p>", "<p id=\"Par49\">\n\n</p>", "<p id=\"Par50\">\n\n</p>", "<p id=\"Par51\">\n\n</p>", "<p id=\"Par52\">\n\n</p>", "<p id=\"Par53\">\n\n</p>", "<p id=\"Par...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>Characteristics of samples in the pilot phase of PigGTEx project.</title><p><bold>a</bold>, Clustering of 7,095 RNA-seq samples based on the normalized expression (log<sub>10</sub>-transformed TPM) of 6,500 highly variable genes, defined as the top 20% of genes...	[]	[ "<inline-formula id=\"IEq1\"><alternatives><tex-math id=\"M1\">\\documentclass[12pt]{minimal}\n\t\t\t\t\\usepackage{amsmath}\n\t\t\t\t\\usepackage{wasysym} \n\t\t\t\t\\usepackage{amsfonts} \n\t\t\t\t\\usepackage{amssymb} \n\t\t\t\t\\usepackage{amsbsy}\n\t\t\t\t\\usepackage{mathrsfs}\n\t\t\t\t\\usepackage{upgreek}\n...	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM3\"></supplementary-material>", "<supplementary-material ...	[ "<fn-group><fn><p><bold>Publisher’s note</bold> Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn><fn><p>These authors contributed equally: Jinyan Teng, Yahui Gao, Hongwei Yin, Zhonghao Bai, Shuli Liu, Haonan Zeng.</p></fn><fn><p>A list of...	[ "<graphic xlink:href=\"41588_2023_1585_Fig1_HTML\" id=\"d32e1528\"/>", "<graphic xlink:href=\"41588_2023_1585_Fig2_HTML\" id=\"d32e1851\"/>", "<graphic xlink:href=\"41588_2023_1585_Fig3_HTML\" id=\"d32e2210\"/>", "<graphic xlink:href=\"41588_2023_1585_Fig4_HTML\" id=\"d32e2427\"/>", "<graphic xlink:href=\"4...	[ "<media xlink:href=\"41588_2023_1585_MOESM1_ESM.pdf\"><label>Supplementary Information</label><caption><p>Supplementary Note and Supplementary Figs. 1–21.</p></caption></media>", "<media xlink:href=\"41588_2023_1585_MOESM2_ESM.pdf\"><caption><p>Reporting Summary</p></caption></media>", "<media xlink:href=\"4158...	[{"label": ["23."], "mixed-citation": ["Pividori, M. et al. 2020 PhenomeXcan: mapping the genome to the phenome through the transcriptome. "], "italic": ["Sci. Adv."], "bold": ["6"]}, {"label": ["25."], "mixed-citation": ["Barbeira A. N. et al. 2018 Exploring the phenotypic consequences of tissue specific gene expressi...	{ "acronym": [], "definition": [] }	65	CC BY	no	2024-01-14 23:40:10	Nat Genet. 2024 Jan 4; 56(1):112-123	oa_package/59/f2/PMC10786720.tar.gz
PMC10786721	0	[ "<title>Introduction</title>", "<p id=\"Par3\">In addition to several genetic and biochemical factors contributing to the metastatic progression, the biomechanical forces are widely reported to be of considerable importance<sup>##REF##21701513##1##,##UREF##0##2##</sup>. Among these forces, the hemodynamic forces ...	[ "<title>Materials and methods</title>", "<title>Cancer cells culture</title>", "<p id=\"Par27\">Immortalized breast cancer cell vials (MCF-7, SK-BR-3, and MDA-MB-231 cell lines with moderate to high metastatic potential<sup>##REF##12527894##65##</sup>) were taken out from storage and cultured in Dulbecco’s Modi...	[ "<title>Results and discussion</title>", "<title>Experimental measurement</title>", "<p id=\"Par10\">In this study, to investigate the deformation behavior of breast cancer cells in a microcapillary similar to that of CTCs passing confined spaces, we measured the entry process of the cells entering narrow const...	[ "<title>Results and discussion</title>", "<title>Experimental measurement</title>", "<p id=\"Par10\">In this study, to investigate the deformation behavior of breast cancer cells in a microcapillary similar to that of CTCs passing confined spaces, we measured the entry process of the cells entering narrow const...	[ "<title>Conclusion</title>", "<p id=\"Par25\">This study investigated the feasibility of numerically replicating the deformation behavior of single CTCs passing confined spaces in microcapillaries using an advanced in-silico method at the cellular scale. The proposed SNM-based in-silico method was enabled by the ...	[ "<p id=\"Par1\">During the multistep process of metastasis, cancer cells encounter various mechanical forces which make them deform drastically. Developing accurate in-silico models, capable of simulating the interactions between the mechanical forces and highly deformable cancer cells, can pave the way for the dev...	[ "<title>Supplementary information</title>", "<p>\n\n</p>" ]	[ "<title>Supplementary information</title>", "<p>The online version contains supplementary material available at 10.1038/s41378-023-00644-7.</p>", "<title>Acknowledgements</title>", "<p>This work was supported by the Natural Sciences and Engineering Research Council of Canada (RGPIN-2020-05522 & RGPIN- 202...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>Experimental set up for cancer cell deformability measurement.</title><p><bold>a</bold> Experimental set up for high-speed measurements of the single breast cancer cell deformability. <bold>b</bold> Captured images from entry process of the single breast cancer...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>The quantities of the 16 μm cell model parameters for the best ones at each generation</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th>Generation</th><th></th><th></th><th></th><th></th><th></th><th></th><th></th><th></th><th></th></tr>...	[ "<inline-formula id=\"IEq1\"><alternatives><tex-math id=\"M1\">\\documentclass[12pt]{minimal}\n\t\t\t\t\\usepackage{amsmath}\n\t\t\t\t\\usepackage{wasysym} \n\t\t\t\t\\usepackage{amsfonts} \n\t\t\t\t\\usepackage{amssymb} \n\t\t\t\t\\usepackage{amsbsy}\n\t\t\t\t\\usepackage{mathrsfs}\n\t\t\t\t\\usepackage{upgreek}\n...	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>" ]	[]	[ "<graphic position=\"anchor\" xlink:href=\"41378_2023_644_Figa_HTML\" id=\"d32e201\"/>", "<inline-graphic xlink:href=\"41378_2023_644_Article_IEq1.gif\"/>", "<inline-graphic xlink:href=\"41378_2023_644_Article_IEq2.gif\"/>", "<graphic xlink:href=\"41378_2023_644_Fig1_HTML\" id=\"d32e560\"/>", "<graphic xlin...	[ "<media xlink:href=\"41378_2023_644_MOESM1_ESM.zip\"><caption><p>Supplementary Videos</p></caption></media>" ]	[{"label": ["2."], "mixed-citation": ["Krog, B. L. & Henry, M. D. Biomechanics of the circulating tumor cell microenvironment. in "], "italic": ["Biomechanics in Oncology,"]}, {"label": ["3."], "mixed-citation": ["Ewing, J. Neoplastic diseases: a treatise on tumours. By James Ewing, A.M., M.D., Sc.D., Professor of Path...	{ "acronym": [], "definition": [] }	69	CC BY	no	2024-01-14 23:40:17	Microsyst Nanoeng. 2024 Jan 12; 10:7	oa_package/7b/d6/PMC10786721.tar.gz
