The PPR MDA5 has two N-terminal CARD domains.

ADAR1 binds to Dicer to cleave pre-miRNA.

CX3CR1 on the Th2 cells impairs T cell survival

Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation

The ureABIEFGH gene cluster is induced by nickel (II) ion.

Hypoglycemia increases the risk of dementia.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

Activation of PPM1D suppresses p53 function.

Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.

PPAR-RXRs can be activated by PPAR ligands.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

N348I mutations cause resistance to zidovudine (AZT).

PPAR-RXRs are inhibited by PPAR ligands.

Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.


The PRR MDA5 has a central DExD/H RNA helices domain.

Podocytes are motile and migrate in the presence of injury.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.

Bone marrow cells contribute to adult macrophage compartments.

0-dimensional biomaterials show inductive properties.

A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

The risk of male prisoners harming themselves is ten times that of female prisoners.

The PPR MDA5 has two N-terminal CARD domains.

The PRR MDA5 is a sensor of RNA virus infection.

The DdrB protein from Deinococcus radiodurans is an alternative SSB.

GATA-3 is important for hematopoietic stem cell (HSC) function.


The PRR MDA5 is a sensor of RNA virus infection.

Subcutaneous fat depots undergo extensive browning processes after cold exposure.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

ALDH1 expression is associated with better breast cancer outcomes.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

CR is associated with higher methylation age.

cSMAC formation enhances weak ligand signalling.

Suboptimal nutrition is not predictive of chronic disease

IRG1 has antiviral effects against neurotropic viruses.

Low expression of miR7a exerts a biological function in testis.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Occupancy of ribosomes by IncRNAs do not make functional peptides.

Enhanced early production of inflammatory chemokines improves viral control in the lung.


The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.

Cold exposure increases BAT recruitment.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

The locus rs647161 is associated with colorectal carcinoma.

Hypertension is frequently observed in type 1 diabetes patients.

There is an inverse relationship between hip fractures and statin use.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

Insulin increases risk of severe kidney failure.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

Incidence of heart failure decreased by 10% in women since 1979.

Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

Transplanted human glial cells can differentiate within the host animal.

Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.


The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.

Women with a higher birth weight are more likely to develop breast cancer later in life.

Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

Bariatric surgery has a positive impact on mental health.

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

Occupancy of ribosomes by IncRNAs do not make functional peptides.

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile

Anthrax spores can be disposed of easily after they are dispersed.

Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.

Localization of PIN1 in the roots of Arabidopsis does not require VPS9a


The amount of publicly available DNA data doubles every 10 years.

Activation of PPM1D suppresses p53 function.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.

Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.

Cataract and trachoma are the primary cause of blindness in Southern Sudan.

Most termination events in Okazaki fragments are sequence specific.

Podocytes are motile and migrate in the presence of injury.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Subcutaneous fat depots undergo extensive browning processes after cold exposure.

Incidence rates of cervical cancer have decreased.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.

5% of perinatal mortality is due to low birth weight.

Low nucleosome occupancy correlates with low methylation levels across species.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.

Birth-weight is positively associated with breast cancer.

Articles published in open access format are more likely to be cited than traditional journals.

Vitamin D deficiency is unrelated to birth weight.

Articles published in open access format are less likely to be cited than traditional journals.


The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

Birth-weight is positively associated with breast cancer.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.

In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.

Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.

IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.

CX3CR1 on the Th2 cells promotes T cell survival

NFAT4 activation requires IP3R-mediated Ca2+ mobilization.

Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

Occupancy of ribosomes by IncRNAs do not make functional peptides.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.


The availability of safe places to study is effective at decreasing homelessness.

Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).

Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

The DdrB protein from Deinococcus radiodurans is an alternative SSB.

Albendazole is used to treat lymphatic filariasis.

Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.

Breast cancer development is determined exclusively by genetic factors.

The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.

The availability of safe places to study is not effective at decreasing homelessness.

