Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts
S. Burel, Christopher E. Hart, Patrick Cauntay, Jill Hsiao, T. Machemer, Melanie Katz, A. Watt, H. Bui, Husam S. Younis, M. Sabripour, S. Freier, G. Hung, Amy Dan, T. Prakash, P. Seth, E. Swayze, C. Bennett, S. Crooke, S. Henry
Nucleic Acids Research