Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.

The locus rs647161 is associated with colorectal carcinoma.

CX3CR1 on the Th2 cells suppresses airway inflammation.

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

IRG1 has antiviral effects against neurotropic viruses.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

Articles published in open access format are more likely to be cited than traditional journals.

A deficiency of vitamin B12 increases blood levels of homocysteine.

Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

0-dimensional biomaterials show inductive properties.

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

CHEK2 is not associated with breast cancer.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

aPKCz causes tumour enhancement by affecting glutamine metabolism.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.


Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.

Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

CX3CR1 on the Th2 cells promotes airway inflammation.

Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Anthrax spores can be disposed of easily after they are dispersed.

Hypoglycemia increases the risk of dementia.

1/2000 in UK have abnormal PrP positivity.

The locus rs647161 is associated with colorectal carcinoma.

The PPR MDA5 has two N-terminal CARD domains.

The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

The PRR MDA5 has a central DExD/H RNA helices domain.

The PRR MDA5 is a sensor of RNA virus infection.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

Localization of PIN1 in the roots of Arabidopsis does not require VPS9a

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.


Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

5% of perinatal mortality is due to low birth weight.

Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.

Chenodeosycholic acid treatment increases whole-body energy expenditure.

The availability of safe places to study is effective at decreasing homelessness.

In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Low nucleosome occupancy correlates with low methylation levels across species.

Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.


Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

Headaches are not correlated with cognitive impairment.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

Rapamycin decreases the concentration of triacylglycerols in fruit flies.

Cellular aging closely links to an older appearance.

Obesity is determined solely by environmental factors.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

Vitamin D deficiency is unrelated to birth weight.

The PPR MDA5 has two N-terminal CARD domains.

There is no association between HNF4A mutations and diabetes risks.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

CX3CR1 on the Th2 cells promotes airway inflammation.

CX3CR1 on the Th2 cells suppresses airway inflammation.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

PD-1 triggering on monocytes reduces IL-10 production by monocytes.


Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.

ALDH1 expression is associated with better breast cancer outcomes.

IRG1 has antiviral effects against neurotropic viruses.

Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Women with a higher birth weight are more likely to develop breast cancer later in life.

Tirasemtiv has no effect on fast-twitch muscle.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

The availability of safe places to study is effective at decreasing homelessness.

Mitochondria are uninvolved in apoptosis.

NFAT4 activation requires IP3R-mediated Ca2+ mobilization.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

A deficiency of vitamin B12 increases blood levels of homocysteine.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.


Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

Mitochondria are uninvolved in apoptosis.

Cell autonomous sex determination in somatic cells does not occur in Galliformes.

GATA-3 is important for hematopoietic stem cell (HSC) function.

CR is associated with higher methylation age.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.

Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

CX3CR1 on the Th2 cells promotes airway inflammation.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

Arginine 90 in p150n is important for interaction with EB1.


DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.

TNFAIP3 is a tumor suppressor in glioblastoma.

Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

Vitamin D deficiency effects the term of delivery.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.

Articles published in open access format are more likely to be cited than traditional journals.

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.

The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

The PPR MDA5 has two N-terminal CARD domains.

Activation of PPM1D suppresses p53 function.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

The locus rs647161 is associated with colorectal carcinoma.

Low expression of miR7a exerts a biological function in testis.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

aPKCz causes tumour enhancement by affecting glutamine metabolism.


De novo assembly of sequence data has more specific contigs than unassembled sequence data.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Subcutaneous fat depots undergo extensive browning processes after cold exposure.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

NR5A2 is important in development of endometrial tissues.

N348I mutations cause resistance to zidovudine (AZT).

1/2000 in UK have abnormal PrP positivity.

Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

The risk of male prisoners harming themselves is ten times that of female prisoners.

Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.

Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

Most termination events in Okazaki fragments are sequence specific.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

0-dimensional biomaterials show inductive properties.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

The amount of publicly available DNA data doubles every 10 years.

1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.

Occupancy of ribosomes by IncRNAs do not make functional peptides.


Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.

Ethanol stress decreases the expression of IBP in bacteria.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

The myocardial lineage develops from cardiac progenitors of mesodermal origin.

The PRR MDA5 has a central DExD/H RNA helices domain.

CX3CR1 on the Th2 cells promotes T cell survival

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.

