Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.

Febrile seizures reduce the threshold for development of epilepsy.

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.

PD-1 triggering on monocytes reduces IL-10 production by monocytes.

Teaching hospitals do not provide better care than non-teaching hospitals.

Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Exposure to fine particulate air pollution is relate to anxiety prevalence.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

Mitochondria are uninvolved in apoptosis.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.

Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.


Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

Articles published in open access format are more likely to be cited than traditional journals.

ADAR1 binds to Dicer to cleave pre-miRNA.

UCB T cells maintain high TCR diversity after transplantation.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.

PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.

Ivermectin is used to treat onchocerciasis.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Leuko-increased blood increases infectious complications in red blood cell transfusion.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

CX3CR1 on the Th2 cells promotes airway inflammation.

CX3CR1 on the Th2 cells suppresses airway inflammation.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.


In adult tissue, most T cells are memory T cells.

Monoclonal antibody targeting of N-cadherin inhibits metastasis.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Arterioles have a larger lumen diameter than venules.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

Transferred UCB T cells acquire a memory-like phenotype in recipients.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

CX3CR1 on the Th2 cells promotes T cell survival

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

UCB T cells maintain high TCR diversity after transplantation.

CX3CR1 on the Th2 cells impairs T cell survival

UCB T cells reduce TCR diversity after transplantation.


In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.

There is no association between HNF4A mutations and diabetes risks.

Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

cSMAC formation enhances weak ligand signalling.

Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.

Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.

During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.

High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

Ivermectin is used to treat onchocerciasis.

Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

All hematopoietic stem cells segregate their chromosomes randomly.

Low nucleosome occupancy correlates with low methylation levels across species.

The repair of Cas9-induced double strand breaks in human DNA is error-prone.

Anthrax spores can be disposed of easily after they are dispersed.

Cell autonomous sex determination in somatic cells does not occur in Galliformes.

Gene expression does not vary appreciably across genetically identical cells.

Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.


In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.

Cell autonomous sex determination in somatic cells occurs in Passeriformes.

Low expression of miR7a exerts a biological function in testis.

Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.

Normal expression of RUNX1 has tumor-promoting effects.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Localization of PIN1 in the roots of Arabidopsis does not require VPS9a

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

Only a minority of cells survive development after differentiation into stress-resistant spores.

Podocytes are motile and migrate in the presence of injury.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile


In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.

Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.

The PRR MDA5 has a central DExD/H RNA helices domain.

Cellular aging closely links to an older appearance.

The PRR MDA5 is a sensor of RNA virus infection.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

N348I mutations cause resistance to zidovudine (AZT).

Ribosomopathies have a low degree of cell and tissue specific pathology.

TNFAIP3 is a tumor suppressor in glioblastoma.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

cSMAC formation enhances weak ligand signalling.

NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).


In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

The DdrB protein from Deinococcus radiodurans is an alternative SSB.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Gene expression does not vary appreciably across genetically identical cells.

The extracellular domain of TMEM27 is cleaved in human beta cells.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

CHEK2 is not associated with breast cancer.

ALDH1 expression is associated with poorer prognosis in breast cancer.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.

ALDH1 expression is associated with better breast cancer outcomes.


In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

0-dimensional biomaterials show inductive properties.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.

Silencing of Bcl2 is important for the maintenance and progression of tumors.

Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

Insomnia can be effectively treated with cognitive behavioral therapy.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Headaches are not correlated with cognitive impairment.

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Dexamethasone decreases risk of postoperative bleeding.

High levels of copeptin decrease risk of diabetes.

Hypertension is frequently observed in type 1 diabetes patients.


Incidence of heart failure decreased by 10% in women since 1979.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

N348I mutations cause resistance to zidovudine (AZT).

ALDH1 expression is associated with better breast cancer outcomes.

PPAR-RXRs are inhibited by PPAR ligands.

Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.

Women with a higher birth weight are more likely to develop breast cancer later in life.

High cardiopulmonary fitness causes increased mortality rate.

5% of perinatal mortality is due to low birth weight.

Incidence rates of cervical cancer have decreased.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Insulin increases risk of severe kidney failure.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.


Incidence rates of cervical cancer have decreased.

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

ALDH1 expression is associated with poorer prognosis in breast cancer.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

Macrolides protect against myocardial infarction.

The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.