Input from  mental and physical health care professionals is effective at decreasing homelessness.

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

Insomnia can be effectively treated with cognitive behavioral therapy.

Obesity is determined solely by environmental factors.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

Patients in stable partnerships have a faster progression from HIV to AIDS.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.


The availability of safe places to study is not effective at decreasing homelessness.

Incidence rates of cervical cancer have decreased.

Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

1/2000 in UK have abnormal PrP positivity.

NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.

Teaching hospitals do not provide better care than non-teaching hospitals.

PPAR-RXRs can be activated by PPAR ligands.

Transplanted human glial cells can differentiate within the host animal.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

The one-child policy has been successful in lowering population growth.


The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

Polymeal nutrition reduces cardiovascular mortality.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.

Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.

Arginine 90 in p150n is important for interaction with EB1.

Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.

Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Dexamethasone decreases risk of postoperative bleeding.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.


The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.

Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).

Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.

Activation of PPM1D suppresses p53 function.

Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.

Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

Headaches are not correlated with cognitive impairment.

Cell autonomous sex determination in somatic cells occurs in Passeriformes.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.

PPAR-RXRs can be activated by PPAR ligands.

The PPR MDA5 has two N-terminal CARD domains.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

PPAR-RXRs are inhibited by PPAR ligands.

The PRR MDA5 has a central DExD/H RNA helices domain.


The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.

Monoclonal antibody targeting of N-cadherin inhibits metastasis.

Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

0-dimensional biomaterials show inductive properties.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

PPAR-RXRs can be activated by PPAR ligands.

Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.

Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

Only a minority of cells survive development after differentiation into stress-resistant spores.

Podocytes are motile and migrate in the presence of injury.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.


The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.

Bariatric surgery has a positive impact on mental health.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

Febrile seizures increase the threshold for development of epilepsy.

CX3CR1 on the Th2 cells suppresses airway inflammation.

The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.

The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile

Activation of PPM1D suppresses p53 function.

The extracellular domain of TMEM27 is cleaved in human beta cells.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

NR5A2 is important in development of endometrial tissues.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.

Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.

CHEK2 is not associated with breast cancer.


The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.

Subcutaneous fat depots undergo extensive browning processes after cold exposure.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

All hematopoietic stem cells segregate their chromosomes randomly.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.

High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

Hypocretin neurones induce panicprone state in rats.

Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.

5% of perinatal mortality is due to low birth weight.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

Arginine 90 in p150n is important for interaction with EB1.

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.


The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis

Bone marrow cells contribute to adult macrophage compartments.

The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Vitamin D deficiency is unrelated to birth weight.

Transferred UCB T cells acquire a memory-like phenotype in recipients.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

PD-1 triggering on monocytes reduces IL-10 production by monocytes.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.

Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.

Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.


The extracellular domain of TMEM27 is cleaved in human beta cells.

Anthrax spores can be disposed of easily after they are dispersed.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

Only a minority of cells survive development after differentiation into stress-resistant spores.

UCB T cells maintain high TCR diversity after transplantation.

Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.

Glycolysis is one of the primary glycometabolic pathways in cells.

Dexamethasone decreases risk of postoperative bleeding.

Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

There is an inverse relationship between hip fractures and statin use.

TNFAIP3 is a tumor suppressor in glioblastoma.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

CHEK2 is not associated with breast cancer.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

Low expression of miR7a exerts a biological function in testis.

CX3CR1 on the Th2 cells promotes T cell survival


The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

Bariatric surgery has a positive impact on mental health.

PD-1 triggering on monocytes reduces IL-10 production by monocytes.

Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.

Subcutaneous fat depots undergo extensive browning processes after cold exposure.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

Localization of PIN1 in the roots of Arabidopsis does not require VPS9a

There is no association between HNF4A mutations and diabetes risks.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

Silencing of Bcl2 is important for the maintenance and progression of tumors.

Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.