PMC10786722	38216550	[ "<title>Introduction</title>", "<p id=\"Par2\">An increasing number of clinically relevant association between drug response and genomic variation has been reported over the past years, resulting in evidence-based pharmacogenetic guidelines [##UREF##0##1##, ##UREF##1##2##]. For instance, the Pharmacogenomics Know...	[ "<title>Materials and methods</title>", "<title>Studied cohort</title>", "<p id=\"Par5\">All patients included in this study were eligible for an uracil analog-based chemotherapy (Supplementary Table S##SUPPL##0##1##). Only those for which both <italic>DPYD</italic> genotype and DPD phenotype were available wer...	[ "<title>Results</title>", "<title>Inter-individual variability of pretherapeutic DPD enzyme activity</title>", "<p id=\"Par9\">This retrospective study included 2972 subjects. Mean patient age was 65 ± 11 years, and the sex ratio (M/F) was 1.2 (Supplementary Table S##SUPPL##0##1##). Using a cut-off value below ...	[ "<title>Discussion</title>", "<p id=\"Par14\">Innovative and collaborative research efforts over the last decades have substantially improved our understanding of the role played by inherited genetic changes on the interindividual variability in drug efficacy or toxicity [##REF##29844222##33##]. Large scale seque...	[]	[ "<p id=\"Par1\">Variability in genes involved in drug pharmacokinetics or drug response can be responsible for suboptimal treatment efficacy or predispose to adverse drug reactions. In addition to common genetic variations, large-scale sequencing studies have uncovered multiple rare genetic variants predicted to ca...	[ "<title>Supplementary information</title>", "<p>\n\n\n\n</p>" ]	[ "<title>Supplementary information</title>", "<p>The online version contains supplementary material available at 10.1038/s41397-023-00322-x.</p>", "<title>Author contributions</title>", "<p>Conceptualization, MP, CC and NP; Formal analysis, RL and BH; Investigation, NS and CD; Methodology, RL; Writing – origin...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>Association between the most clinically relevant <italic>DPYD</italic> defective rare variants and DPD deficiency.</title><p>Box plot showing DPD pretreatment activity assessed by the dihydrouracil/uracil ([UH<sub>2</sub>]/[U]) plasma ratio according to the pat...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Number of patients according to the uracil plasma concentration ([U]) and the dihydrouracil/uracil ([UH<sub>2</sub>]/[U]) plasma ratio.</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th>Phenotype</th><th>[U] < 16 ng/mL</th><th>[U] ≥ 16...	[]	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM3\"></supplementary-material>" ]	[ "<table-wrap-foot><p><italic>Alt</italic> alternative allele, <italic>B</italic> benign, <italic>CADD</italic> Combined Annotation Dependent Depletion, <italic>D</italic> deleterious, <italic>Eur</italic> european, <italic>Freq</italic> frequency, <italic>Het</italic> heterozygous, <italic>Hom</italic> homozygous, ...	[ "<graphic xlink:href=\"41397_2023_322_Fig1_HTML\" id=\"d32e3218\"/>", "<graphic xlink:href=\"41397_2023_322_Fig2_HTML\" id=\"d32e3272\"/>", "<graphic xlink:href=\"41397_2023_322_Fig3_HTML\" id=\"d32e3350\"/>" ]	[ "<media xlink:href=\"41397_2023_322_MOESM1_ESM.xlsx\"><caption><p>Table S1. Demographic parameters of the whole cohort compared in male versus female patients.</p></caption></media>", "<media xlink:href=\"41397_2023_322_MOESM2_ESM.xlsx\"><caption><p>Table S2. Custom-designed primer pairs and Sanger primer pairs.<...	[{"label": ["1."], "surname": ["Relling", "Klein", "Gammal", "Whirl-Carrillo", "Hoffman", "Caudle"], "given-names": ["MV", "TE", "RS", "M", "JM", "KE"], "article-title": ["The clinical pharmacogenetics implementation consortium: 10 years later"], "source": ["Clin Pharm Ther"], "year": ["2020"], "volume": ["107"], "fpag...	{ "acronym": [], "definition": [] }	46	CC BY	no	2024-01-14 23:40:10	Pharmacogenomics J. 2024 Jan 12; 24(1):1	oa_package/99/d7/PMC10786722.tar.gz
PMC10786723	37985676	[ "<title>Introduction</title>", "<p id=\"Par3\">Pluripotent Stem Cells (PSCs) emerged as a model to dissect and recapitulate the molecular events and gene networks that regulate cell fate determination, cell differentiation and organogenesis. Guided differentiation of PSCs into 3D organized tissue by inducible ove...	[ "<title>Material and methods</title>", "<title>Cell culture and mESC_Braf<sup>V637E</sup> line generation</title>", "<p id=\"Par31\">The previously genetically modified G4 RosaLuc mouse embryonic stem cell line (mESC) [##REF##23877658##103##] was initially cultured on gamma-irradiated mouse embryonic fibroblast...	[ "<title>Results</title>", "<title>mESC_BRAF<sup>V637E</sup> cell line generation and characterization</title>", "<p id=\"Par11\">We combined the previously described mESC transient induction thyroid differentiation strategy [##REF##23051751##4##] with a Braf<sup>V637E</sup>-ERT [##REF##27315476##2##] inducible ...	[ "<title>Discussion</title>", "<p id=\"Par25\">Here, we described a Braf<sup>V637E</sup> oncogene-derived thyroid cancer organoid model recapitulating patient tumor features. In vitro thyroid cancer models that recapitulate tumor development and behavior can facilitate the identification of early tumor drivers and...	[]	[ "<p id=\"Par1\">Thyroid cancer is the most common endocrine malignancy and several genetic events have been described to promote the development of thyroid carcinogenesis. Besides the effects of specific mutations on thyroid cancer development, the molecular mechanisms controlling tumorigenesis, tumor behavior, and...	[ "<title>Supplementary information</title>", "<p>\n\n\n</p>" ]	[ "<title>Supplementary information</title>", "<p>The online version contains supplementary material available at 10.1038/s41388-023-02889-y.</p>", "<title>Acknowledgements</title>", "<p>We acknowledge the ULB flow cytometry platform (C. Dubois), the ULB genomic core facility (F. Libert and A. Lefort), LiMIF pl...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>mESC_Nkx2-1/Pax8_bTg_Braf<sup>V637E</sup> cell line differentiation into thyroid organoids.</title><p>Scheme of the thyroid differentiation protocol and Braf<sup>V637E</sup> induction in mature thyroid follicles (<bold>A</bold>). Differentiation of mESC_Nkx2-1/...	[]	[]	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>" ]	[ "<fn-group><fn><p><bold>Publisher’s note</bold> Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn></fn-group>" ]	[ "<graphic position=\"anchor\" xlink:href=\"41388_2023_2889_Figa_HTML\" id=\"d32e353\"/>", "<graphic xlink:href=\"41388_2023_2889_Fig1_HTML\" id=\"d32e741\"/>", "<graphic xlink:href=\"41388_2023_2889_Fig2_HTML\" id=\"d32e852\"/>", "<graphic xlink:href=\"41388_2023_2889_Fig3_HTML\" id=\"d32e1070\"/>", "<graph...	[ "<media xlink:href=\"41388_2023_2889_MOESM1_ESM.pdf\"><caption><p>Supplementary material</p></caption></media>", "<media xlink:href=\"41388_2023_2889_MOESM2_ESM.xlsx\"><caption><p>Supplementary table 4</p></caption></media>" ]	[{"label": ["12."], "surname": ["Serra", "Alysandratos", "Hawkins", "McCauley", "Jacob", "Choi"], "given-names": ["M", "KD", "F", "KB", "A", "J"], "article-title": ["Pluripotent stem cell differentiation reveals distinct developmental pathways regulating Lung-Versus Thyroid-Lineage specification"], "source": ["Developm...	{ "acronym": [], "definition": [] }	107	CC BY	no	2024-01-14 23:40:10	Oncogene. 2024 Nov 20; 43(3):155-170	oa_package/f6/77/PMC10786723.tar.gz