Leuko-increased blood increases infectious complications in red blood cell transfusion.

Venules have a thinner or absent smooth layer compared to arterioles.

Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.

Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

Birth-weight is positively associated with breast cancer.

Breast cancer development is determined exclusively by genetic factors.

A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.


Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.

p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Enhanced early production of inflammatory chemokines improves viral control in the lung.

Cell autonomous sex determination in somatic cells occurs in Passeriformes.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Headaches are not correlated with cognitive impairment.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

Transferred UCB T cells acquire a memory-like phenotype in recipients.

Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.

Articles published in open access format are more likely to be cited than traditional journals.

Ribosomopathies have a low degree of cell and tissue specific pathology.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.


Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.

Bariatric surgery has a positive impact on mental health.

Rapamycin decreases the concentration of triacylglycerols in fruit flies.

All hematopoietic stem cells segregate their chromosomes randomly.

The PPR MDA5 has two N-terminal CARD domains.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

CX3CR1 on the Th2 cells impairs T cell survival

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

PPAR-RXRs can be activated by PPAR ligands.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

CX3CR1 on the Th2 cells promotes T cell survival

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

ADAR1 binds to Dicer to cleave pre-miRNA.


Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

The PRR MDA5 is a sensor of RNA virus infection.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

Normal expression of RUNX1 has tumor-promoting effects.

Patients in stable partnerships have a faster progression from HIV to AIDS.

Albendazole is used to treat lymphatic filariasis.

Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.

Rapid phosphotransfer rates govern fidelity in two component systems

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

Ivermectin is used to treat lymphatic filariasis.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

Leuko-increased blood increases infectious complications in red blood cell transfusion.


Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.

Transplanted human glial cells can differentiate within the host animal.

Articles published in open access format are less likely to be cited than traditional journals.

The risk of male prisoners harming themselves is ten times that of female prisoners.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Cell autonomous sex determination in somatic cells does not occur in Galliformes.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Vitamin D deficiency is unrelated to birth weight.

A deficiency of vitamin B12 increases blood levels of homocysteine.

Hypoglycemia increases the risk of dementia.

Women with a higher birth weight are more likely to develop breast cancer later in life.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.


Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

UCB T cells maintain high TCR diversity after transplantation.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

The locus rs647161 is associated with colorectal carcinoma.

Cells undergoing methionine restriction may activate miRNAs.

Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.

Rapamycin decreases the concentration of triacylglycerols in fruit flies.

NR5A2 is important in development of endometrial tissues.

Insulin increases risk of severe kidney failure.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

Cataract and trachoma are the primary cause of blindness in Southern Sudan.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.


Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.

Incidence of heart failure decreased by 10% in women since 1979.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Low expression of miR7a exerts a biological function in testis.

Teaching hospitals do not provide better care than non-teaching hospitals.

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

Mitochondria are uninvolved in apoptosis.

High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.

S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

GATA-3 is important for hematopoietic stem cell (HSC) function.


Input from  mental and physical health care professionals is effective at decreasing homelessness.

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

Transplanted human glial cells can differentiate within the host animal.

The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.

Only a minority of cells survive development after differentiation into stress-resistant spores.

Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.

Bone marrow cells contribute to adult macrophage compartments.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

Insulin increases risk of severe kidney failure.

The availability of safe places to study is not effective at decreasing homelessness.

The availability of safe places to study is effective at decreasing homelessness.

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

Insomnia can be effectively treated with cognitive behavioral therapy.

Patients in stable partnerships have a faster progression from HIV to AIDS.

Bariatric surgery has a positive impact on mental health.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

Obesity is determined solely by environmental factors.


Insomnia can be effectively treated with cognitive behavioral therapy.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

5% of perinatal mortality is due to low birth weight.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

N348I mutations cause resistance to zidovudine (AZT).

Vitamin D deficiency is unrelated to birth weight.

Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.

Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.

Headaches are not correlated with cognitive impairment.

Febrile seizures reduce the threshold for development of epilepsy.

Febrile seizures increase the threshold for development of epilepsy.

Exposure to fine particulate air pollution is relate to anxiety prevalence.

Hypoglycemia increases the risk of dementia.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Hypertension is frequently observed in type 1 diabetes patients.

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.


Insulin increases risk of severe kidney failure.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

The repair of Cas9-induced double strand breaks in human DNA is error-prone.

Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Occupancy of ribosomes by IncRNAs do not make functional peptides.

Women with a higher birth weight are more likely to develop breast cancer later in life.

Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.

Albendazole is used to treat lymphatic filariasis.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

High levels of copeptin decrease risk of diabetes.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

A deficiency of vitamin B12 increases blood levels of homocysteine.

The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

Incidence of heart failure decreased by 10% in women since 1979.

High cardiopulmonary fitness causes increased mortality rate.


Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

The myocardial lineage develops from cardiac progenitors of mesodermal origin.

In adult tissue, most T cells are memory T cells.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.

Leuko-reduced blood reduces infectious complications in red blood cell transfusion.

Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.

Incidence of heart failure decreased by 10% in women since 1979.

PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

Rapid phosphotransfer rates govern fidelity in two component systems

Input from  mental and physical health care professionals is effective at decreasing homelessness.

The availability of safe places to study is effective at decreasing homelessness.

The availability of safe places to study is not effective at decreasing homelessness.

Participating in six months of physical activity improves cognitive functioning.

Articles published in open access format are more likely to be cited than traditional journals.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.


Ivermectin is used to treat lymphatic filariasis.

Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Ivermectin is used to treat onchocerciasis.

Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).

Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Albendazole is used to treat lymphatic filariasis.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.


Ivermectin is used to treat onchocerciasis.

Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.

CR is associated with higher methylation age.

Bariatric surgery has a positive impact on mental health.

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.

UCB T cells maintain high TCR diversity after transplantation.

The one-child policy has been successful in lowering population growth.

High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

ADAR1 binds to Dicer to cleave pre-miRNA.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Dexamethasone decreases risk of postoperative bleeding.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Aspirin inhibits the production of PGE2.


LDL cholesterol has no involvement in the development of cardiovascular disease.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.

1/2000 in UK have abnormal PrP positivity.

The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years

Cellular aging closely links to an older appearance.

A deficiency of vitamin B12 increases blood levels of homocysteine.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

Vitamin D deficiency is unrelated to birth weight.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.


Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.

Arterioles have a larger lumen diameter than venules.

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

CR is associated with higher methylation age.

Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.

Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.

Ethanol stress decreases the expression of IBP in bacteria.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

aPKCz causes tumour enhancement by affecting glutamine metabolism.

Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.

Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.


Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

CX3CR1 on the Th2 cells promotes airway inflammation.

The DdrB protein from Deinococcus radiodurans is an alternative SSB.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.

Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

Activator-inhibitor pairs are provided dorsally by Admpchordin.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

Cataract and trachoma are the primary cause of blindness in Southern Sudan.

Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years


Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

Ribosomopathies have a low degree of cell and tissue specific pathology.

Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.

Ethanol stress decreases the expression of IBP in bacteria.

The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.

Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

PPAR-RXRs can be activated by PPAR ligands.

Low expression of miR7a exerts a biological function in testis.


Leuko-increased blood increases infectious complications in red blood cell transfusion.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.

Leuko-reduced blood reduces infectious complications in red blood cell transfusion.

Only a minority of cells survive development after differentiation into stress-resistant spores.

S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

Birth-weight is positively associated with breast cancer.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

Hematopoietic Stem Cell purification reaches purity rate of up to 50%.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Dexamethasone decreases risk of postoperative bleeding.


Leuko-reduced blood reduces infectious complications in red blood cell transfusion.

Venules have a thinner or absent smooth layer compared to arterioles.

Auditory entrainment is strengthened when people see congruent visual and auditory information.

Articles published in open access format are more likely to be cited than traditional journals.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Polymeal nutrition reduces cardiovascular mortality.

Activator-inhibitor pairs are provided dorsally by Admpchordin.

Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.

Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.


Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Macrolides have no protective effect against myocardial infarction.

Bone marrow cells contribute to adult macrophage compartments.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

ADAR1 binds to Dicer to cleave pre-miRNA.

During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Women with a higher birth weight are more likely to develop breast cancer later in life.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

Localization of PIN1 in the roots of Arabidopsis does not require VPS9a

IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

The repair of Cas9-induced double strand breaks in human DNA is error-prone.

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs


Localization of PIN1 in the roots of Arabidopsis does not require VPS9a

Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

Leuko-increased blood increases infectious complications in red blood cell transfusion.

