NFAT4 activation requires IP3R-mediated Ca2+ mobilization.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

Tirasemtiv has no effect on fast-twitch muscle.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

Only a minority of cells survive development after differentiation into stress-resistant spores.

0-dimensional biomaterials show inductive properties.

Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.

Arginine 90 in p150n is important for interaction with EB1.

Ivermectin is used to treat lymphatic filariasis.

Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.

Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

PD-1 triggering on monocytes reduces IL-10 production by monocytes.

The extracellular domain of TMEM27 is cleaved in human beta cells.

Activation of PPM1D suppresses p53 function.

Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.


NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.

Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.

Podocytes are motile and migrate in the presence of injury.

Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.

Bone marrow cells contribute to adult macrophage compartments.

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

Peroxynitrite is required for nitration of TCR/CD8.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.

S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

A deficiency of vitamin B12 increases blood levels of homocysteine.


NR5A2 is important in development of endometrial tissues.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.

Auditory entrainment is strengthened when people see congruent visual and auditory information.

Cataract and trachoma are the primary cause of blindness in Southern Sudan.

Ivermectin is used to treat onchocerciasis.

Ethanol stress decreases the expression of IBP in bacteria.

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

CHEK2 is not associated with breast cancer.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

Arginine 90 in p150n is important for interaction with EB1.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

ALDH1 expression is associated with better breast cancer outcomes.

The locus rs647161 is associated with colorectal carcinoma.

GATA-3 is important for hematopoietic stem cell (HSC) function.

TNFAIP3 is a tumor suppressor in glioblastoma.


Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

Birth-weight is positively associated with breast cancer.

The DdrB protein from Deinococcus radiodurans is an alternative SSB.

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

1/2000 in UK have abnormal PrP positivity.

aPKCz causes tumour enhancement by affecting glutamine metabolism.

ALDH1 expression is associated with poorer prognosis in breast cancer.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

0-dimensional biomaterials show inductive properties.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.

Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.

Venules have a thinner or absent smooth layer compared to arterioles.

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.


Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.

Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.

All hematopoietic stem cells segregate their chromosomes randomly.

The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

Hypertension is frequently observed in type 1 diabetes patients.

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

ADAR1 binds to Dicer to cleave pre-miRNA.

Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.

Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).

Glycolysis is one of the primary glycometabolic pathways in cells.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

Transferred UCB T cells acquire a memory-like phenotype in recipients.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.


New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

Ethanol stress decreases the expression of IBP in bacteria.

Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.

Bariatric surgery has a positive impact on mental health.

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

Rapamycin decreases the concentration of triacylglycerols in fruit flies.

Transferred UCB T cells acquire a memory-like phenotype in recipients.

Rapid phosphotransfer rates govern fidelity in two component systems

Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Anthrax spores can be disposed of easily after they are dispersed.

In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.


Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

TNFAIP3 is a tumor suppressor in glioblastoma.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

Obesity is determined solely by environmental factors.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

All hematopoietic stem cells segregate their chromosomes randomly.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.

Subcutaneous fat depots undergo extensive browning processes after cold exposure.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

Exposure to fine particulate air pollution is relate to anxiety prevalence.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.

Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.


Normal expression of RUNX1 has tumor-promoting effects.

Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.

IRG1 has antiviral effects against neurotropic viruses.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

Monoclonal antibody targeting of N-cadherin inhibits metastasis.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

ALDH1 expression is associated with poorer prognosis in breast cancer.

ALDH1 expression is associated with better breast cancer outcomes.

PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

PD-1 triggering on monocytes reduces IL-10 production by monocytes.

Activation of PPM1D suppresses p53 function.

The locus rs647161 is associated with colorectal carcinoma.

Breast cancer development is determined exclusively by genetic factors.

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.


NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.

LDL cholesterol has no involvement in the development of cardiovascular disease.

The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.

Suboptimal nutrition is not predictive of chronic disease

PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Peroxynitrite is required for nitration of TCR/CD8.

Macrolides protect against myocardial infarction.

Exposure to fine particulate air pollution is relate to anxiety prevalence.

Teaching hospitals do not provide better care than non-teaching hospitals.

Obesity is determined solely by environmental factors.

High cardiopulmonary fitness causes increased mortality rate.

Insulin increases risk of severe kidney failure.

5% of perinatal mortality is due to low birth weight.