Aspirin inhibits the production of PGE2.

Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer.

N348I mutations cause resistance to zidovudine (AZT).

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile


Rapamycin decreases the concentration of triacylglycerols in fruit flies.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

Ivermectin is used to treat onchocerciasis.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

N348I mutations cause resistance to zidovudine (AZT).

Mitochondria are uninvolved in apoptosis.

Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.

In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.

cSMAC formation enhances weak ligand signalling.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

Glycolysis is one of the primary glycometabolic pathways in cells.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.


Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Bone marrow cells contribute to adult macrophage compartments.

Arterioles have a larger lumen diameter than venules.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).

Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.

The extracellular domain of TMEM27 is cleaved in human beta cells.

There is an inverse relationship between hip fractures and statin use.

The myocardial lineage develops from cardiac progenitors of mesodermal origin.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

N348I mutations cause resistance to zidovudine (AZT).

Enhanced early production of inflammatory chemokines improves viral control in the lung.

TNFAIP3 is a tumor suppressor in glioblastoma.

p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

PD-1 triggering on monocytes reduces IL-10 production by monocytes.


Dexamethasone decreases risk of postoperative bleeding.

0-dimensional biomaterials show inductive properties.

Rapamycin decreases the concentration of triacylglycerols in fruit flies.

Subcutaneous fat depots undergo extensive browning processes after cold exposure.

Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.

NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

Incidence rates of cervical cancer have decreased.

Bariatric surgery has a positive impact on mental health.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

LDL cholesterol has no involvement in the development of cardiovascular disease.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.


Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

Albendazole is used to treat lymphatic filariasis.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Women with a higher birth weight are more likely to develop breast cancer later in life.

High cardiopulmonary fitness causes increased mortality rate.

Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Hypertension is frequently observed in type 1 diabetes patients.

Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.


Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

Hypocretin neurones induce panicprone state in rats.

The extracellular domain of TMEM27 is cleaved in human beta cells.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.

Glycolysis is one of the primary glycometabolic pathways in cells.

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.

Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.

IRG1 has antiviral effects against neurotropic viruses.

N-terminal cleavage increases success identifying transcription start sites.

N-terminal cleavage reduces success identifying transcription start sites.

Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

Occupancy of ribosomes by IncRNAs do not make functional peptides.

Most termination events in Okazaki fragments are sequence specific.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.


Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

Venules have a larger lumen diameter than arterioles.

Arterioles have a larger lumen diameter than venules.

Only a minority of cells survive development after differentiation into stress-resistant spores.

N348I mutations cause resistance to zidovudine (AZT).

Silencing of Bcl2 is important for the maintenance and progression of tumors.

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

Normal expression of RUNX1 has tumor-promoting effects.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Breast cancer development is determined exclusively by genetic factors.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.


During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.

Vitamin D deficiency effects the term of delivery.

The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Low nucleosome occupancy correlates with low methylation levels across species.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.

Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.

The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.

The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

Activator-inhibitor pairs are provided dorsally by Admpchordin.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.


Enhanced early production of inflammatory chemokines improves viral control in the lung.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

Most termination events in Okazaki fragments are sequence specific.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Bone marrow cells contribute to adult macrophage compartments.

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

The amount of publicly available DNA data doubles every 10 years.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.


Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.

Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer.

IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.

Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.

Cell autonomous sex determination in somatic cells occurs in Passeriformes.

Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.

The myocardial lineage develops from cardiac progenitors of mesodermal origin.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation

Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.

Suboptimal nutrition is not predictive of chronic disease

Obesity is determined solely by environmental factors.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

5% of perinatal mortality is due to low birth weight.

High cardiopulmonary fitness causes increased mortality rate.

Exposure to fine particulate air pollution is relate to anxiety prevalence.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.


Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

Low expression of miR7a exerts a biological function in testis.

Headaches are not correlated with cognitive impairment.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

GATA-3 is important for hematopoietic stem cell (HSC) function.

Cataract and trachoma are the primary cause of blindness in Southern Sudan.

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.


Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.

Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.

Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

Hypertension is frequently observed in type 1 diabetes patients.

Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Dexamethasone decreases risk of postoperative bleeding.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.


Ethanol stress decreases the expression of IBP in bacteria.

Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

The myocardial lineage develops from cardiac progenitors of mesodermal origin.

Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

CX3CR1 on the Th2 cells suppresses airway inflammation.

Tirasemtiv has no effect on fast-twitch muscle.

NFAT4 activation requires IP3R-mediated Ca2+ mobilization.

There is no association between HNF4A mutations and diabetes risks.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.

Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile

Rapamycin decreases the concentration of triacylglycerols in fruit flies.

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.


Exposure to fine particulate air pollution is relate to anxiety prevalence.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

Articles published in open access format are less likely to be cited than traditional journals.

Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.

Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Febrile seizures reduce the threshold for development of epilepsy.

Articles published in open access format are more likely to be cited than traditional journals.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

Headaches are not correlated with cognitive impairment.

Insomnia can be effectively treated with cognitive behavioral therapy.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

Hypoglycemia increases the risk of dementia.

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.


Febrile seizures increase the threshold for development of epilepsy.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.

Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

Obesity is determined solely by environmental factors.

Vitamin D deficiency effects the term of delivery.

A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.

Low nucleosome occupancy correlates with low methylation levels across species.

Febrile seizures reduce the threshold for development of epilepsy.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Hypocretin neurones induce panicprone state in rats.

Activation of PPM1D suppresses p53 function.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.


Febrile seizures reduce the threshold for development of epilepsy.

Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.

High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Dexamethasone decreases risk of postoperative bleeding.

Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.

IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.


Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.

Albendazole is used to treat lymphatic filariasis.

Podocytes are motile and migrate in the presence of injury.

CHEK2 is not associated with breast cancer.

Insulin increases risk of severe kidney failure.

Cell autonomous sex determination in somatic cells does not occur in Galliformes.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.

UCB T cells maintain high TCR diversity after transplantation.

Birth-weight is positively associated with breast cancer.

Occupancy of ribosomes by IncRNAs do not make functional peptides.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

Women with a higher birth weight are more likely to develop breast cancer later in life.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.

5% of perinatal mortality is due to low birth weight.

There is no association between HNF4A mutations and diabetes risks.


Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

N348I mutations cause resistance to zidovudine (AZT).

CX3CR1 on the Th2 cells promotes airway inflammation.

The repair of Cas9-induced double strand breaks in human DNA is error-prone.

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.

NR5A2 is important in development of endometrial tissues.

Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.

Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

0-dimensional biomaterials show inductive properties.

Venules have a thinner or absent smooth layer compared to arterioles.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

Macrolides protect against myocardial infarction.

Macrolides have no protective effect against myocardial infarction.

Arterioles have a larger lumen diameter than venules.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.


FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

A deficiency of vitamin B12 increases blood levels of homocysteine.

CX3CR1 on the Th2 cells promotes T cell survival

The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.

Hematopoietic Stem Cell purification reaches purity rate of up to 50%.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

Arterioles have a larger lumen diameter than venules.

CX3CR1 on the Th2 cells suppresses airway inflammation.

Normal expression of RUNX1 has tumor-promoting effects.

Mitochondria are uninvolved in apoptosis.

The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

TNFAIP3 is a tumor suppressor in glioblastoma.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.


Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

Cells undergoing methionine restriction may activate miRNAs.

Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.

Activator-inhibitor pairs are provided dorsally by Admpchordin.

The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

IRG1 has antiviral effects against neurotropic viruses.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

The repair of Cas9-induced double strand breaks in human DNA is error-prone.

S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.

Low nucleosome occupancy correlates with low methylation levels across species.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

Most termination events in Okazaki fragments are sequence specific.

Ribosomopathies have a low degree of cell and tissue specific pathology.


Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Gene expression does not vary appreciably across genetically identical cells.

Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

Cell autonomous sex determination in somatic cells occurs in Passeriformes.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

There is no association between HNF4A mutations and diabetes risks.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.

Macrolides have no protective effect against myocardial infarction.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.


Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation

The PRR MDA5 is a sensor of RNA virus infection.

In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Birth-weight is positively associated with breast cancer.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.

A deficiency of vitamin B12 increases blood levels of homocysteine.

Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Ivermectin is used to treat lymphatic filariasis.

Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

Activator-inhibitor pairs are provided dorsally by Admpchordin.


Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.

The locus rs647161 is associated with colorectal carcinoma.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.

Normal expression of RUNX1 has tumor-promoting effects.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.