PMC10786724	38049663	[]	[ "<title>Methods</title>", "<title>Cell culture</title>", "<p id=\"Par25\">AB2.2 (ATCC SCRC-1023; male; strain: 129S5/SvEvBrd) mESCs were used in all experiments. Cells were thawed and initially cultured in 2i medium, consisting of Knockout DMEM (Gibco catalog (cat.) no. 10829018) supplemented with 15% ES-qualif...	[ "<title>Results</title>", "<title>RNAPII promoter-proximal pausing promotes BAF occupancy</title>", "<p id=\"Par7\">We used the Cleavage Under Targets and Tagmentation (CUT&Tag)<sup>##REF##31036827##29##</sup> method to determine genome-wide RNAPII and BAF occupancy in mESCs. For RNAPII, we chose antibodies...	[ "<title>Discussion</title>", "<p id=\"Par21\">Our study shows that RNAPII promoter-proximal pausing promotes BAF chromatin occupancy and ATP-dependent nucleosome eviction in mESCs, suggesting that this mechanism helps maintain nucleosome depletion and chromatin accessibility at transcriptionally active gene promo...	[]	[ "<p id=\"Par1\">Chromatin accessibility is a hallmark of active transcription and entails ATP-dependent nucleosome remodeling, which is carried out by complexes such as Brahma-associated factor (BAF). However, the mechanistic links between transcription, nucleosome remodeling and chromatin accessibility are unclear...	[ "<title>Main</title>", "<p id=\"Par3\">The positioning of nucleosomes relative to gene regulatory elements such as promoters and enhancers is pivotal in transcription regulation. Nucleosomes occlude DNA sequences from transcription factors (TFs) and prevent loading of RNAPII and basal transcription machineries<su...	[ "<title>Extended data</title>", "<p id=\"Par42\">\n\n</p>", "<p id=\"Par43\">\n\n</p>", "<p id=\"Par44\">\n\n</p>", "<p id=\"Par45\">\n\n</p>", "<p id=\"Par46\">\n\n</p>", "<p id=\"Par47\">\n\n</p>", "<title>Extended data</title>", "<p id=\"Par38\">is available for this paper at 10.1038/s41588-023-0...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>RNAPII promoter-proximal pausing promotes BAF chromatin occupancy.</title><p><bold>a</bold>, Heatmaps (bottom) and average plots (top) comparing chromatin accessibility assayed by S5P CUTAC, with RNAPII-S5P and BRG1 occupancy (CUT&Tag), relative to the prim...	[]	[]	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM3\"></supplementary-material>", "<supplementary-material ...	[ "<fn-group><fn><p><bold>Publisher’s note</bold> Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"41588_2023_1603_Fig1_HTML\" id=\"d32e457\"/>", "<graphic xlink:href=\"41588_2023_1603_Fig2_HTML\" id=\"d32e589\"/>", "<graphic xlink:href=\"41588_2023_1603_Fig3_HTML\" id=\"d32e726\"/>", "<graphic xlink:href=\"41588_2023_1603_Fig4_HTML\" id=\"d32e785\"/>", "<graphic xlink:href=\"41588...	[ "<media xlink:href=\"41588_2023_1603_MOESM1_ESM.pdf\"><caption><p>Reporting Summary</p></caption></media>", "<media xlink:href=\"41588_2023_1603_MOESM2_ESM.pdf\"><caption><p>Peer Review File</p></caption></media>", "<media xlink:href=\"41588_2023_1603_MOESM3_ESM.xlsx\"><label>Supplementary Data 1</label><captio...	[{"label": ["17."], "mixed-citation": ["Lu, F. & Lionnet, T. Transcription factor dynamics. "], "italic": ["Cold Spring Harb. Perspect. Biol."]}, {"label": ["18."], "mixed-citation": ["Kim, J. M. et al. Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search an...	{ "acronym": [], "definition": [] }	91	CC BY	no	2024-01-14 23:40:11	Nat Genet. 2024 Dec 4; 56(1):100-111	oa_package/f1/be/PMC10786724.tar.gz
PMC10786725	38001268	[ "<title>Introduction</title>", "<p id=\"Par2\">Triple negative breast cancer (TNBC) accounts for approximately 10–15% of all cases and comprise a molecularly diverse group of tumours that lack positivity for the three major diagnostic and prognostic biomarkers clinically assessed in breast carcinomas: the estroge...	[ "<title>Methods</title>", "<title>Test compound</title>", "<p id=\"Par21\">Development and initial characterization of our CDK9 inhibitor, CDDD11-8 (K<sub><italic>i</italic></sub> = 8 nM), was described in [##REF##35267421##30##]. For in vitro assays, a 10 mM stock solution was prepared in 100% dimethyl sulfoxi...	[ "<title>Results</title>", "<title>Therapeutic efficacy of CDDD11-8 in TNBC cell line models</title>", "<p id=\"Par7\">To test the effect of CDDD11-8 on cell proliferation and viability, we investigated a panel of four cell lines that represent three major molecular subgroups of TNBC as described:[##REF##2163316...	[ "<title>Discussion</title>", "<p id=\"Par14\">Herein, we provide pre-clinical evidence demonstrating therapeutic efficacy of a recently developed, selective and orally bioavailable CDK9 inhibitor (CDDD11-8) in TNBC, using a panel of molecularly diverse human cell lines and patient-derived organoid models represen...	[]	[ "<p id=\"Par1\">Targeted therapy for triple-negative breast cancers (TNBC) remains a clinical challenge due to tumour heterogeneity. Since TNBC have key features of transcriptionally addicted cancers, targeting transcription via regulators such as cyclin-dependent kinase 9 (CDK9) has potential as a therapeutic stra...	[ "<title>Supplementary information</title>", "<p>\n\n\n\n\n\n\n\n</p>" ]	[ "<title>Supplementary information</title>", "<p>The online version contains supplementary material available at 10.1038/s41388-023-02892-3.</p>", "<title>Acknowledgements</title>", "<p>We thank M. Pickering, V. Velasco, C. Puiu, D. Thean and T. Donnellan for experimental assistance, and S. Pederson and W. Liu...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>CDDD11-8 inhibits proliferation, promotes cell cycle arrest, and increases apoptosis of TNBC cell lines in vitro.</title><p><bold>a</bold> Representative Western Blots showing basal expression of CDK9, MYC, MCL1 and GAPDH (loading control) in four TNBC cell lin...	[]	[ "<inline-formula id=\"IEq1\"><alternatives><tex-math id=\"M1\">\\documentclass[12pt]{minimal}\n\t\t\t\t\\usepackage{amsmath}\n\t\t\t\t\\usepackage{wasysym} \n\t\t\t\t\\usepackage{amsfonts} \n\t\t\t\t\\usepackage{amssymb} \n\t\t\t\t\\usepackage{amsbsy}\n\t\t\t\t\\usepackage{mathrsfs}\n\t\t\t\t\\usepackage{upgreek}\n...	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM3\"></supplementary-material>", "<supplementary-material ...	[ "<fn-group><fn><p><bold>Publisher’s note</bold> Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"41388_2023_2892_Fig1_HTML\" id=\"d32e553\"/>", "<graphic xlink:href=\"41388_2023_2892_Fig2_HTML\" id=\"d32e661\"/>", "<graphic xlink:href=\"41388_2023_2892_Fig3_HTML\" id=\"d32e748\"/>", "<graphic xlink:href=\"41388_2023_2892_Fig4_HTML\" id=\"d32e856\"/>", "<graphic xlink:href=\"41388...	[ "<media xlink:href=\"41388_2023_2892_MOESM1_ESM.docx\"><caption><p>Supplementary Figure Legends</p></caption></media>", "<media xlink:href=\"41388_2023_2892_MOESM2_ESM.tif\"><caption><p>Supplementary Figure 1</p></caption></media>", "<media xlink:href=\"41388_2023_2892_MOESM3_ESM.tif\"><caption><p>Supplementary...	[{"label": ["13."], "surname": ["Whittaker", "Mallinger", "Workman", "Clarke"], "given-names": ["SR", "A", "P", "PA"], "article-title": ["Inhibitors of cyclin-dependent kinases as cancer therapeutics"], "source": ["Pharm Ther"], "year": ["2017"], "volume": ["173"], "fpage": ["83"], "lpage": ["105"], "pub-id": ["10.1016...	{ "acronym": [], "definition": [] }	73	CC BY	no	2024-01-14 23:40:11	Oncogene. 2024 Nov 24; 43(3):202-215	oa_package/56/40/PMC10786725.tar.gz