Vitamin D deficiency is unrelated to birth weight.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

High levels of copeptin decrease risk of diabetes.


Obesity is determined solely by environmental factors.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

Activator-inhibitor pairs are provided dorsally by Admpchordin.

Bone marrow cells contribute to adult macrophage compartments.

Ivermectin is used to treat onchocerciasis.

Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.

In adult tissue, most T cells are memory T cells.

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

Headaches are not correlated with cognitive impairment.

Birth-weight is positively associated with breast cancer.

Hypertension is frequently observed in type 1 diabetes patients.


Occupancy of ribosomes by IncRNAs do not make functional peptides.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.

In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.

Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Ribosomopathies have a low degree of cell and tissue specific pathology.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

Most termination events in Okazaki fragments are sequence specific.

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.

The PPR MDA5 has two N-terminal CARD domains.


Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

ALDH1 expression is associated with better breast cancer outcomes.

The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

0-dimensional biomaterials show inductive properties.

Obesity is determined solely by environmental factors.

Women with a higher birth weight are more likely to develop breast cancer later in life.

The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.

Low nucleosome occupancy correlates with low methylation levels across species.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

The PRR MDA5 has a central DExD/H RNA helices domain.


Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

Macrolides protect against myocardial infarction.

Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.

The availability of safe places to study is not effective at decreasing homelessness.

Chenodeosycholic acid treatment increases whole-body energy expenditure.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

Insomnia can be effectively treated with cognitive behavioral therapy.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

A deficiency of vitamin B12 increases blood levels of homocysteine.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.


Only a minority of cells survive development after differentiation into stress-resistant spores.

Venules have a larger lumen diameter than arterioles.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

Arginine 90 in p150n is important for interaction with EB1.

Birth-weight is positively associated with breast cancer.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

Breast cancer development is determined exclusively by genetic factors.

The amount of publicly available DNA data doubles every 10 years.

N-terminal cleavage reduces success identifying transcription start sites.

Podocytes are motile and migrate in the presence of injury.

Anthrax spores can be disposed of easily after they are dispersed.

Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.

Bone marrow cells contribute to adult macrophage compartments.

Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.

Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.


PD-1 triggering on monocytes reduces IL-10 production by monocytes.

Incidence rates of cervical cancer have decreased.

N348I mutations cause resistance to zidovudine (AZT).

Cells undergoing methionine restriction may activate miRNAs.

Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.

Gene expression does not vary appreciably across genetically identical cells.

Peroxynitrite is required for nitration of TCR/CD8.

In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.

The DdrB protein from Deinococcus radiodurans is an alternative SSB.

Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.

The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Activation of PPM1D suppresses p53 function.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.


PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

Incidence of heart failure decreased by 10% in women since 1979.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

Cataract and trachoma are the primary cause of blindness in Southern Sudan.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

IRG1 has antiviral effects against neurotropic viruses.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation

The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.

NR5A2 is important in development of endometrial tissues.

PPAR-RXRs can be activated by PPAR ligands.

DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

Activator-inhibitor pairs are provided dorsally by Admpchordin.


PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

N-terminal cleavage increases success identifying transcription start sites.

Cellular aging closely links to an older appearance.

LDL cholesterol has no involvement in the development of cardiovascular disease.

Hematopoietic Stem Cell purification reaches purity rate of up to 50%.

Bone marrow cells contribute to adult macrophage compartments.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Polymeal nutrition reduces cardiovascular mortality.

Febrile seizures increase the threshold for development of epilepsy.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

Aspirin inhibits the production of PGE2.

PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.

Activation of PPM1D suppresses p53 function.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

Normal expression of RUNX1 has tumor-promoting effects.

p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

CX3CR1 on the Th2 cells promotes airway inflammation.


PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.

Chenodeosycholic acid treatment reduces whole-body energy expenditure.

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

The extracellular domain of TMEM27 is cleaved in human beta cells.

0-dimensional biomaterials show inductive properties.

Localization of PIN1 in the roots of Arabidopsis does not require VPS9a

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

Normal expression of RUNX1 has tumor-promoting effects.

IRG1 has antiviral effects against neurotropic viruses.

TNFAIP3 is a tumor suppressor in glioblastoma.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

PPAR-RXRs are inhibited by PPAR ligands.