GATA-3 is important for hematopoietic stem cell (HSC) function.

Obesity is determined solely by environmental factors.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.

High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

Bariatric surgery has a positive impact on mental health.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.

Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

All hematopoietic stem cells segregate their chromosomes randomly.

Hematopoietic Stem Cell purification reaches purity rate of up to 50%.

ALDH1 expression is associated with better breast cancer outcomes.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

TNFAIP3 is a tumor suppressor in glioblastoma.

The PPR MDA5 has two N-terminal CARD domains.

NR5A2 is important in development of endometrial tissues.

ALDH1 expression is associated with poorer prognosis in breast cancer.

The PRR MDA5 has a central DExD/H RNA helices domain.


Gene expression does not vary appreciably across genetically identical cells.

Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Suboptimal nutrition is not predictive of chronic disease

Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.

Febrile seizures reduce the threshold for development of epilepsy.

Bone marrow cells contribute to adult macrophage compartments.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

Podocytes are motile and migrate in the presence of injury.

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

Low nucleosome occupancy correlates with low methylation levels across species.

Breast cancer development is determined exclusively by genetic factors.

Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

Ribosomopathies have a low degree of cell and tissue specific pathology.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

Transplanted human glial cells can differentiate within the host animal.

Cellular aging closely links to an older appearance.


Glycolysis is one of the primary glycometabolic pathways in cells.

Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.

Mitochondria are uninvolved in apoptosis.

Transplanted human glial cells can differentiate within the host animal.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

Ethanol stress decreases the expression of IBP in bacteria.

Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

Cellular aging closely links to an older appearance.

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.

Bone marrow cells contribute to adult macrophage compartments.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.

Hypothalamic glutamate neurotransmission is crucial to energy balance.


Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

Leuko-increased blood increases infectious complications in red blood cell transfusion.

Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.

LDL cholesterol has no involvement in the development of cardiovascular disease.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

cSMAC formation enhances weak ligand signalling.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

In adult tissue, most T cells are memory T cells.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

CX3CR1 on the Th2 cells impairs T cell survival

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

CX3CR1 on the Th2 cells promotes T cell survival


HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years

Glycolysis is one of the primary glycometabolic pathways in cells.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

Cold exposure increases BAT recruitment.

The risk of male prisoners harming themselves is ten times that of female prisoners.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

There is no association between HNF4A mutations and diabetes risks.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.

A deficiency of vitamin B12 increases blood levels of homocysteine.

Vitamin D deficiency is unrelated to birth weight.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Hypertension is frequently observed in type 1 diabetes patients.

Hypoglycemia increases the risk of dementia.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.


Headaches are not correlated with cognitive impairment.

Cataract and trachoma are the primary cause of blindness in Southern Sudan.

Cells undergoing methionine restriction may activate miRNAs.

Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.

Chenodeosycholic acid treatment reduces whole-body energy expenditure.

PPAR-RXRs are inhibited by PPAR ligands.

Cell autonomous sex determination in somatic cells does not occur in Galliformes.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Aspirin inhibits the production of PGE2.

Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.

The myocardial lineage develops from cardiac progenitors of mesodermal origin.

Insomnia can be effectively treated with cognitive behavioral therapy.

Febrile seizures reduce the threshold for development of epilepsy.

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.

Febrile seizures increase the threshold for development of epilepsy.

Auditory entrainment is strengthened when people see congruent visual and auditory information.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

Exposure to fine particulate air pollution is relate to anxiety prevalence.


Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.

N348I mutations cause resistance to zidovudine (AZT).

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Glycolysis is one of the primary glycometabolic pathways in cells.

Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.

Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

Input from  mental and physical health care professionals is effective at decreasing homelessness.

Teaching hospitals do not provide better care than non-teaching hospitals.

The availability of safe places to study is not effective at decreasing homelessness.

The availability of safe places to study is effective at decreasing homelessness.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

Bariatric surgery has a positive impact on mental health.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

Patients in stable partnerships have a faster progression from HIV to AIDS.


Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Macrolides protect against myocardial infarction.

The PRR MDA5 is a sensor of RNA virus infection.

The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.

ADAR1 binds to Dicer to cleave pre-miRNA.

ALDH1 expression is associated with better breast cancer outcomes.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile

Ethanol stress decreases the expression of IBP in bacteria.