PMC10786726	38049664	[]	[ "<title>Methods</title>", "<title>Cell line and growth assays</title>", "<p id=\"Par34\">Cell lines were grown in Roswell Park Memorial Institute-1640 medium (RPMI-1640) with 1% penicillin–streptomycin (10,000 U ml<sup>−1</sup>) and 10% FBS or in Iscove’s modified Dulbecco’s medium (IMDM) with 1% penicillin–str...	[ "<title>Results</title>", "<title>A3B restrains tumor initiation in an epidermal growth factor receptor mutant (EGFRmut) lung cancer mouse model</title>", "<p id=\"Par5\">The role of A3B in tumor initiation was first investigated in a mouse strain combining a new loxP-STOP-loxP (LSL) inducible human <italic>A3B...	[ "<title>Discussion</title>", "<p id=\"Par30\">Our collective findings shed light on the important, context-specific roles of A3B on lung cancer pathogenesis and tumor evolution. Along with other recent findings in the field<sup>##REF##37407818##5##</sup>, our data reinforce the concept that targeted therapies can...	[]	[ "<p id=\"Par1\">In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung cancer was assessed. <italic>A3B</italic> expression in EGFR mutant (EGFRmut) non-small-cell lung cancer (NSCLC) mouse models co...	[ "<title>Main</title>", "<p id=\"Par3\">Apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzymes are cytosine deaminases that have an important role in intrinsic responses to viral infection through deamination of deoxycytidine residues in viral single-stranded DNA<sup>##REF##33671095##1##,##REF##1551...	[ "<title>Extended data</title>", "<p id=\"Par82\">\n\n</p>", "<p id=\"Par83\">\n\n</p>", "<p id=\"Par84\">\n\n</p>", "<p id=\"Par85\">\n\n</p>", "<p id=\"Par86\">\n\n</p>", "<p id=\"Par87\">\n\n</p>", "<p id=\"Par88\">\n\n</p>", "<p id=\"Par89\">\n\n</p>", "<p id=\"Par90\">\n\n</p>", "<p id=\"Par...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>Continuous <italic>APOBEC3B</italic> expression is detrimental for tumorigenesis in a p53 WT EGFR<sup>L858R</sup> mouse model of lung cancer.</title><p><bold>a</bold>, Tumorigenesis in <italic>E</italic> (<italic>TetO-EGFR</italic><sup><italic>L858R</italic></s...	[]	[]	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM3\"></supplementary-material>", "<supplementary-material ...	[ "<fn-group><fn><p><bold>Publisher’s note</bold> Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn><fn><p>These authors contributed equally: Deborah R. Caswell, Philippe Gui, Manasi K. Mayekar.</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"41588_2023_1592_Fig1_HTML\" id=\"d32e1602\"/>", "<graphic xlink:href=\"41588_2023_1592_Fig2_HTML\" id=\"d32e1977\"/>", "<graphic xlink:href=\"41588_2023_1592_Fig3_HTML\" id=\"d32e2364\"/>", "<graphic xlink:href=\"41588_2023_1592_Fig4_HTML\" id=\"d32e2667\"/>", "<graphic xlink:href=\"4...	[ "<media xlink:href=\"41588_2023_1592_MOESM1_ESM.pdf\"><label>Supplementary Information</label><caption><p>Supplementary Note.</p></caption></media>", "<media xlink:href=\"41588_2023_1592_MOESM2_ESM.pdf\"><caption><p>Reporting Summary</p></caption></media>", "<media xlink:href=\"41588_2023_1592_MOESM3_ESM.pdf\">...	[{"label": ["6."], "mixed-citation": ["Jarvis, M. C. et al. Mutational impact of APOBEC3B and APOBEC3A in a human cell line. Preprint at "], "italic": ["bioRxiv"]}, {"label": ["34."], "mixed-citation": ["Haderk, F. et al. A focal adhesion kinase-YAP signaling axis drives drug tolerant persister cells and residual disea...	{ "acronym": [], "definition": [] }	109	CC BY	no	2024-01-14 23:40:11	Nat Genet. 2024 Dec 4; 56(1):60-73	oa_package/57/18/PMC10786726.tar.gz
PMC10786727	38195860	[]	[ "<title>Methods</title>", "<title>Ethics statement</title>", "<p id=\"Par44\">This research complies with all relevant ethical regulations. All animal protocols were approved by the Institutional Animal Care and Use Committees of Peking University, which are accredited by the Association for Assessment and Accr...	[ "<title>Results</title>", "<title>LncRNAs across vertebrates share little sequence conservation</title>", "<p id=\"Par9\">To explore lncRNA homology, we initially annotated lncRNA datasets for six vertebrates, including cow, opossum, chicken, lizard, frog and zebrafish, as an addition to the existing high-quali...	[ "<title>Discussion</title>", "<p id=\"Par38\">We here developed lncHOME, a computational pipeline that identifies coPARSE-lncRNAs, a unique class of lncRNAs with conserved genomic locations and patterns of RBP-binding sites. We also developed a KO screen using Cas12a with paired crRNAs and identified 75 coPARSE-l...	[]	[ "<p id=\"Par1\">Functional studies of long noncoding RNAs (lncRNAs) have been hindered by the lack of methods to assess their evolution. Here we present lncRNA Homology Explorer (lncHOME), a computational pipeline that identifies a unique class of long noncoding RNAs (lncRNAs) with conserved genomic locations and p...	[ "<title>Main</title>", "<p id=\"Par3\">A major advance in molecular biology and genomics over the last few decades is the discovery and characterization of long noncoding RNAs (lncRNAs), transcripts that are larger than 200 nucleotides (nt) without protein-coding potential<sup>##REF##22955988##1##</sup>. LncRNAs ...	[ "<title>Extended data</title>", "<p id=\"Par125\">\n\n</p>", "<p id=\"Par126\">\n\n</p>", "<p id=\"Par127\">\n\n</p>", "<p id=\"Par128\">\n\n</p>", "<p id=\"Par129\">\n\n</p>", "<p id=\"Par130\">\n\n</p>", "<p id=\"Par131\">\n\n</p>", "<p id=\"Par132\">\n\n</p>", "<p id=\"Par133\">\n\n</p>", "<p...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><title>Identification of coPARSE-lncRNA and their homologs across vertebrates.</title><p><bold>a</bold>, A simplified workflow for lncHOME analysis of vertebrate lncRNAs. The phylogenetic tree shows the evolutionary descent of eight vertebrates, with the number of ann...	[]	[ "<disp-formula id=\"Equa\"><alternatives><tex-math id=\"M1\">\\documentclass[12pt]{minimal}\n\t\t\t\t\\usepackage{amsmath}\n\t\t\t\t\\usepackage{wasysym} \n\t\t\t\t\\usepackage{amsfonts} \n\t\t\t\t\\usepackage{amssymb} \n\t\t\t\t\\usepackage{amsbsy}\n\t\t\t\t\\usepackage{mathrsfs}\n\t\t\t\t\\usepackage{upgreek}\n\t...	[]	[ "<code>$findMotifs.pl binding_site.fa fasta output_directory/ -fasta background.fa</code>", "<code>$meme input_file -p 5 -nostatus -time 36000 -dna -revcomp -text -mod anr -nmotifs 5 -minw 5 -maxw 30 -maxsites 600 -maxsize 1000000 > motif_file</code>", "<code>$fimo --verbosity 1 --text motif_file sequence_fi...	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM3\"></supplementary-material>", "<supplementary-material ...	[ "<fn-group><fn><p><bold>Publisher’s note</bold> Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn><fn><p>These authors contributed equally: Wenze Huang, Tuanlin Xiong, Yuting Zhao.</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"41588_2023_1620_Fig1_HTML\" id=\"d32e589\"/>", "<graphic xlink:href=\"41588_2023_1620_Fig2_HTML\" id=\"d32e880\"/>", "<graphic xlink:href=\"41588_2023_1620_Fig3_HTML\" id=\"d32e978\"/>", "<graphic xlink:href=\"41588_2023_1620_Fig4_HTML\" id=\"d32e1154\"/>", "<graphic xlink:href=\"4158...	[ "<media xlink:href=\"41588_2023_1620_MOESM1_ESM.pdf\"><caption><p>Reporting Summary</p></caption></media>", "<media xlink:href=\"41588_2023_1620_MOESM2_ESM.xlsx\"><label>Supplementary Tables 1 and 2</label><caption><p>Identification of syntenic lncRNAs across species.</p></caption></media>", "<media xlink:href=...	[{"label": ["62."], "mixed-citation": ["Wang, T., Lander, E. S. & Sabatini, D. M. Large-scale single guide RNA library construction and use for CRISPR\u2013Cas9-based genetic screens. "], "italic": ["Cold Spring Harb. Protoc"], "bold": ["2016"]}, {"label": ["89."], "mixed-citation": ["Hu, X. et al. ZFLNC: a comprehensi...	{ "acronym": [], "definition": [] }	102	CC BY	no	2024-01-14 23:40:11	Nat Genet. 2024 Jan 9; 56(1):124-135	oa_package/a9/0d/PMC10786727.tar.gz