PPAR-RXRs are inhibited by PPAR ligands.

ALDH1 expression is associated with poorer prognosis in breast cancer.

Venules have a larger lumen diameter than arterioles.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

Chenodeosycholic acid treatment increases whole-body energy expenditure.

High levels of copeptin decrease risk of diabetes.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Febrile seizures increase the threshold for development of epilepsy.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

PPAR-RXRs can be activated by PPAR ligands.

The PPR MDA5 has two N-terminal CARD domains.

The PRR MDA5 has a central DExD/H RNA helices domain.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.


PPAR-RXRs can be activated by PPAR ligands.

cSMAC formation enhances weak ligand signalling.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.

Bariatric surgery has a positive impact on mental health.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.


Participating in six months of physical activity improves cognitive functioning.

Peroxynitrite is required for nitration of TCR/CD8.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.

Ethanol stress decreases the expression of IBP in bacteria.

During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Headaches are not correlated with cognitive impairment.

Insomnia can be effectively treated with cognitive behavioral therapy.

Input from  mental and physical health care professionals is effective at decreasing homelessness.

Auditory entrainment is strengthened when people see congruent visual and auditory information.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.


Patients in stable partnerships have a faster progression from HIV to AIDS.

Cold exposure increases BAT recruitment.

Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

0-dimensional biomaterials show inductive properties.

Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Teaching hospitals do not provide better care than non-teaching hospitals.

Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Occupancy of ribosomes by IncRNAs do not make functional peptides.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

Monoclonal antibody targeting of N-cadherin inhibits metastasis.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.

The availability of safe places to study is not effective at decreasing homelessness.

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.


Peroxynitrite is required for nitration of TCR/CD8.

Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.

Arterioles have a larger lumen diameter than venules.

cSMAC formation enhances weak ligand signalling.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.

Aspirin inhibits the production of PGE2.

Insulin increases risk of severe kidney failure.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.

N348I mutations cause resistance to zidovudine (AZT).

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.


Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

Gene expression does not vary appreciably across genetically identical cells.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

CX3CR1 on the Th2 cells suppresses airway inflammation.

The DdrB protein from Deinococcus radiodurans is an alternative SSB.

5% of perinatal mortality is due to low birth weight.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Glycolysis is one of the primary glycometabolic pathways in cells.

PPAR-RXRs can be activated by PPAR ligands.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.


Podocytes are motile and migrate in the presence of injury.

Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.

Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.

Normal expression of RUNX1 has tumor-promoting effects.

High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

CX3CR1 on the Th2 cells promotes airway inflammation.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

Vitamin D deficiency effects the term of delivery.

Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile

PPAR-RXRs are inhibited by PPAR ligands.

Only a minority of cells survive development after differentiation into stress-resistant spores.

Venules have a thinner or absent smooth layer compared to arterioles.

Mitochondria are uninvolved in apoptosis.

In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.

Arterioles have a larger lumen diameter than venules.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

Venules have a larger lumen diameter than arterioles.

Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.

Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.


Polymeal nutrition reduces cardiovascular mortality.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

CX3CR1 on the Th2 cells promotes T cell survival

Febrile seizures increase the threshold for development of epilepsy.

N-terminal cleavage increases success identifying transcription start sites.

Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Dexamethasone decreases risk of postoperative bleeding.

Macrolides have no protective effect against myocardial infarction.

The one-child policy has been successful in lowering population growth.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

5% of perinatal mortality is due to low birth weight.

LDL cholesterol has no involvement in the development of cardiovascular disease.

Obesity is determined solely by environmental factors.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

Macrolides protect against myocardial infarction.

Suboptimal nutrition is not predictive of chronic disease

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

Input from  mental and physical health care professionals is effective at decreasing homelessness.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.


Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.

Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.

Anthrax spores can be disposed of easily after they are dispersed.

Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).

Cell autonomous sex determination in somatic cells occurs in Passeriformes.

Teaching hospitals do not provide better care than non-teaching hospitals.

Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.

p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.

Activation of PPM1D suppresses p53 function.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

N348I mutations cause resistance to zidovudine (AZT).

Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.


Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.

Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.

Localization of PIN1 in the roots of Arabidopsis does not require VPS9a

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.

Mitochondria are uninvolved in apoptosis.

Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.

