protocolSection identificationModule nctId: NCT06389825, orgStudyIdInfo id: FH-Diet-RX, briefTitle: Unravelling the Impact of Diet on Cardiovascular Health in Treated Heterozygous Familial Hypercholesterolemia., statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2024-06-30, completionDateStruct date: 2024-06-30, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: Laval University, class: OTHER, descriptionModule briefSummary: The investigators will conduct a fully controlled dietary randomized crossover trial (RCT) including 10 adults with HeFH using lipid-lowering medication to investigate the impact of a diet low in red and processed meats and high in plant foods, reflecting Canada's Food Guide, in place of a standard North-American diet on LDL-cholesterol (LDL-C) levels and the plasma metabolome., conditionsModule conditions: Familial Hypercholesterolemia, conditions: Nutrition, Healthy, conditions: Cholesterol, Elevated, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: Healthy diet, outcomesModule primaryOutcomes measure: Post-diet differences in LDL-C levels., secondaryOutcomes measure: Post-diet differences in plasma metabolomics profiles, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: INAF-NUTRISS Université Laval, status: RECRUITING, city: Québec, zip: G1V0a6, country: Canada, contacts name: Valérie Guay, role: CONTACT, phone: 418-656-2131, email: valerie.guay@fsaa.ulaval.ca, geoPoint lat: 46.81228, lon: -71.21454, hasResults: False