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.


Hematopoietic Stem Cell purification reaches purity rate of up to 50%.

Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Auditory entrainment is strengthened when people see congruent visual and auditory information.

PD-1 triggering on monocytes reduces IL-10 production by monocytes.

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

All hematopoietic stem cells segregate their chromosomes randomly.

GATA-3 is important for hematopoietic stem cell (HSC) function.

Leuko-reduced blood reduces infectious complications in red blood cell transfusion.

Leuko-increased blood increases infectious complications in red blood cell transfusion.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Peroxynitrite is required for nitration of TCR/CD8.

Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.

The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.


High cardiopulmonary fitness causes increased mortality rate.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.

Febrile seizures increase the threshold for development of epilepsy.

Venules have a larger lumen diameter than arterioles.

Leuko-reduced blood reduces infectious complications in red blood cell transfusion.

High levels of copeptin decrease risk of diabetes.

Ivermectin is used to treat onchocerciasis.

ALDH1 expression is associated with poorer prognosis in breast cancer.

The amount of publicly available DNA data doubles every 10 years.

Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

Incidence of heart failure decreased by 10% in women since 1979.

5% of perinatal mortality is due to low birth weight.

Insulin increases risk of severe kidney failure.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Hypoglycemia increases the risk of dementia.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.


High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

0-dimensional biomaterials show inductive properties.

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

N-terminal cleavage reduces success identifying transcription start sites.

In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.

The availability of safe places to study is effective at decreasing homelessness.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

A deficiency of vitamin B12 increases blood levels of homocysteine.

LDL cholesterol has no involvement in the development of cardiovascular disease.

Chenodeosycholic acid treatment increases whole-body energy expenditure.

Chenodeosycholic acid treatment reduces whole-body energy expenditure.

High levels of copeptin decrease risk of diabetes.

Vitamin D deficiency is unrelated to birth weight.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.


High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

The locus rs647161 is associated with colorectal carcinoma.

Silencing of Bcl2 is important for the maintenance and progression of tumors.

Polymeal nutrition reduces cardiovascular mortality.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.

Glycolysis is one of the primary glycometabolic pathways in cells.

Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Exposure to fine particulate air pollution is relate to anxiety prevalence.

Dexamethasone decreases risk of postoperative bleeding.

Hypertension is frequently observed in type 1 diabetes patients.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.


High levels of copeptin decrease risk of diabetes.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

Ivermectin is used to treat lymphatic filariasis.

High cardiopulmonary fitness causes increased mortality rate.

The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.

Febrile seizures increase the threshold for development of epilepsy.

Hypertension is frequently observed in type 1 diabetes patients.

In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.

The PPR MDA5 has two N-terminal CARD domains.

Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

Insulin increases risk of severe kidney failure.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Headaches are not correlated with cognitive impairment.


High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Cold exposure increases BAT recruitment.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

CX3CR1 on the Th2 cells impairs T cell survival

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

LDL cholesterol has no involvement in the development of cardiovascular disease.

CX3CR1 on the Th2 cells promotes T cell survival


Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Arterioles have a larger lumen diameter than venules.

Incidence of heart failure decreased by 10% in women since 1979.

Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.

Breast cancer development is determined exclusively by genetic factors.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

Women with a higher birth weight are more likely to develop breast cancer later in life.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

N-terminal cleavage increases success identifying transcription start sites.

N-terminal cleavage reduces success identifying transcription start sites.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Low nucleosome occupancy correlates with low methylation levels across species.

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

CR is associated with higher methylation age.


Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

PD-1 triggering on monocytes reduces IL-10 production by monocytes.

Chenodeosycholic acid treatment increases whole-body energy expenditure.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.

N348I mutations cause resistance to zidovudine (AZT).

Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

CX3CR1 on the Th2 cells impairs T cell survival

In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.

Ethanol stress decreases the expression of IBP in bacteria.

Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.


Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.

Activator-inhibitor pairs are provided dorsally by Admpchordin.

Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.

The extracellular domain of TMEM27 is cleaved in human beta cells.

Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

TNFAIP3 is a tumor suppressor in glioblastoma.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

Cataract and trachoma are the primary cause of blindness in Southern Sudan.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.


Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Insomnia can be effectively treated with cognitive behavioral therapy.