PMC10786729	37891388	[ "<title>Introduction</title>", "<p id=\"Par2\">The majority of the world’s rivers, wetlands and floodplains (RWFs) are under considerable stress because of human impacts (e.g., Best ##UREF##4##2019##). The challenge in achieving better management of freshwater ecosystems is that they occur at the food-energy-wate...	[ "<title>Methods</title>", "<title>Survey design and distribution</title>", "<p id=\"Par6\">We designed and implemented an online survey to ascertain perspectives about the value and function of NWV in river-floodplain systems (Online Resource ##SUPPL##0##1##). This paper describes the outcomes of a sub-set of t...	[ "<title>Results</title>", "<title>Participant knowledge and relationships with RWFs</title>", "<p id=\"Par11\">Seventy-two percent of survey participants self-identified as being at least moderately knowledgeable in relation to NWV and EWM, with 16% indicating an expert level of knowledge, and less than 3% indi...	[ "<title>Discussion</title>", "<p id=\"Par27\">This study sought to ascertain perspectives on the value of NWV in RWFs using an online survey instrument. The two questions we posed yielded responses with differing thematic emphases. The first question elicited perspectives with an emphasis on ecological functions ...	[ "<title>Conclusions</title>", "<p id=\"Par41\">While holistic management of river-floodplain systems is advocated the pragmatic reality, in the biophysical sciences at least, is that objectives, management actions, and the evaluation of outcomes may be structured in a hierarchical framework that, at its lower lev...	[ "<p id=\"Par1\">How people value rivers, wetlands and floodplains influences their attitudes, beliefs and behaviours towards these ecosystems, and can shape policy and management interventions. Better understanding why people value rivers, wetlands and floodplains and their key ecosystem components, such as vegetat...	[ "<title>Supplementary Information</title>", "<p>\n\n\n</p>" ]	[ "<title>Supplementary information</title>", "<p>The online version contains supplementary material available at 10.1007/s00267-023-01900-2. Two pieces of supplementary material have been provided: Online Resource 1: survey questions and Online Resource 2: supporting information, which includes graphs of results t...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><p>Number and percentage of selections in each of the options provided for interests or relationships with rivers, wetlands, floodplains and environmental water management, <italic>n</italic> = 443 selections from 165 respondents, EWM environmental water management, R...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Details of, and relationship between, research question, survey questions, question format, options provided, and data analysis approach</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th>Research question</th><th>Applicable survey questio...	[]	[]	[]	[ "<disp-quote><p id=\"Par13\">“<italic>Yorta Yorta Country: The way in which I connect, see, feel, hear, taste, sound, connect (sing, language) and speak of Country is essential to the way in which the water must be there for the rivers, wetlands, floodplain and biodiversity. If it is no longer there, then I will be...	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>", "<supplementary-material content-type=\"local-data\" id=\"MOESM2\"></supplementary-material>" ]	[ "<fn-group><fn><p><bold>Publisher’s note</bold> Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn></fn-group>" ]	[ "<graphic xlink:href=\"267_2023_1900_Fig1_HTML\" id=\"d32e618\"/>", "<graphic xlink:href=\"267_2023_1900_Fig2_HTML\" id=\"d32e706\"/>", "<graphic xlink:href=\"267_2023_1900_Fig3_HTML\" id=\"d32e804\"/>", "<graphic xlink:href=\"267_2023_1900_Fig4_HTML\" id=\"d32e880\"/>" ]	[ "<media xlink:href=\"267_2023_1900_MOESM1_ESM.pdf\"><caption><p>Online-Resource-1-survey-questions</p></caption></media>", "<media xlink:href=\"267_2023_1900_MOESM2_ESM.pdf\"><caption><p>Online-Resource-2-supporting-information</p></caption></media>" ]	[{"surname": ["Allan", "Watts"], "given-names": ["C", "RJ"], "article-title": ["Framing two environmental flow trials in the murray-darling basin, South-Eastern Australia"], "source": ["Water"], "year": ["2022"], "volume": ["14"], "issue": ["3"], "fpage": ["411"], "pub-id": ["10.3390/w14030411"]}, {"surname": ["Anderso...	{ "acronym": [], "definition": [] }	78	CC BY	no	2024-01-14 23:40:11	Environ Manage. 2024 Oct 27; 73(1):130-143	oa_package/aa/f2/PMC10786729.tar.gz
PMC10786730	38216710	[ "<title>Introduction</title>", "<p id=\"Par2\">Influenza A viruses (IAVs) exhibit zoonotic potential to infect both birds and mammals (e.g., pigs and humans) [##REF##28302313##1##, ##REF##22032844##2##]. IAVs remain a persistent health threat due to the presence of populations of quasispecies [##REF##17262054##3#...	[ "<title>Materials and methods</title>", "<title>Compounds</title>", "<p id=\"Par5\">BXA was synthesized at Shionogi & Co., Ltd. OSA was purchased from Toronto Research Chemicals Inc. (Toronto, Ontario, Canada). FPV was supplied by PharmaBlock Sciences, Inc. (Nanjing, China).</p>", "<title>Cells and viruse...	[ "<title>Results</title>", "<title>BXA susceptibility and replicative fitness of recombinant A/Hong Kong/483/97 (H5N1) with variations in PA</title>", "<p id=\"Par11\">In order to assess the impact of PA/I38 substitutions on BXA susceptibility and replicative fitness, recombinant A/Hong Kong/483/97 (H5N1) strain...	[ "<title>Discussion</title>", "<p id=\"Par17\">Several reports have shown that PA/I38F, M, and T variant viruses isolated from BXM-treated patients exhibit reduced susceptibility to BXA [##REF##31768027##31##, ##REF##31419295##40##]. Natural variants harboring PA polymorphisms, such as PA/I38M, I38L, and E23G, exh...	[]	[ "<p>Communicated by Sheela Ramamoorthy</p>", "<p id=\"Par1\">Genetic reassortment of avian, swine, and human influenza A viruses (IAVs) poses potential pandemic risks. Surveillance is important for influenza pandemic preparedness, but the susceptibility of zoonotic IAVs to the cap-dependent endonuclease inhibitor...	[ "<title>Electronic Supplementary Material</title>", "<p>Below is the link to the electronic supplementary material</p>", "<p>\n\n</p>" ]	[ "<p>We thank Takehiro Saito and Nobuhiro Takemae (National Agriculture and Food Research Organization) for generously providing A/swine/Miyazaki/1/2006 (H1N2) and A/swine/Yokohama/aq114/2011 (H3N2) strains. We also thank Yuki Maruyama, Naoko Kurihara, and Masatomo Rokushima (Shionogi & Co., Ltd., Japan) and Shi...