Incidence rates of cervical cancer have decreased.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

Women with a higher birth weight are more likely to develop breast cancer later in life.

Breast cancer development is determined exclusively by genetic factors.

A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.

CHEK2 is not associated with breast cancer.

Birth-weight is positively associated with breast cancer.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.


Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

Articles published in open access format are less likely to be cited than traditional journals.

The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation

Albendazole is used to treat lymphatic filariasis.

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

Activator-inhibitor pairs are provided dorsally by Admpchordin.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.


Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.

Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Exposure to fine particulate air pollution is relate to anxiety prevalence.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Dexamethasone decreases risk of postoperative bleeding.

High levels of copeptin decrease risk of diabetes.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Glycolysis is one of the primary glycometabolic pathways in cells.

Only a minority of cells survive development after differentiation into stress-resistant spores.

0-dimensional biomaterials show inductive properties.

Mitochondria are uninvolved in apoptosis.

Podocytes are motile and migrate in the presence of injury.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.


Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

Only a minority of cells survive development after differentiation into stress-resistant spores.

N348I mutations cause resistance to zidovudine (AZT).

Low expression of miR7a exerts a biological function in testis.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.

Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

TNFAIP3 is a tumor suppressor in glioblastoma.

IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.

Activation of PPM1D suppresses p53 function.

The extracellular domain of TMEM27 is cleaved in human beta cells.

ADAR1 binds to Dicer to cleave pre-miRNA.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.


Pyridostatin destabilizes the G - quadruplex in the telomeric region.

N348I mutations cause resistance to zidovudine (AZT).

Chenodeosycholic acid treatment increases whole-body energy expenditure.

Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

UCB T cells maintain high TCR diversity after transplantation.

A deficiency of vitamin B12 increases blood levels of homocysteine.

Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.


Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.

Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.

Polymeal nutrition reduces cardiovascular mortality.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.

Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Peroxynitrite is required for nitration of TCR/CD8.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Dexamethasone decreases risk of postoperative bleeding.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.


Rapamycin decreases the concentration of triacylglycerols in fruit flies.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

The PRR MDA5 has a central DExD/H RNA helices domain.

ALDH1 expression is associated with poorer prognosis in breast cancer.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

Low nucleosome occupancy correlates with low methylation levels across species.

Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.

In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.

Aspirin inhibits the production of PGE2.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

Ethanol stress decreases the expression of IBP in bacteria.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.


Rapid phosphotransfer rates govern fidelity in two component systems

The PRR MDA5 has a central DExD/H RNA helices domain.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Hypertension is frequently observed in type 1 diabetes patients.

Monoclonal antibody targeting of N-cadherin inhibits metastasis.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

0-dimensional biomaterials show inductive properties.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

Low nucleosome occupancy correlates with low methylation levels across species.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

Gene expression does not vary appreciably across genetically identical cells.

Peroxynitrite is required for nitration of TCR/CD8.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.


Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.

PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.

Cell autonomous sex determination in somatic cells occurs in Passeriformes.

NR5A2 is important in development of endometrial tissues.

Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.

1/2000 in UK have abnormal PrP positivity.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).

The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

IRG1 has antiviral effects against neurotropic viruses.


Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.

Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.

Cell autonomous sex determination in somatic cells does not occur in Galliformes.

Aspirin inhibits the production of PGE2.

Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

IRG1 has antiviral effects against neurotropic viruses.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.

Subcutaneous fat depots undergo extensive browning processes after cold exposure.

Ivermectin is used to treat lymphatic filariasis.

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.


Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

Obesity is determined solely by environmental factors.

Articles published in open access format are more likely to be cited than traditional journals.

S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

Mitochondria are uninvolved in apoptosis.

The PPR MDA5 has two N-terminal CARD domains.

Occupancy of ribosomes by IncRNAs do not make functional peptides.

Ribosomopathies have a low degree of cell and tissue specific pathology.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.

In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.

The repair of Cas9-induced double strand breaks in human DNA is error-prone.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.


Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

Normal expression of RUNX1 has tumor-promoting effects.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

ADAR1 binds to Dicer to cleave pre-miRNA.

Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

Arginine 90 in p150n is important for interaction with EB1.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

CX3CR1 on the Th2 cells impairs T cell survival

CX3CR1 on the Th2 cells promotes T cell survival

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.


Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

aPKCz causes tumour enhancement by affecting glutamine metabolism.