N-terminal cleavage increases success identifying transcription start sites.

Chenodeosycholic acid treatment increases whole-body energy expenditure.

The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.

Transferred UCB T cells acquire a memory-like phenotype in recipients.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

UCB T cells reduce TCR diversity after transplantation.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

Low expression of miR7a exerts a biological function in testis.

The PPR MDA5 has two N-terminal CARD domains.

N348I mutations cause resistance to zidovudine (AZT).

Low nucleosome occupancy correlates with low methylation levels across species.


Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

Chenodeosycholic acid treatment reduces whole-body energy expenditure.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

UCB T cells maintain high TCR diversity after transplantation.

Dexamethasone decreases risk of postoperative bleeding.

Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.

ADAR1 binds to Dicer to cleave pre-miRNA.

Cells undergoing methionine restriction may activate miRNAs.

TNFAIP3 is a tumor suppressor in glioblastoma.

ALDH1 expression is associated with better breast cancer outcomes.

ALDH1 expression is associated with poorer prognosis in breast cancer.

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

The locus rs647161 is associated with colorectal carcinoma.


Low expression of miR7a exerts a biological function in testis.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

CR is associated with higher methylation age.

Auditory entrainment is strengthened when people see congruent visual and auditory information.

In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).


Low nucleosome occupancy correlates with low methylation levels across species.

The PPR MDA5 has two N-terminal CARD domains.

Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.

aPKCz causes tumour enhancement by affecting glutamine metabolism.

Glycolysis is one of the primary glycometabolic pathways in cells.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.

CR is associated with higher methylation age.

Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.

Gene expression does not vary appreciably across genetically identical cells.

N-terminal cleavage reduces success identifying transcription start sites.

A deficiency of vitamin B12 increases blood levels of homocysteine.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

N-terminal cleavage increases success identifying transcription start sites.


Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.

Tirasemtiv has no effect on fast-twitch muscle.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

Rapamycin decreases the concentration of triacylglycerols in fruit flies.

Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

1/2000 in UK have abnormal PrP positivity.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.

Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.


Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

PD-1 triggering on monocytes reduces IL-10 production by monocytes.

Cell autonomous sex determination in somatic cells occurs in Passeriformes.

Mitochondria are uninvolved in apoptosis.

Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

The PPR MDA5 has two N-terminal CARD domains.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

CX3CR1 on the Th2 cells promotes airway inflammation.

CX3CR1 on the Th2 cells suppresses airway inflammation.


Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.

NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.

1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.

CHEK2 is not associated with breast cancer.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.

Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.

CR is associated with higher methylation age.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

Bone marrow cells contribute to adult macrophage compartments.


Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.

Exposure to fine particulate air pollution is relate to anxiety prevalence.

Incidence rates of cervical cancer have decreased.

The repair of Cas9-induced double strand breaks in human DNA is error-prone.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.

Albendazole is used to treat lymphatic filariasis.

Articles published in open access format are more likely to be cited than traditional journals.

Participating in six months of physical activity improves cognitive functioning.


Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.

The extracellular domain of TMEM27 is cleaved in human beta cells.

Obesity is determined solely by environmental factors.

The availability of safe places to study is effective at decreasing homelessness.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

There is an inverse relationship between hip fractures and statin use.

IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.

Insomnia can be effectively treated with cognitive behavioral therapy.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

CX3CR1 on the Th2 cells impairs T cell survival

Arginine 90 in p150n is important for interaction with EB1.


Macrolides have no protective effect against myocardial infarction.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.

Dexamethasone decreases risk of postoperative bleeding.

Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

CR is associated with higher methylation age.

Macrolides protect against myocardial infarction.

LDL cholesterol has no involvement in the development of cardiovascular disease.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Ribosomopathies have a low degree of cell and tissue specific pathology.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.


Macrolides protect against myocardial infarction.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

Hypertension is frequently observed in type 1 diabetes patients.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.

Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).

Albendazole is used to treat lymphatic filariasis.


Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Obesity is determined solely by environmental factors.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).

Suboptimal nutrition is not predictive of chronic disease

Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

Auditory entrainment is strengthened when people see congruent visual and auditory information.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

Ethanol stress decreases the expression of IBP in bacteria.

Bone marrow cells contribute to adult macrophage compartments.

Glycolysis is one of the primary glycometabolic pathways in cells.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Cells undergoing methionine restriction may activate miRNAs.