The locus rs647161 is associated with colorectal carcinoma.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.

During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

Rapamycin decreases the concentration of triacylglycerols in fruit flies.

5% of perinatal mortality is due to low birth weight.

Silencing of Bcl2 is important for the maintenance and progression of tumors.

TNFAIP3 is a tumor suppressor in glioblastoma.

ALDH1 expression is associated with poorer prognosis in breast cancer.

ALDH1 expression is associated with better breast cancer outcomes.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

NR5A2 is important in development of endometrial tissues.

N348I mutations cause resistance to zidovudine (AZT).

The PPR MDA5 has two N-terminal CARD domains.

ADAR1 binds to Dicer to cleave pre-miRNA.


The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.

Bone marrow cells contribute to adult macrophage compartments.

High cardiopulmonary fitness causes increased mortality rate.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.

IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.

Insulin increases risk of severe kidney failure.

Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Normal expression of RUNX1 has tumor-promoting effects.

PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.


The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.

The extracellular domain of TMEM27 is cleaved in human beta cells.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

Auditory entrainment is strengthened when people see congruent visual and auditory information.

Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Silencing of Bcl2 is important for the maintenance and progression of tumors.

Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

There is no association between HNF4A mutations and diabetes risks.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

TNFAIP3 is a tumor suppressor in glioblastoma.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.


The myocardial lineage develops from cardiac progenitors of mesodermal origin.

During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.

Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.

Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

The repair of Cas9-induced double strand breaks in human DNA is error-prone.

Arterioles have a larger lumen diameter than venules.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Bone marrow cells contribute to adult macrophage compartments.

All hematopoietic stem cells segregate their chromosomes randomly.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

Macrolides have no protective effect against myocardial infarction.

Macrolides protect against myocardial infarction.

GATA-3 is important for hematopoietic stem cell (HSC) function.


The one-child policy has been successful in lowering population growth.

CX3CR1 on the Th2 cells promotes airway inflammation.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

Bariatric surgery has a positive impact on mental health.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Transplanted human glial cells can differentiate within the host animal.

5% of perinatal mortality is due to low birth weight.

The availability of safe places to study is not effective at decreasing homelessness.

The availability of safe places to study is effective at decreasing homelessness.

Birth-weight is positively associated with breast cancer.

The amount of publicly available DNA data doubles every 10 years.

Women with a higher birth weight are more likely to develop breast cancer later in life.

Incidence rates of cervical cancer have decreased.

Patients in stable partnerships have a faster progression from HIV to AIDS.

Vitamin D deficiency is unrelated to birth weight.


The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Podocytes are motile and migrate in the presence of injury.

Glycolysis is one of the primary glycometabolic pathways in cells.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

Hypertension is frequently observed in type 1 diabetes patients.

High cardiopulmonary fitness causes increased mortality rate.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

Breast cancer development is determined exclusively by genetic factors.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Monoclonal antibody targeting of N-cadherin inhibits metastasis.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.


The repair of Cas9-induced double strand breaks in human DNA is error-prone.

Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.

Only a minority of cells survive development after differentiation into stress-resistant spores.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Anthrax spores can be disposed of easily after they are dispersed.

Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

Most termination events in Okazaki fragments are sequence specific.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

Low nucleosome occupancy correlates with low methylation levels across species.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

N348I mutations cause resistance to zidovudine (AZT).


The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

Gene expression does not vary appreciably across genetically identical cells.

aPKCz causes tumour enhancement by affecting glutamine metabolism.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.

1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.

Transplanted human glial cells can differentiate within the host animal.

Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.

Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.

Hypertension is frequently observed in type 1 diabetes patients.

Women with a higher birth weight are more likely to develop breast cancer later in life.

Birth-weight is positively associated with breast cancer.

Breast cancer development is determined exclusively by genetic factors.

Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.

Incidence rates of cervical cancer have decreased.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

5% of perinatal mortality is due to low birth weight.