Articles published in open access format are less likely to be cited than traditional journals.

PPAR-RXRs are inhibited by PPAR ligands.

Ivermectin is used to treat lymphatic filariasis.

PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.

Normal expression of RUNX1 has tumor-promoting effects.

The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years

The ureABIEFGH gene cluster is induced by nickel (II) ion.

Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.


Ribosomopathies have a low degree of cell and tissue specific pathology.

Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.

Cell autonomous sex determination in somatic cells does not occur in Galliformes.

Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Incidence of heart failure decreased by 10% in women since 1979.

CR is associated with higher methylation age.

Occupancy of ribosomes by IncRNAs do not make functional peptides.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

Macrolides protect against myocardial infarction.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.


S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

Podocytes are motile and migrate in the presence of injury.

Activator-inhibitor pairs are provided dorsally by Admpchordin.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

Peroxynitrite is required for nitration of TCR/CD8.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

The PRR MDA5 has a central DExD/H RNA helices domain.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.


Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

Participating in six months of physical activity improves cognitive functioning.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.

The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.

Dexamethasone decreases risk of postoperative bleeding.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

Monoclonal antibody targeting of N-cadherin inhibits metastasis.

LDL cholesterol has no involvement in the development of cardiovascular disease.


Silencing of Bcl2 is important for the maintenance and progression of tumors.

Insomnia can be effectively treated with cognitive behavioral therapy.

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

Low expression of miR7a exerts a biological function in testis.

Input from  mental and physical health care professionals is effective at decreasing homelessness.

NFAT4 activation requires IP3R-mediated Ca2+ mobilization.

CR is associated with higher methylation age.

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

Transferred UCB T cells acquire a memory-like phenotype in recipients.

Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.


Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

N-terminal cleavage reduces success identifying transcription start sites.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

Activation of PPM1D suppresses p53 function.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

The PPR MDA5 has two N-terminal CARD domains.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.


Incidence rates of cervical cancer have decreased.

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.

Ivermectin is used to treat onchocerciasis.

1/2000 in UK have abnormal PrP positivity.

Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Only a minority of cells survive development after differentiation into stress-resistant spores.

LDL cholesterol has no involvement in the development of cardiovascular disease.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

A deficiency of vitamin B12 increases blood levels of homocysteine.

Leuko-increased blood increases infectious complications in red blood cell transfusion.

High levels of copeptin decrease risk of diabetes.

Leuko-reduced blood reduces infectious complications in red blood cell transfusion.

Dexamethasone decreases risk of postoperative bleeding.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.


Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

The PRR MDA5 is a sensor of RNA virus infection.

Exposure to fine particulate air pollution is relate to anxiety prevalence.

The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.

Vitamin D deficiency effects the term of delivery.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.

Hypothalamic glutamate neurotransmission is crucial to energy balance.


Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Peroxynitrite is required for nitration of TCR/CD8.

Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.

S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Auditory entrainment is strengthened when people see congruent visual and auditory information.

Arterioles have a larger lumen diameter than venules.

The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.

Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.

Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.


Subcutaneous fat depots undergo extensive browning processes after cold exposure.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.

p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Normal expression of RUNX1 has tumor-promoting effects.

Obesity is determined solely by environmental factors.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

Bone marrow cells contribute to adult macrophage compartments.

Ethanol stress decreases the expression of IBP in bacteria.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

High levels of copeptin decrease risk of diabetes.

Suboptimal nutrition is not predictive of chronic disease


Suboptimal nutrition is not predictive of chronic disease

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

Chenodeosycholic acid treatment increases whole-body energy expenditure.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Cellular aging closely links to an older appearance.

Localization of PIN1 in the roots of Arabidopsis does not require VPS9a

The myocardial lineage develops from cardiac progenitors of mesodermal origin.

Macrolides have no protective effect against myocardial infarction.

Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Vitamin D deficiency is unrelated to birth weight.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Polymeal nutrition reduces cardiovascular mortality.

Vitamin D deficiency effects the term of delivery.


Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.

Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Febrile seizures reduce the threshold for development of epilepsy.

The availability of safe places to study is not effective at decreasing homelessness.

The PRR MDA5 is a sensor of RNA virus infection.

Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.

5% of perinatal mortality is due to low birth weight.

The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Activator-inhibitor pairs are provided dorsally by Admpchordin.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.