Occupancy of ribosomes by IncRNAs do not make functional peptides.


Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

Macrolides protect against myocardial infarction.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

The amount of publicly available DNA data doubles every 10 years.

The extracellular domain of TMEM27 is cleaved in human beta cells.

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

Cell autonomous sex determination in somatic cells does not occur in Galliformes.

Insulin increases risk of severe kidney failure.

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Ribosomopathies have a low degree of cell and tissue specific pathology.

Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.


Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

aPKCz causes tumour enhancement by affecting glutamine metabolism.

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

CX3CR1 on the Th2 cells suppresses airway inflammation.

Rapamycin decreases the concentration of triacylglycerols in fruit flies.

ADAR1 binds to Dicer to cleave pre-miRNA.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.


Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

Leuko-increased blood increases infectious complications in red blood cell transfusion.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

Obesity is determined solely by environmental factors.

All hematopoietic stem cells segregate their chromosomes randomly.

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.

There is no association between HNF4A mutations and diabetes risks.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Peroxynitrite is required for nitration of TCR/CD8.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.

N348I mutations cause resistance to zidovudine (AZT).

Monoclonal antibody targeting of N-cadherin inhibits metastasis.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.


Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

Gene expression does not vary appreciably across genetically identical cells.

Cold exposure increases BAT recruitment.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

Hypoglycemia increases the risk of dementia.

During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.

Cataract and trachoma are the primary cause of blindness in Southern Sudan.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Dexamethasone decreases risk of postoperative bleeding.

Albendazole is used to treat lymphatic filariasis.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.


Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).

CHEK2 is not associated with breast cancer.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

Hypocretin neurones induce panicprone state in rats.

Insulin increases risk of severe kidney failure.

Incidence of heart failure decreased by 10% in women since 1979.

The PRR MDA5 has a central DExD/H RNA helices domain.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Only a minority of cells survive development after differentiation into stress-resistant spores.

PD-1 triggering on monocytes reduces IL-10 production by monocytes.

Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.

p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

The repair of Cas9-induced double strand breaks in human DNA is error-prone.

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

Ethanol stress decreases the expression of IBP in bacteria.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.


Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Albendazole is used to treat lymphatic filariasis.

High cardiopulmonary fitness causes increased mortality rate.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

Podocytes are motile and migrate in the presence of injury.

Insomnia can be effectively treated with cognitive behavioral therapy.

Transplanted human glial cells can differentiate within the host animal.

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Polymeal nutrition reduces cardiovascular mortality.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

IRG1 has antiviral effects against neurotropic viruses.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.


Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

Patients in stable partnerships have a faster progression from HIV to AIDS.

Cellular aging closely links to an older appearance.

Venules have a thinner or absent smooth layer compared to arterioles.

Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.

Subcutaneous fat depots undergo extensive browning processes after cold exposure.

Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

There is no association between HNF4A mutations and diabetes risks.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.


MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

Articles published in open access format are more likely to be cited than traditional journals.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.

Cell autonomous sex determination in somatic cells does not occur in Galliformes.

1/2000 in UK have abnormal PrP positivity.

Obesity is determined solely by environmental factors.

The myocardial lineage develops from cardiac progenitors of mesodermal origin.

UCB T cells maintain high TCR diversity after transplantation.

Silencing of Bcl2 is important for the maintenance and progression of tumors.

The amount of publicly available DNA data doubles every 10 years.

IRG1 has antiviral effects against neurotropic viruses.

NR5A2 is important in development of endometrial tissues.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

TNFAIP3 is a tumor suppressor in glioblastoma.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

Low expression of miR7a exerts a biological function in testis.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.


Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

Vitamin D deficiency is unrelated to birth weight.

The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.

GATA-3 is important for hematopoietic stem cell (HSC) function.

Headaches are not correlated with cognitive impairment.

Cellular aging closely links to an older appearance.

Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.

Gene expression does not vary appreciably across genetically identical cells.

In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Low nucleosome occupancy correlates with low methylation levels across species.

In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.

Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.


Mitochondria are uninvolved in apoptosis.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

CHEK2 is not associated with breast cancer.

IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.

Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.

Articles published in open access format are more likely to be cited than traditional journals.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.

Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.

Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.

Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.

Activation of PPM1D suppresses p53 function.