The risk of male prisoners harming themselves is ten times that of female prisoners.

NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.

High cardiopulmonary fitness causes increased mortality rate.

The PRR MDA5 has a central DExD/H RNA helices domain.

Venules have a larger lumen diameter than arterioles.

Articles published in open access format are more likely to be cited than traditional journals.

Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

The availability of safe places to study is not effective at decreasing homelessness.

The availability of safe places to study is effective at decreasing homelessness.

Input from  mental and physical health care professionals is effective at decreasing homelessness.

Incidence of heart failure decreased by 10% in women since 1979.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years

Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.


The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

The locus rs647161 is associated with colorectal carcinoma.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.

The myocardial lineage develops from cardiac progenitors of mesodermal origin.

The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.

The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

Silencing of Bcl2 is important for the maintenance and progression of tumors.

Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.

A deficiency of vitamin B12 increases blood levels of homocysteine.


The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.

The extracellular domain of TMEM27 is cleaved in human beta cells.

Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.

PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.

Articles published in open access format are less likely to be cited than traditional journals.

Activator-inhibitor pairs are provided dorsally by Admpchordin.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

Only a minority of cells survive development after differentiation into stress-resistant spores.

During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.

The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

IRG1 has antiviral effects against neurotropic viruses.

PD-1 triggering on monocytes reduces IL-10 production by monocytes.

Hypocretin neurones induce panicprone state in rats.

Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.

Transferred UCB T cells acquire a memory-like phenotype in recipients.


The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.

Arterioles have a larger lumen diameter than venules.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

ALDH1 expression is associated with better breast cancer outcomes.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Activator-inhibitor pairs are provided dorsally by Admpchordin.

Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation


The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.

TNFAIP3 is a tumor suppressor in glioblastoma.

ADAR1 binds to Dicer to cleave pre-miRNA.

Peroxynitrite is required for nitration of TCR/CD8.

Headaches are not correlated with cognitive impairment.

CX3CR1 on the Th2 cells promotes airway inflammation.

Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.

All hematopoietic stem cells segregate their chromosomes randomly.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

The PRR MDA5 has a central DExD/H RNA helices domain.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.


The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.

Arterioles have a larger lumen diameter than venules.

Anthrax spores can be disposed of easily after they are dispersed.

Patients in stable partnerships have a faster progression from HIV to AIDS.

Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.

Cell autonomous sex determination in somatic cells occurs in Passeriformes.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

IRG1 has antiviral effects against neurotropic viruses.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.


The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.

Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.

The extracellular domain of TMEM27 is cleaved in human beta cells.

Venules have a larger lumen diameter than arterioles.

Ethanol stress decreases the expression of IBP in bacteria.

TNFAIP3 is a tumor suppressor in glioblastoma.

Mitochondria are uninvolved in apoptosis.

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.

Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.


The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

Occupancy of ribosomes by IncRNAs do not make functional peptides.

Insomnia can be effectively treated with cognitive behavioral therapy.

Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.

Vitamin D deficiency is unrelated to birth weight.

Cellular aging closely links to an older appearance.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.

The PPR MDA5 has two N-terminal CARD domains.

DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.

Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.


The ureABIEFGH gene cluster is induced by nickel (II) ion.

Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.

NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.

Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.

The availability of safe places to study is effective at decreasing homelessness.

The PRR MDA5 has a central DExD/H RNA helices domain.

PPAR-RXRs are inhibited by PPAR ligands.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Arginine 90 in p150n is important for interaction with EB1.

The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.

NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

N348I mutations cause resistance to zidovudine (AZT).


Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.

cSMAC formation enhances weak ligand signalling.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

Activator-inhibitor pairs are provided dorsally by Admpchordin.

A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.

All hematopoietic stem cells segregate their chromosomes randomly.

The PRR MDA5 is a sensor of RNA virus infection.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

Albendazole is used to treat lymphatic filariasis.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Ivermectin is used to treat lymphatic filariasis.