NFAT4 activation requires IP3R-mediated Ca2+ mobilization.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Hematopoietic Stem Cell purification reaches purity rate of up to 50%.

Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Dexamethasone decreases risk of postoperative bleeding.

Hypertension is frequently observed in type 1 diabetes patients.

Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Hypoglycemia increases the risk of dementia.


Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.

Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.

Bone marrow cells contribute to adult macrophage compartments.

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

CR is associated with higher methylation age.

Transplanted human glial cells can differentiate within the host animal.

PPAR-RXRs are inhibited by PPAR ligands.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.


Hypertension is frequently observed in type 1 diabetes patients.

Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

Vitamin D deficiency effects the term of delivery.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

Cells undergoing methionine restriction may activate miRNAs.

Exposure to fine particulate air pollution is relate to anxiety prevalence.

Women with a higher birth weight are more likely to develop breast cancer later in life.

Insulin increases risk of severe kidney failure.

Headaches are not correlated with cognitive impairment.

High levels of copeptin decrease risk of diabetes.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years


Hypocretin neurones induce panicprone state in rats.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Monoclonal antibody targeting of N-cadherin inhibits metastasis.

ALDH1 expression is associated with poorer prognosis in breast cancer.

Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

GATA-3 is important for hematopoietic stem cell (HSC) function.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.

The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Febrile seizures increase the threshold for development of epilepsy.

Febrile seizures reduce the threshold for development of epilepsy.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

Exposure to fine particulate air pollution is relate to anxiety prevalence.

The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

IRG1 has antiviral effects against neurotropic viruses.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).


Hypoglycemia increases the risk of dementia.

The PRR MDA5 is a sensor of RNA virus infection.

Febrile seizures reduce the threshold for development of epilepsy.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Aspirin inhibits the production of PGE2.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

Bone marrow cells contribute to adult macrophage compartments.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.

Headaches are not correlated with cognitive impairment.

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Insomnia can be effectively treated with cognitive behavioral therapy.

Hypertension is frequently observed in type 1 diabetes patients.

A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.


Hypothalamic glutamate neurotransmission is crucial to energy balance.

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

5% of perinatal mortality is due to low birth weight.

Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.

N-terminal cleavage increases success identifying transcription start sites.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Auditory entrainment is strengthened when people see congruent visual and auditory information.

aPKCz causes tumour enhancement by affecting glutamine metabolism.

Glycolysis is one of the primary glycometabolic pathways in cells.


IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.

A deficiency of vitamin B12 increases blood levels of homocysteine.

Venules have a larger lumen diameter than arterioles.

Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.

Gene expression does not vary appreciably across genetically identical cells.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

The availability of safe places to study is not effective at decreasing homelessness.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

IRG1 has antiviral effects against neurotropic viruses.

The repair of Cas9-induced double strand breaks in human DNA is error-prone.

Cells undergoing methionine restriction may activate miRNAs.

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

ADAR1 binds to Dicer to cleave pre-miRNA.

Occupancy of ribosomes by IncRNAs do not make functional peptides.

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.


IRG1 has antiviral effects against neurotropic viruses.

Cold exposure increases BAT recruitment.

The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

Low expression of miR7a exerts a biological function in testis.

Hypertension is frequently observed in type 1 diabetes patients.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

ADAR1 binds to Dicer to cleave pre-miRNA.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

TNFAIP3 is a tumor suppressor in glioblastoma.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Arginine 90 in p150n is important for interaction with EB1.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.


ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Low nucleosome occupancy correlates with low methylation levels across species.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

The amount of publicly available DNA data doubles every 10 years.

In adult tissue, most T cells are memory T cells.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

CX3CR1 on the Th2 cells promotes T cell survival

CX3CR1 on the Th2 cells impairs T cell survival

Low expression of miR7a exerts a biological function in testis.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.


IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.

The availability of safe places to study is effective at decreasing homelessness.

Auditory entrainment is strengthened when people see congruent visual and auditory information.

IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.

ALDH1 expression is associated with poorer prognosis in breast cancer.

Chenodeosycholic acid treatment increases whole-body energy expenditure.

Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.

High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

Activation of PPM1D suppresses p53 function.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

Glycolysis is one of the primary glycometabolic pathways in cells.

Arginine 90 in p150n is important for interaction with EB1.

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.