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><p>In vitro replicative fitness of recombinant A/Hong Kong/483/97 (H5N1) viruses. MDCK cells were infected with recombinant viruses at 100 TCID<sub>50</sub>/well. Supernatants were harvested at the indicated time points, and the mean virus titers of triplicate wells ±...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Susceptibility of recombinant A/Hong Kong/483/97 (H5N1) viruses harboring PA amino acid substitutions to BXA, oseltamivir acid, and favipiravir</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th align=\"left\"/><th align=\"left\" colspan=\...	[]	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>" ]	[ "<table-wrap-foot><p>Data represent the mean and standard deviation (SD) from three independent experiments</p><p>WT, wild type; NA, not applicable</p></table-wrap-foot>", "<table-wrap-foot><p><sup>a</sup> The indicated amino acids were previously shown to be involved in binding of BXA to the active center of the...	[ "<graphic xlink:href=\"705_2023_5958_Fig1_HTML\" id=\"d32e650\"/>", "<graphic xlink:href=\"705_2023_5958_Fig2_HTML\" id=\"d32e710\"/>" ]	[ "<media xlink:href=\"705_2023_5958_MOESM1_ESM.pdf\"><caption><p>Supplementary Material 1</p></caption></media>" ]	[{"label": ["10."], "mixed-citation": ["Sun X, Pulit-Penaloza JA, Belser JA et al (2018) Pathogenesis and Transmission of Genetically Diverse Swine-Origin H3N2 Variant Influenza A Viruses from Multiple Lineages Isolated in the United States, 2011\u20132016. J Virol 92. 10.1128/JVI.00665-18"]}, {"label": ["14."], "mixed...	{ "acronym": [], "definition": [] }	51	CC BY	no	2024-01-14 23:40:11	Arch Virol. 2024 Jan 12; 169(2):29	oa_package/bf/d5/PMC10786730.tar.gz
PMC10786734	38217254	[ "<title>Introduction</title>", "<p id=\"Par6\">Marine sponges (Porifera) are the oldest animals on Earth. Widely distributed all over the world, marine sponges harbor highly diverse and dense microbial communities, which may represent up to 60% of sponge biomass (Webster and Thomas ##REF##27103626##2016##; Hentsc...	[ "<title>Materials and methods</title>", "<title>General experimental procedures</title>", "<p id=\"Par11\">Optical rotations were recorded on a Polartronic H Schmidt + Haensch polarimeter. Ultraviolet spectra were recorded on a Shimadzu UV-3600 spectrophotometer. Infrared spectra were recorded on a Shimadzu IRA...	[ "<title>Results</title>", "<title>Extraction and isolation of compounds 1–4</title>", "<p id=\"Par29\"><italic>M. testaceum</italic> media were first adsorbed onto HP-20 and then extracted with EtOAc. Both extracts were analyzed by HPLC–MS and showed similar chemical profiles. The extracts were pooled and fract...	[ "<title>Discussion</title>", "<p id=\"Par39\">Testacosides A–C were inactive against <italic>P. falciparum</italic> at concentration of 10 μM, as well as when tested in antimicrobial activity against a panel of multi-resistant ESKAPE bacterial strains at concentration of 60 μM.</p>", "<p id=\"Par40\">Testacosid...	[]	[ "<title>Abstract</title>", "<p id=\"Par1\">Marine bacteria living in association with marine sponges have proven to be a reliable source of biologically active secondary metabolites. However, no studies have yet reported natural products from <italic>Microbacterium testaceum</italic> spp. We herein report the iso...	[ "<title>Supplementary Information</title>", "<p>Below is the link to the electronic supplementary material.</p>" ]	[ "<title>Author contribution</title>", "<p>JIQB and RGSB conceived and planned the experiments. JIQB conducted experiments. LACT and LFM contributed to taxonomical identification of bacterial strain. EH collected the sponge samples. AGF optimized and recorded NMR data. JIQB and RGSB wrote the manuscript. All autho...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><p>Structures of testacosides <bold>1</bold>–<bold>4</bold></p></caption></fig>", "<fig id=\"Fig2\"><label>Fig. 2</label><caption><p>Molecular networking analysis of <italic>Microbacterium testaceum</italic> media extract and C<sub>18</sub> column fractions. <bold>a...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p><sup>1</sup>H (600 MHz) and <sup>13</sup>C (150 MHz) NMR data for testacosides A–C (<bold>1</bold>–<bold>3</bold>) in MeOH-<italic>d</italic><sub><italic>4</italic></sub></p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th align=\"left\"/><...	[]	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>" ]	[ "<fn-group><fn><p><bold>Publisher's Note</bold></p><p>Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn></fn-group>" ]	[ "<graphic position=\"anchor\" xlink:href=\"253_2023_12870_Figa_HTML\" id=\"MO1\"/>", "<graphic xlink:href=\"253_2023_12870_Fig1_HTML\" id=\"MO2\"/>", "<graphic xlink:href=\"253_2023_12870_Fig2_HTML\" id=\"MO3\"/>", "<graphic xlink:href=\"253_2023_12870_Fig3_HTML\" id=\"MO4\"/>", "<graphic xlink:href=\"253_2...	[ "<media xlink:href=\"253_2023_12870_MOESM1_ESM.pdf\"><caption><p>Supplementary file1 (PDF 1828 KB)</p></caption></media>" ]	[{"surname": ["Almeida", "Marques", "Oliveira", "Egas", "Mil-Homens", "Viana", "Cleary", "Huang", "Fialho", "Teixeira", "Gomes", "Costa", "Keller-Costa"], "given-names": ["JF", "M", "V", "C", "D", "R", "DFR", "YM", "AM", "MC", "NCM", "R", "T"], "article-title": ["Marine sponge and octocoral-associated bacteria show ver...	{ "acronym": [], "definition": [] }	69	CC BY	no	2024-01-14 23:40:12	Appl Microbiol Biotechnol. 2024 Jan 12; 108(1):1-13	oa_package/56/7a/PMC10786734.tar.gz
PMC10786737	37419991	[ "<title>Introduction</title>", "<p id=\"Par5\">In humans, repeated episodic increases in blood flow are associated with improvement in arterial health, at least partly due to shear-stress-induced upregulation of endothelial cell function and the bioavailability of paracrine hormones including nitric oxide (NO) (J...	[ "<title>Methods</title>", "<title>Participants</title>", "<p id=\"Par7\">Eleven healthy young participants were recruited (nine males; age 23.8 ± 3.1 yrs; height 180 ± 12 cm; weight 75.0 ± 16.5 kg; BMI 23.0 ± 2.9 kg/m<sup>2</sup>). Exclusion criteria included any history of cardiovascular, cerebrovascular, meta...	[ "<title>Results</title>", "<title>Cerebrovascular and respiratory variables</title>", "<p id=\"Par14\">Whilst MCAv increased significantly from the onset of exercise in all conditions (<italic>P</italic> < 0.001), MCAv was significantly higher at rest in the 32 °C condition compared to the Land (61 ± 10 vs 5...	[ "<title>Discussion</title>", "<p id=\"Par18\">We examined the impact of water immersion and temperature on CBF velocity during aqua-cycling in healthy young subjects. Our findings extend our previous observations, and reinforce other studies (Carter et al. ##UREF##0##2014##; Pugh et al. ##UREF##3##2014##; Parfitt...	