Glycolysis is one of the primary glycometabolic pathways in cells.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

Podocytes are motile and migrate in the presence of injury.

Cells undergoing methionine restriction may activate miRNAs.

Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.


Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

The DdrB protein from Deinococcus radiodurans is an alternative SSB.

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

Febrile seizures reduce the threshold for development of epilepsy.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.

N-terminal cleavage increases success identifying transcription start sites.

Cellular aging closely links to an older appearance.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

Headaches are not correlated with cognitive impairment.

Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.


Monoclonal antibody targeting of N-cadherin inhibits metastasis.

Women with a higher birth weight are more likely to develop breast cancer later in life.

Incidence of heart failure decreased by 10% in women since 1979.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

Gene expression does not vary appreciably across genetically identical cells.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

N348I mutations cause resistance to zidovudine (AZT).

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Dexamethasone decreases risk of postoperative bleeding.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.


Most termination events in Okazaki fragments are sequence specific.

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.

Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.

Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

Teaching hospitals do not provide better care than non-teaching hospitals.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

The repair of Cas9-induced double strand breaks in human DNA is error-prone.

N-terminal cleavage reduces success identifying transcription start sites.

Occupancy of ribosomes by IncRNAs do not make functional peptides.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

N-terminal cleavage increases success identifying transcription start sites.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.

Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.


Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

Monoclonal antibody targeting of N-cadherin inhibits metastasis.

High levels of copeptin decrease risk of diabetes.

NFAT4 activation requires IP3R-mediated Ca2+ mobilization.

Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

NR5A2 is important in development of endometrial tissues.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

Low expression of miR7a exerts a biological function in testis.

CX3CR1 on the Th2 cells impairs T cell survival

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

A deficiency of vitamin B12 increases blood levels of homocysteine.

In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

Hypertension is frequently observed in type 1 diabetes patients.

Aspirin inhibits the production of PGE2.


Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

Podocytes are motile and migrate in the presence of injury.

Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.

Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.

Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.

Rapid phosphotransfer rates govern fidelity in two component systems

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

The extracellular domain of TMEM27 is cleaved in human beta cells.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

There is no association between HNF4A mutations and diabetes risks.

Arginine 90 in p150n is important for interaction with EB1.


N-terminal cleavage increases success identifying transcription start sites.

LDL cholesterol has no involvement in the development of cardiovascular disease.

Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.

Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.

In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.

Hypertension is frequently observed in type 1 diabetes patients.

Polymeal nutrition reduces cardiovascular mortality.

Vitamin D deficiency is unrelated to birth weight.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

N-terminal cleavage reduces success identifying transcription start sites.

Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

Most termination events in Okazaki fragments are sequence specific.

Low nucleosome occupancy correlates with low methylation levels across species.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Activation of PPM1D suppresses p53 function.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

Cells undergoing methionine restriction may activate miRNAs.


N-terminal cleavage reduces success identifying transcription start sites.

1/2000 in UK have abnormal PrP positivity.

The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Cell autonomous sex determination in somatic cells does not occur in Galliformes.

CX3CR1 on the Th2 cells suppresses airway inflammation.

Cell autonomous sex determination in somatic cells occurs in Passeriformes.

CX3CR1 on the Th2 cells promotes airway inflammation.

Macrolides protect against myocardial infarction.


N348I mutations cause resistance to zidovudine (AZT).

Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.

Leuko-increased blood increases infectious complications in red blood cell transfusion.

Incidence rates of cervical cancer have decreased.

NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.

Insulin increases risk of severe kidney failure.

Activation of PPM1D suppresses p53 function.

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

The PPR MDA5 has two N-terminal CARD domains.

Monoclonal antibody targeting of N-cadherin inhibits metastasis.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

There is no association between HNF4A mutations and diabetes risks.


NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

Normal expression of RUNX1 has tumor-promoting effects.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

A deficiency of vitamin B12 increases blood levels of homocysteine.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.

NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.

TNFAIP3 is a tumor suppressor in glioblastoma.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.


NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Cellular aging closely links to an older appearance.

Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

Ethanol stress decreases the expression of IBP in bacteria.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

The extracellular domain of TMEM27 is cleaved in human beta cells.

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

Teaching hospitals do not provide better care than non-teaching hospitals.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

The ureABIEFGH gene cluster is induced by nickel (II) ion.