There is an inverse relationship between hip fractures and statin use.

Hematopoietic Stem Cell purification reaches purity rate of up to 50%.

New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.

CX3CR1 on the Th2 cells impairs T cell survival

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

In adult tissue, most T cells are memory T cells.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.

0-dimensional biomaterials show inductive properties.

The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Bariatric surgery has a positive impact on mental health.

Headaches are not correlated with cognitive impairment.

In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.

Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.

High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

Dexamethasone decreases risk of postoperative bleeding.


There is no association between HNF4A mutations and diabetes risks.

Incidence rates of cervical cancer have decreased.

Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

aPKCz causes tumour enhancement by affecting glutamine metabolism.

N-terminal cleavage increases success identifying transcription start sites.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

Monoclonal antibody targeting of N-cadherin inhibits metastasis.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.

Tirasemtiv has no effect on fast-twitch muscle.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years

A deficiency of vitamin B12 increases blood levels of homocysteine.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.

Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Hypertension is frequently observed in type 1 diabetes patients.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.

Vitamin D deficiency is unrelated to birth weight.

Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.


Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.

Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.

Febrile seizures reduce the threshold for development of epilepsy.

Articles published in open access format are more likely to be cited than traditional journals.

Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.

Normal expression of RUNX1 has tumor-promoting effects.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia

Peroxynitrite is required for nitration of TCR/CD8.

Headaches are not correlated with cognitive impairment.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.

Bariatric surgery has a positive impact on mental health.

Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).

There is an inverse relationship between hip fractures and statin use.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.


Tirasemtiv has no effect on fast-twitch muscle.

Peroxynitrite is required for nitration of TCR/CD8.

NFAT4 activation requires IP3R-mediated Ca2+ mobilization.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.

Hypertension is frequently observed in type 1 diabetes patients.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Auditory entrainment is strengthened when people see congruent visual and auditory information.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

The risk of male prisoners harming themselves is ten times that of female prisoners.

Macrolides have no protective effect against myocardial infarction.

Participating in six months of physical activity improves cognitive functioning.

High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

IRG1 has antiviral effects against neurotropic viruses.

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

Activation of PPM1D suppresses p53 function.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.


Transferred UCB T cells acquire a memory-like phenotype in recipients.

Ivermectin is used to treat lymphatic filariasis.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

Only a minority of cells survive development after differentiation into stress-resistant spores.

Ethanol stress decreases the expression of IBP in bacteria.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.

cSMAC formation enhances weak ligand signalling.

UCB T cells maintain high TCR diversity after transplantation.

UCB T cells reduce TCR diversity after transplantation.

In adult tissue, most T cells are memory T cells.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.

The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.


Transplanted human glial cells can differentiate within the host animal.

Input from  mental and physical health care professionals is effective at decreasing homelessness.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.

The extracellular domain of TMEM27 is cleaved in human beta cells.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

Bone marrow cells contribute to adult macrophage compartments.

Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

Gene expression does not vary appreciably across genetically identical cells.

Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.

The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.


Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.

Only a minority of cells survive development after differentiation into stress-resistant spores.

Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile

Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

Vitamin D deficiency is unrelated to birth weight.

The center of the granuloma in an immune cell induces a pro-inflammatory immune response.

CX3CR1 on the Th2 cells impairs T cell survival

Podocytes are motile and migrate in the presence of injury.

Chenodeosycholic acid treatment increases whole-body energy expenditure.

Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.

Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.


Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

Activation of PPM1D suppresses p53 function.

Articles published in open access format are less likely to be cited than traditional journals.

Vitamin D deficiency effects the term of delivery.

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.

Leuko-increased blood increases infectious complications in red blood cell transfusion.

Transplanted human glial cells can differentiate within the host animal.

The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.

Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

TNFAIP3 is a tumor suppressor in glioblastoma.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.