[ "<title>Conclusion</title>", "<p id=\"Par23\">Our study confirms previous experiments regarding the impact of 32 °C water immersion on cerebrovascular responses and extends this observation to a beneficial impact during aquatic cycle ergometry. It is also the first study to address the impact of water temperature...	[ "<p>Communicated by Narihiko Kondo.</p>", "<title>Purpose</title>", "<p id=\"Par1\">Recent studies suggest that episodic increases in cerebral blood flow (CBF) may contribute to the improvement in brain health associated with exercise training. Optimising CBF during exercise may enhance this benefit. Water imme...	[]	[ "<title>Author contribution</title>", "<p>HHC, MJM, LHN and DJG conceived and designed the research project. HHC, OP, AC and JLC conducted experiments. HHC and OP analysed the data. HHC, LHN and DJG drafted the manuscript, and all authors read and approved the manuscript.</p>", "<title>Funding</title>", "<p>O...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><p>Middle cerebral artery velocity (MCAv, panel <bold>A,</bold>\n<bold>B</bold>), partial pressure of end-tidal carbon dioxide (PETCO<sub>2</sub>, panel <bold>C</bold>, <bold>D</bold>), mean arterial pressure (panel <bold>E</bold>, <bold>F</bold>) and core temperature...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Resting values in the separate exercise conditions</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th align=\"left\">Resting values (10 min)</th><th align=\"left\">Land</th><th align=\"left\">32 °C</th><th align=\"left\">38 °C</th></tr></t...	[]	[]	[]	[]	[]	[]	[ "<table-wrap-foot><p>Values are means ± SD</p><p><italic>MCAv</italic> middle cerebral artery velocity, <italic>MCA CVC</italic> middle cerebral artery cerebrovascular conductance.</p><p>Statistical significance was set at <italic>P</italic> < 0.05. *denotes significant difference from 32 °C<bold>.</bold> <sup>#...	[ "<graphic xlink:href=\"421_2023_5264_Fig1_HTML\" id=\"MO1\"/>", "<graphic xlink:href=\"421_2023_5264_Fig2_HTML\" id=\"MO2\"/>" ]	[]	[{"surname": ["Carter", "Spence", "Pugh", "Ainslie", "Naylor", "Green"], "given-names": ["HH", "AL", "CJA", "P", "LH", "DJ"], "article-title": ["Cardiovascular responses to water immersion in humans: impact on cerebral perfusion"], "source": ["Am J Physiol Reg I"], "year": ["2014"], "volume": ["306"], "fpage": ["R636"]...	{ "acronym": [], "definition": [] }	25	CC BY	no	2024-01-14 23:40:12	Eur J Appl Physiol. 2024 Jul 7; 124(1):219-225	oa_package/61/c8/PMC10786737.tar.gz
PMC10786739	37439906	[ "<title>Introduction</title>", "<p id=\"Par26\">Endogenous enzymatic antioxidants including catalase (CAT) and glutathione reductase (GR) maintain redox balance and suppress oxidative damage by scavenging reactive oxygen and nitrogen species (RONS) such as hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), superoxid...	[ "<title>Methods</title>", "<title>Participants</title>", "<p id=\"Par32\">Twenty-four male participants (mean [SD]; 23 [3] years, 179.6 [6.1] cm, 78.8 [10.6] kg) who were classified as recreationally active according to a recently published participant classification framework (McKay et al. ##REF##34758453##202...	[ "<title>Results</title>", "<p id=\"Par46\">In total, 24 participants successfully completed the study. No significant differences between groups were reported for physical characteristics or 3 d average energy, macronutrient, and micronutrient intake, and TPI (Table ##TAB##0##1##). Examination of food diaries rev...	[ "<title>Discussion</title>", "<p id=\"Par52\">This study tested the hypothesis that the combination of eccentric exercise with a 6 days supplementation period of green tea would augment NRF2 activity to a greater extent than eccentric exercise alone, and that this would have favorable downstream effects on NRF2-t...	[ "<title>Conclusion</title>", "<p id=\"Par59\">Taken together, this study demonstrates that neither mechanically demanding eccentric exercise or a 6 days supplementation period with green tea (poly)phenols increases NRF2 activity in PBMCs. These interventions should therefore be avoided in scenarios where enhancin...	[ "<p>Communicated by Michalis G Nikolaidis.</p>", "<title>Purpose</title>", "<p id=\"Par1\">This study investigated whether combining eccentric exercise and green tea supplementation synergistically increased nuclear factor erythroid 2-related factor 2 (NRF2) activity, a transcription factor responsible for coor...	[]	[ "<title>Acknowledgements</title>", "<p>The authors would like to thank Mr. Tristan Boetti, and Miss Sophie Bitton for their support with data collectionand recruitment.</p>", "<title>Author contributions</title>", "<p>Conceptualization (T.C, J.T, S.B, N.M, N.B). Collection, analysis, or interpretation of data...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><p>Total leukocyte (<bold>a</bold>), neutrophil (<bold>b</bold>) and monocyte (<bold>c</bold>) concentrations, and 8-OHdG excretion (<bold>d</bold>) measured at pre-, post-, 1 h and 24 h post-exercise. Symbols represent individual values. * significantly different to ...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Comparison of participants’ physical characteristics and 3-day average dietary intakes </p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th align=\"left\"/><th align=\"left\">Green tea</th><th align=\"left\">Placebo</th><th align=\"left\"><...	[ "<inline-formula id=\"IEq2\"><alternatives><tex-math id=\"M1\">\\documentclass[12pt]{minimal}\n\t\t\t\t\\usepackage{amsmath}\n\t\t\t\t\\usepackage{wasysym} \n\t\t\t\t\\usepackage{amsfonts} \n\t\t\t\t\\usepackage{amssymb} \n\t\t\t\t\\usepackage{amsbsy}\n\t\t\t\t\\usepackage{mathrsfs}\n\t\t\t\t\\usepackage{upgreek}\n...	[]	[]	[]	[]	[]	[ "<table-wrap-foot><p>Values are mean ± SD. <italic>n</italic> = 12 per group</p><p><italic>CMJ</italic> counter movement jump</p></table-wrap-foot>", "<table-wrap-foot><p>Values are mean ± SD. <italic>n</italic> = 12 per group</p><p><italic>CMJ</italic> counter movement jump</p></table-wrap-foot>", "<fn-group><...	[ "<graphic position=\"anchor\" xlink:href=\"421_2023_5271_Figa_HTML\" id=\"MO1\"/>", "<inline-graphic xlink:href=\"421_2023_5271_Article_IEq2.gif\"/>", "<inline-graphic xlink:href=\"421_2023_5271_Article_IEq3.gif\"/>", "<inline-graphic xlink:href=\"421_2023_5271_Article_IEq4.gif\"/>", "<graphic xlink:href=\"...	[]	[{"mixed-citation": ["Bigagli E, Cinci L, Paccosi S, Parenti A, D'Ambrosio M, Luceri C. (2017) Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages. In...	{ "acronym": [ "ARE", "ANOVA", "CAT", "CMJ", "CV", "Cys", "EGCG", "ERK", "FBS", "GR", "KEAP1", "NRF2", "PBMCs", "PBS", "RONS", "SD", "TPI", "\\documentclass[12pt]{minimal}\n\t\t\t\t\\usepackage{amsmath}\n\t\t\t\t\\usepackage{wasysym} \n\t\t\t\t\\...	73	CC BY	no	2024-01-14 23:40:12	Eur J Appl Physiol. 2024 Jul 13; 124(1):245-256	oa_package/8e/5d/PMC10786739.tar.gz