T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

There is an inverse relationship between hip fractures and statin use.

The PPR MDA5 has two N-terminal CARD domains.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Mitochondria are uninvolved in apoptosis.

Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

In adult tissue, most T cells are memory T cells.

CX3CR1 on the Th2 cells promotes T cell survival

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

CX3CR1 on the Th2 cells impairs T cell survival

UCB T cells reduce TCR diversity after transplantation.


TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

ADAR1 binds to Dicer to cleave pre-miRNA.

CR is associated with higher methylation age.

Leuko-increased blood increases infectious complications in red blood cell transfusion.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

Most termination events in Okazaki fragments are sequence specific.

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.

Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.

UCB T cells maintain high TCR diversity after transplantation.


TNFAIP3 is a tumor suppressor in glioblastoma.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

Rapid phosphotransfer rates govern fidelity in two component systems

CHEK2 is not associated with breast cancer.

Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

Teaching hospitals do not provide better care than non-teaching hospitals.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years

Low expression of miR7a exerts a biological function in testis.

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

The extracellular domain of TMEM27 is cleaved in human beta cells.

ALDH1 expression is associated with better breast cancer outcomes.

ALDH1 expression is associated with poorer prognosis in breast cancer.

IRG1 has antiviral effects against neurotropic viruses.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

The locus rs647161 is associated with colorectal carcinoma.


Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer.

PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).

Venules have a thinner or absent smooth layer compared to arterioles.

Ivermectin is used to treat lymphatic filariasis.

Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.

Albendazole is used to treat lymphatic filariasis.

Low nucleosome occupancy correlates with low methylation levels across species.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

The availability of safe places to study is not effective at decreasing homelessness.

The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Dexamethasone decreases risk of postoperative bleeding.

Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).


Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.

Febrile seizures reduce the threshold for development of epilepsy.

Peroxynitrite is required for nitration of TCR/CD8.

Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

0-dimensional biomaterials show inductive properties.

Macrolides have no protective effect against myocardial infarction.

Dexamethasone decreases risk of postoperative bleeding.

There is an inverse relationship between hip fractures and statin use.

Leuko-reduced blood reduces infectious complications in red blood cell transfusion.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.

Hypertension is frequently observed in type 1 diabetes patients.

Hypoglycemia increases the risk of dementia.

LDL cholesterol has no involvement in the development of cardiovascular disease.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

Insulin increases risk of severe kidney failure.

Obesity is determined solely by environmental factors.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.


Teaching hospitals do not provide better care than non-teaching hospitals.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

Activator-inhibitor pairs are provided dorsally by Admpchordin.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

Rapid phosphotransfer rates govern fidelity in two component systems

A deficiency of vitamin B12 increases blood levels of homocysteine.

Ivermectin is used to treat lymphatic filariasis.

Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

Bariatric surgery has a positive impact on mental health.

Patients in stable partnerships have a faster progression from HIV to AIDS.

The availability of safe places to study is not effective at decreasing homelessness.

Articles published in open access format are less likely to be cited than traditional journals.

Input from  mental and physical health care professionals is effective at decreasing homelessness.

The availability of safe places to study is effective at decreasing homelessness.

Articles published in open access format are more likely to be cited than traditional journals.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.


Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

Bone marrow cells contribute to adult macrophage compartments.

Auditory entrainment is strengthened when people see congruent visual and auditory information.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).

Birth-weight is positively associated with breast cancer.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

N348I mutations cause resistance to zidovudine (AZT).

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Ivermectin is used to treat lymphatic filariasis.

Albendazole is used to treat lymphatic filariasis.

TNFAIP3 is a tumor suppressor in glioblastoma.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

CHEK2 is not associated with breast cancer.


The DdrB protein from Deinococcus radiodurans is an alternative SSB.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

Ivermectin is used to treat onchocerciasis.

Incidence of heart failure decreased by 10% in women since 1979.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.

aPKCz causes tumour enhancement by affecting glutamine metabolism.

Cells undergoing methionine restriction may activate miRNAs.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

The PRR MDA5 has a central DExD/H RNA helices domain.

The PPR MDA5 has two N-terminal CARD domains.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

The PRR MDA5 is a sensor of RNA virus infection.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Peroxynitrite is required for nitration of TCR/CD8.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.