UCB T cells maintain high TCR diversity after transplantation.

Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.

Exposure to fine particulate air pollution is relate to anxiety prevalence.

Aspirin inhibits the production of PGE2.

Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.

De novo assembly of sequence data has more specific contigs than unassembled sequence data.

UCB T cells reduce TCR diversity after transplantation.

Transferred UCB T cells acquire a memory-like phenotype in recipients.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

CX3CR1 on the Th2 cells promotes T cell survival

In adult tissue, most T cells are memory T cells.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

CX3CR1 on the Th2 cells impairs T cell survival


UCB T cells reduce TCR diversity after transplantation.

Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.

Articles published in open access format are less likely to be cited than traditional journals.

Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile

Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.

IRG1 has antiviral effects against neurotropic viruses.

NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.

Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.

IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.

N-terminal cleavage increases success identifying transcription start sites.

All hematopoietic stem cells segregate their chromosomes randomly.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.


Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.

Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).

Hematopoietic Stem Cell purification reaches purity rate of up to 50%.

Dexamethasone decreases risk of postoperative bleeding.

The one-child policy has been successful in lowering population growth.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.

CX3CR1 on the Th2 cells promotes airway inflammation.

Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.

The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.

N348I mutations cause resistance to zidovudine (AZT).

Arginine 90 in p150n is important for interaction with EB1.

Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

The extracellular domain of TMEM27 is cleaved in human beta cells.

The ureABIEFGH gene cluster is induced by nickel (II) ion.

Localization of PIN1 in the roots of Arabidopsis does not require VPS9a

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs


Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.

Macrolides protect against myocardial infarction.

Auditory entrainment is strengthened when people see congruent visual and auditory information.

NR5A2 is important in development of endometrial tissues.

Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.

Leuko-reduced blood reduces infectious complications in red blood cell transfusion.

Articles published in open access format are more likely to be cited than traditional journals.

PD-1 triggering on monocytes reduces IL-10 production by monocytes.

Ethanol stress decreases the expression of IBP in bacteria.

Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.

Cells undergoing methionine restriction may activate miRNAs.

Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.

CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

There is an inverse relationship between hip fractures and statin use.

Bariatric surgery has a positive impact on mental health.

Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.


Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.

LDL cholesterol has no involvement in the development of cardiovascular disease.

Silencing of Bcl2 is important for the maintenance and progression of tumors.

Participating in six months of physical activity improves cognitive functioning.

1/2000 in UK have abnormal PrP positivity.

Occupancy of ribosomes by IncRNAs do not make functional peptides.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Cold exposure increases BAT recruitment.

FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).

Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.

Activation of PPM1D suppresses p53 function.

Breast cancer development is determined exclusively by genetic factors.

Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.

Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

Normal expression of RUNX1 has tumor-promoting effects.

The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.


Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

Insomnia can be effectively treated with cognitive behavioral therapy.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

N-terminal cleavage reduces success identifying transcription start sites.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.

The risk of male prisoners harming themselves is ten times that of female prisoners.

Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.

Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.

Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia


Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.

Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

Leuko-increased blood increases infectious complications in red blood cell transfusion.

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Gene expression does not vary appreciably across genetically identical cells.

Enhanced early production of inflammatory chemokines improves viral control in the lung.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.

Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.

Dexamethasone decreases risk of postoperative bleeding.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.


Venules have a larger lumen diameter than arterioles.

Macrolides have no protective effect against myocardial infarction.

PPAR-RXRs are inhibited by PPAR ligands.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.

N348I mutations cause resistance to zidovudine (AZT).

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).

Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Arterioles have a larger lumen diameter than venules.

Venules have a thinner or absent smooth layer compared to arterioles.

Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.

Podocytes are motile and migrate in the presence of injury.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.

Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.

The PRR MDA5 has a central DExD/H RNA helices domain.

Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.


Venules have a thinner or absent smooth layer compared to arterioles.