PMC10786740	37020043	[ "<title>Introduction</title>", "<p id=\"Par2\">Schizophrenia (SCZ) is a disorder with a multifaceted etiology that involves genetic and environmental factors, as well as their interactions [##UREF##0##1##–##REF##20819981##3##]. Individuals with SCZ have a considerably higher risk of developing obsessive–compulsiv...	[ "<title>Materials and methods</title>", "<title>Recruitment and study population</title>", "<p id=\"Par10\">The study population was recruited as a part of the larger multicenter Clozapine International Consortium (CLOZIN), which is led by the University Medical Center Utrecht. This study aimed to investigate t...	[ "<title>Results</title>", "<title>Sociodemographic and clinical characteristics of the study sample</title>", "<p id=\"Par19\">The study sample consisted of 91 individuals, with a mean age of 42.8 years (SD = 10.6). Of these, 63.2% were male and 57.0% had a family history of psychiatric disorder. The majority (...	[ "<title>Discussion</title>", "<p id=\"Par23\">The present proof-of-concept study is the first to compare PRS in individuals with SCZ treated with CLZ with and without OCS or OCD. The study included 91 participants and analyzed 90,687 autosomal SNPs.</p>", "<p id=\"Par24\">In terms of clinical findings, the stud...	[ "<title>Conclusion</title>", "<p id=\"Par36\">Individuals with SCZ who receive CLZ treatment represent a homogenous subgroup of individuals with SCZ, since CLZ is usually only prescribed to subjects with treatment-resistant SCZ. In line with former research OCS and OCD were common in our sample and a significant ...	[ "<p id=\"Par1\">Obsessive–compulsive symptoms (OCS) are frequently observed in individuals with schizophrenia (SCZ) treated with clozapine (CLZ). This study aimed to analyze prevalence of OCS and obsessive–compulsive disorder (OCD) in this subgroup and find possible correlations with different phenotypes. Additiona...	[ "<title>Supplementary Information</title>", "<p>Below is the link to the electronic supplementary material.</p>" ]	[ "<title>Author contributions</title>", "<p>All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by CLM, EW, TOS, and PK. The first draft of the manuscript was written by CLM and all authors commented on previous versions of the manuscript. ...	[]	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Comparison of sociodemographic and clinical characteristics of participants with and without obsessive–compulsive symptoms</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th align=\"left\" rowspan=\"2\">Variables</th><th align=\"left\">Ent...	[]	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>" ]	[ "<table-wrap-foot><p>Significant results are marked in bold</p><p>CDSS, Calgary Depression Scale for Schizophrenia; CGI, Clinical Global Impression; CLZ, clozapine; GAF, Global Assessment of Functioning Scale; OCD, obsessive–compulsive disorder; OCS, obsessive–compulsive symptoms; PANSS, Positive and negative Sympt...	[]	[ "<media xlink:href=\"406_2023_1593_MOESM1_ESM.docx\"><caption><p>Supplementary file1 (DOCX 61 KB)</p></caption></media>" ]	[{"label": ["1."], "surname": ["Zink"], "given-names": ["M"], "article-title": ["Comorbid obsessive\u2013compulsive symptoms in schizophrenia: insight into pathomechanisms facilitates treatment"], "source": ["Adv Med"], "year": ["2014"], "volume": ["2014"], "fpage": ["1"], "lpage": ["18"], "pub-id": ["10.1155/2014/3179...	{ "acronym": [], "definition": [] }	64	CC BY	no	2024-01-14 23:40:12	Eur Arch Psychiatry Clin Neurosci. 2024 Apr 5; 274(1):181-193	oa_package/66/3f/PMC10786740.tar.gz
PMC10786741	38214751	[ "<title>Introduction</title>", "<p id=\"Par2\">Colorectal cancer (CRC), one of the most common malignant tumors of the digestive system, has the third-highest incidence rate and the second-highest death rate. Despite the remarkable advances in therapeutic strategies, the 5-year overall survival rate with CRC rema...	[ "<title>Materials and methods</title>", "<title>Cell culture</title>", "<p id=\"Par6\">CRC cell lines, including SW480, SW620, DLD1, HCT116, LoVo and HT-29 and mouse colorectal tumor cells MC38 were purchased from the American Type Culture Collection (ATCC) (Manassas, VA, USA). The normal human colon mucosal ep...	[ "<title>Results</title>", "<title>Increased expression of STOML2 correlates with CRC progression and poor prognosis</title>", "<p id=\"Par20\">To explore the importance of STOML2 in CRC progression, we first analyzed the expression level of STOML2 in CRC and adjacent noncancerous tissues (ANTs) from public data...	[ "<title>Discussion</title>", "<p id=\"Par31\">STOML2 has been reported to closely related to the occurrence and progression of various tumors, and overexpression of STOML2 is associated to poor prognosis in several cancers, including CRC [##REF##34781982##19##, ##REF##30389319##20##]. Thus, the role of STOML2 in ...	[]	[ "<p id=\"Par1\">Colorectal cancer (CRC) is characterized by a complex tumor inflammatory microenvironment, while angiogenesis and immunosuppression frequently occur concomitantly. However, the exact mechanism that controls angiogenesis and immunosuppression in CRC microenvironment remains unclear. Herein, we found ...	[ "<title>Supplementary Information</title>", "<p>Below is the link to the electronic supplementary material.</p>" ]	[ "<title>Acknowledegments</title>", "<p>This work was supported by the Natural Science Foundation of China (81,402,310, 81,672,957, 82,203,671, 82,372,913, 81,902,885); the Natural Science Foundation of Guangdong Province, China (2020A1515011303, 2017A030313761, 2022A1515012172); Huazhong University of Science and...	[ "<fig id=\"Fig1\"><label>Fig. 1</label><caption><p>STOML2 is upregulated in CRC cell lines and CRC tissues. <bold>a</bold> Relative expression levels of STOML2 in CRC and normal tissues analyzed using the GSE8671 GSE21510, GSE20916 and TCGA datasets. <bold>b</bold> STOML2 mRNA expression in 2 normal colonic epithel...	[ "<table-wrap id=\"Tab1\"><label>Table 1</label><caption><p>Correlation between the clinicopathological features and expression of STOML2</p></caption><table frame=\"hsides\" rules=\"groups\"><thead><tr><th align=\"left\" rowspan=\"2\">Patient characteristics</th><th align=\"left\" colspan=\"2\">STOML2 expression</t...	[]	[]	[]	[]	[]	[ "<supplementary-material content-type=\"local-data\" id=\"MOESM1\"></supplementary-material>" ]	[ "<fn-group><fn><p><bold>Publisher's Note</bold></p><p>Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn><fn><p>Hui Gong, Shaojing Chen, Shuguang Liu and Qianying Hu contributed equally to this work and share first authorship.</p></fn></fn-...	[ "<graphic xlink:href=\"18_2023_5105_Fig1_HTML\" id=\"MO1\"/>", "<graphic xlink:href=\"18_2023_5105_Fig2_HTML\" id=\"MO2\"/>", "<graphic xlink:href=\"18_2023_5105_Fig3_HTML\" id=\"MO3\"/>", "<graphic xlink:href=\"18_2023_5105_Fig4_HTML\" id=\"MO4\"/>", "<graphic xlink:href=\"18_2023_5105_Fig5_HTML\" id=\"MO5...	[ "<media xlink:href=\"18_2023_5105_MOESM1_ESM.doc\"><caption><p>Supplementary file1 (DOC 564 KB)</p></caption></media>" ]	[{"label": ["25."], "mixed-citation": ["Park, M., J.W. Lim, and H. Kim, "], "italic": ["Docoxahexaenoic Acid Induces Apoptosis of Pancreatic Cancer Cells by Suppressing Activation of STAT3 and NF-kappaB."], "bold": ["10"]}]	{ "acronym": [], "definition": [] }	27	CC BY	no	2024-01-14 23:40:12	Cell Mol Life Sci. 2024 Jan 12; 81(1):39	oa_package/82/1f/PMC10786741.tar.gz

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