CX3CR1 on the Th2 cells impairs T cell survival

Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs

Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.

Ivermectin is used to treat onchocerciasis.

Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Cell autonomous sex determination in somatic cells occurs in Passeriformes.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

The genomic aberrations found in matasteses are very similar to those found in the primary tumor.

Ribosomopathies have a low degree of cell and tissue specific pathology.


Vitamin D deficiency effects the term of delivery.

Pyridostatin destabilizes the G - quadruplex in the telomeric region.

Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.

Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation

Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.

The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.

Cells undergoing methionine restriction may activate miRNAs.

Febrile seizures increase the threshold for development of epilepsy.

Macrolides protect against myocardial infarction.

Vitamin D deficiency is unrelated to birth weight.

A deficiency of vitamin B12 increases blood levels of homocysteine.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.

Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.

Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.

Dexamethasone decreases risk of postoperative bleeding.

High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.

Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype.

LDL cholesterol has no involvement in the development of cardiovascular disease.


Vitamin D deficiency is unrelated to birth weight.

Hypertension is frequently observed in type 1 diabetes patients.

Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.

ADAR1 binds to Dicer to cleave pre-miRNA.

Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.

Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance

In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.

Birth-weight is positively associated with breast cancer.

T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation.

Articles published in open access format are less likely to be cited than traditional journals.

5% of perinatal mortality is due to low birth weight.

Obesity is determined solely by environmental factors.

HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years


Women with a higher birth weight are more likely to develop breast cancer later in life.

The myocardial lineage develops from cardiac progenitors of mesodermal origin.

Peroxynitrite is required for nitration of TCR/CD8.

The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.

Ethanol stress decreases the expression of IBP in bacteria.

Subcutaneous fat depots undergo extensive browning processes after cold exposure.

Hypocretin neurones induce panicprone state in rats.

Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation

Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.

The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.

Breast cancer development is determined exclusively by genetic factors.

Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.

Incidence rates of cervical cancer have decreased.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.

Incidence of heart failure decreased by 10% in women since 1979.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.


aPKCz causes tumour enhancement by affecting glutamine metabolism.

N-terminal cleavage increases success identifying transcription start sites.

Activation of PPM1D suppresses p53 function.

ALDH1 expression is associated with poorer prognosis in breast cancer.

The locus rs647161 is associated with colorectal carcinoma.

Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

Low expression of miR7a does represses target genes and exerts a biological function in ovaries.

Headaches are not correlated with cognitive impairment.

N-terminal cleavage reduces success identifying transcription start sites.

Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.

Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).

ALDH1 expression is associated with better breast cancer outcomes.

mTORC2 regulates intracellular cysteine levels through xCT inhibition.

Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.

Hypothalamic glutamate neurotransmission is crucial to energy balance.

TNFAIP3 is a tumor suppressor in glioblastoma.

CHEK2 is not associated with breast cancer.


cSMAC formation enhances weak ligand signalling.

Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.

A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.

The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.

Localization of PIN1 in the Arabidopsis embryo does not require VPS9a

Glycolysis is one of the primary glycometabolic pathways in cells.

Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.

Normal expression of RUNX1 has tumor-promoting effects.

There is an inverse relationship between hip fractures and statin use.

GATA-3 is important for hematopoietic stem cell (HSC) function.

There is no association between HNF4A mutations and diabetes risks.

In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.

TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.

Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.

Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.

Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA.


mTORC2 regulates intracellular cysteine levels through xCT inhibition.

Suboptimal nutrition is not predictive of chronic disease

Albendazole is used to treat lymphatic filariasis.

Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.

Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.

CX3CR1 on the Th2 cells promotes T cell survival

Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Aspirin inhibits the production of PGE2.

Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.

ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

A deficiency of vitamin B12 increases blood levels of homocysteine.

Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.

NFAT4 activation requires IP3R-mediated Ca2+ mobilization.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.

CX3CR1 on the Th2 cells impairs T cell survival

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.